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1.发明授权Nucleotide and amino acid sequences encoding an exported protein 1 derived from Plasmodium vivax and uses thereof 有权编码来自间日疟原虫的出口蛋白质1的核苷酸和氨基酸序列及其用途公开(公告)号：US08318897B2
公开(公告)日：2012-11-27
申请号：US13219802
申请日：2011-08-29
申请人： Larry G. Birkenmeyer , Ruthie E. Coffey , George J. Dawson , Suresh M. Desai , Bruce J. Dille , Anthony Scott Muerhoff
发明人： Larry G. Birkenmeyer , Ruthie E. Coffey , George J. Dawson , Suresh M. Desai , Bruce J. Dille , Anthony Scott Muerhoff
IPC分类号： G01N33/531 , C07K14/445 , A61K39/002
CPC分类号： C07K14/445 , A61K39/00 , G01N33/56905 , G01N2333/445 , Y02A50/412
摘要： The present invention is directed to novel polynucleotides and polypeptides directed to EXP1 of Plasmodium vivax, and methods of using these polynucleotides and polypeptides in the detection of P. vivax antibodies or anti-P. vivax antibodies in a subject. The invention finds particular useful application in identifying recent exposure to P. vivax.
摘要翻译： 本发明涉及针对间日疟原虫的EXP1的新型多核苷酸和多肽，以及在检测间日疟原虫抗体或抗-P中使用这些多核苷酸和多肽的方法。 受试者中的间日疟原虫抗体。 本发明在识别最近暴露于间日疟原虫方面特别有用。
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2.发明申请NUCLEOTIDE AND AMINO ACID SEQUENCES ENCODING AN EXPORTED PROTEIN 1 DERIVED FROM PLASMODIUM VIVAX AND USES THEREOF 有权编码从PLASMODIUM VIVAX衍生的出口蛋白质1的核苷酸和氨基酸序列及其用途公开(公告)号：US20110311572A1
公开(公告)日：2011-12-22
申请号：US13219802
申请日：2011-08-29
申请人： Larry G. Birkenmeyer , Ruthie E. Coffey , George J. Dawson , Suresh M. Desai , Bruce J. Dille , Anthony S. Muerhoff
发明人： Larry G. Birkenmeyer , Ruthie E. Coffey , George J. Dawson , Suresh M. Desai , Bruce J. Dille , Anthony S. Muerhoff
IPC分类号： A61K39/015 , G01N33/566 , A61P33/02 , C07K14/00 , A61P37/04
CPC分类号： C07K14/445 , A61K39/00 , G01N33/56905 , G01N2333/445 , Y02A50/412
摘要： The present invention is directed to novel polynucleotides and polypeptides directed to EXP1 of Plasmodium vivax, and methods of using these polynucleotides and polypeptides in the detection of P. vivax antibodies or anti-P. vivax antibodies in a subject. The invention finds particular useful application in identifying recent exposure to P. vivax.
摘要翻译： 本发明涉及针对间日疟原虫的EXP1的新型多核苷酸和多肽，以及在检测间日疟原虫抗体或抗-P中使用这些多核苷酸和多肽的方法。 受试者中的间日疟原虫抗体。 本发明在识别最近暴露于间日疟原虫方面特别有用。
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3.发明授权Nucleotide and amino acid sequences encoding an exported protein 1 derived from Plasmodium vivax and uses thereof 有权编码来自间日疟原虫的出口蛋白质1的核苷酸和氨基酸序列及其用途公开(公告)号：US08063193B2
公开(公告)日：2011-11-22
申请号：US12412529
申请日：2009-03-27
申请人： Larry G. Birkenmeyer , Ruthie E. Coffey , George J. Dawson , Suresh M. Desai , Bruce J. Dille , Anthony S. Muerhoff
发明人： Larry G. Birkenmeyer , Ruthie E. Coffey , George J. Dawson , Suresh M. Desai , Bruce J. Dille , Anthony S. Muerhoff
IPC分类号： C07H23/00
CPC分类号： C07K14/445 , A61K39/00 , G01N33/56905 , G01N2333/445 , Y02A50/412
摘要： The present invention is directed to novel polynucleotides and polypeptides directed to EXP1 of Plasmodium vivax, and methods of using these polynucleotides and polypeptides in the detection of P. vivax antibodies or anti-P. vivax antibodies in a subject. The invention finds particular useful application in identifying recent exposure to P. vivax.
