公开(公告)号：US20100056916A1

公开(公告)日：2010-03-04

申请号：US12515023

申请日：2007-11-16

申请人： Levinus Peter Bakker ,  Michael Cornelis Van Beek ,  Martinus Bernardus Van Der Mark ,  Rene Van Den Ham ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Ralf Hoffmann ,  Nijs Cornelis Van Der Vaart ,  Marjolein Van Der Voort

发明人： Levinus Peter Bakker ,  Michael Cornelis Van Beek ,  Martinus Bernardus Van Der Mark ,  Rene Van Den Ham ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Ralf Hoffmann ,  Nijs Cornelis Van Der Vaart ,  Marjolein Van Der Voort

IPC分类号： A61B8/14 ,  A61B6/00

CPC分类号： A61B5/0095 ,  A61B5/0035 ,  A61B5/0084 ,  A61B5/0086 ,  A61B8/12 ,  A61B8/4416

摘要： A system is provided that may be used for locating and diagnosing lesions in the human body in vivo. In some embodiments, once the exact position of a lesion is found, a biopsy may be taken from the lesion using e.g. ultra sound techniques for guidance of the biopsy needle. Use of the system drastically reduces the negative biopsy samples compared to currently used “blind sampling” techniques. This reduces patient discomfort and minimizes infections as the number of biopsy samples is reduced. A method and computer-readable medium is also provided.

摘要翻译： 提供了可用于在体内定位和诊断人体损伤的系统。 在一些实施例中，一旦发现病变的确切位置，可以使用例如病变从病变中取出活组织检查。 超声技术用于指导活检针。 与目前使用的“盲采”技术相比，使用该系统大大减少了活检样本的阴性。 随着活检样本的数量减少，这减少了患者的不适，并使感染最小化。 还提供了一种方法和计算机可读介质。

公开(公告)号：US20100030067A1

公开(公告)日：2010-02-04

申请号：US12515297

申请日：2007-11-14

申请人： Michael Cornelis Van Beek ,  Martinus Bernardus Van Der Mark ,  Levinus Pieter Bakker ,  Rene Van Den Ham ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Ralf Hoffmann ,  Nijs Cornelis Van Der Vaart ,  Marjolein Van Der Voort

发明人： Michael Cornelis Van Beek ,  Martinus Bernardus Van Der Mark ,  Levinus Pieter Bakker ,  Rene Van Den Ham ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Ralf Hoffmann ,  Nijs Cornelis Van Der Vaart ,  Marjolein Van Der Voort

IPC分类号： A61B5/05 ,  A61B8/14

CPC分类号： A61B5/4381 ,  A61B5/0073 ,  A61B5/0084 ,  A61B5/0086 ,  A61B8/12

摘要： A system for imaging of prostate cancer in a prostate in vivo is provided. The system utilizes Diffuse Optical Tomography (DOT) for creating a 3D image for the detection of suspicious prostate tissue. The DOT image may be used to guide the biopsy, thereby reducing the number of false negatives. A method, computer-readable medium and use are also provided.

摘要翻译： 提供了一种用于前列腺体内前列腺癌成像的系统。 该系统利用漫射光学层析成像（DOT）创建用于检测可疑前列腺组织的3D图像。 DOT图像可用于指导活组织检查，从而减少假阴性的数量。 还提供了一种方法，计算机可读介质和使用。

公开(公告)号：US08946580B2

公开(公告)日：2015-02-03

申请号：US13139208

申请日：2009-12-04

申请人： Ralf Hoffmann ,  Matthias Kroeker

发明人： Ralf Hoffmann ,  Matthias Kroeker

IPC分类号： H01H1/54 ,  H01H9/44 ,  H01H1/20 ,  H01H50/54

CPC分类号： H01H1/54 ,  H01H1/20 ,  H01H9/443 ,  H01H50/546 ,  H01H2001/545

摘要： The present invention relates to contactors for unidirectional DC operation with permanent magnetic arc extinguishing. In addition to the blow magnets, the contactors are equipped with compensatory permanent magnets for compensating the magnetic field in the vicinity of the contact bridge in order to prevent contact levitation, i.e., an uncontrolled opening of the contacts that is due to a magnetic force generated by a strong current flowing through the contact bridge. To this end, the compensatory permanent magnets are arranged in the vicinity of the contact bridge and polarized in the opposite direction of the blow magnets. The magnetic field of the compensatory magnets and the current flowing through the contact bridge are generating a magnetic force that acts on the contact bridge and tends to keep the electrical contacts closed.

