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    Drug delivery catheter with manifold
    1.
    发明授权
    Drug delivery catheter with manifold 失效
    药物输送导管与歧管

    公开(公告)号：US5554119A

    公开(公告)日：1996-09-10

    申请号：US187614

    申请日：1994-01-27

    申请人： Kent D. Harrison ,  Gary L. Hendrickson ,  Thomas J. Holman ,  Daniel M. Lafontaine ,  Matthew J. Miller ,  David B. Robinson

    发明人： Kent D. Harrison ,  Gary L. Hendrickson ,  Thomas J. Holman ,  Daniel M. Lafontaine ,  Matthew J. Miller ,  David B. Robinson

    IPC分类号： A61M25/00 ,  A61F2/958 ,  A61M16/04 ,  A61M29/02 ,  A61M5/32

    CPC分类号： A61M25/1002 ,  A61M16/0481 ,  A61M2025/105 ,  A61M2025/1052 ,  A61M2025/1072 ,  A61M2025/1097

    摘要： A drug delivery catheter which may be inserted into a vessel, such as a blood vessel is disclosed. The drug delivery catheter comprises any elongated tubular member which has a proximal end and a distal end. A drug lumen which provides a communication path for fluid is provided in the elongated tubular member for delivering a fluid, such as the drug to be administered. An inflatable balloon assembly is provided at the distal end of the elongated tubular member. The balloon assembly includes apertures which communicate with the drug lumen. The balloon assembly comprises a tubular balloon which is helically wound through the elongated tubular member and a sheath. The sheath is attached to the helically wound tubular balloon such that when the balloon member is uninflated, the first fluid in the vessel flows around the balloon assembly and such that when the balloon member is inflated, sections of the helically wound balloon contact the vessel wall to form a containment pocket between the vessel wall, the contacting sections of the balloon and the sheath. The apertures are provided in the containment pocket. An inflatable lumen is defined through the interior of the helically wound balloon and the sheath to allow perfusion of the first fluid.

    摘要翻译： 公开了一种可插入容器（如血管）中的药物输送导管。 药物递送导管包括具有近端和远端的任何细长管状构件。 提供用于流体的连通路径的药物腔室设置在细长管状构件中，用于输送流体，例如待施用的药物。 在细长管状构件的远端处设置可充气气囊组件。 气囊组件包括与药物腔连通的孔。 球囊组件包括通过细长管状构件和护套螺旋缠绕的管状球囊。 护套附接到螺旋形缠绕的管状气囊，使得当球囊构件未膨胀时，容器中的第一流体围绕球囊组件流动，使得当球囊构件膨胀时，螺旋形卷绕的球囊的部分接触血管壁 以在容器壁，球囊和护套的接触部分之间形成容纳袋。 孔口设置在容纳口袋中。 通过螺旋缠绕气囊和护套的内部限定可充气腔，以允许第一流体的灌注。

    Closure device and method
    5.
    发明授权
    Closure device and method 失效
    封闭装置和方法

    公开(公告)号：US5964782A

    公开(公告)日：1999-10-12

    申请号：US932990

    申请日：1997-09-18

    申请人： Daniel M. Lafontaine ,  Kent D. Harrison

    发明人： Daniel M. Lafontaine ,  Kent D. Harrison

    IPC分类号： A61B17/04 ,  A61B17/00 ,  A61B17/10 ,  A61B18/04 ,  A61B18/14

    CPC分类号： A61B18/148 ,  A61B17/0057 ,  A61B2017/00637 ,  A61B2017/00663 ,  A61B2017/00668 ,  A61B2017/00672 ,  A61B2018/00196 ,  A61B2018/0022 ,  A61B2018/00273 ,  A61B2018/00279

    摘要： An apparatus is provided for closing a perforation in a wall of a patient's blood vessel or other organs, and a method of introducing the apparatus and causing the closure are described. The apparatus includes an elongated support member having a distal end supporting one or more tissue engaging hooks configured to engage fibrous vessel tissue when moved in a first direction and to disengage the tissue when moved in a second direction, and a proximal end for applying rotational torque to the support member to cause the hooks to engage collagen fibrous tissue in the adventitia of the blood vessel or fibrous tissue in other body organs. The hooks engaging the collagen fiber causes the blood vessel tissue surrounding the perforation to be drawn into close proximity such that the perforation can be closed. The apparatus can be removed by applying reverse rotation of the support member, whereby the hooks are disengaged. The apparatus is deployed in an outer sheath with the hooks encased until a selected engaging location has been achieved. When positioned in the aperture to be closed, the hooks are exposed to allow interaction with the adventitia. Puncture closure can be accomplished by various techniques, including stasis, cauterizing, or by clamping. Various embodiments of the apparatus are described.

