公开(公告)号：US20070078102A1

公开(公告)日：2007-04-05

申请号：US11368060

申请日：2006-03-03

申请人： Leslie McEvoy ,  Christi Parham ,  Jie Zhang ,  Rolf Ehrhardt

发明人： Leslie McEvoy ,  Christi Parham ,  Jie Zhang ,  Rolf Ehrhardt

IPC分类号： A61K48/00 ,  C07H21/04

CPC分类号： C12N15/115 ,  C12N15/113 ,  C12N2310/13 ,  C12N2310/315 ,  C12N2310/345 ,  C12N2310/53

摘要： The present invention concerns double-stranded NF-κB decoy oligodeoxynucleotide (NF-κB dsODN) molecules that contain a core sequence capable of specific binding to an NF-κB transcription factor. In a particular aspect, the invention concerns NF-κB decoy molecules that preferentially bind p50/p65 and/or cRel/p50 heterodimers over p50/p50 homodimers. In another aspect, the invention concerns NF-κB decoy molecules with improved binding affinity to p65.

摘要翻译： 本发明涉及含有能够与NF-κB转录因子特异性结合的核心序列的双链NF-κB诱饵寡脱氧核苷酸（NF-kappaB dsODN）分子。 在一个特定方面，本发明涉及在p50 / p50同源二聚体上优先结合p50 / p65和/或cRel / p50异二聚体的NF-kappaB诱饵分子。 另一方面，本发明涉及对p65具有改善的结合亲和力的NF-κB诱饵分子。

公开(公告)号：US20050182012A1

公开(公告)日：2005-08-18

申请号：US11004512

申请日：2004-12-02

申请人： Leslie McEvoy ,  Christi Parham ,  Jie Zhang ,  Rolf Ehrhardt

发明人： Leslie McEvoy ,  Christi Parham ,  Jie Zhang ,  Rolf Ehrhardt

IPC分类号： A61K48/00 ,  C07H21/04 ,  C12N15/113 ,  C12N15/115

CPC分类号： C12N15/115 ,  C12N15/113 ,  C12N2310/13 ,  C12N2310/315 ,  C12N2310/345 ,  C12N2310/53

摘要： The present invention concerns double-stranded NF-κB decoy oligodeoxynucleotide (NF-κB dsODN) molecules that contain a core sequence capable of specific binding to an NF-κB transcription factor. In a particular aspect, the invention concerns NF-κB decoy molecules that preferentially bind p50/p65 and/or cRel/p50 heterodimers over p50/p50 homodimers. In another aspect, the invention concerns NF-κB decoy molecules with improved binding affinity to p65.

摘要翻译： 本发明涉及含有能够与NF-κB转录因子特异性结合的核心序列的双链NF-κB诱饵寡脱氧核苷酸（NF-kappaB dsODN）分子。 在一个特定方面，本发明涉及在p50 / p50同源二聚体上优先结合p50 / p65和/或cRel / p50异二聚体的NF-kappaB诱饵分子。 另一方面，本发明涉及对p65具有改善的结合亲和力的NF-κB诱饵分子。

公开(公告)号：US20070010474A1

公开(公告)日：2007-01-11

申请号：US11521714

申请日：2006-09-14

申请人： Leslie McEvoy ,  Christi Parham ,  Jie Zhang ,  Rolf Ehrhardt

发明人： Leslie McEvoy ,  Christi Parham ,  Jie Zhang ,  Rolf Ehrhardt

IPC分类号： A61K48/00 ,  A61K9/127

CPC分类号： C12N15/115 ,  C12N15/113 ,  C12N2310/13 ,  C12N2310/315 ,  C12N2310/345 ,  C12N2310/53

摘要： The present invention concerns double-stranded NF-κB decoy oligodeoxynucleotide (NF-κB dsODN) molecules that contain a core sequence capable of specific binding to an NF-κB transcription factor. In a particular aspect, the invention concerns NF-κB decoy molecules that preferentially bind p50/p65 and/or cRel/p50 heterodimers over p50/p50 homodimers. In another aspect, the invention concerns NF-κB decoy molecules with improved binding affinity to p65.

