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公开(公告)号:US20230366607A1
公开(公告)日:2023-11-16
申请号:US18196139
申请日:2023-05-11
发明人: Sorin Musat , Lilian Nicolae Nisif
CPC分类号: F25D17/06 , F25D23/10 , F25D2201/10 , B33Y80/00
摘要: A cooling device suitable for cooling paraffin tissue blocks with little or no moisture artefacts, as well as the use thereof to obtain good quality serial sections for microscope slides. The slides can be used in histology and anatomical pathology, for example. The cooling device may include a cold plate, a lid, and a sheet of insulating material over the cold plate.
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公开(公告)号:US20230324265A1
公开(公告)日:2023-10-12
申请号:US18298912
申请日:2023-04-11
发明人: Sorin Musat
CPC分类号: G01N1/31 , G01N1/36 , G01N2001/366
摘要: A tamper for making paraffin blocks for histology may include a pliable tamper head and a handle. The handle may be permanently or removably attached to the tamper by using screws, magnets, or the like. The tamper may be made from a pliable material, such as a silicone rubber, with improved thermal transfer and high latent heat. In use, the tamper may be warmed in advance to a working temperature by placing the tamper on a hot plate of the embedding station or on a dedicated smaller hot plate. Alternatively, the tamper may be heated with an electric resistive element, a thermoelectric device, or an electric induction coil.
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公开(公告)号:US10670593B2
公开(公告)日:2020-06-02
申请号:US15853251
申请日:2017-12-22
发明人: Sorin Musat
IPC分类号: G01N33/543 , G01N1/36 , G01N1/30 , G01N1/42
摘要: A custom-made matrix suitable for receiving a tissue sample is described, as well as the use thereof to obtain a multiplex histological preparation. The disclosure also relates to a multiplex biopsy array comprising tissue and/or cell samples arranged in a matrix material and to a method for the preparation of a multiplex biopsy array. Methods for preparing blocks of matrix material to be used in multiplex biopsy arrays are also described, as well as methods for loading biopsy samples in the blocks, and methods for treating and processing the blocks to form biopsy arrays. The biopsy arrays made using the block of matrix material can be used to prepare sections and slides for histological procedures, including quantitative analyses and parallel processing.
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公开(公告)号:US20180120308A1
公开(公告)日:2018-05-03
申请号:US15853251
申请日:2017-12-22
发明人: Sorin Musat
IPC分类号: G01N33/543 , G01N1/36 , G01N1/30 , G01N1/42
CPC分类号: G01N33/5436 , A61K2300/00 , G01N1/30 , G01N1/36 , G01N1/42
摘要: A custom-made matrix suitable for receiving a tissue sample is described, as well as the use thereof to obtain a multiplex histological preparation. The disclosure also relates to a multiplex biopsy array comprising tissue and/or cell samples arranged in a matrix material and to a method for the preparation of a multiplex biopsy array. Methods for preparing blocks of matrix material to be used in multiplex biopsy arrays are also described, as well as methods for loading biopsy samples in the blocks, and methods for treating and processing the blocks to form biopsy arrays. The biopsy arrays made using the block of matrix material can be used to prepare sections and slides for histological procedures, including quantitative analyses and parallel processing.
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公开(公告)号:US20210181075A1
公开(公告)日:2021-06-17
申请号:US17188955
申请日:2021-03-01
发明人: Sorin Musat
摘要: The disclosed methods for preparing cytological samples may include placing a cytological sample in a concave filter in a filtration system, applying a negative pressure to an outer side of the concave filter with a vacuum device to withdraw a liquid from the cytological sample, applying a sectionable matrix material over the filtered cellular material within the concave filter, and removing an assembly including the filtered cellular material and the sectionable matrix material from the filtration system. Various other related methods, systems, and materials are also disclosed.
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公开(公告)号:US20200033238A1
公开(公告)日:2020-01-30
申请号:US16523904
申请日:2019-07-26
发明人: Sorin Musat
摘要: The disclosed methods for preparing cytological samples may include placing a cytological sample in a concave filter in a filtration system, applying a negative pressure to an outer side of the concave filter with a vacuum device to withdraw a liquid from the cytological sample, applying a sectionable matrix material over the filtered cellular material within the concave filter, and removing an assembly including the filtered cellular material and the sectionable matrix material from the filtration system. Various other related methods, systems, and materials are also disclosed.
