-
公开(公告)号:US07879834B2
公开(公告)日:2011-02-01
申请号:US11208386
申请日:2005-08-19
申请人: Lewis R. Makings , Miguel Garcia-Guzman Blanco , Dennis R. Hurley , Ioana Drutu , Gabriel Raffai , Daniele J. Bergeron , Akiko Nakatani , Andreas P. Termin , Alina Silina
发明人: Lewis R. Makings , Miguel Garcia-Guzman Blanco , Dennis R. Hurley , Ioana Drutu , Gabriel Raffai , Daniele J. Bergeron , Akiko Nakatani , Andreas P. Termin , Alina Silina
IPC分类号: A61K31/33 , A61K31/55 , A61K31/44 , C07D225/00 , C07D295/00 , C07D223/00 , C07D243/00 , C07D471/20 , A01N43/00 , A01N43/62 , A01N43/42
CPC分类号: C07D401/06 , A61K31/435 , A61K31/438 , A61K31/4747 , A61K31/55 , C07D221/20 , C07D223/32 , C07D405/04 , C07D405/06 , C07D405/12 , C07D451/02 , C07D451/04 , C07D471/10 , C07D491/10
摘要: The present invention relates to spiroindoline modulators of muscarinic receptors. The present invention also provides compositions comprising such spiroindoline modulators, and methods therewith for treating muscarinic receptor mediated diseases.
摘要翻译: 本发明涉及毒蕈碱受体的螺二氢吲哚调节剂。 本发明还提供包含这样的螺二氢吲哚调节剂的组合物,及其用于治疗毒蕈碱受体介导的疾病的方法。
-
公开(公告)号:US08263605B2
公开(公告)日:2012-09-11
申请号:US12224270
申请日:2007-02-22
申请人: Lewis R. Makings , Miguel Garcia-Guzman Blanco , Dennis J. Hurley , Ioana Drutu , Gabriel Raffai , Daniele M. Bergeron , Akiko Nakatani , Andreas P. Termin , Alina Silina
发明人: Lewis R. Makings , Miguel Garcia-Guzman Blanco , Dennis J. Hurley , Ioana Drutu , Gabriel Raffai , Daniele M. Bergeron , Akiko Nakatani , Andreas P. Termin , Alina Silina
IPC分类号: A61K31/44 , C07D401/00 , C07D451/00 , C07D453/00
CPC分类号: C07D471/10
摘要: The present invention relates to modulators of muscarinic receptors of formula (I). The present invention also provides impositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
摘要翻译: 本发明涉及式(I)的毒蕈碱受体的调节剂。 本发明还提供包含这种调节剂的作用,及其用于治疗毒蕈碱受体介导的疾病的方法。
-
公开(公告)号:US20100311720A1
公开(公告)日:2010-12-09
申请号:US12785676
申请日:2010-05-24
申请人: Lewis R. Makings , Miguel Garcia-Guzman Blanco , Dennis J. Hurley , Ioana Drutu , Gabriel Raffai , Daniele M. Bergeron , Akiko Nakatani , Andreas P. Termin , Alina Silina
发明人: Lewis R. Makings , Miguel Garcia-Guzman Blanco , Dennis J. Hurley , Ioana Drutu , Gabriel Raffai , Daniele M. Bergeron , Akiko Nakatani , Andreas P. Termin , Alina Silina
IPC分类号: A61K31/55 , C12N5/02 , A61K31/438 , A61P25/28 , A61P3/04 , A61P25/18 , A61P25/16 , A61P25/24 , A61P27/06 , A61P17/02 , A61P11/06 , A61P1/04
CPC分类号: C07D401/06 , A61K31/435 , A61K31/438 , A61K31/4747 , A61K31/55 , C07D221/20 , C07D223/32 , C07D405/04 , C07D405/06 , C07D405/12 , C07D451/02 , C07D451/04 , C07D471/10 , C07D491/10
摘要: The present invention relates to spiroindoline modulators of muscarinic receptors. The present invention also provides compositions comprising such spiroindoline modulators, and methods therewith for treating muscarinic receptor mediated diseases.
