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    NANOPARTICLE AND MAGNETIC RESONANCE IMAGING CONTRAST AGENT
    2.
    发明申请
    NANOPARTICLE AND MAGNETIC RESONANCE IMAGING CONTRAST AGENT 有权
    纳米颗粒和磁共振成像对比剂

    公开(公告)号：US20110092672A1

    公开(公告)日：2011-04-21

    申请号：US12760396

    申请日：2010-04-14

    申请人： Yun-Ming Wang ,  Ting-Jung Chen

    发明人： Yun-Ming Wang ,  Ting-Jung Chen

    IPC分类号： C07F7/18 ,  C07K7/06 ,  C07K14/54

    CPC分类号： B82Y5/00 ,  A61K49/1848 ,  A61K49/186 ,  A61K49/1866 ,  C07B2200/11 ,  C07F7/1804 ,  G01N2333/78 ,  G01N2446/20 ,  G01N2446/90

    摘要： A nanoparticle contains a core including superparamagnetic nanoparticles and having an outer surface, and siloxanyl moieties covalently coupled to the outer surface of the core and having Formula (I): In formula (I): X1 and X2 independently represent methylene, ethylene or propylene; R represents an optionally substituted pyridyl group, or —S—R is a group derived from a targeting ligand containing —SH group and effective to bind specifically with a predetermined targeted cell in an object; n and m independently represent an integer ranging from 1 to 3; and p represents an integer ranging from 9 to 45. The nanoparticles are suitable for use as a magnetic resonance imaging contrast agent.

    摘要翻译： 纳米颗粒含有包含超顺磁性纳米颗粒并具有外表面的核心和与核心外表面共价连接并具有式（I）的硅氧烷基部分：式（I）中：X 1和X 2独立地表示亚甲基，亚乙基或亚丙基; R表示任选取代的吡啶基，或-S-R是衍生自含有-SH基团的靶向配体的基团，并有效结合物体中的预定靶向细胞; n和m独立地表示1〜3的整数; 并且p表示9至45的整数。纳米颗粒适合用作磁共振成像造影剂。

    Ligand and metal complex
    4.
    发明授权
    Ligand and metal complex 有权
    配体和金属配合物

    公开(公告)号：US08354512B2

    公开(公告)日：2013-01-15

    申请号：US12658332

    申请日：2010-02-08

    申请人： Yun-Ming Wang ,  Ting-Jung Chen

    发明人： Yun-Ming Wang ,  Ting-Jung Chen

    IPC分类号： A61K51/04

    CPC分类号： C07C229/16 ,  C07C331/28 ,  C07C2601/04

    摘要： A ligand of Formula (I) is provided: wherein A4 represents a hydrogen atom, a nitro group, an amino group, a thiocyanato group, or —Z—Y, in which Z is a divalent linking group and Y is a group derived from a biocompatible molecule, with the proviso that when X is methylene, A4 cannot be a hydrogen atom or a nitro group. A metal complex having the ligand is also provided and is useful as a blood pool contrast agent or a targeting contrast agent.

    摘要翻译： 提供式（I）的配体：其中A4表示氢原子，硝基，氨基，硫氰酸根基或-Z-Y，其中Z是二价连接基团，Y是衍生自 生物相容性分子，条件是当X是亚甲基时，A4不能是氢原子或硝基。 还提供了具有配体的金属络合物，并且可用作血液池造影剂或靶向造影剂。

    Nanoparticle and magnetic resonance imaging contrast agent
    6.
    发明授权
    Nanoparticle and magnetic resonance imaging contrast agent 有权
    纳米颗粒和磁共振成像造影剂

    公开(公告)号：US08344102B2

    公开(公告)日：2013-01-01

    申请号：US12760396

    申请日：2010-04-14

    申请人： Yun-Ming Wang ,  Ting-Jung Chen

    发明人： Yun-Ming Wang ,  Ting-Jung Chen

    IPC分类号： A61K38/04 ,  C07K5/00 ,  C07K7/00 ,  C07K16/00 ,  C07K17/00 ,  C07F7/02

    CPC分类号： B82Y5/00 ,  A61K49/1848 ,  A61K49/186 ,  A61K49/1866 ,  C07B2200/11 ,  C07F7/1804 ,  G01N2333/78 ,  G01N2446/20 ,  G01N2446/90