摘要翻译： 本发明涉及用于具有永久磁性灭弧的单向直流操作的接触器。 除了吹制磁体之外，接触器还配备有补偿永磁体，用于补偿接触桥附近的磁场，以防止接触悬浮，即由于产生的磁力引起的触头的不受控的打开 通过流过接触桥的强电流。 为此，补偿永久磁铁布置在接触桥附近，并沿着吹塑磁体的相反方向极化。 补偿磁体的磁场和流过接触桥的电流产生作用在接触桥上的磁力，并且趋向于保持电触点闭合。

公开(公告)号：US20140309161A1

公开(公告)日：2014-10-16

申请号：US14128083

申请日：2012-06-20

申请人： Ralf Hoffmann ,  Nicole Berthold ,  Friederike Nollmann

发明人： Ralf Hoffmann ,  Nicole Berthold ,  Friederike Nollmann

IPC分类号： A61K47/48 ,  A01N25/22 ,  A61K38/10

CPC分类号： C07K14/43572 ,  A01N25/22 ,  A01N37/46 ,  A01N63/02 ,  A61K38/00 ,  A61K38/10 ,  A61K38/16 ,  A61K38/1767 ,  A61K47/60 ,  C07K7/08 ,  C07K11/00 ,  C07K14/43563 ,  C12Q1/37

摘要： The invention relates to modified antibiotic peptides, in particular derivatives of apidaecin and oncocin, preferably having increased stability, reduced immunoreaction, and improved pharmacokinetics. In the invention, the peptide antibiotics are reversibly protected by means of a linker having the polymer polyethylene glycol (PEG). The peptide linker contains a recognition sequence for trypsin-like serum proteases. In the apidaecin derivatives, the linker and the PEG are bonded to a side chain. In the serum, the linker is cut by serum proteases and PEG is separated off. The released peptide still contains remnants of the linker, which are still bonded to the amino group in the side chain. Astonishingly, said remaining remnants of the linker impair the activity of the antimicrobial peptide only a little or not at all.

摘要翻译： 本发明涉及修饰的抗生素肽，特别是apidaecin和oncocin的衍生物，优选具有增加的稳定性，降低的免疫反应和改善的药代动力学。 在本发明中，肽抗生素通过具有聚合物聚乙二醇（PEG）的接头可逆地保护。 肽接头包含胰蛋白酶样血清蛋白酶的识别序列。 在apidaecin衍生物中，接头和PEG与侧链结合。 在血清中，用血清蛋白酶切割接头，分离出PEG。 释放的肽仍然含有仍然与侧链中的氨基键合的接头残基。 令人惊讶的是，所述接头的剩余残留物仅仅少量地损害了抗微生物肽的活性。

公开(公告)号：US08686113B2

公开(公告)日：2014-04-01

申请号：US13147095

申请日：2010-01-29

申请人： Ralf Hoffmann ,  Daniel Knappe ,  Anna Klara Brigitte Hansen

发明人： Ralf Hoffmann ,  Daniel Knappe ,  Anna Klara Brigitte Hansen

IPC分类号： A61K38/10 ,  A61P31/04 ,  C07K1/00 ,  C07K7/08

CPC分类号： C07K7/08 ,  A01N47/44 ,  A61K38/00 ,  A61K38/10 ,  A61K47/48246 ,  A61K47/64 ,  C07K14/43563 ,  C12Q1/18 ,  G01N2500/10 ,  Y02A50/473 ,  Y02A50/475 ,  Y02A50/478 ,  Y02A50/481 ,  Y02A50/483

摘要： The invention relates to a peptide or peptide derivative having the general formula: Sub1-X1-D2K3-P4-P5-Y6-L7-P8-R9-P10-X2-P12-P13-R14-X3-I16-P17/Y17-N18-N19-X4-Sub2, wherein X1 is a non-polar, hydrophobic group or a positively charged group, D2 is asparagine or glutamine, K3, X2, and X4 are positively charged groups, X3 is a positively charged group, proline, or a proline derivative; L7 and I16 are non-polar, hydrophobic groups, Y6 and Y17 are tyrosine, R9 and R14 are arginine, N18 and N19 are asparagine or glutamine, P4, P5, P8, P10, P12, P13, and P17 are proline, hydroxyproline, or derivatives thereof, wherein possibly one or two of the groups selected from D2, P4, P5, P8, P10, P12, P13, P17, and Y17 are replaced by an arbitrary group and/or P13 and R14 are exchanged, Sub1 is the free or modified N-terminus, and Sub2 is the free or modified C-terminus. The invention further relates to the use of the peptides and peptide derivatives in medicine, as an antibiotic, in a disinfectant or cleaning agent, as a preservative or in a packaging material, in pharmaceutical research, or in a screening method.