摘要翻译: 本发明涉及毒蕈碱受体的螺二氢吲哚调节剂。 本发明还提供包含这样的螺二氢吲哚调节剂的组合物,及其用于治疗毒蕈碱受体介导的疾病的方法。
-
公开(公告)号:US08367691B2
公开(公告)日:2013-02-05
申请号:US12794202
申请日:2010-06-04
申请人: Lewis R. Makings , Miguel Garcia-Guzman Blanco , Dennis J. Hurley , Ioana Drutu , Gabriel Raffai , Daniele M. Bergeron , Akiko Nakatani , Andreas P. Termin , Alina Silina
发明人: Lewis R. Makings , Miguel Garcia-Guzman Blanco , Dennis J. Hurley , Ioana Drutu , Gabriel Raffai , Daniele M. Bergeron , Akiko Nakatani , Andreas P. Termin , Alina Silina
IPC分类号: A61K31/44 , C07D471/00
CPC分类号: A61K31/4747 , A61K31/435 , A61K31/438 , A61K31/55 , C07D221/20 , C07D223/32 , C07D405/06 , C07D451/02 , C07D471/10 , C07D491/10
摘要: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
-
公开(公告)号:US08258148B2
公开(公告)日:2012-09-04
申请号:US12785676
申请日:2010-05-24
申请人: Lewis R. Makings , Miguel Garcia-Guzman Blanco , Dennis J. Hurley , Ioana Drutu , Gabriel Raffai , Daniele M. Bergeron , Akiko Nakatani , Andreas P. Termin , Alina Silina
发明人: Lewis R. Makings , Miguel Garcia-Guzman Blanco , Dennis J. Hurley , Ioana Drutu , Gabriel Raffai , Daniele M. Bergeron , Akiko Nakatani , Andreas P. Termin , Alina Silina
IPC分类号: A61K31/44
CPC分类号: C07D401/06 , A61K31/435 , A61K31/438 , A61K31/4747 , A61K31/55 , C07D221/20 , C07D223/32 , C07D405/04 , C07D405/06 , C07D405/12 , C07D451/02 , C07D451/04 , C07D471/10 , C07D491/10
摘要: The present invention relates to spiroindoline modulators of muscarinic receptors. The present invention also provides compositions comprising such spiroindoline modulators, and methods therewith for treating muscarinic receptor mediated diseases.
摘要翻译: 本发明涉及毒蕈碱受体的螺二氢吲哚调节剂。 本发明还提供包含这样的螺二氢吲哚调节剂的组合物,及其用于治疗毒蕈碱受体介导的疾病的方法。
-
公开(公告)号:US20100311746A1
公开(公告)日:2010-12-09
申请号:US12794202
申请日:2010-06-04
申请人: Lewis R. Makings , Miguel Garcia-Guzman Blanco , Dennis J. Hurley , Ioana Drutu , Gabriel Raffai , Daniele M. Bergeron , Akiko Nakatani , Andreas P. Termin , Alina Silina
发明人: Lewis R. Makings , Miguel Garcia-Guzman Blanco , Dennis J. Hurley , Ioana Drutu , Gabriel Raffai , Daniele M. Bergeron , Akiko Nakatani , Andreas P. Termin , Alina Silina
IPC分类号: A61K31/5377 , A61K31/501 , A61K31/497 , A61K31/506 , A61K31/444 , C07D401/04 , C07D471/10 , A61K31/438 , C12N5/071
CPC分类号: A61K31/4747 , A61K31/435 , A61K31/438 , A61K31/55 , C07D221/20 , C07D223/32 , C07D405/06 , C07D451/02 , C07D471/10 , C07D491/10
摘要: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
摘要翻译: 本发明涉及毒蕈碱受体的调节剂。 本发明还提供包含这种调节剂的组合物,及其用于治疗毒蕈碱受体介导的疾病的方法。
-
公开(公告)号:US07858635B2
公开(公告)日:2010-12-28
申请号:US11644124
申请日:2006-12-22
申请人: Lewis R. Makings , Miguel Garcia-Guzman Blanco , Dennis J. Hurley , Ioana Drutu , Gabriel Raffai , Daniele M. Bergeron , Akiko Nakatani , Andreas P. Termin , Alina Silina
发明人: Lewis R. Makings , Miguel Garcia-Guzman Blanco , Dennis J. Hurley , Ioana Drutu , Gabriel Raffai , Daniele M. Bergeron , Akiko Nakatani , Andreas P. Termin , Alina Silina
IPC分类号: A61K31/438 , A61K31/497 , C07D487/00 , C07D487/10
CPC分类号: A61K31/4545 , A61K31/438 , A61K31/46 , A61K31/497 , A61K31/498 , A61K31/501 , A61K31/506 , C07D221/20 , C07D401/04 , C07D401/06 , C07D405/04 , C07D417/14 , C07D471/10 , C07D487/08 , C07D491/10
