-
公开(公告)号：US20200231663A1
公开(公告)日：2020-07-23
申请号：US16780325
申请日：2020-02-03
申请人： Lentigen Technology Inc. , The U.S.A., as represented by the Secretary, Department of Health and Human Services
IPC分类号： C07K16/18 , C07K14/725 , C07K14/705 , C07K16/30 , C12N15/63 , C12N5/0783 , C12N15/62 , C12N15/09 , C12N15/10 , A61P35/02 , A61P35/00 , A61K35/17
摘要： Chimeric antigen receptors containing mesothelin antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the chimeric antigen receptors are also disclosed. Methods of treating or preventing cancer in a subject, and methods of making chimeric antigen receptor T cells are also disclosed.
-
公开(公告)号：US11970528B2
公开(公告)日：2024-04-30
申请号：US16780325
申请日：2020-02-03
申请人： Lentigen Technology Inc. , The U.S.A., as represented by the Secretary, Department of Health and Human Services
IPC分类号： C07K16/18 , A61K35/17 , A61P35/00 , A61P35/02 , C07K14/705 , C07K14/725 , C07K16/30 , C12N5/0783 , C12N15/07 , C12N15/09 , C12N15/10 , C12N15/62 , C12N15/63
CPC分类号： C07K16/18 , A61K35/17 , A61P35/00 , A61P35/02 , C07K14/7051 , C07K14/70517 , C07K14/70521 , C07K14/70578 , C07K16/30 , C12N5/0636 , C12N5/0638 , C12N15/09 , C12N15/10 , C12N15/62 , C12N15/63 , C07K2317/21 , C07K2317/622 , C07K2319/02 , C07K2319/03 , C07K2319/33
摘要： Chimeric antigen receptors containing mesothelin antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the chimeric antigen receptors are also disclosed. Methods of treating or preventing cancer in a subject, and methods of making chimeric antigen receptor T cells are also disclosed.
-
公开(公告)号：US11464801B2
公开(公告)日：2022-10-11
申请号：US16588357
申请日：2019-09-30
申请人： Lentigen Technology, Inc. , The U.S.A., as represented by the Secretary, Department of Health and Human Services
IPC分类号： A61K35/17 , C07K16/28 , C07K14/725 , C07K14/705 , A61P35/02 , A61K39/395 , A61K48/00 , A61K39/00
摘要： Chimeric antigen receptors containing CD33 antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the chimeric antigen receptors are also disclosed. Methods of treating or preventing cancer in a subject, and methods of making chimeric antigen receptor T cells are also disclosed.
-
公开(公告)号：US20180208645A1
公开(公告)日：2018-07-26
申请号：US15866222
申请日：2018-01-09
申请人： Lentigen Technology Inc. , The U.S.A., as represented by the Secretary, Department of Health and Human Services
IPC分类号： C07K16/18 , A61K35/17 , A61P35/00 , C07K14/705 , C07K14/725 , A61P35/02
CPC分类号： C07K16/18 , A61K35/17 , A61P35/00 , A61P35/02 , C07K14/7051 , C07K14/70517 , C07K14/70521 , C07K14/70578 , C07K16/30 , C07K2317/21 , C07K2317/622 , C07K2319/02 , C07K2319/03 , C07K2319/33
摘要： Chimeric antigen receptors containing mesothelin antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the chimeric antigen receptors are also disclosed. Methods of treating or preventing cancer in a subject, and methods of making chimeric antigen receptor T cells are also disclosed.
-
公开(公告)号：US10426797B2
公开(公告)日：2019-10-01
申请号：US15934770
申请日：2018-03-23
申请人： Lentigen Technology, Inc. , The United States of America, as represented by the Secretary, Department of Health and Human Services
IPC分类号： A61K39/00 , C12Q1/6876 , C12N15/86 , A61K35/17 , C07K14/725 , C07K14/705 , C07K16/28 , A61P35/02 , A61K39/395 , A61K48/00
摘要： Chimeric antigen receptors containing CD33 antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the chimeric antigen receptors are also disclosed. Methods of treating or preventing cancer in a subject, and methods of making chimeric antigen receptor T cells are also disclosed.
