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公开(公告)号：US6063082A
公开(公告)日：2000-05-16
申请号：US35738
申请日：1998-03-05
申请人： Lauri DeVore , Louis Ellis , Gary L. Hendrickson , Daniel M. Lafontaine , Zihong Guo , Ryan Kaveckis
发明人： Lauri DeVore , Louis Ellis , Gary L. Hendrickson , Daniel M. Lafontaine , Zihong Guo , Ryan Kaveckis
IPC分类号： A61B17/00 , A61B17/22 , A61B17/32 , A61B17/34 , A61B18/14 , A61B19/00 , A61F2/02 , A61M25/00
CPC分类号： A61F2/2493 , A61B17/3468 , A61B17/3478 , A61B18/1477 , A61B18/1492 , A61B17/32037 , A61B17/32056 , A61B17/3207 , A61B2017/00247 , A61B2017/003 , A61B2017/22077 , A61B2017/320084 , A61B2018/00077 , A61B2018/00083 , A61B2018/00136 , A61B2018/00148 , A61B2018/00196 , A61B2018/00214 , A61B2018/00267 , A61B2018/00279 , A61B2018/00351 , A61B2018/00392 , A61B2018/1253 , A61B2018/126 , A61B2018/1407 , A61B2018/1425 , A61B2018/143 , A61B2018/1432 , A61B2018/1435 , A61B2018/1467 , A61B2090/3966 , A61B2218/002 , A61B90/39 , A61M2025/009
摘要： An intravascular device and methods for forming multiple percutaneous myocardial revascularization (PMR) holes in a heart chamber wall simultaneously. One device includes a basket formed of flexible arms carrying cutting probes over their length. The basket arms are outwardly arcuately biased so as to assume an outwardly bowed, arcuate shape when unconstrained. The device includes an inner shaft distally secured to a proximal portion of the basket and slidably disposed within an outer shaft. The inner shaft and collapsed basket can be retracted within the outer shaft, delivered intravascularly to the left ventricle, and distally advanced, forcing the basket to assume the bowed shape. Radio frequency current supplied to the electrical cutting probes burn holes into the ventricle wall and myocardium. One embodiment has high pressure fluid jet cutting means. Another embodiment uses a basket as an anchor to position a steerable cutting probe. Yet another embodiment includes a brush formed of multiple, arcuate, outwardly splayed electrodes that can contact heart chamber walls once advanced distally from a constraining outer shaft.
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2.发明授权公开(公告)号：US06660003B1
公开(公告)日：2003-12-09
申请号：US09544348
申请日：2000-04-06
申请人： Lauri DeVore , Louis Ellis , Gary L. Hendrickson , Daniel M. Lafontaine , Zihong Guo , Ryan Kaveckis
发明人： Lauri DeVore , Louis Ellis , Gary L. Hendrickson , Daniel M. Lafontaine , Zihong Guo , Ryan Kaveckis
IPC分类号： A61B1814
CPC分类号： A61F2/2493 , A61B17/32037 , A61B17/32056 , A61B17/3207 , A61B17/3468 , A61B17/3478 , A61B18/1477 , A61B18/1492 , A61B90/39 , A61B2017/00247 , A61B2017/003 , A61B2017/22077 , A61B2017/320084 , A61B2018/00077 , A61B2018/00083 , A61B2018/00136 , A61B2018/00148 , A61B2018/00196 , A61B2018/00214 , A61B2018/00267 , A61B2018/00279 , A61B2018/00351 , A61B2018/00392 , A61B2018/1253 , A61B2018/126 , A61B2018/1407 , A61B2018/1425 , A61B2018/143 , A61B2018/1432 , A61B2018/1435 , A61B2018/1467 , A61B2090/3966 , A61B2218/002 , A61M2025/009
摘要： An intravascular device and methods for forming multiple percutaneous myocardial revascularization (PMR) holes in a heart chamber wall simultaneously. One device includes a basket formed of flexible arms carrying cutting probes over their length. The basket arms are outwardly arcuately biased so as to assume an outwardly bowed, arcuate shape when unconstrained. The device includes an inner shaft distally secured to a proximal portion of the basket and slidably disposed within an outer shaft. The inner shaft and collapsed basket can be retracted within the outer shaft, delivered intravascularly to the left ventricle, and distally advanced, forcing the basket to assume the bowed shape. Radio frequency current supplied to the electrical cutting probes burn holes into the ventricle wall and myocardium. One embodiment has high pressure fluid jet cutting means. Another embodiment uses a basket as an anchor to position a steerable cutting probe. Yet another embodiment includes a brush formed of multiple, arcuate, outwardly splayed electrodes that can contact heart chamber walls once advanced distally from a constraining outer shaft.