摘要翻译： 本发明涉及含有能够与NF-κB转录因子特异性结合的核心序列的双链NF-κB诱饵寡脱氧核苷酸（NF-kappaB dsODN）分子。 在一个特定方面，本发明涉及在p50 / p50同源二聚体上优先结合p50 / p65和/或cRel / p50异二聚体的NF-kappaB诱饵分子。 另一方面，本发明涉及对p65具有改善的结合亲和力的NF-κB诱饵分子。

公开(公告)号：US20050164240A1

公开(公告)日：2005-07-28

申请号：US10960165

申请日：2004-10-06

申请人： Christi Parham ,  Leslie McEvoy ,  Jie Zhang ,  Xiaoping Rao

发明人： Christi Parham ,  Leslie McEvoy ,  Jie Zhang ,  Xiaoping Rao

IPC分类号： A61K38/00 ,  C12N15/113 ,  C12Q1/68

CPC分类号： C12N15/113 ,  A61K38/00 ,  C12N2310/111 ,  C12N2310/13

摘要： The invention concerns E2F oligonucleotide decoy molecules with improved properties. In particular, the invention concerns a double-stranded E2F decoy oligodeoxynucleotide (dsODN) molecule comprising a core sequence that is capable of specific binding to an E2F transcription factor, flanked by 5′ and 3′ sequences, wherein (i) the core sequence consists of about 5 to 12 base pairs; (ii) the molecule comprises an about 12 to 28 base-pair long double-stranded region composed of two fully complementary strands; and (iii) the E2F dsODN binds to said E2F transcription factor with a binding affinity that is at least about 5-fold of the binding affinity of a reference decoy molecule shown in FIG. 1 (SEQ ID NOS: 1 and 2), as determined by a competitive gel mobility shift binding assay performed on nuclear extract from THP-1 cells.

摘要翻译： 本发明涉及具有改进性质的E2F寡核苷酸诱饵分子。 特别地，本发明涉及双链E2F诱饵寡脱氧核苷酸（dsODN）分子，其包含能够与侧翼为5'和3'序列的E2F转录因子特异性结合的核心序列，其中（i）核心序列组成 约5至12个碱基对; （ii）分子包含由两个完全互补的链组成的约12至28个碱基对长双链区域; 和（iii）E2F dsODN以与图1所示的参考诱饵分子的结合亲和力的至少约5倍的结合亲和力结合所述E2F转录因子。 1（SEQ ID NO：1和2），其通过对来自THP-1细胞的核提取物进行的竞争性凝胶迁移率转移结合测定法测定。

公开(公告)号：US07378509B2

公开(公告)日：2008-05-27

申请号：US11004512

申请日：2004-12-02

申请人： Leslie M. McEvoy ,  Christi Parham ,  Jie Zhang ,  Rolf Ehrhardt

发明人： Leslie M. McEvoy ,  Christi Parham ,  Jie Zhang ,  Rolf Ehrhardt

IPC分类号： C07H21/04

CPC分类号： C12N15/115 ,  C12N15/113 ,  C12N2310/13 ,  C12N2310/315 ,  C12N2310/345 ,  C12N2310/53

摘要： The present invention concerns double-stranded NF-κB decoy oligodeoxynucleotide (NF-κB dsODN) molecules that contain a core sequence capable of specific binding to an NF-κB transcription factor. In a particular aspect, the invention concerns NF-κB decoy molecules that preferentially bind p50/p65 and/or cRel/p50 heterodimers over p50/p50 homodimers. In another aspect, the invention concerns NF-κB decoy molecules with improved binding affinity to p65.

