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10 条记录 (耗时 0.029 秒)

    .omega.-Aminocarboxylic acid amides
    3.
    发明授权
    .omega.-Aminocarboxylic acid amides 失效
    ω-氨基羧酸酰胺

    公开(公告)号：US4218404A

    公开(公告)日：1980-08-19

    申请号：US884640

    申请日：1978-03-08

    申请人： Laszlo Feuer ,  Arpad Furka ,  Ferenc Sebestyen ,  Aniko Horvath ,  Jolan Hercsel, nee Szepespataki

    发明人： Laszlo Feuer ,  Arpad Furka ,  Ferenc Sebestyen ,  Aniko Horvath ,  Jolan Hercsel, nee Szepespataki

    IPC分类号： C07F9/09 ,  A61K31/66 ,  C07C143/15 ,  C07C143/53

    CPC分类号： C07F9/091 ,  Y10S514/866

    摘要： The invention relates to novel .omega.-aminocarboxylic acid amides having the formula (I) ##STR1## wherein A is --SO.sub.2 OH or --OPO(OH).sub.2,R.sup.1 is hydrogen, an acyl group, such as benzoyl, arylsulfonyl, alkoxycarbonyl, cycloalkoxycarbonyl or aralkoxycarbonyl group or an aralkoxycarbonyl group having a halogen, alkoxy, nitro, phenylazo or alkoxyphenylazo substituent, alkyl-substituted aryloxycarbonyl or carbonyl,R.sup.2 is hydrogen or a carbonyl group, with the proviso that when R.sup.1 and R.sup.2 each stand for carbonyl, the two carbonyl groups form a ring through an intervening o-phenylene, alkylene or vinylene group when A is --SO.sub.2 OH and R.sup.1 is an acyl group such as benzoyl, aryl sulfonyl, alkoxy-carbonyl, cycloalkoxycarbonyl or aryloxycarbonyl group or an aralkoxy carbonyl group having a halogen, alkoxy, nitro, phenylozo or alkoxyphenylazo substituent or an alkyl-substituted aryloxycarbonyl group or carbonyl group,R.sup.2 is hydrogen or a carbonyl group, with the proviso that when R.sup.1 and R.sup.2 each stand for carbonyl, the two carbonyl groups form a ring through an intervening o-phenylene, alkylene or vinylene group when A is --O--P--O(OH).sub.2 and n is equal to 2 or 3, and salts of the above compounds, furthermore to a process for the preparation thereof.The novel compounds according to the invention possess valuable pharmacological effects in reducing blood sugar levels or can be applied as intermediate in the synthesis of biologically active compounds.

    摘要翻译： 本发明涉及具有式（I）的新型ω-氨基羧酸酰胺其中A为-SO 2 OH或-OPO（OH）2，R 1为氢，酰基如苯甲酰基，芳基磺酰基，烷氧基羰基 ，环烷氧羰基或芳烷氧基羰基或具有卤素，烷氧基，硝基，苯偶氮或烷氧基苯基偶氮取代基的芳烷氧基羰基，烷基取代的芳氧基羰基或羰基，R2是氢或羰基，条件是当R1和R2各自代表羰基时， 当A为-SO 2 OH且R 1为酰基如苯甲酰基，芳基磺酰基，烷氧基 - 羰基，环烷氧基羰基或芳氧基羰基或芳烷氧基羰基时，两个羰基通过中间的邻亚苯基，亚烷基或亚乙烯基形成环， 卤素，烷氧基，硝基，苯偶氮或烷氧基苯基偶氮基取代基或烷基取代的芳氧基羰基或羰基，R2是氢或羰基，条件是当R1和R2各自代表c 当A是-OPO（OH）2且n等于2或3时，两个羰基通过中间的邻亚苯基，亚烷基或亚乙烯基形成环，以及上述化合物的盐，此外， 其制备。 根据本发明的新化合物在降低血糖水平方面具有有价值的药理学作用，或者可以作为中间体应用于生物活性化合物的合成中。

    L-gamma-glutamyl-taurine as extracted from parathyroid gland and method of treatment using same
    7.
    发明授权
    L-gamma-glutamyl-taurine as extracted from parathyroid gland and method of treatment using same 失效
    从甲状旁腺提取的L-γ-谷氨酰 - 牛磺酸及其使用方法