摘要翻译： 血管内装置和在心室壁中同时形成多个经皮心肌血运重建（PMR）孔的方法。 一个装置包括由其长度上承载切割探针的柔性臂形成的篮。 筐臂向外弯曲偏置，以便在无约束时呈现向外弯曲的弓形形状。 该装置包括一个远离固定在篮子的近端部分并可滑动地设置在外轴内的内轴。 内轴和塌缩的筐可以缩回到外轴内，血管内递送到左心室，并且向远侧前进，迫使篮筐呈现弓形。 提供给电切割探头的射频电流将孔插入心室壁和心肌。 一个实施例具有高压流体射流切割装置。 另一个实施例使用篮子作为锚定器来定位可操纵的切割探针。 另一个实施例包括由多个弓形的向外张开的电极形成的电刷，其可以一旦从约束外轴向远侧远端接触心室壁。
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公开(公告)号：US07832406B2
公开(公告)日：2010-11-16
申请号：US11191056
申请日：2005-07-28
CPC分类号： A61B17/3207 , A61B18/1492 , A61B90/39 , A61B2017/00247 , A61B2017/22077 , A61B2017/3488 , A61B2018/00273 , A61B2018/00291 , A61B2018/00392 , A61B2018/144 , A61B2090/395 , A61M2210/125
摘要： Devices and methods for creating a series of percutaneous myocardial revascularization (PMR) channels in the heart. One method includes forming a pattern of channels in the myocardium leading from healthy tissue to hibernating tissue. Suitable channel patterns include lines and arrays. One method includes anchoring a radiopaque marker to a position in the ventricle wall, then using fluoroscopy repeatedly to guide positioning of a cutting tip in the formation of multiple channels. Another method uses radiopaque material injected into each channel formed, as a marker. Yet another method utilizes an anchorable, rotatable cutting probe for channel formation about an anchor member, where the cutting probe can vary in radial distance from the anchor. Still another method utilizes a multiple wire radio frequency burning probe, for formation of multiple channels simultaneously. Still another method utilizes liquid nitrogen to cause localized tissue death.
摘要翻译： 在心脏中创建一系列经皮心肌血运重建（PMR）通道的装置和方法。 一种方法包括在从健康组织导向冬眠组织的心肌中形成通道图案。 合适的渠道模式包括线和阵列。 一种方法包括将不透射线标记物固定在心室壁中的位置，然后重复使用荧光透视来引导切割尖端在形成多个通道中的定位。 另一种方法使用注射到形成的每个通道中的不透射线材料作为标记。 另一种方法利用可锚定的，可旋转的切割探针，用于围绕锚定构件的通道形成，其中切割探针可以与锚固件的径向距离变化。 另一种方法是利用多线射频燃烧探头，同时形成多个通道。 另一种方法利用液氮引起局部组织死亡。
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公开(公告)号：US06951557B2
公开(公告)日：2005-10-04
申请号：US10231033
申请日：2002-08-30
IPC分类号： A61B19/00 , A61B6/00 , A61B17/00 , A61B17/22 , A61B17/32 , A61B17/34 , A61B18/00 , A61B18/02 , A61B18/12 , A61B18/14 , A61B18/18
CPC分类号： A61B17/3207 , A61B18/1492 , A61B90/39 , A61B2017/00247 , A61B2017/22077 , A61B2017/3488 , A61B2018/00273 , A61B2018/00291 , A61B2018/00392 , A61B2018/144 , A61B2090/395 , A61M2210/125
摘要： Devices and methods for creating a series of percutaneous myocardial revascularization (PMR) channels in the heart. One method includes forming a pattern of channels in the myocardium leading from healthy tissue to hibernating tissue. Suitable channel patterns include lines and arrays. One method includes anchoring a radiopaque marker to a position in the ventricle wall, then using fluoroscopy repeatedly to guide positioning of a cutting tip in the formation of multiple channels. Another method uses radiopaque material injected into each channel formed, as a marker. Yet another method utilizes an anchorable, rotatable cutting probe for channel formation about an anchor member, where the cutting probe can vary in radial distance from the anchor. Still another method utilizes a multiple wire radio frequency burning probe, for formation of multiple channels simultaneously. Still another method utilizes liquid nitrogen to cause localized tissue death.
