摘要:
Methods and compositions are provided for delivery of a polynucleotide encoding a gene of interest, typically an antigen, to a dendritic cell (DC). The virus envelope comprises a DC-SIGN specific targeting molecule. The methods and related compositions can be used to treat patients suffering from a wide range of conditions, including infection, such as HIV/AIDS, and various types of cancers.
摘要:
Methods and compositions are provided for delivery of a polynucleotide encoding a gene of interest, typically an antigen, to a dendritic cell (DC). The virus envelope comprises a DC-SIGN specific targeting molecule. The methods and related compositions can be used to treat patients suffering from a wide range of conditions, including infection, such as HIV/AIDS, and various types of cancers.
摘要:
The present disclosure discloses a method, apparatus and system for transmitting UE information in a multimedia subsystem. The method includes: a call session control function entity obtains capability information of UE, and transmits the capability information of the UE to an AS; the AS obtaining the capability information of the UE sent from the call session control function entity. The solution of the present disclosure ensures that the AS in the IMS can obtain the capability information of the UE. Therefore, services based on the capability information of the UE can be implemented on the AS successfully.
摘要:
A system and method for remote party restrictions in a communications system are provided. A method for controller operations includes receiving a request from a first communications device to replicate a media flow that is being transmitted to the first communications device from a second communications device during a session, where the replicated media flow is to be provided to a third communications device, and where the second communications device is operated by a remote user. The method also includes allocating resources to a transmission of the replicated media flow to the third communications device, notifying the remote user of the request, and determining a response of the remote user to the request.
摘要:
Methods and compositions are provided for delivering a polynucleotide encoding a gene of interest to a target cell using a virus. The virus envelope comprises a cell-specific binding determinant that recognizes and binds to a component on the target cell surface, leading to endocytosis of the virus. A separate fusogenic molecule is also present on the envelope and facilitates delivery of the polynucleotide across the membrane and into the cytosol of the target cell. The methods and related compositions can be used for treating patients having suffering from a wide range of conditions, including infection, such as HIV; cancers, such as non-Hodgkin's lymphoma and breast cancer; and hematological disorders, such as severe combined immunodeficiency.
摘要:
Methods and compositions are provided for delivery of a polynucleotide encoding a gene of interest, typically an antigen, to a dendritic cell (DC). The virus envelope comprises a DC-SIGN specific targeting molecule. The methods and related compositions can be used to treat patients suffering from a wide range of conditions, including infection, such as HIV/AIDS, and various types of cancers.
摘要:
Methods and compositions are provided for delivery of a polynucleotide encoding a gene of interest, typically an antigen, to a dendritic cell (DC). The virus envelope comprises a DC-SIGN specific targeting molecule. The methods and related compositions can be used to treat patients suffering from a wide range of conditions, including infection, such as HIV/AIDS, and various types of cancers.
摘要:
A system and method for remote party restrictions in a communications system are provided. A method for controller operations includes receiving a request from a first communications device to replicate a media flow that is being transmitted to the first communications device from a second communications device during a session, where the replicated media flow is to be provided to a third communications device, and where the second communications device is operated by a remote user. The method also includes allocating resources to a transmission of the replicated media flow to the third communications device, notifying the remote user of the request, and determining a response of the remote user to the request.
摘要:
The invention provides systems and methods for the generation of lymphocytes having a unique antigen specificity. In a preferred embodiment, the invention provides methods of virally infecting cells from bone marrow with one or more viral vectors that encode antigen-specific antibodies for the production of, for example B cells and T cells. In some embodiments, the viral vectors include an IRES or 2A element to promote separation of, for example, the α subunit and β subunit of a T cell receptor (TCR) or heavy and light chains of a B-cell antibody. The resulting lymphocytes, express the particular antibody that was introduced in the case of B cells and TCR in the case of T cells. The lymphocytes generated can be used for a variety of therapeutic purposes including the treatment of various cancers and the generation of a desired immune response to viruses and other pathogens. The resulting cells develop normally and respond to antigen both in vitro and in vivo. We also show that it is possible to modify the function of lymphocytes by using stem cells from different genetic backgrounds. Thus our system constitutes a powerful tool to generate desired lymphocyte populations both for research and therapy. Future applications of this technology may include treatments for infectious diseases, such as HIV/AIDS, cancer therapy, allergy, and autoimmune disease.