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公开(公告)号:US20240183764A1
公开(公告)日:2024-06-06
申请号:US18439949
申请日:2024-02-13
发明人: Sorin Musat
CPC分类号: G01N1/31 , G01N1/14 , G01N1/40 , G01N2001/1418
摘要: The disclosed methods for preparing cytological samples may include placing a cytological sample in a concave filter in a filtration system, applying a negative pressure to an outer side of the concave filter with a vacuum device to withdraw a liquid from the cytological sample, applying a sectionable matrix material over the filtered cellular material within the concave filter, and removing an assembly including the filtered cellular material and the sectionable matrix material from the filtration system. Various other related methods, systems, and materials are also disclosed.
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公开(公告)号:USD914238S1
公开(公告)日:2021-03-23
申请号:US29674485
申请日:2018-12-21
设计人: Matthew O. Leavitt , Sorin Musat
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公开(公告)号:US20240221876A1
公开(公告)日:2024-07-04
申请号:US18607070
申请日:2024-03-15
发明人: Mattew O. Leavitt , Sorin Musat
IPC分类号: G16H10/40 , A61B6/00 , A61B8/08 , B01L3/00 , G01N1/31 , G01N35/00 , G16H10/60 , G16H30/40 , G16H50/20 , G16H80/00 , H04M17/00
CPC分类号: G16H10/40 , A61B6/5252 , A61B8/5292 , B01L3/508 , G01N1/312 , G01N35/00029 , G01N35/00732 , G01N35/00871 , G16H10/60 , G16H30/40 , G16H50/20 , G16H80/00 , H04M17/307 , B01L2300/021 , B01L2300/12 , G01N2035/00772 , G01N2035/00831 , G01N2035/00851 , G01N2035/00881
摘要: Tissue sample management systems include a central network, a medical professional system, and a pathology lab system for processing a tissue sample in a matrix having a sectionable code. At least the pathology lab system includes at least one imaging device, and the central network is configured to process images from the at least one imaging device to identify and record at least the sectionable code of the matrix. Methods for tissue sample processing include providing a matrix having a sectionable code and measurement marks, the matrix for receiving a tissue sample, and identifying the sectionable code from an image taken of the tissue sample in the matrix. Tissue sample-receiving matrices include a sectionable alphanumeric code or bar code, a tissue sample receptacle, and measurement marks formed along a sidewall thereof. The matrices include one or more proteins and one or more lipids.
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公开(公告)号:US11935632B2
公开(公告)日:2024-03-19
申请号:US16984134
申请日:2020-08-03
发明人: Matthew O. Leavitt , Sorin Musat
IPC分类号: G16H10/40 , A61B6/00 , A61B8/08 , B01L3/00 , G01N1/31 , G01N35/00 , G16H10/60 , G16H30/40 , G16H50/20 , G16H80/00 , H04M17/00
CPC分类号: G16H10/40 , A61B6/5252 , A61B8/5292 , B01L3/508 , G01N1/312 , G01N35/00029 , G01N35/00732 , G01N35/00871 , G16H10/60 , G16H30/40 , G16H50/20 , G16H80/00 , H04M17/307 , B01L2300/021 , B01L2300/12 , G01N2035/00772 , G01N2035/00831 , G01N2035/00851 , G01N2035/00881
摘要: Tissue sample management systems include a central network, a medical professional system, and a pathology lab system for processing a tissue sample in a matrix having a sectionable code. At least the pathology lab system includes at least one imaging device, and the central network is configured to process images from the at least one imaging device to identify and record at least the sectionable code of the matrix. Methods for tissue sample processing include providing a matrix having a sectionable code and measurement marks, the matrix for receiving a tissue sample, and identifying the sectionable code from an image taken of the tissue sample in the matrix. Tissue sample-receiving matrices include a sectionable alphanumeric code or bar code, a tissue sample receptacle, and measurement marks formed along a sidewall thereof. The matrices include one or more proteins and one or more lipids.
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