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公开(公告)号：US6063082A
公开(公告)日：2000-05-16
申请号：US35738
申请日：1998-03-05
申请人： Lauri DeVore , Louis Ellis , Gary L. Hendrickson , Daniel M. Lafontaine , Zihong Guo , Ryan Kaveckis
发明人： Lauri DeVore , Louis Ellis , Gary L. Hendrickson , Daniel M. Lafontaine , Zihong Guo , Ryan Kaveckis
IPC分类号： A61B17/00 , A61B17/22 , A61B17/32 , A61B17/34 , A61B18/14 , A61B19/00 , A61F2/02 , A61M25/00
CPC分类号： A61F2/2493 , A61B17/3468 , A61B17/3478 , A61B18/1477 , A61B18/1492 , A61B17/32037 , A61B17/32056 , A61B17/3207 , A61B2017/00247 , A61B2017/003 , A61B2017/22077 , A61B2017/320084 , A61B2018/00077 , A61B2018/00083 , A61B2018/00136 , A61B2018/00148 , A61B2018/00196 , A61B2018/00214 , A61B2018/00267 , A61B2018/00279 , A61B2018/00351 , A61B2018/00392 , A61B2018/1253 , A61B2018/126 , A61B2018/1407 , A61B2018/1425 , A61B2018/143 , A61B2018/1432 , A61B2018/1435 , A61B2018/1467 , A61B2090/3966 , A61B2218/002 , A61B90/39 , A61M2025/009
摘要： An intravascular device and methods for forming multiple percutaneous myocardial revascularization (PMR) holes in a heart chamber wall simultaneously. One device includes a basket formed of flexible arms carrying cutting probes over their length. The basket arms are outwardly arcuately biased so as to assume an outwardly bowed, arcuate shape when unconstrained. The device includes an inner shaft distally secured to a proximal portion of the basket and slidably disposed within an outer shaft. The inner shaft and collapsed basket can be retracted within the outer shaft, delivered intravascularly to the left ventricle, and distally advanced, forcing the basket to assume the bowed shape. Radio frequency current supplied to the electrical cutting probes burn holes into the ventricle wall and myocardium. One embodiment has high pressure fluid jet cutting means. Another embodiment uses a basket as an anchor to position a steerable cutting probe. Yet another embodiment includes a brush formed of multiple, arcuate, outwardly splayed electrodes that can contact heart chamber walls once advanced distally from a constraining outer shaft.
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2.发明授权公开(公告)号：US06660003B1
公开(公告)日：2003-12-09
申请号：US09544348
申请日：2000-04-06
申请人： Lauri DeVore , Louis Ellis , Gary L. Hendrickson , Daniel M. Lafontaine , Zihong Guo , Ryan Kaveckis
发明人： Lauri DeVore , Louis Ellis , Gary L. Hendrickson , Daniel M. Lafontaine , Zihong Guo , Ryan Kaveckis
IPC分类号： A61B1814
CPC分类号： A61F2/2493 , A61B17/32037 , A61B17/32056 , A61B17/3207 , A61B17/3468 , A61B17/3478 , A61B18/1477 , A61B18/1492 , A61B90/39 , A61B2017/00247 , A61B2017/003 , A61B2017/22077 , A61B2017/320084 , A61B2018/00077 , A61B2018/00083 , A61B2018/00136 , A61B2018/00148 , A61B2018/00196 , A61B2018/00214 , A61B2018/00267 , A61B2018/00279 , A61B2018/00351 , A61B2018/00392 , A61B2018/1253 , A61B2018/126 , A61B2018/1407 , A61B2018/1425 , A61B2018/143 , A61B2018/1432 , A61B2018/1435 , A61B2018/1467 , A61B2090/3966 , A61B2218/002 , A61M2025/009
摘要： An intravascular device and methods for forming multiple percutaneous myocardial revascularization (PMR) holes in a heart chamber wall simultaneously. One device includes a basket formed of flexible arms carrying cutting probes over their length. The basket arms are outwardly arcuately biased so as to assume an outwardly bowed, arcuate shape when unconstrained. The device includes an inner shaft distally secured to a proximal portion of the basket and slidably disposed within an outer shaft. The inner shaft and collapsed basket can be retracted within the outer shaft, delivered intravascularly to the left ventricle, and distally advanced, forcing the basket to assume the bowed shape. Radio frequency current supplied to the electrical cutting probes burn holes into the ventricle wall and myocardium. One embodiment has high pressure fluid jet cutting means. Another embodiment uses a basket as an anchor to position a steerable cutting probe. Yet another embodiment includes a brush formed of multiple, arcuate, outwardly splayed electrodes that can contact heart chamber walls once advanced distally from a constraining outer shaft.