    摘要： A nanoparticle contains a core including superparamagnetic nanoparticles and having an outer surface, and siloxanyl moieties covalently coupled to the outer surface of the core and having Formula (I): In formula (I): X1 and X2 independently represent methylene, ethylene or propylene; R represents an optionally substituted pyridyl group, or —S—R is a group derived from a targeting ligand containing —SH group and effective to bind specifically with a predetermined targeted cell in an object; n and m independently represent an integer ranging from 1 to 3; and p represents an integer ranging from 9 to 45. The nanoparticles are suitable for use as a magnetic resonance imaging contrast agent.

    摘要翻译： 纳米颗粒含有包含超顺磁性纳米颗粒并具有外表面的核心和与核心外表面共价连接并具有式（I）的硅氧烷基部分：式（I）中：X 1和X 2独立地表示亚甲基，亚乙基或亚丙基; R表示任选取代的吡啶基，或-S-R是衍生自含有-SH基团的靶向配体的基团，并有效结合物体中的预定靶向细胞; n和m独立地表示1〜3的整数; 并且p表示9至45的整数。纳米颗粒适合用作磁共振成像造影剂。

    Ligand and metal complex
    7.
    发明申请
    Ligand and metal complex 有权
    配体和金属配合物

    公开(公告)号：US20110065905A1

    公开(公告)日：2011-03-17

    申请号：US12658332

    申请日：2010-02-08

    申请人： Yun-Ming Wang ,  Ting-Jung Chen

    发明人： Yun-Ming Wang ,  Ting-Jung Chen

    IPC分类号： C07F5/00 ,  C07C229/28 ,  C07C255/50

    CPC分类号： C07C229/16 ,  C07C331/28 ,  C07C2601/04

    摘要： A ligand of Formula (I) is provided: wherein A4 represents a hydrogen atom, a nitro group, an amino group, a thiocyanato group, or —Z—Y, in which Z is a divalent linking group and Y is a group derived from a biocompatible molecule, with the proviso that when X is methylene, A4 cannot be a hydrogen atom or a nitro group. A metal complex having the ligand is also provided and is useful as a blood pool contrast agent or a targeting contrast agent.

    摘要翻译： 提供式（I）的配体：其中A4表示氢原子，硝基，氨基，硫氰酸根基或-Z-Y，其中Z是二价连接基团，Y是衍生自 生物相容性分子，条件是当X是亚甲基时，A4不能是氢原子或硝基。 还提供了具有配体的金属络合物，可用作血液池造影剂或靶向造影剂。

    Ligand and metal complex having the same
    8.
    发明授权
    Ligand and metal complex having the same 有权
    配体和具有相同的金属络合物

    公开(公告)号：US08961928B2

    公开(公告)日：2015-02-24

    申请号：US13467471

    申请日：2012-05-09

    申请人： Yun-Ming Wang ,  Gin-Chung Liu ,  Chiao-Yun Chen ,  Teng-Wen Li

    发明人： Yun-Ming Wang ,  Gin-Chung Liu ,  Chiao-Yun Chen ,  Teng-Wen Li

    IPC分类号： A61K51/00 ,  A61K49/00 ,  A61B5/00 ,  A61K38/04

    CPC分类号： C07K1/13 ,  C07K7/06 ,  C12N9/6491

    摘要： A ligand and a metal complex having the ligand are provided. The ligand and a paramagnetic metal ion form a metal complex with high stability, high relaxivity and high biocompatibility. The metal complex of the present invention is applicable to the preparation of MRI contrast agents for detecting atherosclerosis. The MRI contrast agent includes a peptide sequence specific to a matrix metalloprotease, and can be recognized by a pathological thrombocyte to target a specific site, so as to enhance the imaging contrast.

    摘要翻译： 提供配体和具有配体的金属络合物。 配体和顺磁金属离子形成具有高稳定性，高弛豫性和高生物相容性的金属络合物。 本发明的金属络合物可用于制备用于检测动脉粥样硬化的MRI造影剂。 MRI造影剂包括对基质金属蛋白酶特异性的肽序列，并且可以通过病理性血小板被识别以靶向特定部位，从而增强成像对比度。