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    Use of antagonist anti-cd40 antibodies for treatment of chronic lymphocytic leukemia
    1.
    发明申请
    Use of antagonist anti-cd40 antibodies for treatment of chronic lymphocytic leukemia 审中-公开
    使用拮抗剂抗CD40抗体治疗慢性淋巴细胞性白血病

    公开(公告)号：US20070110754A1

    公开(公告)日：2007-05-17

    申请号：US10577642

    申请日：2004-11-04

    申请人： Li Long ,  Mohammad Luqman ,  Asha Yabannavar ,  Isabet Zaror ,  Sharon Aukerman

    发明人： Li Long ,  Mohammad Luqman ,  Asha Yabannavar ,  Isabet Zaror ,  Sharon Aukerman

    IPC分类号： A61K39/395 ,  C07K16/30

    CPC分类号： C07K16/2878 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/92

    摘要： Methods of therapy for treating a subject for chronic lymphocytic leukemia are provided. The methods comprise administering a therapeutically effective amount of an antagonist anti-CN40 antibody or antigen-binding fragment thereof to a patient in need thereof. The antagonist anti-CD40 antibody or antigen-binding fragment thereof is free of significant agonist activity, but exhibits antagonist activity when the antibody binds a CD40 antigen on a human CD40-expressing cell. Antagonist activity of the anti-CD40 antibody or antigen-binding fragment thereof beneficially inhibits proliferation and/or differentiation of human CD40-expressing chronic lymphocytic leukemia cells.

    摘要翻译： 提供了治疗慢性淋巴细胞性白血病受试者的治疗方法。 所述方法包括向有需要的患者施用治疗有效量的拮抗性抗CN40抗体或其抗原结合片段。 拮抗性抗CD40抗体或其抗原结合片段没有显着的激动剂活性，但当抗体结合表达人CD40的细胞上的CD40抗原时，其表现出拮抗剂活性。 抗CD40抗体或其抗原结合片段的拮抗作用有益地抑制人CD40表达慢性淋巴细胞白血病细胞的增殖和/或分化。

    Use of Antagonist Anti-Cd40 Monoclonal Antibodies for Treatment of Multiple Myeloma
    2.
    发明申请
    Use of Antagonist Anti-Cd40 Monoclonal Antibodies for Treatment of Multiple Myeloma 审中-公开
    使用拮抗剂抗Cd40单克隆抗体治疗多发性骨髓瘤

    公开(公告)号：US20070218060A1

    公开(公告)日：2007-09-20

    申请号：US10578387

    申请日：2004-11-04

    申请人： Li Long ,  Mohammad Luqman ,  Asha Yabannavar ,  Isabel Zaror

    发明人： Li Long ,  Mohammad Luqman ,  Asha Yabannavar ,  Isabel Zaror

    IPC分类号： C07K16/00

    CPC分类号： C07K16/2878 ,  A61K38/2013 ,  A61K39/39558 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/76 ,  A61K2300/00

    摘要： Methods of therapy for treating a subject for multiple myeloma are provided. The methods comprise administering a therapeutically effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment thereof to a patient in need thereof. The antagonist anti-CD40 antibody or antigen-binding fragment thereof is free of significant agonist activity, but exhibits antagonist activity when the antibody binds a CD40 antigen on a human CD40-expressing cell. Antagonist activity of the anti-antibody or antigen-binding fragment thereof beneficially inhibits proliferation and/or differentiation of human CD40 expressing multiple myeloma cells.

    摘要翻译： 提供了治疗多发性骨髓瘤受试者的治疗方法。 所述方法包括向有需要的患者施用治疗有效量的拮抗性抗CD40抗体或其抗原结合片段。 拮抗性抗CD40抗体或其抗原结合片段没有显着的激动剂活性，但当抗体结合表达人CD40的细胞上的CD40抗原时，其表现出拮抗剂活性。 抗体抗体或其抗原结合片段的拮抗作用有利地抑制人CD40表达多发性骨髓瘤细胞的增殖和/或分化。

    USES OF ANTI-CD40 ANTIBODIES
    9.
    发明申请
    USES OF ANTI-CD40 ANTIBODIES 审中-公开
    抗CD40抗体的使用

    公开(公告)号：US20090202531A1

    公开(公告)日：2009-08-13

    申请号：US12092256

    申请日：2006-11-01

    申请人： Sharon Lea Aukerman ,  Mohammad Luqman

    发明人： Sharon Lea Aukerman ,  Mohammad Luqman

    IPC分类号： A61K39/395 ,  C12Q1/68

    CPC分类号： C07K16/2878 ,  C07K16/2887 ,  C07K2317/732 ,  C07K2317/77

    摘要： Methods for treating a human patient for an inflammatory or autoimmune disease that is associated with CD40-expressing cells are provided, where the human patient is heterozygous or homozygous for FcγRIIIa-158F (genotype V/F or F/F). Also provided are methods of inhibiting antibody production by B cells in a human patient who is heterozygous or homozygous for FcγRIIIa-158F (genotype V/F or F/F). The methods comprise administering to the human patient a therapeutically or prophylactically effective amount of an anti-CD40 antibody. Methods and kits for identifying a human patient with an inflammatory or autoimmune disease that is treatable with an anti-CD40 antibody and which is non-responsive or refractory to treatment with rituximab (Rituxan®), as well as methods and kits for selecting an antibody therapy for treatment of a human patient having an inflammatory or autoimmune disease that is non-responsive or refractory to treatment with rituximab (Rituxan®), are also provided. The methods of the present invention find use in treatment of inflammatory diseases and autoimmune diseases that are associated with CD40-expressing cells. These methods are particularly advantageous with respect to inflammatory diseases and autoimmune diseases that are associated with cells expressing both CD40 and CD20, as the methods enable the treatment of patients having an inflammatory or autoimmune disease that is non-responsive or refractory to therapy with other therapeutic agents such as anti-CD20 antibodies.

    摘要翻译： 提供了用于治疗患有与表达CD40的细胞相关的炎性或自身免疫性疾病的人类患者的方法，其中人类患者对于FcgammaRIIIa-158F（基因型V / F或F / F）是杂合的或纯合的。 还提供了抑制对FcgammaRIIIa-158F（基因型V / F或F / F）是杂合的或纯合的人类患者中B细胞的抗体产生的方法。 所述方法包括向人类患者施用治疗或预防有效量的抗CD40抗体。 用于鉴定具有可用抗CD40抗体治疗并且对利妥昔单抗治疗无反应或难治性的炎性或自身免疫性疾病的人类患者的方法和试剂盒以及用于选择的方法和试剂盒 还提供了用于治疗具有对利妥昔单抗治疗无反应或难治的炎性或自身免疫性疾病的人类患者的抗体疗法（Rituxan）。 本发明的方法可用于治疗与CD40表达细胞相关的炎性疾病和自身免疫性疾病。 这些方法对于与表达CD40和CD20的细胞相关的炎性疾病和自身免疫性疾病是特别有利的，因为该方法能够治疗患有对其他治疗无效或难治的炎性或自身免疫性疾病的患者 药物如抗CD20抗体。