摘要翻译： 血管内装置和在心室壁中同时形成多个经皮心肌血运重建（PMR）孔的方法。 一个装置包括由其长度上承载切割探针的柔性臂形成的篮。 筐臂向外弯曲偏置，以便在无约束时呈现向外弯曲的弓形形状。 该装置包括一个远离固定在篮子的近端部分并可滑动地设置在外轴内的内轴。 内轴和塌缩的筐可以缩回到外轴内，血管内递送到左心室，并且向远侧前进，迫使篮筐呈现弓形。 提供给电切割探头的射频电流将孔插入心室壁和心肌。 一个实施例具有高压流体射流切割装置。 另一个实施例使用篮子作为锚定器来定位可操纵的切割探针。 另一个实施例包括由多个弓形的向外张开的电极形成的电刷，其可以一旦从约束外轴向远侧远端接触心室壁。
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公开(公告)号：US07832406B2
公开(公告)日：2010-11-16
申请号：US11191056
申请日：2005-07-28
CPC分类号： A61B17/3207 , A61B18/1492 , A61B90/39 , A61B2017/00247 , A61B2017/22077 , A61B2017/3488 , A61B2018/00273 , A61B2018/00291 , A61B2018/00392 , A61B2018/144 , A61B2090/395 , A61M2210/125
摘要： Devices and methods for creating a series of percutaneous myocardial revascularization (PMR) channels in the heart. One method includes forming a pattern of channels in the myocardium leading from healthy tissue to hibernating tissue. Suitable channel patterns include lines and arrays. One method includes anchoring a radiopaque marker to a position in the ventricle wall, then using fluoroscopy repeatedly to guide positioning of a cutting tip in the formation of multiple channels. Another method uses radiopaque material injected into each channel formed, as a marker. Yet another method utilizes an anchorable, rotatable cutting probe for channel formation about an anchor member, where the cutting probe can vary in radial distance from the anchor. Still another method utilizes a multiple wire radio frequency burning probe, for formation of multiple channels simultaneously. Still another method utilizes liquid nitrogen to cause localized tissue death.
摘要翻译： 在心脏中创建一系列经皮心肌血运重建（PMR）通道的装置和方法。 一种方法包括在从健康组织导向冬眠组织的心肌中形成通道图案。 合适的渠道模式包括线和阵列。 一种方法包括将不透射线标记物固定在心室壁中的位置，然后重复使用荧光透视来引导切割尖端在形成多个通道中的定位。 另一种方法使用注射到形成的每个通道中的不透射线材料作为标记。 另一种方法利用可锚定的，可旋转的切割探针，用于围绕锚定构件的通道形成，其中切割探针可以与锚固件的径向距离变化。 另一种方法是利用多线射频燃烧探头，同时形成多个通道。 另一种方法利用液氮引起局部组织死亡。
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公开(公告)号：US06951557B2
公开(公告)日：2005-10-04
申请号：US10231033
申请日：2002-08-30
IPC分类号： A61B19/00 , A61B6/00 , A61B17/00 , A61B17/22 , A61B17/32 , A61B17/34 , A61B18/00 , A61B18/02 , A61B18/12 , A61B18/14 , A61B18/18
CPC分类号： A61B17/3207 , A61B18/1492 , A61B90/39 , A61B2017/00247 , A61B2017/22077 , A61B2017/3488 , A61B2018/00273 , A61B2018/00291 , A61B2018/00392 , A61B2018/144 , A61B2090/395 , A61M2210/125
摘要： Devices and methods for creating a series of percutaneous myocardial revascularization (PMR) channels in the heart. One method includes forming a pattern of channels in the myocardium leading from healthy tissue to hibernating tissue. Suitable channel patterns include lines and arrays. One method includes anchoring a radiopaque marker to a position in the ventricle wall, then using fluoroscopy repeatedly to guide positioning of a cutting tip in the formation of multiple channels. Another method uses radiopaque material injected into each channel formed, as a marker. Yet another method utilizes an anchorable, rotatable cutting probe for channel formation about an anchor member, where the cutting probe can vary in radial distance from the anchor. Still another method utilizes a multiple wire radio frequency burning probe, for formation of multiple channels simultaneously. Still another method utilizes liquid nitrogen to cause localized tissue death.
