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公开(公告)号：US06599928B2
公开(公告)日：2003-07-29
申请号：US09910387
申请日：2001-07-20
申请人： Lawrence L. Kunz , Richard A. Klein
发明人： Lawrence L. Kunz , Richard A. Klein
IPC分类号： A61K3140
CPC分类号： A61K31/04 , A61K9/0024 , A61K31/00 , A61K31/131 , A61K31/135 , A61K31/138 , A61K31/165 , A61K31/17 , A61K31/337 , A61K31/352 , A61K31/365 , A61K31/40 , A61K31/4025 , A61K31/4035 , A61K31/407 , A61K31/519 , A61K31/551 , A61K31/704 , A61K47/50 , A61K47/51 , A61K47/6803 , A61K47/6809 , A61K47/6817 , A61K47/6831 , A61K47/6843 , A61K47/6923 , A61K47/6927 , A61K47/6957 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2300/604 , A61L2300/606 , B82Y5/00 , G01N2800/323 , Y10S977/775 , Y10S977/808 , Y10S977/905 , Y10S977/906 , Y10S977/916
摘要： Methods are provided for inhibiting stenosis following vascular trauma or disease in a mammalian host, comprising administering to the host a therapeutically effective dosage of a therapeutic conjugate containing a vascular smooth muscle binding protein that associates in a specific manner with a cell surface of the vascular smooth muscle cell, coupled to a therapeutic agent dosage form that inhibits a cellular activity of the muscle cell. Methods are also provided for the direct and/or targeted delivery of therapeutic agents to vascular smooth muscle cells that cause a dilation and fixation of the vascular lumen by inhibiting smooth muscle cell contraction, thereby constituting a biological stent.
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公开(公告)号：US06515009B1
公开(公告)日：2003-02-04
申请号：US08389712
申请日：1995-02-15
申请人： Lawrence L. Kunz , Richard A. Klein
发明人： Lawrence L. Kunz , Richard A. Klein
IPC分类号： A61K3140
CPC分类号： A61K31/04 , A61K9/0024 , A61K31/00 , A61K31/131 , A61K31/135 , A61K31/138 , A61K31/165 , A61K31/17 , A61K31/337 , A61K31/352 , A61K31/365 , A61K31/40 , A61K31/4025 , A61K31/4035 , A61K31/407 , A61K31/519 , A61K31/551 , A61K31/704 , A61K47/50 , A61K47/51 , A61K47/6803 , A61K47/6809 , A61K47/6817 , A61K47/6831 , A61K47/6843 , A61K47/6923 , A61K47/6927 , A61K47/6957 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2300/604 , A61L2300/606 , B82Y5/00 , G01N2800/323 , Y10S977/775 , Y10S977/808 , Y10S977/905 , Y10S977/906 , Y10S977/916
摘要： Methods are provided for inhibiting stenosis following vascular trauma or disease in a mammalian host, comprising administering to the host a therapeutically effective dosage of a therapeutic conjugate containing a vascular smooth muscle binding protein that associates in a specific manner with a cell surface of the vascular smooth muscle cell, coupled to a therapeutic agent dosage form that inhibits a cellular activity of the muscle cell. Methods are also provided for the direct and/or targeted delivery of therapeutic agents to vascular smooth muscle cells that cause a dilation and fixation of the vascular lumen by inhibiting smooth muscle cell contraction, thereby constituting a biological stent.
