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公开(公告)号：US20090297581A1
公开(公告)日：2009-12-03
申请号：US12472234
申请日：2009-05-26
IPC分类号： A61F2/06
CPC分类号： A61L31/16 , A61L31/08 , A61L2300/416 , A61L2300/606 , A61L2300/624 , A61L2420/04
摘要： According to one aspect, the present invention provides implantable or insertable medical devices that comprise a conductive substrate and an electrodeposited coating over the substrate. The electrodeposited coating includes (a) one or more types of inorganic materials, (b) one or more types of polymeric materials and (c) optionally, one or more types of therapeutic agents. Still other aspects of the invention concern methods of making and using such devices.
摘要翻译： 根据一个方面，本发明提供了可植入或可插入的医疗装置，其包括导电基底和在基底上的电沉积涂层。 电沉积涂层包括（a）一种或多种类型的无机材料，（b）一种或多种类型的聚合材料和（c）任选的一种或多种类型的治疗剂。 本发明的其它方面涉及制造和使用这些装置的方法。
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2.发明申请Medical devices having sol-gel derived ceramic regions with molded submicron surface features 审中-公开具有溶胶 - 凝胶衍生的陶瓷区域的模制亚微米表面特征的医疗装置公开(公告)号：US20090048659A1
公开(公告)日：2009-02-19
申请号：US11893849
申请日：2007-08-17
IPC分类号： A61F2/06 , A61K45/00 , C04B35/119
CPC分类号： A61L31/16 , A61L27/306 , A61L27/54 , A61L27/56 , A61L29/106 , A61L29/146 , A61L29/16 , A61L31/088 , A61L31/146 , A61L2300/00 , A61L2400/12
摘要： According to one aspect of the present invention, implantable or insertable medical devices are provided, which contain sol-gel derived ceramic regions which have molded submicron surface features.
摘要翻译： 根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含具有模制亚微米表面特征的溶胶 - 凝胶衍生的陶瓷区域。
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3.发明申请Blood-contacting medical devices for the release of nitric oxide and anti-restenotic agents 审中-公开用于释放一氧化氮和抗再狭窄剂的血液接触医疗装置公开(公告)号：US20080175881A1
公开(公告)日：2008-07-24
申请号：US11654884
申请日：2007-01-18
申请人： J. Thomas Ippoliti , Scott Schewe , Michele Zoromski , Robert W. Warner , Liliana Atanasoska , Jan Weber
发明人： J. Thomas Ippoliti , Scott Schewe , Michele Zoromski , Robert W. Warner , Liliana Atanasoska , Jan Weber
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/114 , A61L2300/416 , A61L2300/45
摘要： According to an aspect of the present invention, implantable or insertable blood-contacting devices are provided, which contain one or more release regions that release nitric oxide and one or more anti-restenotic agents. The release region contains one or more polymeric components. The release region also optionally contains one or more inorganic components. Nitric oxide producing groups may be attached to the polymeric component(s), to the optional inorganic component(s), or both. The one or more anti-restenotic agents may be admixed with the polymeric and optional inorganic components, attached to the polymeric component(s), attached to the optional inorganic component(s), or a combination thereof.
摘要翻译： 根据本发明的一个方面，提供了可植入或可插入的血液接触装置，其包含一个或多个释放一氧化氮的释放区域和一种或多种抗再狭窄剂。 释放区域包含一种或多种聚合物组分。 释放区域还任选地含有一种或多种无机组分。 一氧化碳生成基团可以连接到聚合物组分，任选的无机组分或两者。 一种或多种抗再狭窄剂可以与附着于任选的无机组分的一种或多种聚合物组分的聚合物和任选的无机组分或其组合物混合。
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4.发明申请MEDICAL DEVICES HAVING NANOSTRUCTURED COATING FOR MACROMOLECULE DELIVERY 审中-公开具有用于大分子递送的纳米结构涂层的医疗装置公开(公告)号：US20080057105A1
公开(公告)日：2008-03-06
申请号：US11847934
申请日：2007-08-30
IPC分类号： A61F2/02 , A61K31/7052 , A61P43/00
CPC分类号： A61L27/58 , A61L27/28 , A61L31/08 , A61L31/148 , A61L2400/12 , A61L2420/04
摘要： A medical device having a biodegradable coating comprising an inorganic material complexed to macromolecules. Biodegradation of the biodegradable coating releases nanoparticles of the inorganic material with macromolecules complexed to the released nanoparticles. The inorganic material may be applied directly onto the medical device as a nanostructured coating or be dispersed within or under a layer of biodegradable polymer. The medical device body may comprise a biodegradable metallic material. Also provided is a method of delivering macromolecules to body tissue using the medical device of the present invention.