摘要翻译： 在心脏中创建一系列经皮心肌血运重建（PMR）通道的装置和方法。 一种方法包括在从健康组织导向冬眠组织的心肌中形成通道图案。 合适的渠道模式包括线和阵列。 一种方法包括将不透射线标记物固定在心室壁中的位置，然后重复使用荧光透视来引导切割尖端在形成多个通道中的定位。 另一种方法使用注射到形成的每个通道中的不透射线材料作为标记。 另一种方法利用可锚定的，可旋转的切割探针，用于围绕锚定构件的通道形成，其中切割探针可以与锚固件的径向距离变化。 另一种方法是利用多线射频燃烧探头，同时形成多个通道。 另一种方法利用液氮引起局部组织死亡。
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公开(公告)号：US06491689B1
公开(公告)日：2002-12-10
申请号：US09536068
申请日：2000-03-24
IPC分类号： A61B1818
CPC分类号： A61B17/3207 , A61B18/1492 , A61B90/39 , A61B2017/00247 , A61B2017/22077 , A61B2017/3488 , A61B2018/00273 , A61B2018/00291 , A61B2018/00392 , A61B2018/144 , A61B2090/395 , A61M2210/125
摘要： Devices and methods for creating a series of percutaneous myocardial revascularization (PMR) channels in the heart. One method includes forming a pattern of channels in the myocardium leading from healthy tissue to hibernating tissue. Suitable channel patterns include lines and arrays. One method includes anchoring a radiopaque marker to a position in the ventricle wall, then using fluoroscopy repeatedly to guide positioning of a cutting tip in the formation of multiple channels. Another method uses radiopaque material injected into each channel formed, as a marker. Yet another method utilizes an anchorable, rotatable cutting probe for channel formation about an anchor member, where the cutting probe can vary in radial distance from the anchor. Still another method utilizes a multiple wire radio frequency burning probe, for formation of multiple channels simultaneously. Still another method utilizes liquid nitrogen to cause localized tissue death.
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公开(公告)号：US6056743A
公开(公告)日：2000-05-02
申请号：US35625
申请日：1998-03-05
IPC分类号： A61B19/00 , A61B6/00 , A61B17/00 , A61B17/22 , A61B17/32 , A61B17/34 , A61B18/00 , A61B18/02 , A61B18/12 , A61B18/14 , A61B17/36
CPC分类号： A61B17/3207 , A61B18/1492 , A61B2017/00247 , A61B2017/22077 , A61B2017/3488 , A61B2018/00273 , A61B2018/00291 , A61B2018/00392 , A61B2018/144 , A61B2090/395 , A61B90/39 , A61M2210/125
摘要： Devices and methods for creating a series of percutaneous myocardial revascularization (PMR) channels in the heart. One method includes forming a pattern of channels in the myocardium leading from healthy tissue to hibernating tissue. Suitable channel patterns include lines and arrays. One method includes anchoring a radiopaque marker to a position in the ventricle wall, then using fluoroscopy repeatedly to guide positioning of a cutting tip in the formation of multiple channels. Another method uses radiopaque material injected into each channel formed, as a marker. Yet another method utilizes an anchorable, rotatable cutting probe for channel formation about an anchor member, where the cutting probe can vary in radial distance from the anchor. Still another method utilizes a multiple wire radio frequency burning probe, for formation of multiple channels simultaneously. Still another method utilizes liquid nitrogen to cause localized tissue death.
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公开(公告)号：US5554119A
公开(公告)日：1996-09-10
申请号：US187614
申请日：1994-01-27
申请人： Kent D. Harrison , Gary L. Hendrickson , Thomas J. Holman , Daniel M. Lafontaine , Matthew J. Miller , David B. Robinson
发明人： Kent D. Harrison , Gary L. Hendrickson , Thomas J. Holman , Daniel M. Lafontaine , Matthew J. Miller , David B. Robinson
CPC分类号： A61M25/1002 , A61M16/0481 , A61M2025/105 , A61M2025/1052 , A61M2025/1072 , A61M2025/1097
摘要： A drug delivery catheter which may be inserted into a vessel, such as a blood vessel is disclosed. The drug delivery catheter comprises any elongated tubular member which has a proximal end and a distal end. A drug lumen which provides a communication path for fluid is provided in the elongated tubular member for delivering a fluid, such as the drug to be administered. An inflatable balloon assembly is provided at the distal end of the elongated tubular member. The balloon assembly includes apertures which communicate with the drug lumen. The balloon assembly comprises a tubular balloon which is helically wound through the elongated tubular member and a sheath. The sheath is attached to the helically wound tubular balloon such that when the balloon member is uninflated, the first fluid in the vessel flows around the balloon assembly and such that when the balloon member is inflated, sections of the helically wound balloon contact the vessel wall to form a containment pocket between the vessel wall, the contacting sections of the balloon and the sheath. The apertures are provided in the containment pocket. An inflatable lumen is defined through the interior of the helically wound balloon and the sheath to allow perfusion of the first fluid.