摘要翻译： 在心脏中创建一系列经皮心肌血运重建（PMR）通道的装置和方法。 一种方法包括在从健康组织导向冬眠组织的心肌中形成通道图案。 合适的渠道模式包括线和阵列。 一种方法包括将不透射线标记物固定在心室壁中的位置，然后重复使用荧光透视来引导切割尖端在形成多个通道中的定位。 另一种方法使用注射到形成的每个通道中的不透射线材料作为标记。 另一种方法利用可锚定的，可旋转的切割探针，用于围绕锚定构件的通道形成，其中切割探针可以与锚固件的径向距离变化。 另一种方法是利用多线射频燃烧探头，同时形成多个通道。 另一种方法利用液氮引起局部组织死亡。
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公开(公告)号：US06491689B1
公开(公告)日：2002-12-10
申请号：US09536068
申请日：2000-03-24
IPC分类号： A61B1818
CPC分类号： A61B17/3207 , A61B18/1492 , A61B90/39 , A61B2017/00247 , A61B2017/22077 , A61B2017/3488 , A61B2018/00273 , A61B2018/00291 , A61B2018/00392 , A61B2018/144 , A61B2090/395 , A61M2210/125
摘要： Devices and methods for creating a series of percutaneous myocardial revascularization (PMR) channels in the heart. One method includes forming a pattern of channels in the myocardium leading from healthy tissue to hibernating tissue. Suitable channel patterns include lines and arrays. One method includes anchoring a radiopaque marker to a position in the ventricle wall, then using fluoroscopy repeatedly to guide positioning of a cutting tip in the formation of multiple channels. Another method uses radiopaque material injected into each channel formed, as a marker. Yet another method utilizes an anchorable, rotatable cutting probe for channel formation about an anchor member, where the cutting probe can vary in radial distance from the anchor. Still another method utilizes a multiple wire radio frequency burning probe, for formation of multiple channels simultaneously. Still another method utilizes liquid nitrogen to cause localized tissue death.
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公开(公告)号：US6056743A
公开(公告)日：2000-05-02
申请号：US35625
申请日：1998-03-05
IPC分类号： A61B19/00 , A61B6/00 , A61B17/00 , A61B17/22 , A61B17/32 , A61B17/34 , A61B18/00 , A61B18/02 , A61B18/12 , A61B18/14 , A61B17/36
CPC分类号： A61B17/3207 , A61B18/1492 , A61B2017/00247 , A61B2017/22077 , A61B2017/3488 , A61B2018/00273 , A61B2018/00291 , A61B2018/00392 , A61B2018/144 , A61B2090/395 , A61B90/39 , A61M2210/125
摘要： Devices and methods for creating a series of percutaneous myocardial revascularization (PMR) channels in the heart. One method includes forming a pattern of channels in the myocardium leading from healthy tissue to hibernating tissue. Suitable channel patterns include lines and arrays. One method includes anchoring a radiopaque marker to a position in the ventricle wall, then using fluoroscopy repeatedly to guide positioning of a cutting tip in the formation of multiple channels. Another method uses radiopaque material injected into each channel formed, as a marker. Yet another method utilizes an anchorable, rotatable cutting probe for channel formation about an anchor member, where the cutting probe can vary in radial distance from the anchor. Still another method utilizes a multiple wire radio frequency burning probe, for formation of multiple channels simultaneously. Still another method utilizes liquid nitrogen to cause localized tissue death.