    公开(公告)号：US4226884A

    公开(公告)日：1980-10-07

    申请号：US756409

    申请日：1977-01-03

    申请人： Laszlo Feuer

    发明人： Laszlo Feuer

    IPC分类号： A61K8/44 ,  A61K8/64 ,  A61K31/195 ,  A61K35/55 ,  A61K38/22 ,  A61Q11/00 ,  A61K31/255 ,  C07C143/12

    CPC分类号： A61K8/64 ,  A61K31/195 ,  A61K8/447 ,  A61Q11/00

    摘要： A deproteinized, defatted aqueous extract of the parathyroid gland insoluble in benzene, chloroform and carbon tetrachloride is found to be L-gamma-glutamyl-taurine which has vitamin-A type activity and is generally effective for the treatment of a wide range of mammalian disorders which are directly or indirectly connected with pathological alterations of the aerobiospherical genetical adaptational system (AGAS).

    摘要翻译： 发现不溶于苯，氯仿和四氯化碳的甲状旁腺脱蛋白脱脂含水提取物是具有维生素A型活性的L-谷氨酰基牛磺酸，对于治疗广泛的哺乳动物疾病通常是有效的 它们直接或间接地与空气微球基因适应系统（AGAS）的病理改变相关。

    Synergistic radiation protective pharmaceutical compositions
    8.
    发明授权
    Synergistic radiation protective pharmaceutical compositions 失效
    协同辐射防护药物组合物

    公开(公告)号：US4563479A

    公开(公告)日：1986-01-07

    申请号：US571856

    申请日：1984-01-18

    申请人： Laszlo Feuer ,  Gyorgy Benko

    发明人： Laszlo Feuer ,  Gyorgy Benko

    IPC分类号： A61K31/255 ,  A61K8/46 ,  A61K31/095 ,  A61K31/13 ,  A61K31/155 ,  A61K31/16 ,  A61K31/185 ,  A61K31/195 ,  A61K31/205 ,  A61K31/22 ,  A61K31/27 ,  A61K31/66 ,  A61K45/00 ,  A61P43/00 ,  A61Q17/04

    CPC分类号： A61K8/466 ,  A61K31/185 ,  A61K31/195 ,  A61K31/66 ,  A61K8/46 ,  A61Q17/04 ,  A61K2800/59 ,  Y10S514/917

    摘要： The invention is directed to a synergistic radiation protective pharmaceutical composition comprising 50 to 350 parts by weight of aminoalkyl-thiol-derivatives of the general formula II ##STR1## wherein R.sup.3 stands for hydrogen, or carboxamidinoR.sup.4 stands for hydrogen or carboxy,B represents hydrogen or carboxamidino with the restriction that at least two of R.sup.3, R.sup.4 and B stand for hydrogen--or a pharmaceutically acceptable acid addition salt thereof, 0.2 to 2 parts by weight of .omega.-acylamino-alkane-derivative of the general formula ##STR2## wherein R.sup.1 stands for hydrogen, C.sub.1-4 alkanoyl, aroyl or aryl-(C.sub.1-4)-alkoxy-carbonyl,R.sup.2 stands for hydrogen, or carboxy optionally esterified by C.sub.1-4 alkoxy or aryl-(C.sub.1-4)alkoxy,A stands for --SO.sub.2 OH or --O--PO(OH).sub.2,n stands for 1, 2 or 3 andm stands for 2, 3 or 4--or a pharmaceutically acceptable salt thereof,and pharmaceutically acceptable carriers, diluents and/or solvents, and/or other formulating excipients.

    摘要翻译： 本发明涉及一种协同的放射线保护性药物组合物，其包含50至350重量份的通式II（II）的氨基烷基硫醇衍生物，其中R3代表氢，或羧酰胺基R4代表氢或羧基， B表示氢或甲脒基，其限制为R3，R4和B中的至少两个表示氢或其药学上可接受的酸加成盐，0.2至2重量份通式为ω-酰基氨基 - 烷烃衍生物， （I）其中R1代表氢，C1-4烷酰基，芳酰基或芳基 - （C1-4） - 烷氧基 - 羰基，R2代表氢或任选被C 1-4烷氧基或芳基 - （C1- 4）烷氧基，A表示-SO 2 OH或-O-PO（OH）2，n表示1,2或3，m表示2,3或4-或其药学上可接受的盐，以及药学上可接受的载体，稀释剂 和/或溶剂，和/或其它配制赋形剂。