摘要翻译： 本发明涉及含有能够与NF-κB转录因子特异性结合的核心序列的双链NF-κB诱饵寡脱氧核苷酸（NF-kappaB dsODN）分子。 在一个特定方面，本发明涉及在p50 / p50同源二聚体上优先结合p50 / p65和/或cRel / p50异二聚体的NF-kappaB诱饵分子。 另一方面，本发明涉及对p65具有改善的结合亲和力的NF-κB诱饵分子。

公开(公告)号：US20050215503A1

公开(公告)日：2005-09-29

申请号：US11003907

申请日：2004-12-02

申请人： Leslie McEvoy ,  Lyn Powell ,  Jie Zhang ,  Karen Morris

发明人： Leslie McEvoy ,  Lyn Powell ,  Jie Zhang ,  Karen Morris

IPC分类号： A61K38/00 ,  A61K48/00 ,  C07H21/02 ,  C12N15/11 ,  C12N15/113 ,  C12N15/88

CPC分类号： C12N15/113 ,  A01K2267/0331 ,  A61K38/00 ,  C12N15/111 ,  C12N2310/111 ,  C12N2310/13 ,  C12N2310/315 ,  C12N2320/31

摘要： The invention concerns double-stranded HIF decoy oligodeoxynucleotide (dsODN) molecules comprising a core sequence that is capable of specific binding to a HIF transcription factor, compositions containing such molecules, and their use in the treatment of various diseases and pathologic conditions associated with the regulation of gene transcription by a HIF transcription factor.

摘要翻译： 本发明涉及包含能够与HIF转录因子特异性结合的核心序列的双链HIF诱饵寡聚脱氧核苷酸（dsODN）分子，以及其用于治疗与调节相关的各种疾病和病理状况的用途 的基因转录通过HIF转录因子。

公开(公告)号：USD1041229S1

公开(公告)日：2024-09-10

申请号：US29832192

申请日：2022-03-25

申请人： Jie Zhang

设计人： Jie Zhang

摘要： FIG. 1 is a perspective view of a heating stove, showing my new design;
FIG. 2 is another perspective view thereof;
FIG. 3 is a front view thereof;
FIG. 4 is a rear view thereof;
FIG. 5 is a left side view thereof;
FIG. 6 is a right side view thereof;
FIG. 7 is a top plan view thereof;
FIG. 8 is a bottom plan view thereof;
FIG. 9 is an enlarged view of portion of FIG. 1; and,
FIG. 10 is another enlarged view of portion of FIG. 1.
The dash-dash broken lines show portions of the heating stove and form no part of the claimed design. The dot-dash broken lines shown in FIGS. 1, 9 & 10 define the boundary of the enlargement area and form no part of the claimed design.

公开(公告)号：US20160345828A1

公开(公告)日：2016-12-01

申请号：US15158803

申请日：2016-05-19

申请人： Qiang Yang ,  Jie Zhang

发明人： Qiang Yang ,  Jie Zhang

IPC分类号： A61B3/15 ,  G02B26/10 ,  A61B3/12 ,  A61B3/113 ,  A61B3/00

CPC分类号： A61B3/152 ,  A61B3/0025 ,  A61B3/113 ,  A61B3/1225 ,  G02B26/105

摘要： A system for multi-scale closed-loop eye tracking to compensate for translation and rotation motion while imaging in vivo a surface area of an internal structure of an eye of a subject includes a narrow field imaging device optically coupled to an optical path to receive light reflected from the surface area of the structure of the eye. A wide field camera is optically coupled to the optical path by a beam splitter disposed in the optical path. A tracking mirror is disposed in the optical path between the beam splitter and the structure of the eye. A control process algorithm actively compensates substantially in real time for both translational and rotational movements of the eye. A system where a torsional correction device causes a rotating movement of a subject's head and a method for multi-scale closed-loop eye tracking are also described.