-
公开(公告)号：US20200079849A1
公开(公告)日：2020-03-12
申请号：US16579082
申请日：2019-09-23
发明人： Rimas Orentas , Dina Schneider , Boro Dropulic
IPC分类号： C07K16/28 , C12N15/87 , C07K14/705 , A61K35/17 , C07K19/00 , C07K14/725
摘要： Chimeric antigen receptors containing tumor necrosis factor receptor superfamily member transmembrane domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the chimeric antigen receptors are also disclosed. Methods of treating or preventing cancer in a subject, and methods of making chimeric antigen receptor T cells are also disclosed.
-
公开(公告)号：US20210206839A1
公开(公告)日：2021-07-08
申请号：US17122847
申请日：2020-12-15
IPC分类号： C07K16/10 , C07K14/705 , A61P35/00 , A61P31/18 , A61K35/17 , C07K14/725
摘要： Chimeric antigen receptors (CARs) containing HIV envelope antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the CARs are also disclosed. Methods of treating or preventing HIV-infection in a subject, and methods of making CAR T cells are also disclosed. Results of treating or preventing HIV-infection, and results of making CAR T cells are also disclosed.
-
公开(公告)号：US20190241641A1
公开(公告)日：2019-08-08
申请号：US16078269
申请日：2017-09-01
IPC分类号： C07K14/725 , A61P35/02 , C12N15/85 , C07K14/705 , C07K16/28 , A61K35/17
CPC分类号： C07K14/7051 , A61K35/17 , A61K39/001112 , A61K39/001124 , A61K2039/5156 , A61P35/02 , C07K14/70517 , C07K14/70521 , C07K14/70578 , C07K16/2803 , C07K16/2887 , C07K2317/31 , C07K2317/622 , C07K2319/00 , C07K2319/02 , C07K2319/03 , C07K2319/75 , C12N15/85
摘要： Novel therapeutic immunotherapy compositions comprising at least two vectors, each vector encoding a functional CAR, whereby the combination of vectors results in the expression of two or more non-identical binding domains, wherein each vector encoded binding domain(s) are covalently linked to a transmembrane domain and one or more non-identical intracellular signaling motifs are provided herein as well as are methods of use of same in a patient-specific immunotherapy that can be used to treat cancers and other diseases and conditions.
-
公开(公告)号：US20190202895A1
公开(公告)日：2019-07-04
申请号：US16228077
申请日：2018-12-20
IPC分类号： C07K16/10 , C07K14/705 , A61P35/00 , A61P31/18 , A61K35/17 , C07K14/725
CPC分类号： C07K16/1063 , A61K35/17 , A61K38/00 , A61K2039/505 , A61P31/18 , A61P35/00 , C07K14/7051 , C07K14/70517 , C07K14/70578 , C07K2317/31 , C07K2317/76 , C07K2319/02 , C07K2319/03 , C07K2319/30
摘要： Chimeric antigen receptors (CARs) containing HIV envelope antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the CARs are also disclosed. Methods of treating or preventing HIV-infection in a subject, and methods of making CAR T cells are also disclosed. Results of treating or preventing HIV-infection, and results of making CAR T cells are also disclosed.
-
公开(公告)号：US11453712B2
公开(公告)日：2022-09-27
申请号：US16078269
申请日：2017-09-01
IPC分类号： C12N15/63 , C12N15/13 , C07K14/47 , A61K39/395 , C07K14/725 , C07K14/705 , C07K16/28 , A61P35/02 , A61K39/00 , A61K35/17 , C12N15/85
摘要： Novel therapeutic immunotherapy compositions comprising at least two vectors, each vector encoding a functional CAR, whereby the combination of vectors results in the expression of two or more non-identical binding domains, wherein each vector encoded binding domain(s) are covalently linked to a transmembrane domain and one or more non-identical intracellular signaling motifs are provided herein as well as are methods of use of same in a patient-specific immunotherapy that can be used to treat cancers and other diseases and conditions.
-
-
-
-
-
-
-
-
-
搜索结果
16 条记录 (耗时 0.035 秒)