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公开(公告)号：US06416490B1
公开(公告)日：2002-07-09
申请号：US09035736
申请日：1998-03-05
申请人： Louis Ellis , Gary L. Hendrickson , Lauri DeVore
发明人： Louis Ellis , Gary L. Hendrickson , Lauri DeVore
IPC分类号： A61B1720
CPC分类号： A61B18/1492 , A61B17/3468 , A61B17/3478 , A61B18/1477 , A61B90/39 , A61B2017/00247 , A61B2017/00296 , A61B2017/00867 , A61B2017/320084 , A61B2018/00148 , A61B2018/0016 , A61B2018/00279 , A61B2018/00392 , A61B2018/1253 , A61B2018/126 , A61B2018/1425 , A61B2018/162 , A61B2218/002 , A61F2/2493 , A61M2025/0089
摘要： A catheter having an elongate shaft including a proximal and a distal end. The shaft includes a conductor. An electrode is disposed at the distal end of the shaft and is connected to the conductor. The electrode has a generally annular, cross-sectional shape. The annular shape defines an opening within the electrode. An insulator surrounds the conductor. In accordance with the method of the present invention, a crater wound can be formed through the endocardium and into the myocardium of a patient's heart. Collateral damage to the myocardium can be made by infusing pressurized fluid into the crater wound.
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公开(公告)号：US20080314394A9
公开(公告)日：2008-12-25
申请号：US11191056
申请日：2005-07-28
申请人： Louis Ellis , Daniel Lafontaine , Roger Hastings , Lauri DeVore
发明人： Louis Ellis , Daniel Lafontaine , Roger Hastings , Lauri DeVore
CPC分类号： A61B17/3207 , A61B18/1492 , A61B90/39 , A61B2017/00247 , A61B2017/22077 , A61B2017/3488 , A61B2018/00273 , A61B2018/00291 , A61B2018/00392 , A61B2018/144 , A61B2090/395 , A61M2210/125
摘要： Devices and methods for creating a series of percutaneous myocardial revascularization (PMR) channels in the heart. One method includes forming a pattern of channels in the myocardium leading from healthy tissue to hibernating tissue. Suitable channel patterns include lines and arrays. One method includes anchoring a radiopaque marker to a position in the ventricle wall, then using fluoroscopy repeatedly to guide positioning of a cutting tip in the formation of multiple channels. Another method uses radiopaque material injected into each channel formed, as a marker. Yet another method utilizes an anchorable, rotatable cutting probe for channel formation about an anchor member, where the cutting probe can vary in radial distance from the anchor. Still another method utilizes a multiple wire radio frequency burning probe, for formation of multiple channels simultaneously. Still another method utilizes liquid nitrogen to cause localized tissue death.
