摘要:
Compositions and methods of therapy for treating diseases mediated by stimulation of CD40 signaling on CD40-expressing cells are provided. The methods comprise administering a therapeutically effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment thereof to a patient in need thereof. The antagonist anti-CD40 antibody or antigen-binding fragment thereof is free of significant agonist activity, but exhibits antagonist activity when the antibody binds a CD40 antigen on a human CD40-expressing cell. Antagonist activity of the anti-CD40 antibody or antigen-binding fragment thereof beneficially inhibits proliferation and/or differentiation of human CD40-expressing cells, such as B cells.
摘要:
Compositions and methods of therapy for treating diseases mediated by stimulation of CD40 signaling on CD40-expressing cells are provided. The methods comprise administering a therapeutically effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment thereof to a patient in need thereof. The antagonist anti-CD40 antibody or antigen-binding fragment thereof is free of significant agonist activity, but exhibits antagonist activity when the antibody binds a CD40 antigen on a human CD40-expressing cell. Antagonist activity of the anti-CD40 antibody or antigen-binding fragment thereof beneficially inhibits proliferation and/or differentiation of human CD40-expressing cells, such as B cells.
摘要:
Compositions and methods of therapy for treating diseases mediated by stimulation of CD40 signaling on CD40-expressing cells are provided. The methods comprise administering a therapeutically effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment thereof to a patient in need thereof. The antagonist anti-CD40 antibody or antigen-binding fragment thereof is free of significant agonist activity, but exhibits antagonist activity when the antibody binds a CD40 antigen on a human CD40-expressing cell. Antagonist activity of the anti-CD40 antibody or antigen-binding fragment thereof beneficially inhibits proliferation and/or differentiation of human CD40-expressing cells, such as B cells.
摘要:
Methods of therapy for treating diseases mediated by stimulation of CD40 signaling on CD40-expressing cells are provided. The methods comprise administering a therapeutically effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment thereof to a patient in need thereof. The antagonist anti-CD40 antibody or antigen-binding fragment thereof is free of significant agonist activity, but exhibits antagonist activity when the antibody binds a CD40 antigen on a human CD40-expressing cell. Antagonist activity of the anti-CD40 antibody or antigen-binding fragment thereof beneficially inhibits proliferation and/or differentiation of human CD40 expressing cells, such as B cells.
摘要:
Stable liquid pharmaceutical compositions comprising an antagonist anti-CD40 antibody as a therapeutically or prophylactically active component and methods useful in their preparation are provided. These compositions comprise the antagonist anti-CD40 antibody, a buffering agent to maintain the pH of the composition between about pH 5.0 and about pH 7.0, and an amount of arginine-HCl sufficient to render the liquid composition near isotonic. The stable liquid antagonist anti-CD40 antibody-containing pharmaceutical compositions of the invention find use in methods for treating proliferative diseases and diseases having an autoimmune and/or inflammatory component.
摘要:
Stable liquid pharmaceutical compositions comprising an antagonist anti-CD40 antibody as a therapeutically or prophylactically active component and methods useful in their preparation are provided. These compositions comprise the antagonist anti-CD40 antibody, a buffering agent to maintain the pH of the composition between about pH 5.0 and about pH 7.0, and an amount of arginine-HCl sufficient to render the liquid composition near isotonic. The stable liquid antagonist anti-CD40 antibody-containing pharmaceutical compositions of the invention find use in methods for treating proliferative diseases and diseases having an autoimmune and/or inflammatory component.
摘要:
Two magnetic poles of a permanent magnet of a permanent magnet switch and the two ends of an iron core wound with an excitation coil are connected to each other with the soft magnet having a salient pole. A motor uses the switch as the basic component of the stator and rotor, with two magnetic salient poles of each component being arranged axially, wherein the salient pole of the stator component and that of the rotor component are arranged in an opposite manner with an air gap, the excitation coil of the stator component and the rotor component at the symmetric axis position is taken as a phase line to access an excitation control power supply after serial connection or parallel connection. Electric excitation is carried out on the combined motor formed by shaft connection and rotation dislocation among single motors and the stator component in a bi-phase way simultaneously.
摘要:
Provided are multiple switched reluctance motors and excitation control methods for same. Motors with various structures are provided having the same structural characteristics, a stator formed of an even number of salient pole pairs and a rotor formed of an even number of salient pole pairs. The salient poles of the stator salient pole pairs are arranged opposite the salient poles of the rotor salient pole pairs, with minimal air gaps left between said salient pole pairs, thus leaving the shortest magnetic return paths between the stator salient pole pairs and the rotor salient pole pairs arranged opposite one another, thus satisfying the minimum reluctance principle of the switched reluctance motor. In addition, due to the magnetic isolation between each stator salient pole pair, the performance of the magnetic pole of each stator salient pole pair is controlled by an excitation control power source and changed independently.
摘要:
Provided are multiple switched reluctance motors and excitation control methods for same. Motors with various structures are provided having the same structural characteristics, a stator formed of an even number of salient pole pairs and a rotor formed of an even number of salient pole pairs. The salient poles of the stator salient pole pairs are arranged opposite the salient poles of the rotor salient pole pairs, with minimal air gaps left between said salient pole pairs, thus leaving the shortest magnetic return paths between the stator salient pole pairs and the rotor salient pole pairs arranged opposite one another, thus satisfying the minimum reluctance principle of the switched reluctance motor. In addition, due to the magnetic isolation between each stator salient pole pair, the performance of the magnetic pole of each stator salient pole pair is controlled by an excitation control power source and changed independently.
摘要:
The present invention relates to Trash field. More particularly, the present invention relates to Trash can lid. The present invention provides a design of a big lid and a small lid. When an inhabitant usually disposes trash, he or she need only press a button to open the small lid. Since the small lid is connected with the big lid by magnetism and a spring buffer unit is installed in the seat of small lid, opening the small lid is very smooth, without any noise or vibration. When a dustman collects the trash, what he needs to do is only to open the big lid, being very convenient and sanitary.