摘要翻译： 具有包含与大分子复合的无机材料的可生物降解涂层的医疗装置。 可生物降解涂层的生物降解通过与释放的纳米颗粒络合的大分子释放无机材料的纳米颗粒。 无机材料可以作为纳米结构涂层直接施加到医疗装置上，或者分散在可生物降解的聚合物层内或下面。 医疗装置主体可以包括可生物降解的金属材料。 还提供了使用本发明的医疗装置将大分子递送到身体组织的方法。
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5.发明授权Organic-inorganic hybrid particle material and polymer compositions containing same 有权有机 - 无机杂化颗粒材料和含有它们的聚合物组合物公开(公告)号：US08008395B2
公开(公告)日：2011-08-30
申请号：US11235743
申请日：2005-09-27
CPC分类号： A61L27/427 , A61L31/124 , C08G77/458 , Y10T428/2982
摘要： Particulate materials useful as fillers, reinforcing agents, radioopacifiers, or impact modifiers. The particulate material has an average particle size range of about 10,000 nm or less and comprises an organic-inorganic hybrid material that has a ceramic material network having organic polymer segments distributed throughout the ceramic network. The ceramic network may be prepared by a sol-gel technique. The particulate material may be compounded in thermoplastic polymer compositions useful in a variety of applications such as preparation of medical device components.
摘要翻译： 可用作填料，增强剂，放射线光刻胶或抗冲改性剂的颗粒材料。 颗粒材料具有约10,000nm或更小的平均粒度范围，并且包含具有分布在整个陶瓷网络中的有机聚合物链段的陶瓷材料网络的有机 - 无机混合材料。 陶瓷网络可以通过溶胶 - 凝胶技术制备。 颗粒材料可以在可用于各种应用的热塑性聚合物组合物中复合，例如制备医疗装置组分。
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公开(公告)号：US20070149690A1
公开(公告)日：2007-06-28
申请号：US11317614
申请日：2005-12-23
IPC分类号： C08K3/40
CPC分类号： A61L31/128 , A61L27/446 , A61L29/126 , C08K9/02 , C08K9/04 , C08K2201/013 , C08L53/00
摘要： Reinforced copolymers formed from a functionalized copolymer that undergoes a reactive extrusion process with an inorganic component to form the reinforced copolymer. The functionalized copolymer in the form of a block and/or graft copolymer includes hard segments and soft segments, where the soft segments are covalently bonded with a coupling agent either before or after copolymerization with the hard segments. The reinforced copolymer of the present disclosure can be suitable for use as a biomaterial and/or in medical devices.
