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公开(公告)号:US08119772B2
公开(公告)日:2012-02-21
申请号:US11864841
申请日:2007-09-28
申请人: Lili Yang , David Baltimore , Pin Wang , James Economou , Antoni Ribas
发明人: Lili Yang , David Baltimore , Pin Wang , James Economou , Antoni Ribas
IPC分类号: A61K35/14
CPC分类号: C07K14/4748
摘要: T-cell receptors that recognize MART-1 antigen are provided. The TCRs can be used, for example, to treat patients suffering from melanoma.
摘要翻译: 提供了识别MART-1抗原的T细胞受体。 TCR可用于例如治疗患有黑素瘤的患者。
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公开(公告)号:US08552150B2
公开(公告)日:2013-10-08
申请号:US13399922
申请日:2012-02-17
申请人: Lili Yang , David Baltimore , Pin Wang , James Economou , Antoni Ribas
发明人: Lili Yang , David Baltimore , Pin Wang , James Economou , Antoni Ribas
IPC分类号: C07K14/00
CPC分类号: C07K14/4748
摘要: T-cell receptors that recognize MART-1 antigen are provided. The TCRs can be used, for example, to treat patients suffering from melanoma.
摘要翻译: 提供了识别MART-1抗原的T细胞受体。 TCR可用于例如治疗患有黑素瘤的患者。
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公开(公告)号:US20080199424A1
公开(公告)日:2008-08-21
申请号:US11864841
申请日:2007-09-28
申请人: Lili Yang , David Baltimore , Pin Wang , James Economou , Antoni Ribas
发明人: Lili Yang , David Baltimore , Pin Wang , James Economou , Antoni Ribas
IPC分类号: A61K45/00 , C07H21/00 , C07K14/00 , C12N5/06 , C12N15/87 , A61P43/00 , A61K39/00 , C12N7/00 , A61K35/12
CPC分类号: C07K14/4748
摘要: T-cell receptors that recognize MART-1 antigen are provided. The TCRs can be used, for example, to treat patients suffering from melanoma.
摘要翻译: 提供了识别MART-1抗原的T细胞受体。 TCR可用于例如治疗患有黑素瘤的患者。
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公开(公告)号:US20120196361A1
公开(公告)日:2012-08-02
申请号:US13399922
申请日:2012-02-17
申请人: Lili Yang , David Baltimore , Pin Wang , James Economou , Antoni Ribas
发明人: Lili Yang , David Baltimore , Pin Wang , James Economou , Antoni Ribas
IPC分类号: C12N5/10 , C07K14/725
CPC分类号: C07K14/4748
摘要: T-cell receptors that recognize MART-1 antigen are provided. The TCRs can be used, for example, to treat patients suffering from melanoma.
摘要翻译: 提供了识别MART-1抗原的T细胞受体。 TCR可用于例如治疗患有黑素瘤的患者。
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公开(公告)号:US20060286075A1
公开(公告)日:2006-12-21
申请号:US11506467
申请日:2006-08-16
CPC分类号: A61K39/0011 , A61K38/1709 , A61K39/00 , A61K2039/5154 , A61K2039/5158 , A61K2039/5256 , A61K2039/55566 , C07K14/4715 , C12N15/86 , C12N2710/10343
摘要: A method for preventing or for treating cancer in a mammal, where the cancer cells express at least a part of an alpha fetoprotein molecule at the cell surface. The method comprises creating an immune response in the mammal to at least part of the amino acid sequence of an alpha fetoprotein molecule, where the immune response comprises activating alpha fetoprotein peptide specific T lymphocytes against the cancer cells, and where the part of the alpha fetoprotein molecule is selected from the group consisting of residues 137-145 of SEQ ID NO:2, and residues 325-334 of SEQ ID NO:2 and a combination of the preceeding.
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