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公开(公告)号：US5981568A
公开(公告)日：1999-11-09
申请号：US829685
申请日：1997-03-31
申请人： Lawrence L. Kunz , Richard A. Klein , John M. Reno
发明人： Lawrence L. Kunz , Richard A. Klein , John M. Reno
IPC分类号： A61K9/00 , A61K31/00 , A61K31/04 , A61K31/131 , A61K31/135 , A61K31/138 , A61K31/165 , A61K31/17 , A61K31/337 , A61K31/352 , A61K31/365 , A61K31/40 , A61K31/4025 , A61K31/4035 , A61K31/407 , A61K31/519 , A61K31/551 , A61K31/704 , A61K47/48 , A61L31/08 , A61L31/14 , A61L31/16 , A61P7/00 , A61P9/00 , A61P43/00
CPC分类号： A61K9/0024 , A61K31/00 , A61K31/04 , A61K31/131 , A61K31/135 , A61K31/138 , A61K31/165 , A61K31/17 , A61K31/337 , A61K31/352 , A61K31/365 , A61K31/40 , A61K31/4025 , A61K31/4035 , A61K31/407 , A61K31/519 , A61K31/551 , A61K31/704 , A61K47/48384 , A61K47/48407 , A61K47/48438 , A61K47/48492 , A61K47/48538 , A61K47/48561 , A61K47/48861 , A61K47/48876 , A61L31/08 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2300/432 , A61L2300/602 , A61L2300/606 , A61L2300/622 , G01N2800/323 , Y10S977/906 , Y10S977/915 , Y10S977/92
摘要： Methods are provided for inhibiting stenosis or restenosis following vascular trauma in a mammalian host, comprising administering to the host a therapeutically effective dosage of a cytostatic agent and/or cytoskeletal inhibitor so as to biologically stent the traumatized vessel. Also provided is a method to inhibit or reduce vascular remodeling following vascular trauma, comprising administering an effective amount of a cytoskeletal inhibitor. Further provided are pharmaceutical compositions and kits comprising the therapeutic agents of the invention.
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公开(公告)号：US5811447A
公开(公告)日：1998-09-22
申请号：US450793
申请日：1995-05-25
申请人： Lawrence L. Kunz , Richard A. Klein , John M. Reno , David J. Grainger , James C. Metcalfe , Peter L. Weissberg , Peter G. Anderson
发明人： Lawrence L. Kunz , Richard A. Klein , John M. Reno , David J. Grainger , James C. Metcalfe , Peter L. Weissberg , Peter G. Anderson
IPC分类号： A61K9/00 , A61K31/00 , A61K31/135 , A61K31/138 , A61K31/337 , A61K31/40 , A61K31/4025 , A61K31/4035 , A61K31/407 , A61K47/48
CPC分类号： A61K9/0024 , A61K31/00 , A61K31/135 , A61K31/138 , A61K31/337 , A61K31/40 , A61K31/4025 , A61K31/4035 , A61K31/407 , A61K47/48384 , A61K47/48407 , A61K47/48438 , A61K47/48492 , A61K47/48538 , A61K47/48876 , A61K47/48892 , G01N2800/323
摘要： Methods are provided for inhibiting stenosis following vascular trauma or disease in a mammalian host, comprising administering to the host a therapeutically effective dosage of a therapeutic conjugate containing a vascular smooth muscle binding protein that associates in a specific manner with a cell surface of the vascular smooth muscle cell, coupled to a therapeutic agent dosage form that inhibits a cellular activity of the muscle cell. Methods are also provided for the direct and/or targeted delivery of therapeutic agents to vascular smooth muscle cells that cause a dilation and fixation of the vascular lumen by inhibiting smooth muscle cell contraction, thereby constituting a biological stent. Also discussed are mechanisms for in vivo vascular smooth muscle cell proliferation modulation, agents that impact those mechanisms and protocols for the use of those agents.
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公开(公告)号：US06720350B2
公开(公告)日：2004-04-13
申请号：US10330834
申请日：2002-12-27
申请人： Lawrence L. Kunz , Richard A. Klein , John M. Reno
发明人： Lawrence L. Kunz , Richard A. Klein , John M. Reno
IPC分类号： A61K3140
CPC分类号： A61K9/0024 , A61K31/00 , A61K31/04 , A61K31/131 , A61K31/135 , A61K31/138 , A61K31/165 , A61K31/17 , A61K31/337 , A61K31/352 , A61K31/365 , A61K31/40 , A61K31/4025 , A61K31/4035 , A61K31/407 , A61K31/519 , A61K31/551 , A61K31/704 , A61K47/6803 , A61K47/6809 , A61K47/6817 , A61K47/6831 , A61K47/6843 , A61K47/6849 , A61K47/6923 , A61K47/6927 , A61L31/08 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2300/432 , A61L2300/602 , A61L2300/606 , A61L2300/622 , G01N2800/323 , Y10S977/906 , Y10S977/915 , Y10S977/92
摘要： Methods are provided for inhibiting stenosis or restenosis following vascular trauma in a mammalian host, comprising administering to the host a therapeutically effective dosage of a cytostatic agent and/or cytoskeletal inhibitor so as to biologically stent the traumatized vessel. Also provided is a method to inhibit or reduce vascular remodeling following vascular trauma, comprising administering an effective amount of a cytoskeletal inhibitor. Further provided are pharmaceutical compositions and kits comprising the therapeutic agents of the invention.