    摘要翻译： 提供了用于封闭患者血管或其他器官的壁中的穿孔的装置，并且描述了引入该装置并引起闭合件的方法。 该装置包括细长的支撑构件，其具有支撑一个或多个组织接合钩的远端，所述组织接合钩构造成当沿第一方向移动时接合纤维血管组织，并且在沿第二方向移动时使组织脱离，以及用于施加旋转扭矩的近端 到支撑构件以引起钩将胶原纤维组织接合在血管的外膜或其他身体器官中的纤维组织中。 接合胶原纤维的钩使得穿孔周围的血管组织被拉近，使得穿孔可以闭合。 可以通过施加支撑构件的反向旋转来移除该装置，由此钩脱开。 该装置部署在外护套中，钩被包住，直到达到选定的接合位置。 当定位在要关闭的孔中时，钩暴露以允许与外膜相互作用。 穿刺闭合可以通过各种技术来实现，包括瘀斑，烧灼或夹紧。 描述该装置的各种实施例。

    Method for percutaneous coronary artery bypass
    6.
    发明授权
    Method for percutaneous coronary artery bypass 失效
    经皮冠状动脉搭桥方法

    公开(公告)号：US06253769B1

    公开(公告)日：2001-07-03

    申请号：US09391112

    申请日：1999-09-07

    申请人： Daniel M. LaFontaine ,  Kent D. Harrison ,  Charles L. Euteneuer ,  Roger N. Hastings ,  Lixiao Wang

    发明人： Daniel M. LaFontaine ,  Kent D. Harrison ,  Charles L. Euteneuer ,  Roger N. Hastings ,  Lixiao Wang

    IPC分类号： A61B1900

    CPC分类号： A61F2/82 ,  A61B17/32053 ,  A61B2017/00243 ,  A61B2017/00252 ,  A61B2017/1135 ,  A61B2017/306 ,  A61B2090/3929 ,  A61B2090/3945 ,  A61B2090/3958 ,  A61F2/06 ,  A61F2/064 ,  A61F2/90 ,  A61F2/958 ,  A61F2250/0098 ,  Y10S623/902

    摘要： A percutaneous system for bypassing a restriction in an artery of a mammal having an aorta includes providing a graft having a body portion with a first end, a second end and a lumen therebetween. First and second expandable stents are provided at the first and second ends of the graft, respectively. Apertures are formed in the artery, distal of the restriction, and in the aorta and the graft is inserted between the apertures. At least a portion of the first stent is inserted through the aperture in the artery and the stent is deployed to connect the first end of the graft within the artery. The second stent is positioned such that a first expandable portion is outside the aorta and a second expandable portion is within the aorta. The first and second expandable portions of the second stent are expanded to have outer diameters at least as large as the aperture in the aorta to anchor the first end of the graft in the aorta such that the lumen in the graft communicates with the aorta and the artery.

    摘要翻译： 用于绕过具有主动脉的哺乳动物的动脉中的限制的经皮系统包括提供具有主体部分的移植物，其具有第一端，第二端和内腔。 第一和第二可扩张支架分别设置在移植物的第一和第二端。 孔径形成在动脉的远端，在主动脉的远侧，移植物插入孔之间。 第一支架的至少一部分插入通过动脉中的孔，并且支架被展开以将移植物的第一端连接在动脉内。 第二支架定位成使得第一可膨胀部分在主动脉外侧，第二可膨胀部分在主动脉内。 第二支架的第一和第二可膨胀部分被扩张以具有至少与主动脉中的孔相同的外径，以将移植物的第一端锚定在主动脉中，使得移植物中的内腔与主动脉连通，并且 动脉。

    Percutaneous myocardial revascularization growth factor mediums and method
    9.
    发明授权
    Percutaneous myocardial revascularization growth factor mediums and method 有权
    经皮心肌血运重建生长因子介质及方法

    公开(公告)号：US06238406B1

    公开(公告)日：2001-05-29

    申请号：US09516531

    申请日：2000-03-01

    申请人： Louis Ellis ,  Gary L. Hendrickson ,  Kent D. Harrison ,  Lixiao Wang ,  Timothy J. Mickley

    发明人： Louis Ellis ,  Gary L. Hendrickson ,  Kent D. Harrison ,  Lixiao Wang ,  Timothy J. Mickley

    IPC分类号： A61B1732

    CPC分类号： A61B17/32002 ,  A61B17/320758 ,  A61B17/3468 ,  A61B17/3478 ,  A61B90/39 ,  A61B2017/00247 ,  A61B2017/003 ,  A61B2017/22077 ,  A61B2017/320084 ,  A61B2018/00208 ,  A61B2018/00392 ,  A61B2018/1425 ,  A61B2018/1861 ,  A61F2/2493 ,  A61M2025/0089

    摘要： Devices and methods for increasing blood perfusion within the myocardium of the heart by wounding the myocardium and applying growth factors to promote vascularization. One method includes driving spikes into the myocardium from within the heart, with the spikes being formed of biodegradable material, containing releasable growth factors, and having lumens and side holes. An alternative method utilizes non-biodegradable spikes with lumens and side holes. Another method promotes vascularization by injecting angiogenic material into holes bored into the myocardium, leaving a patent hole. Another method includes injecting angiogenic material into the myocardium without boring, leaving no patent hole. The angiogenic material can be carried in a biodegradable adhesive. Revascularization of the myocardium is promoted in one method by externally wounding the heart and applying a patch including growth factors.

    摘要翻译： 通过伤害心肌并应用生长因子促进血管形成来增加心脏心肌内的血液灌注的装置和方法。 一种方法包括从心脏内将尖峰驱动到心肌中，其中尖峰由可生物降解的材料形成，包含可释放的生长因子，并具有流明和侧孔。 一种替代方法是利用不可生物降解的钉与流明和侧孔。 另一种方法通过将血管生成材料注入穿入心肌的孔中来促进血管形成，留下专利孔。 另一种方法包括将血管生成物质注入到心肌中而无需镗孔，没有留下专利孔。 血管生成物质可以携带在可生物降解的粘合剂中。 通过外部伤心并施用包括生长因子的贴片在一种方法中促进心肌的血运重建。