摘要:
The present invention is directed to quinoline amide compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.
摘要:
A software-based privacy filter is provided on a computing device. First, a content window is opened and displayed on a display of the computing device. Then a semi-transparent topmost window is created, wherein the semi-transparent topmost window includes a moving privacy pattern designed to obscure first portions of the content window at a first time and obscure second portions of the content window at a second time. The semi-transparent topmost window is then displayed on top of the first content window on the display of the computing device.
摘要:
The present invention is directed to isoindolone compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.
摘要:
The present invention relates to a method and a device for enclosed recycling of oil-water-sludge in an oil shale dry distillation system. According to the method, the technology is advanced, equipment investment costs are low, the occupied area is small, the failure rate is low, a highly pure shale oil product and a highly concentrated oil sludge product can be obtained efficiently, and the waste water generated in the purification and concentration processes can be recycled, thereby achieving full enclosure of the device system, greatly reducing the energy consumption, and improving the oil shale dry distillation process in the prior art.
摘要:
Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: Formula (I); are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of asthma, COPD, ARDS, rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions; inflamed joints, eczema, psoriasis or other inflammatory skin conditions such as sunburn; inflammatory eye conditions including conjunctivitis; pyresis, pain and other conditions associated with inflammation.
摘要:
The present invention is directed to certain Oxazole derivatives which are useful as modulators of Fatty Acid Amide Hydrolase (FAAH) and as FAAH imaging agents. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including osteoarthritis, rheumatoid arthritis, diabetic neuropathy, postherpetic neuralgia, skeletomuscular pain, and fibromyalgia, as well as acute pain, migraine, sleep disorder, Alzheimer Disease, and Parkinson's Disease.
摘要:
A head gimbal assembly includes a rotary fine actuator attached to the head mounting tongue. The rotary fine actuator includes a fixed portion, a head mounting platform, first and second piezoelectric elements, and first and second curved compliant members. The first piezoelectric element is bonded to the fixed portion at a first bonding surface, and to the head mounting platform at a second bonding surface. The second piezoelectric element extends between the fixed portion and the head mounting platform. The first and second curved compliant members extend between the fixed portion and the head mounting platform. A read head is bonded to a mounting surface of the head mounting platform. The first and second bonding surfaces are parallel to the mounting surface. The read head is disposed between the first and second piezoelectric elements.
摘要:
The present invention is directed to quinoline amide compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.
摘要:
The present invention is directed to pyridyl amide compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels are involved.
摘要:
The present invention is directed to heterocycle amide compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels are involved.