摘要翻译： 提供用于抑制哺乳动物宿主血管创伤后的狭窄或再狭窄的方法，包括向宿主施用治疗有效剂量的细胞生长抑制剂和/或细胞骨架抑制剂，以便对创伤血管进行生物支架。 还提供了抑制或减少血管创伤后血管重塑的方法，包括施用有效量的细胞骨架抑制剂。 还提供了包含本发明治疗剂的药物组合物和试剂盒。
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公开(公告)号：US06358989B1
公开(公告)日：2002-03-19
申请号：US09361194
申请日：1999-07-26
申请人： Lawrence L. Kunz , Richard A. Klein , John M. Reno
发明人： Lawrence L. Kunz , Richard A. Klein , John M. Reno
IPC分类号： A61K3140
CPC分类号： A61K9/0024 , A61K31/00 , A61K31/04 , A61K31/131 , A61K31/135 , A61K31/138 , A61K31/165 , A61K31/17 , A61K31/337 , A61K31/352 , A61K31/365 , A61K31/40 , A61K31/4025 , A61K31/4035 , A61K31/407 , A61K31/519 , A61K31/551 , A61K31/704 , A61K47/6803 , A61K47/6809 , A61K47/6817 , A61K47/6831 , A61K47/6843 , A61K47/6849 , A61K47/6923 , A61K47/6927 , A61L31/08 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2300/432 , A61L2300/602 , A61L2300/606 , A61L2300/622 , G01N2800/323 , Y10S977/906 , Y10S977/915 , Y10S977/92
摘要： Methods are provided for inhibiting stenosis or restenosis following vascular trauma in a mammalian host, comprising administering to the host a therapeutically effective dosage of a cytostatic agent and/or cytoskeletal inhibitor so as to biologically stent the traumatized vessel. Also provided is a method to inhibit or reduce vascular remodeling following vascular trauma, comprising administering an effective amount of a cytoskeletal inhibitor. Further provided are pharmaceutical compositions and kits comprising the therapeutic agents of the invention.
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公开(公告)号：US6074659A
公开(公告)日：2000-06-13
申请号：US113733
申请日：1998-07-10
申请人： Lawrence L. Kunz , Richard A. Klein , John M. Reno , David J. Grainger , James C. Metcalfe , Peter L. Weissberg , Peter G. Anderson
发明人： Lawrence L. Kunz , Richard A. Klein , John M. Reno , David J. Grainger , James C. Metcalfe , Peter L. Weissberg , Peter G. Anderson
IPC分类号： A61K9/00 , A61K31/00 , A61K31/135 , A61K31/138 , A61K31/337 , A61K31/40 , A61K31/4025 , A61K31/4035 , A61K31/407 , A61K47/48 , A61F2/00
CPC分类号： A61K9/0024 , A61K31/00 , A61K31/135 , A61K31/138 , A61K31/337 , A61K31/40 , A61K31/4025 , A61K31/4035 , A61K31/407 , A61K47/48384 , A61K47/48407 , A61K47/48438 , A61K47/48492 , A61K47/48538 , A61K47/48876 , A61K47/48892 , G01N2800/323
摘要： Methods are provided for inhibiting stenosis following vascular trauma or disease in a mammalian host, comprising administering to the host a therapeutically effective dosage of a therapeutic conjugate containing a vascular smooth muscle binding protein that associates in a specific manner with a cell surface of the vascular smooth muscle cell, coupled to a therapeutic agent dosage form that inhibits a cellular activity of the muscle cell. Methods are also provided for the direct and/or targeted delivery of therapeutic agents to vascular smooth muscle cells that cause a dilation and fixation of the vascular lumen by inhibiting smooth muscle cell contraction, thereby constituting a biological stent. Also discussed are mechanisms for in vivo vascular smooth muscle cell proliferation modulation, agents that impact those mechanisms and protocols for the use of those agents.