摘要翻译： 公开了一种可插入容器（如血管）中的药物输送导管。 药物递送导管包括具有近端和远端的任何细长管状构件。 提供用于流体的连通路径的药物腔室设置在细长管状构件中，用于输送流体，例如待施用的药物。 在细长管状构件的远端处设置可充气气囊组件。 气囊组件包括与药物腔连通的孔。 球囊组件包括通过细长管状构件和护套螺旋缠绕的管状球囊。 护套附接到螺旋形缠绕的管状气囊，使得当球囊构件未膨胀时，容器中的第一流体围绕球囊组件流动，使得当球囊构件膨胀时，螺旋形卷绕的球囊的部分接触血管壁 以在容器壁，球囊和护套的接触部分之间形成容纳袋。 孔口设置在容纳口袋中。 通过螺旋缠绕气囊和护套的内部限定可充气腔，以允许第一流体的灌注。
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公开(公告)号：US20080171974A1
公开(公告)日：2008-07-17
申请号：US11541735
申请日：2006-10-02
IPC分类号： A61M29/00
CPC分类号： A61M25/1011 , A61B2018/0022 , A61B2018/00577 , A61B2018/0212 , A61B2018/0262 , A61M25/1034 , A61M2025/1013 , A61M2025/1079
摘要： A method of manufacturing a catheter can include assembling an inner balloon within a separate outer balloon. The inner and outer balloons can each be open on opposing longitudinal ends and have a central radially expandable portion, and proximal and distal reduced diameter portions on opposite longitudinal end portions of the balloon. The method can further include bonding a portion of an inner surface of the outer balloon proximal reduced diameter portion to a portion of an outer surface of the inner balloon proximal reduced diameter portion and bonding a distal end portion of an elongate catheter shaft to a proximal portion of the bonded inner and outer balloons.
摘要翻译： 制造导管的方法可以包括将内气囊组装在单独的外气囊中。 内部和外部气囊可以在相对的纵向端部上敞开，并且具有中心径向可膨胀部分，并且在气囊的相对的纵向端部上具有近端和远端缩径部分。 该方法还可以包括将外球囊近端缩小直径部分的内表面的一部分粘合到内球囊近直径部分的外表面的一部分，并将细长导管轴的远端部分接合到近端部分 的粘合内外气球。
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公开(公告)号：US08617149B2
公开(公告)日：2013-12-31
申请号：US11541735
申请日：2006-10-02
CPC分类号： A61M25/1011 , A61B2018/0022 , A61B2018/00577 , A61B2018/0212 , A61B2018/0262 , A61M25/1034 , A61M2025/1013 , A61M2025/1079
摘要： A method of manufacturing a catheter can include assembling an inner balloon within a separate outer balloon. The inner and outer balloons can each be open on opposing longitudinal ends and have a central radially expandable portion, and proximal and distal reduced diameter portions on opposite longitudinal end portions of the balloon. The method can further include bonding a portion of an inner surface of the outer balloon proximal reduced diameter portion to a portion of an outer surface of the inner balloon proximal reduced diameter portion and bonding a distal end portion of an elongate catheter shaft to a proximal portion of the bonded inner and outer balloons.
摘要翻译： 制造导管的方法可以包括将内气囊组装在单独的外气囊中。 内部和外部气囊可以在相对的纵向端部上敞开，并且具有中心径向可膨胀部分，并且在气囊的相对的纵向端部上具有近端和远端缩径部分。 该方法还可以包括将外球囊近端缩小直径部分的内表面的一部分粘合到内球囊近直径部分的外表面的一部分，并将细长导管轴的远端部分接合到近端部分 的粘合内外气球。
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公开(公告)号：US08585689B2
公开(公告)日：2013-11-19
申请号：US13252817
申请日：2011-10-04
申请人： Daniel M. Lafontaine
发明人： Daniel M. Lafontaine
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B18/0218 , A61B2018/0212 , A61B2018/0262 , A61B2018/0293
摘要： Cryotreatment devices and methods of ablating tissue within the body are disclosed. A cryotreatment device in accordance with an exemplary embodiment of the present invention includes an elongated member having one or more needle-like ablation tips configured to induce necrosis at a target site within the heart. A cooling fluid such as a cryogen may be injected through a lumen extending into the distal portion of the device. The ablation tips can be configured to pierce and ablate surrounding tissue, blocking electrical stimuli that can cause fibrillations or other arrhythmias of the heart. The device may also include means for controlling the transmural depth at which the ablation tips are inserted into the cardiac tissue. Methods of forming a contiguous line of conduction block in accordance with the present invention are also disclosed.
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