摘要翻译： 一种用于多尺度闭环眼睛跟踪的系统，用于补偿平移和旋转运动，同时在体内成像对象的眼睛的内部结构的表面区域包括光学耦合到光路以接收光的窄场成像装置 从眼睛结构的表面积反射出来。 通过设置在光路中的分束器将宽视场摄像机光耦合到光路。 跟踪镜设置在分束器和眼睛结构之间的光路中。 控制过程算法主动地实时补偿眼睛的平移和旋转运动。 还描述了一种系统，其中扭转校正装置引起受试者的头部的旋转运动以及用于多尺度闭环眼睛跟踪的方法。

公开(公告)号：US09346245B2

公开(公告)日：2016-05-24

申请号：US13083161

申请日：2011-04-08

申请人： Chengdong Wu ,  Jie Zhang

发明人： Chengdong Wu ,  Jie Zhang

IPC分类号： A47K13/14 ,  B32B21/02 ,  A47K13/02 ,  B32B27/30

CPC分类号： B32B21/02 ,  A47K13/02 ,  B32B27/308 ,  B32B2307/412 ,  B32B2317/12 ,  B32B2317/16 ,  B32B2333/12 ,  B32B2509/00 ,  Y10T428/24802

摘要： Embodiments of the present disclosure include a laminate composite toilet lid and seat and a method of manufacturing thereof. The toilet lid includes a core structural layer having a shape and size associated with the toilet lid. The toilet lid also includes a first decorative graphic layer disposed on a first surface of the core structural layer. The toilet lid further includes a plurality of exterior layers disposed on exterior surfaces of the core structural layer and the first decorative graphic layer, the exterior layers configured to envelop the toilet lid.

摘要翻译： 本公开的实施例包括层压复合马桶盖和座椅及其制造方法。 马桶盖包括具有与马桶盖相关联的形状和尺寸的芯结构层。 马桶盖还包括设置在芯结构层的第一表面上的第一装饰图形层。 马桶盖还包括设置在芯结构层和第一装饰图形层的外表面上的多个外层，外层构造成包封马桶盖。

公开(公告)号：US09205180B2

公开(公告)日：2015-12-08

申请号：US13522819

申请日：2011-01-19

申请人： Jie Zhang ,  Bo Yi ,  Changsheng Wu ,  Zhirong Tang ,  Qiyi Luo

发明人： Jie Zhang ,  Bo Yi ,  Changsheng Wu ,  Zhirong Tang ,  Qiyi Luo

IPC分类号： A61L33/00 ,  A61L31/06 ,  A61L31/16 ,  A61F2/91

CPC分类号： A61F2/82 ,  A61F2/91 ,  A61F2240/001 ,  A61F2250/0068 ,  A61L31/06 ,  A61L31/16 ,  A61L2300/416 ,  B05C21/00 ,  C08L67/04

摘要： A method and a device for loading a medical appliance with a medicament and/or polymer includes capturing images of a plurality of grooves or holes of the medical appliance using an image capturing device; performing digital image processing on the image of each of the grooves or holes to obtain a pattern of each of the grooves or holes; calculating a central position of the pattern of each of the grooves or holes, and determining a loading position of each of the grooves or holes based on the central position; and adjusting a relative position between a loading device and the medical appliance to align an outlet of the loading device with the loading position of the medical appliance, and loading each of the grooves or holes with the medicament and/or polymer. The method and device can load the medical appliance with the medicament and/or polymer fast and efficiently.

摘要翻译： 一种用于装载具有药物和/或聚合物的医疗器具的方法和装置包括使用图像捕获装置捕获医疗器具的多个凹槽或孔的图像; 对每个凹槽或孔的图像执行数字图像处理以获得每个凹槽或孔的图案; 计算每个凹槽或孔的图案的中心位置，以及基于中心位置确定每个凹槽或孔的装载位置; 以及调整加载装置和医疗器具之间的相对位置，以将装载装置的出口与医疗器具的装载位置对齐，并且用药物和/或聚合物装载每个凹槽或孔。 该方法和装置可以快速且有效地加载具有药物和/或聚合物的医疗器具。