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公开(公告)号：US5733925A
公开(公告)日：1998-03-31
申请号：US738733
申请日：1996-10-28
申请人： Lawrence L. Kunz , Richard A. Klein , John M. Reno , David J. Grainger , James C. Metcalfe , Peter L. Weissberg , Peter G. Anderson
发明人： Lawrence L. Kunz , Richard A. Klein , John M. Reno , David J. Grainger , James C. Metcalfe , Peter L. Weissberg , Peter G. Anderson
IPC分类号： A61K9/00 , A61K31/00 , A61K31/135 , A61K31/138 , A61K31/337 , A61K31/40 , A61K31/4025 , A61K31/4035 , A61K31/407 , A61K47/48 , A61K31/335
CPC分类号： A61K9/0024 , A61K31/00 , A61K31/135 , A61K31/138 , A61K31/337 , A61K31/40 , A61K31/4025 , A61K31/4035 , A61K31/407 , A61K47/48384 , A61K47/48407 , A61K47/48438 , A61K47/48492 , A61K47/48538 , A61K47/48876 , A61K47/48892 , G01N2800/323
摘要： Methods are provided for inhibiting stenosis following vascular trauma or disease in a mammalian host, comprising administering to the host a therapeutically effective dosage of a therapeutic conjugate containing a vascular smooth muscle binding protein that associates in a specific manner with a cell surface of the vascular smooth muscle cell, coupled to a therapeutic agent dosage form that inhibits a cellular activity of the muscle cell. Methods are also provided for the direct and/or targeted delivery of therapeutic agents to vascular smooth muscle cells that cause a dilation and fixation of the vascular lumen by inhibiting smooth muscle cell contraction, thereby constituting a biological stent. Also discussed are mechanisms for in vivo vascular smooth muscle cell proliferation modulation, agents that impact those mechanisms and protocols for the use of those agents.
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公开(公告)号：US20120191019A1
公开(公告)日：2012-07-26
申请号：US13189179
申请日：2011-07-22
IPC分类号： A61N7/00
CPC分类号： A61N7/02 , A61N2007/0008 , A61N2007/0034
摘要： Methods and devices for applying high intensity focused ultrasound to modulate collagen in animal tissue (such as to disrupt collagen fibrils in a mammal, such as a human), particularly to enhance the aesthetic appearance of skin, and/or to otherwise improve skin conditions.
摘要翻译： 用于应用高强度聚焦超声来调节动物组织中的胶原蛋白的方法和装置（例如破坏哺乳动物如人的胶原原纤维），特别是增强皮肤的美学外观和/或以其它方式改善皮肤状况。
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公开(公告)号：US08158670B2
公开(公告)日：2012-04-17
申请号：US11650059
申请日：2007-01-04
CPC分类号： A61K31/04 , A61K9/0024 , A61K31/00 , A61K31/131 , A61K31/135 , A61K31/138 , A61K31/165 , A61K31/17 , A61K31/337 , A61K31/352 , A61K31/365 , A61K31/40 , A61K31/4025 , A61K31/4035 , A61K31/407 , A61K31/519 , A61K31/551 , A61K31/704 , A61K47/50 , A61K47/51 , A61K47/6803 , A61K47/6809 , A61K47/6817 , A61K47/6831 , A61K47/6843 , A61K47/6923 , A61K47/6927 , A61K47/6957 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2300/604 , A61L2300/606 , B82Y5/00 , G01N2800/323 , Y10S977/775 , Y10S977/808 , Y10S977/905 , Y10S977/906 , Y10S977/916
摘要： Methods are provided for inhibiting stenosis following vascular trauma or disease in a mammalian host, comprising administering to the host a therapeutically effective dosage of a therapeutic conjugate containing a vascular smooth muscle binding protein that associates in a specific manner with a cell surface of the vascular smooth muscle cell, coupled to a therapeutic agent dosage form that inhibits a cellular activity of the muscle cell. Methods are also provided for the direct and/or targeted delivery of therapeutic agents to vascular smooth muscle cells that cause a dilation and fixation of the vascular lumen by inhibiting smooth muscle cell contraction, thereby constituting a biological stent.
摘要翻译： 提供了用于在哺乳动物宿主中的血管创伤或疾病之后抑制狭窄的方法，包括向宿主施用治疗有效剂量的含有血管平滑肌结合蛋白的治疗性缀合物，其以特定方式与血管平滑的细胞表面相关联 肌肉细胞，与抑制肌肉细胞的细胞活性的治疗剂剂型偶联。 还提供了用于通过抑制平滑肌细胞收缩导致血管腔的扩张和固定的血管平滑肌细胞的治疗剂的直接和/或靶向递送的方法，从而构成生物支架。
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