摘要翻译： 在心脏中创建一系列经皮心肌血运重建（PMR）通道的装置和方法。 一种方法包括在从健康组织导向冬眠组织的心肌中形成通道图案。 合适的渠道模式包括线和阵列。 一种方法包括将不透射线标记物固定在心室壁中的位置，然后重复使用荧光透视来引导切割尖端在形成多个通道中的定位。 另一种方法使用注射到形成的每个通道中的不透射线材料作为标记。 另一种方法利用可锚定的，可旋转的切割探针，用于围绕锚定构件的通道形成，其中切割探针可以与锚固件的径向距离变化。 另一种方法是利用多线射频燃烧探头，同时形成多个通道。 另一种方法利用液氮引起局部组织死亡。
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公开(公告)号：US20050257796A1
公开(公告)日：2005-11-24
申请号：US11191056
申请日：2005-07-28
申请人： Louis Ellis , Daniel Lafontaine , Roger Hastings , Lauri DeVore
发明人： Louis Ellis , Daniel Lafontaine , Roger Hastings , Lauri DeVore
IPC分类号： A61B19/00 , A61B6/00 , A61B17/00 , A61B17/22 , A61B17/32 , A61B17/34 , A61B18/00 , A61B18/02 , A61B18/12 , A61B18/14 , A61B18/18
CPC分类号： A61B17/3207 , A61B18/1492 , A61B90/39 , A61B2017/00247 , A61B2017/22077 , A61B2017/3488 , A61B2018/00273 , A61B2018/00291 , A61B2018/00392 , A61B2018/144 , A61B2090/395 , A61M2210/125
摘要： Devices and methods for creating a series of percutaneous myocardial revascularization (PMR) channels in the heart. One method includes forming a pattern of channels in the myocardium leading from healthy tissue to hibernating tissue. Suitable channel patterns include lines and arrays. One method includes anchoring a radiopaque marker to a position in the ventricle wall, then using fluoroscopy repeatedly to guide positioning of a cutting tip in the formation of multiple channels. Another method uses radiopaque material injected into each channel formed, as a marker. Yet another method utilizes an anchorable, rotatable cutting probe for channel formation about an anchor member, where the cutting probe can vary in radial distance from the anchor. Still another method utilizes a multiple wire radio frequency burning probe, for formation of multiple channels simultaneously. Still another method utilizes liquid nitrogen to cause localized tissue death.
摘要翻译： 在心脏中创建一系列经皮心肌血运重建（PMR）通道的装置和方法。 一种方法包括在从健康组织导向冬眠组织的心肌中形成通道图案。 合适的渠道模式包括线和阵列。 一种方法包括将不透射线标记物固定在心室壁中的位置，然后重复使用荧光透视来引导切割尖端在形成多个通道中的定位。 另一种方法使用注射到形成的每个通道中的不透射线材料作为标记。 另一种方法利用可锚定的，可旋转的切割探针，用于围绕锚定构件的通道形成，其中切割探针可以与锚固件的径向距离变化。 另一种方法是利用多线射频燃烧探头，同时形成多个通道。 另一种方法利用液氮引起局部组织死亡。
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10.发明授权公开(公告)号：US06238406B1
公开(公告)日：2001-05-29
申请号：US09516531
申请日：2000-03-01
IPC分类号： A61B1732
CPC分类号： A61B17/32002 , A61B17/320758 , A61B17/3468 , A61B17/3478 , A61B90/39 , A61B2017/00247 , A61B2017/003 , A61B2017/22077 , A61B2017/320084 , A61B2018/00208 , A61B2018/00392 , A61B2018/1425 , A61B2018/1861 , A61F2/2493 , A61M2025/0089
摘要： Devices and methods for increasing blood perfusion within the myocardium of the heart by wounding the myocardium and applying growth factors to promote vascularization. One method includes driving spikes into the myocardium from within the heart, with the spikes being formed of biodegradable material, containing releasable growth factors, and having lumens and side holes. An alternative method utilizes non-biodegradable spikes with lumens and side holes. Another method promotes vascularization by injecting angiogenic material into holes bored into the myocardium, leaving a patent hole. Another method includes injecting angiogenic material into the myocardium without boring, leaving no patent hole. The angiogenic material can be carried in a biodegradable adhesive. Revascularization of the myocardium is promoted in one method by externally wounding the heart and applying a patch including growth factors.
摘要翻译： 通过伤害心肌并应用生长因子促进血管形成来增加心脏心肌内的血液灌注的装置和方法。 一种方法包括从心脏内将尖峰驱动到心肌中，其中尖峰由可生物降解的材料形成，包含可释放的生长因子，并具有流明和侧孔。 一种替代方法是利用不可生物降解的钉与流明和侧孔。 另一种方法通过将血管生成材料注入穿入心肌的孔中来促进血管形成，留下专利孔。 另一种方法包括将血管生成物质注入到心肌中而无需镗孔，没有留下专利孔。 血管生成物质可以携带在可生物降解的粘合剂中。 通过外部伤心并施用包括生长因子的贴片在一种方法中促进心肌的血运重建。
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