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    Antimicrobial agent
    1.
    发明授权
    Antimicrobial agent 失效
    抗微生物剂

    公开(公告)号：US07335355B2

    公开(公告)日：2008-02-26

    申请号：US10333319

    申请日：2001-07-17

    申请人： Lars Bjorck ,  Inga-Maria Frick ,  Artur Schmidtchen

    发明人： Lars Bjorck ,  Inga-Maria Frick ,  Artur Schmidtchen

    IPC分类号： G01N33/53 ,  G01N33/567 ,  G01N33/554 ,  G01N33/569 ,  C08B37/00 ,  A61K38/47

    CPC分类号： C12Q1/18 ,  A61K31/721 ,  A61K31/722 ,  A61K31/785 ,  A61K38/02 ,  G01N2400/40 ,  A61K2300/00

    摘要： A method of identifying an agent that enhances the anti-microbial activity of cationic anti-microbial peptides by blocking the inhibitory effects of the proteinase/glycosaminoglycan pathway, which method comprises: (i) providing, as a first component, a cationic anti-microbial peptide; (ii) providing, as a second component, bacteria; (iii) providing, as a third component, part of all of the components of a proteinase/glycosaminoglycan pathway such that the third component reduces the antimicrobial effect of the first component, for example, a glycosaminoglycan or bacteria or bacteria and a proteoglycan or a bacterial proteinase or a bacterial proteinase and a proteoglycan; (iv) contacting the first, second and third components with a test agent under conditions that would permit the killing of the bacteria by the antimicrobial agent in the absence of the third component, and that would permit the inhibition of the anti-microbial activity of the first component by the third component in the absence of the test agent; (v) monitoring the survival of the bacterial culture thereby determining whether the test agent is capable of enhancing anti-microbial activity wherein a test agent capable of enhancing anti-microbial activity promotes killing of the bacterial culture. Agents identified by such a method are useful in the therapy of acute and chronic infections, particularly in the treatment of ulcers and in the promotion of wound healing.

    摘要翻译： 鉴定通过阻断蛋白酶/糖胺聚糖途径的抑制作用来增强阳离子抗微生物肽的抗微生物活性的试剂的方法，该方法包括：（i）提供阳离子抗微生物 肽; （ii）作为第二组分提供细菌; （iii）提供蛋白酶/糖胺聚糖途径的所有组分的一部分作为第三组分，使得第三组分降低第一组分例如糖胺聚糖或细菌或细菌的抗微生物作用，以及蛋白聚糖或 细菌蛋白酶或细菌蛋白酶和蛋白多糖; （iv）在允许在不存在第三组分的情况下允许由抗微生物剂杀死细菌的条件下将第一，第二和第三组分与测试试剂接触，并且这将允许抑制抗微生物活性 在没有测试代理的情况下第三个组分的第一个组分; （v）监测细菌培养物的存活，从而确定测试剂是否能够增强抗微生物活性，其中能够增强抗微生物活性的测试剂促进细菌培养物的杀死。 通过这种方法鉴定的药物可用于治疗急性和慢性感染，特别是治疗溃疡和促进伤口愈合。