摘要: The present invention relates to spiro compounds of formula XX as modulators of muscarinic receptors, wherein R1, R2, R3, Z1, Z2, L, G, n, m, t and p are defined herein. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
摘要翻译: 本发明涉及式XX的螺环化合物作为毒蕈碱受体的调节剂,其中R1,R2,R3,Z1,Z2,L,G,n,m,t和p在本文中定义。 本发明还提供包含这种调节剂的组合物,及其用于治疗毒蕈碱受体介导的疾病的方法。
-
公开(公告)号:US08497295B2
公开(公告)日:2013-07-30
申请号:US13546185
申请日:2012-07-11
申请人: Lewis R. Makings , Miguel Garcia-Guzman Blanco , Dennis J. Hurley , Ioana Drutu , Gabriel Raffai , Daniele M. Bergeron , Akiko Nakatani , Andreas P. Termin , Alina Silina
发明人: Lewis R. Makings , Miguel Garcia-Guzman Blanco , Dennis J. Hurley , Ioana Drutu , Gabriel Raffai , Daniele M. Bergeron , Akiko Nakatani , Andreas P. Termin , Alina Silina
IPC分类号: A61K31/40 , C07D209/54 , C07D209/96
CPC分类号: C07D401/06 , A61K31/435 , A61K31/438 , A61K31/4747 , A61K31/55 , C07D221/20 , C07D223/32 , C07D405/04 , C07D405/06 , C07D405/12 , C07D451/02 , C07D451/04 , C07D471/10 , C07D491/10
摘要: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
摘要翻译: 本发明涉及毒蕈碱受体的调节剂。 本发明还提供包含这种调节剂的组合物,及其用于治疗毒蕈碱受体介导的疾病的方法。
-
公开(公告)号:US20120283243A1
公开(公告)日:2012-11-08
申请号:US13546185
申请日:2012-07-11
申请人: Lewis R. Makings , Miguel Garcia-Guzman Blanco , Dennis J. Hurley , Ioana Drutu , Gabriel Raffai , Daniele M. Bergeron , Akiko Nakatani , Andreas P. Termin , Alina Silina
发明人: Lewis R. Makings , Miguel Garcia-Guzman Blanco , Dennis J. Hurley , Ioana Drutu , Gabriel Raffai , Daniele M. Bergeron , Akiko Nakatani , Andreas P. Termin , Alina Silina
IPC分类号: A61K31/438 , C07D401/04 , C07D491/107 , A61K31/439 , A61K31/55 , A61P27/06 , A61P3/10 , A61P25/28 , A61P25/18 , A61P25/24 , A61P25/16 , C07D221/20 , A61P25/00
CPC分类号: C07D401/06 , A61K31/435 , A61K31/438 , A61K31/4747 , A61K31/55 , C07D221/20 , C07D223/32 , C07D405/04 , C07D405/06 , C07D405/12 , C07D451/02 , C07D451/04 , C07D471/10 , C07D491/10
摘要: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
摘要翻译: 本发明涉及毒蕈碱受体的调节剂。 本发明还提供包含这种调节剂的组合物,及其用于治疗毒蕈碱受体介导的疾病的方法。
-
公开(公告)号:US07786141B2
公开(公告)日:2010-08-31
申请号:US11359960
申请日:2006-02-22
申请人: Lewis R. Makings , Miguel Garcia-Guzman Blanco , Dennis J. Hurley , Ioana Drutu , Gabriel Raffai , Daniele M. Bergeron , Akiko Nakatani , Andreas P. Termin , Alina Silina
发明人: Lewis R. Makings , Miguel Garcia-Guzman Blanco , Dennis J. Hurley , Ioana Drutu , Gabriel Raffai , Daniele M. Bergeron , Akiko Nakatani , Andreas P. Termin , Alina Silina
IPC分类号: A01N43/40 , A61K31/445 , C07D211/08 , C07D401/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00 , C07D421/00
CPC分类号: A61K31/4747 , A61K31/435 , A61K31/438 , A61K31/55 , C07D221/20 , C07D223/32 , C07D405/06 , C07D451/02 , C07D471/10 , C07D491/10
摘要: The present invention relates to dihydrospiroindene modulators of muscarinic receptors. The present invention also provides compositions comprising such dihydrospiroindene modulators, and methods therewith for treating muscarinic receptor mediated diseases.
摘要翻译: 本发明涉及毒蕈碱受体的二氢螺环茚调节剂。 本发明还提供了包含这种二氢螺茚二酮调节剂的组合物及其用于治疗毒蕈碱受体介导的疾病的方法。
-
-
-
-
-
-
-
-
-