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公开(公告)号:US20070111220A1
公开(公告)日:2007-05-17
申请号:US11286621
申请日:2005-11-23
申请人: Laszlo Kish , Maria Dobozi-King , Ryland Young , Mosong Cheng , James Biard , Sergey Bezrukov
发明人: Laszlo Kish , Maria Dobozi-King , Ryland Young , Mosong Cheng , James Biard , Sergey Bezrukov
IPC分类号: C12Q1/68
CPC分类号: B82Y30/00 , B01L3/5088 , C12N7/00 , C12N2795/10311 , C12N2795/10322 , C12N2799/00 , C12Q1/04 , C12Q1/6825 , C12Q1/689 , G01N33/48707 , G01N33/54373 , G01N33/56911
摘要: The present invention provides a method for detecting bacteria and a nano-well device having one or more input/output connections about a gap and one or more bacteriophages at or about the gap that trigger a detectable electrical field fluctuation when the one or more bacteriophages contact a cognate target within a liquid sample.
摘要翻译: 本发明提供一种用于检测细菌的方法和具有一个或多个输入/输出连接的纳米孔装置,所述输入/输出连接围绕间隙和在间隙处或周围的一个或多个噬菌体,当一个或多个噬菌体接触时触发可检测的电场波动 液体样品中的同源靶标。
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公开(公告)号:US07229754B2
公开(公告)日:2007-06-12
申请号:US11286621
申请日:2005-11-23
申请人: Laszlo B. Kish , Maria Dobozi-King , Ryland Young , Mosong Cheng , James R. Biard , Sergey Bezrukov
发明人: Laszlo B. Kish , Maria Dobozi-King , Ryland Young , Mosong Cheng , James R. Biard , Sergey Bezrukov
IPC分类号: C12Q1/70
CPC分类号: B82Y30/00 , B01L3/5088 , C12N7/00 , C12N2795/10311 , C12N2795/10322 , C12N2799/00 , C12Q1/04 , C12Q1/6825 , C12Q1/689 , G01N33/48707 , G01N33/54373 , G01N33/56911
摘要: The present invention provides a method for detecting bacteria and a nano-well device having one or more input/output connections about a gap and one or more bacteriophages at or about the gap that trigger a detectable electrical field fluctuation when the one or more bacteriophages contact a cognate target within a liquid sample.
摘要翻译: 本发明提供一种用于检测细菌的方法和具有一个或多个输入/输出连接的纳米孔装置,所述输入/输出连接围绕间隙和在间隙处或周围的一个或多个噬菌体,当一个或多个噬菌体接触时触发可检测的电场波动 液体样品中的同源靶标。
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公开(公告)号:US20050191628A1
公开(公告)日:2005-09-01
申请号:US10625357
申请日:2003-07-23
申请人: Ryland Young , William Roof , Douglas Struck , Thomas Bernhardt , Ing-Nang Wang
发明人: Ryland Young , William Roof , Douglas Struck , Thomas Bernhardt , Ing-Nang Wang
CPC分类号: C07K14/005 , C12N2795/14222 , C12N2795/18122
摘要: This invention relates to polypeptide antibiotics, including materials and methods related thereto, based upon the observation that bacteriophage elaborate proteins that cause host cell lysis by interfering with specific steps in cell wall biosynthesis. Examples of antibiotics based upon this invention include the bacteriophage φX174 gene E product and structurally and/or functionally related polypeptide and small protein antibiotics that interact with MraY, and the bacteriophage Qβ gene A2 product and structurally and/or functionally related polypeptide and small protein antibiotics that interact with MurA. This leads to the general model for obtaining new polypeptide antibiotics by using genetic approaches based on these findings to find polypeptide sequences which cause bacterial cell lysis.
摘要翻译: 本发明涉及多肽抗生素,包括与其有关的材料和方法,基于观察到噬菌体通过干扰细胞壁生物合成中的特定步骤而引起宿主细胞裂解的精细蛋白质。 基于本发明的抗生素的实例包括噬菌体phiX174基因E产物以及与MraY相互作用的结构和/或功能相关多肽和小蛋白抗生素,以及噬菌体Qbeta基因A 2 N 2产物,结构和/ 或与MurA相互作用的功能相关多肽和小蛋白抗生素。 这导致通过使用基于这些发现的遗传方法获得新多肽抗生素的一般模型来发现导致细菌细胞裂解的多肽序列。
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