公开(公告)号：US11867698B2

公开(公告)日：2024-01-09

申请号：US17027391

申请日：2020-09-21

Applicant: Life Technologies Corporation

Inventor： Jeffrey Dzubay ,  Kyle Gee ,  Vladimir Martin ,  Aleksey Rukavishnikov ,  Daniel Beacham

IPC: G01N33/58 ,  G01N33/50 ,  G01N33/84 ,  C09B11/24 ,  C09B11/28 ,  C07D311/82 ,  C07D311/90 ,  C07D405/12 ,  C07D413/04 ,  C07D491/22 ,  C07D209/14 ,  C09K11/06 ,  C07F5/02 ,  C07K1/13 ,  C09B7/00 ,  C09B11/12 ,  C09B57/00 ,  C09B69/00 ,  G01N31/22 ,  G01N33/80

CPC classification number: G01N33/582 ,  C07D209/14 ,  C07D311/82 ,  C07D311/90 ,  C07D405/12 ,  C07D413/04 ,  C07D491/22 ,  C07F5/02 ,  C07K1/13 ,  C09B7/00 ,  C09B11/12 ,  C09B11/24 ,  C09B11/28 ,  C09B57/00 ,  C09B69/00 ,  C09K11/06 ,  G01N31/22 ,  G01N33/5005 ,  G01N33/5058 ,  G01N33/5091 ,  G01N33/80 ,  G01N33/84 ,  G01N2333/245 ,  Y10T436/143333

Abstract: A new class of pH sensitive fluorescent dyes and assays relating thereto are described. The dyes and assays are particularly suited for biological applications including phagocytosis and monitoring intracellular processes. The pH sensitive fluorescent dyes of the present invention include compounds of Formula I:






wherein the variables are described throughout the application.

公开(公告)号：US09939454B2

公开(公告)日：2018-04-10

申请号：US14937736

申请日：2015-11-10

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Jeffrey Dzubay ,  Kyle Gee ,  Vladimir Martin ,  Aleksey Rukavishnikov ,  Daniel Beacham

IPC: G01N33/84 ,  G01N33/58 ,  C07K1/13 ,  C09B7/00 ,  C09B11/12 ,  C09B11/28 ,  C09B57/00 ,  C09B69/00 ,  G01N31/22 ,  C09B11/24 ,  G01N33/50 ,  G01N33/80 ,  C07D311/82 ,  C07D311/90 ,  C07D405/12 ,  C07D413/04 ,  C07D491/22 ,  C07D209/14 ,  C09K11/06 ,  C07F5/02

CPC classification number: G01N33/84 ,  C07D209/14 ,  C07D311/82 ,  C07D311/90 ,  C07D405/12 ,  C07D413/04 ,  C07D491/22 ,  C07F5/02 ,  C07K1/13 ,  C09B7/00 ,  C09B11/12 ,  C09B11/24 ,  C09B11/28 ,  C09B57/00 ,  C09B69/00 ,  C09K11/06 ,  G01N31/22 ,  G01N33/5005 ,  G01N33/5058 ,  G01N33/5091 ,  G01N33/582 ,  G01N33/80 ,  G01N2333/245 ,  Y10T436/143333

Abstract: A new class of pH sensitive fluorescent dyes and assays relating thereto are described. The dyes and assays are particularly suited for biological applications including phagocytosis and monitoring intracellular processes. The pH sensitive fluorescent dyes of the present invention include compounds of Formula I: wherein the variables are described throughout the application.

公开(公告)号：US09910051B2

公开(公告)日：2018-03-06

申请号：US14455550

申请日：2014-08-08

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Daniel Beacham ,  Jeffrey Dzubay ,  Kyle Gee ,  Vladimir Martin ,  Aleksey Rukavishnikov

IPC: G01N33/84 ,  C07K1/13 ,  C09B7/00 ,  C09B11/12 ,  C09B11/28 ,  C09B57/00 ,  C09B69/00 ,  G01N31/22 ,  C09B11/24 ,  G01N33/50 ,  G01N33/58 ,  G01N33/80 ,  C07D311/82 ,  C07D311/90 ,  C07D405/12 ,  C07D413/04 ,  C07D491/22 ,  C07D209/14 ,  C09K11/06 ,  C07F5/02

CPC classification number: G01N33/84 ,  C07D209/14 ,  C07D311/82 ,  C07D311/90 ,  C07D405/12 ,  C07D413/04 ,  C07D491/22 ,  C07F5/02 ,  C07K1/13 ,  C09B7/00 ,  C09B11/12 ,  C09B11/24 ,  C09B11/28 ,  C09B57/00 ,  C09B69/00 ,  C09K11/06 ,  G01N31/22 ,  G01N33/5005 ,  G01N33/5058 ,  G01N33/5091 ,  G01N33/582 ,  G01N33/80 ,  G01N2333/245 ,  Y10T436/143333

Abstract: A new class of pH sensitive fluorescent dyes and assays relating thereto are described. The dyes and assays are particularly suited for biological applications including phagocytosis and monitoring intracellular processes. The pH sensitive fluorescent dyes of the present invention include compounds of Formula I: wherein the variables are described throughout the application.