摘要翻译： 本发明涉及针对间日疟原虫的EXP1的新型多核苷酸和多肽，以及在检测间日疟原虫抗体或抗-P中使用这些多核苷酸和多肽的方法。 受试者中的间日疟原虫抗体。 本发明在识别最近暴露于间日疟原虫方面特别有用。
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4.发明申请NUCLEOTIDE AND AMINO ACID SEQUENCES ENCODING AN EXPORTED PROTEIN 1 DERIVED FROM PLASMODIUM VIVAX AND USES THEREOF 有权编码从PLASMODIUM VIVAX衍生的出口蛋白质1的核苷酸和氨基酸序列及其用途公开(公告)号：US20100247576A1
公开(公告)日：2010-09-30
申请号：US12412529
申请日：2009-03-27
申请人： Larry G. Birkenmeyer , Ruthie E. Coffey , George J. Dawson , Suresh M. Desai , Bruce J. Dille , Anthony S. Muerhoff
发明人： Larry G. Birkenmeyer , Ruthie E. Coffey , George J. Dawson , Suresh M. Desai , Bruce J. Dille , Anthony S. Muerhoff
IPC分类号： A61K39/002 , C07H21/04 , C07K14/445 , C12P21/02 , C12N15/63 , C12N1/00 , G01N33/53 , A61P33/02
CPC分类号： C07K14/445 , A61K39/00 , G01N33/56905 , G01N2333/445 , Y02A50/412
摘要： The present invention is directed to novel polynucleotides and polypeptides directed to EXP1 of Plasmodium vivax, and methods of using these polynucleotides and polypeptides in the detection of P. vivax antibodies or anti-P. vivax antibodies in a subject. The invention finds particular useful application in identifying recent exposure to P. vivax.
摘要翻译： 本发明涉及针对间日疟原虫的EXP1的新型多核苷酸和多肽，以及在检测间日疟原虫抗体或抗-P中使用这些多核苷酸和多肽的方法。 受试者中的间日疟原虫抗体。 本发明在识别最近暴露于间日疟原虫方面特别有用。
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公开(公告)号：US08030471B2
公开(公告)日：2011-10-04
申请号：US12143137
申请日：2008-06-20
申请人： Larry G. Birkenmeyer , Anthony S. Muerhoff , Suresh M. Desai , George J. Dawson , Bruce J. Dille
发明人： Larry G. Birkenmeyer , Anthony S. Muerhoff , Suresh M. Desai , George J. Dawson , Bruce J. Dille
IPC分类号： C07H21/04 , C07H19/00 , A01N25/26 , A01N25/28 , A61K39/015 , A61K39/00 , A61K45/00 , A61K39/40 , A61B5/055 , C12P1/00 , C12P21/06 , G01N33/53 , C12N15/09 , C12N1/10 , C12M1/34 , C12M3/00 , C07K1/00
CPC分类号： C07K14/445 , A61K39/00 , A61K2039/505 , G01N33/6893 , G01N2469/20 , G01N2800/26 , Y02A50/412
摘要： The subject invention relates to nucleic acid sequences and amino acid sequences encoded thereby, derived from the Merozoite Surface Protein (MSP1) gene of the Plasmodium species P. malariae and P. ovale. Such genes and proteins have many beneficial diagnostic as well as therapeutic uses.
摘要翻译： 本发明涉及源自疟原虫种类疟原虫和卵白念珠菌的裂殖子表面蛋白（MSP1）基因的由其编码的核酸序列和氨基酸序列。 这些基因和蛋白质具有许多有益的诊断和治疗用途。
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公开(公告)号：US20090232797A1
公开(公告)日：2009-09-17
申请号：US12397558
申请日：2009-03-04
申请人： Larry G. Birkenmeyer , Anthony S. Muerhoff , Suresh M. Desai , George J. Dawson , Bruce J. Dille
发明人： Larry G. Birkenmeyer , Anthony S. Muerhoff , Suresh M. Desai , George J. Dawson , Bruce J. Dille
IPC分类号： A61K39/395 , C07H21/00 , C07H21/04 , C07K14/445 , C12P21/02 , C12N15/63 , C12N5/10 , G01N33/536 , A61K39/015
CPC分类号： C07K14/445 , A61K39/00 , G01N33/56905 , G01N2333/445 , G01N2469/20 , Y02A50/412
摘要： The subject invention relates to nucleic acid sequences and amino acid sequences encoded thereby, derived from the Merozoite Surface Protein (MSP1) gene of the Plasmodium species P. malariae and P. ovale. Such genes and proteins have many beneficial diagnostic as well as therapeutic uses.