摘要翻译： 本发明涉及具有以下通式的肽或肽衍生物：Sub1-X1-D2K3-P4-P5-Y6-L7-P8-R9-P10-X2-P12-P13-R14-X3-I16-P17 / Y17- N18-N19-X4-Sub2，其中X1是非极性疏水基团或带正电荷的基团，D2是天冬酰胺或谷氨酰胺，K 3，X 2和X 4是带正电荷的基团，X 3是带正电荷的基团， 或脯氨酸衍生物; L7和I16是非极性疏水基团，Y6和Y17是酪氨酸，R9和R14是精氨酸，N18和N19是天冬酰胺或谷氨酰胺，P4，P5，P8，P10，P12，P13和P17是脯氨酸，羟脯氨酸， 或其衍生物，其中可选地一个或两个选自D2，P4，P5，P8，P10，P12，P13，P17和Y17的基团被任意基团替代和/或P13和R14被交换，Sub1是 游离或修饰的N末端，Sub2是游离或修饰的C-末端。 本发明还涉及肽和肽衍生物在药物，作为抗生素，在消毒剂或清洁剂中，作为防腐剂或在包装材料中，在药物研究中或在筛选方法中的用途。

公开(公告)号：US08050477B2

公开(公告)日：2011-11-01

申请号：US12162671

申请日：2007-01-22

申请人： Lothar Spies ,  Helga Hummel ,  Carolina Ribbing ,  Ralf Hoffmann ,  Peter Klaus Bachmann

发明人： Lothar Spies ,  Helga Hummel ,  Carolina Ribbing ,  Ralf Hoffmann ,  Peter Klaus Bachmann

IPC分类号： A61N5/10

CPC分类号： A61N5/1031

摘要： An improved radiation therapy planning procedure is suggested. The procedure comprises the steps of specifying and determining the absolute grade of cell degeneracy by in-vitro tests, whereby marker(s) indicative for specific cell degeneracy are detected and quantified, establishing a biology-based segmentation of areas with similar grade of relative cell degeneracy and applying the absolute grade of cell degeneracy to the biology-based segmentation data, thereby establishing an improved radiation therapy planning procedure. Moreover, the present invention suggests a system for an improved radiation therapy planning procedure and its use in procedures of diagnosis and/or therapy management of cancer.

摘要翻译： 建议采用改进的放射治疗计划程序。 该方法包括以下步骤：通过体外测试来指定和确定细胞退化的绝对等级，由此检测和量化指示特异性细胞退化的标志物，建立具有相似等级的相对细胞的区域的基于生物学的分割 退化并将绝对等级的细胞退化应用于基于生物学的分割数据，从而建立改进的放射治疗计划程序。 此外，本发明提出了一种改进的放射治疗计划程序及其在癌症诊断和/或治疗管理程序中的应用的系统。

公开(公告)号：US08035468B2

公开(公告)日：2011-10-11

申请号：US10535052

申请日：2003-11-06

申请人： Ralf Hoffmann ,  Heinz Stadler

发明人： Ralf Hoffmann ,  Heinz Stadler

IPC分类号： H01H67/02

CPC分类号： H01H50/042 ,  H01H49/00 ,  H01H50/26 ,  H01H50/36

摘要： A relay has a magnet system with a core partially enclosed by a coil. A yoke has a first yoke leg attached to a first end of the core and a second yoke leg extending parallel to the core. The second yoke leg has an armature mounting portion formed on an upper side of the second yoke leg remote from the coil. A pole has a first pole leg connected to a second end of the core and a second pole leg extending parallel to the core. The second pole leg has an upper surface substantially aligned with the armature mounting portion. A fixed contact is arranged on a fixed contact carrier substantially aligned with the second pole leg. The arrangement of the magnet system ensures precise positional alignment during extrusion coating with a plastic material.