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公开(公告)号：US20090226445A1
公开(公告)日：2009-09-10
申请号：US12143137
申请日：2008-06-20
申请人： Larry G. Birkenmeyer , Anthony S. Muerhoff , Suresh M. Desai , George J. Dawson , Bruce J. Dille
发明人： Larry G. Birkenmeyer , Anthony S. Muerhoff , Suresh M. Desai , George J. Dawson , Bruce J. Dille
IPC分类号： A61K39/395 , C07H21/00 , C07K14/00 , C12P21/00 , C12N15/63 , A61P37/04 , A61P33/02 , C12N5/00 , C12N1/00 , G01N33/53 , A61K39/015
CPC分类号： C07K14/445 , A61K39/00 , A61K2039/505 , G01N33/6893 , G01N2469/20 , G01N2800/26 , Y02A50/412
摘要： The subject invention relates to nucleic acid sequences and amino acid sequences encoded thereby, derived from the Merozoite Surface Protein (MSP1) gene of the Plasmodium species P. malariae and P. ovale. Such genes and proteins have many beneficial diagnostic as well as therapeutic uses.
摘要翻译： 本发明涉及源自疟原虫种类疟原虫和卵白念珠菌的裂殖子表面蛋白（MSP1）基因的由其编码的核酸序列和氨基酸序列。 这些基因和蛋白质具有许多有益的诊断和治疗用途。
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公开(公告)号：US08268981B2
公开(公告)日：2012-09-18
申请号：US12397558
申请日：2009-03-04
申请人： Larry G. Birkenmeyer , Anthony S. Muerhoff , Suresh M. Desai , George J. Dawson , Bruce J. Dille
发明人： Larry G. Birkenmeyer , Anthony S. Muerhoff , Suresh M. Desai , George J. Dawson , Bruce J. Dille
IPC分类号： C07H21/04 , C07H19/00 , C07H21/02 , A61K39/015 , A61K45/00
CPC分类号： C07K14/445 , A61K39/00 , G01N33/56905 , G01N2333/445 , G01N2469/20 , Y02A50/412
摘要： The subject invention relates to nucleic acid sequences and amino acid sequences encoded thereby, derived from the Merozoite Surface Protein (MSP1) gene of the Plasmodium species P. malariae and P. ovale. Such genes and proteins have many beneficial diagnostic as well as therapeutic uses.
摘要翻译： 本发明涉及源自疟原虫种类疟原虫和卵白念珠菌的裂殖子表面蛋白（MSP1）基因的由其编码的核酸序列和氨基酸序列。 这些基因和蛋白质具有许多有益的诊断和治疗用途。
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9.发明授权
公开(公告)号：US5427930A
公开(公告)日：1995-06-27
申请号：US722798
申请日：1991-06-28
申请人： Larry G. Birkenmeyer , John J. Carrino , Bruce J. Dille , Hsiang-Yun Hu , Jon D. Kratochvil , Thomas G. Laffler , Ronald L. Marshall , Laurie A. Rinehardt , Natalie A. Solomon
发明人： Larry G. Birkenmeyer , John J. Carrino , Bruce J. Dille , Hsiang-Yun Hu , Jon D. Kratochvil , Thomas G. Laffler , Ronald L. Marshall , Laurie A. Rinehardt , Natalie A. Solomon
CPC分类号： C07H21/00 , C12Q1/6862 , C12Q1/6883 , C12Q1/689 , C12Q1/703 , C12Q1/705 , C12Q1/708
摘要： An improved, "gap filling" embodiment of the Ligase Chain Reaction (LCR) is described. Gap filling LCR is LCR wherein at least one of the probes is recessed so that a gap is formed between the adjacent probes when they are hybridized to target. The gap is filled using polymerase and deoxyribonucleotide triphosphates before ligation of the probes together. There are single and double gap versions, depending on whether one or two probes are recessed and require filling before ligation. The improvement resides in selecting and using target sequences such that only a single type, or two types, of deoxyribonucleotide triphosphate(s) are required to fill double gaps each being 1-10 bases in length, preferably 1-3 bases. Probes having specific sequences are claimed for a number of pathogens.
摘要翻译： 描述了连接酶链式反应（LCR）的改进的“间隙填充”实施方案。 间隙填充LCR是LCR，其中至少一个探针凹入，使得当它们与靶杂交时，在相邻探针之间形成间隙。 在将探针连接在一起之前，使用聚合酶和脱氧核糖核苷三磷酸填充间隙。 有单和双间隙版本，取决于一个或两个探针是否凹进，需要在结扎前填充。 改进在于选择和使用靶序列，使得仅需要一种类型或两种类型的脱氧核糖核苷酸三磷酸酯来填充每个长度为1-10个碱基，优选1-3个碱基的双重间隙。 具有特定序列的探针被要求用于多种病原体。
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