摘要翻译： 继电器具有磁体系统，其中芯部被线圈部分地包围。 轭具有附接到芯的第一端的第一轭腿和平行于芯延伸的第二轭腿。 第二轭腿具有形成在远离线圈的第二轭腿的上侧上的电枢安装部分。 杆具有连接到芯的第二端的第一极腿和平行于芯延伸的第二极腿。 第二极腿具有与电枢安装部分大致对准的上表面。 固定触点布置在基本上与第二极腿对齐的固定触点支架上。 磁体系统的布置确保了在用塑料材料的挤出涂覆期间精确的位置对准。

公开(公告)号：US20110045989A1

公开(公告)日：2011-02-24

申请号：US12936417

申请日：2009-04-02

申请人： Ralf Hoffmann ,  Hugo Matthieu Visser ,  Edwin Peter Romijn

发明人： Ralf Hoffmann ,  Hugo Matthieu Visser ,  Edwin Peter Romijn

IPC分类号： C40B10/00

CPC分类号： C07K1/13 ,  C07K1/36

摘要： The present invention relates to methods allowing the selective enrichment of N-terminal fragments of polypeptides and/or peptides from complex samples by combining a particular polypeptide/peptide labeling and fractionation strategy with specific chemical and/or enzymatic reactions targeting the N-terminal fragments to be analyzed.

摘要翻译： 本发明涉及通过将特定的多肽/肽标记和分级分离策略与针对N末端片段的特定化学和/或酶反应组合而允许从复杂样品中选择性富集多肽和/或肽的N-末端片段的方法 分析。

公开(公告)号：US20100304493A1

公开(公告)日：2010-12-02

申请号：US12744486

申请日：2008-11-17

申请人： Ralf Hoffmann ,  Hugo M. Visser ,  Edwin P. Romijn

发明人： Ralf Hoffmann ,  Hugo M. Visser ,  Edwin P. Romijn

IPC分类号： G01N33/68 ,  C07K1/14

CPC分类号： C07K1/14

摘要： The present invention relates to the selective enrichment of post-translationally modified proteins and/or peptides from complex samples by combining a particular protein/peptide labeling and fractionation strategy with specific chemical and/or enzymatic reactions targeting the post-translational modification to be analyzed. More specifically, the invention relates to methods for the enrichment and/or separation of phospho-proteins and/or -peptides, and particularly for the discrimination between different subsets of phospho-proteins and/or -peptides in complex samples.

摘要翻译： 本发明涉及通过将特定的蛋白质/肽标记和分级分离策略与针对待分析的翻译后修饰的特定化学和/或酶反应结合从复杂样品中选择性富集翻译后修饰的蛋白质和/或肽。 更具体地，本发明涉及用于富集和/或分离磷酸蛋白和/或肽的方法，特别是用于鉴定复杂样品中磷酸蛋白和/或肽的不同子集之间的差异。

公开(公告)号：US07800467B2

公开(公告)日：2010-09-21

申请号：US11924905

申请日：2007-10-26

申请人： Ralf Hoffmann

发明人： Ralf Hoffmann

IPC分类号： H01H67/02

CPC分类号： H01H50/546 ,  H01H1/2025 ,  H01H50/646

摘要： An electrical switch element for a relay includes a base, a compensating element, and an actuating device. The base is provided with fixed contacts. The compensating element includes first and second switch contact carriers provided with switch contacts that correspond to the fixed contacts. The first and second switch contact carriers are connected by a rigid body joint arranged there between such that the first and second switch contact carriers are pivotable about a pivot axis. The rigid body joint has a support surface. The actuating device is in contact with the support surface. The actuating device applies a switching force to the support surface to cause the first and second switch contact carriers to pivot about the pivot axis to move the switch contacts into or out of electrical contact with the fixed contacts.

摘要翻译： 用于继电器的电开关元件包括底座，补偿元件和致动装置。 基座设有固定触点。 补偿元件包括设置有对应于固定触点的开关触点的第一和第二开关触点支架。 第一和第二开关触点支架通过布置在其间的刚体接头连接，使得第一和第二开关触点支架围绕枢转轴线枢转。 刚体接头具有支撑表面。 致动装置与支撑表面接触。 致动装置向支撑表面施加切换力，以使第一和第二开关触点支架围绕枢转轴线枢转，以将开关触点移动到与固定触点电接触或脱离与固定触点的电接触。