摘要翻译： 由官能化共聚物形成的增强共聚物，其经历与无机组分的反应性挤出方法以形成增强共聚物。 块状和/或接枝共聚物形式的官能化共聚物包括硬链段和软链段，其中软链段在与硬链段共聚合之前或之后与偶联剂共价键合。 本公开的增强共聚物可适用于生物材料和/或医疗装置。
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7.发明授权Medical device articles formed from polymer-inorganic hybrids prepared by ester-alkoxy transesterification reaction during melt processing 有权在熔融加工过程中由酯 - 烷氧基酯交换反应制备的聚合物 - 无机杂化物形成的医疗器械制品公开(公告)号：US07365126B2
公开(公告)日：2008-04-29
申请号：US11229086
申请日：2005-09-16
IPC分类号： C08F8/00
CPC分类号： A61L27/446 , A61M25/1027 , C08G63/91 , C08G77/42 , C08L31/02 , C08L31/04 , C08L67/02 , C08L83/10 , Y10T428/31663 , Y10T428/3188 , C08L31/00 , C08L83/00
摘要： A shaped medical device article prepared from a polymer melt composition comprising a polymer ester, a transesterification catalyst, and a tri- or tetraalkoxy silane, by forming and solidifying said composition, and after solidification, subjecting the composition to reaction conditions to effect hydrolysis at least some alkoxysilyl groups remaining in the composition to form silanol groups and to effect condensation of said silanol groups to form a ceramic network. The polymer ester may be a vinyl ester homopolymer or copolymer, or a polymer having ester groups in the backbone thereof.
摘要翻译： 通过形成和固化所述组合物，由包含聚合物酯，酯交换催化剂和三 - 或四烷氧基硅烷的聚合物熔体组合物制备的成形医疗装置制品，并且在固化后，使组合物至少进行水解 残留在组合物中的一些烷氧基甲硅烷基形成硅烷醇基团，并实现所述硅烷醇基团的缩合形成陶瓷网络。 聚合物酯可以是乙烯基酯均聚物或共聚物，或其主链中具有酯基的聚合物。
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公开(公告)号：US20070144124A1
公开(公告)日：2007-06-28
申请号：US11318027
申请日：2005-12-23
IPC分类号： B01D50/00
CPC分类号： D04H1/42 , A61L27/306 , A61L27/446 , A61L29/126 , A61L31/088 , A61L31/128 , A61L2400/12 , B82Y30/00 , C03B37/011 , D01D5/003 , D01F9/00 , D04H3/02 , D04H3/16 , Y10T428/249924 , Y10T428/24994 , Y10T428/249941
摘要： The present disclosure relates to compounds from which nanofibers can be produced, the resulting nanofibers produced from the compounds, and nanofiber reinforced polymers prepared using the nanofibers and a polymer. The compounds used in forming the nanofibers include chemical linkage moieties that are capable of forming non-covalent bonds with portions of the polymer so as to form the nanofiber reinforced polymers. The nanofiber reinforced polymers are useful as biomaterials in medical devices.
摘要翻译： 本公开涉及可以从其制备纳米纤维的化合物，由化合物制备的所得纳米纤维，以及使用纳米纤维和聚合物制备的纳米纤维增强聚合物。 用于形成纳米纤维的化合物包括能与聚合物部分形成非共价键以形成纳米纤维增强聚合物的化学连接部分。 纳米纤维增强聚合物可用作医疗器械中的生物材料。
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公开(公告)号：US08449603B2
公开(公告)日：2013-05-28
申请号：US12486295
申请日：2009-06-17
申请人： Jan Weber , Liliana Atanasoska , Michele Zoromski
发明人： Jan Weber , Liliana Atanasoska , Michele Zoromski
IPC分类号： A61F2/82
CPC分类号： A61F2/82 , A61L31/088 , A61L31/146
摘要： An endoprosthesis, e.g., a stent (e.g., a drug eluting stent), that includes a porous surface and hollow elements integrated with a coating on the surface and a method of making the same are disclosed.
摘要翻译： 公开了一种内置假体，例如支架（例如，药物洗脱支架），其包括多孔表面和与表面上的涂层成一体的中空元件及其制造方法。
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10.发明申请公开(公告)号：US20070208155A1
公开(公告)日：2007-09-06
申请号：US11366230
申请日：2006-03-02
IPC分类号： C08G77/42 , C08G65/336
CPC分类号： C08G77/42 , A61L27/26 , A61L27/34 , A61L29/049 , A61L29/085 , A61L31/041 , A61L31/10 , C08L51/06 , C08L83/10
摘要： The present disclosure relates to hybrid polymers, methods of making such hybrid polymers, and medical devices that include the hybrid polymers. Such hybrid polymers are suitable for forming biomaterials in a predetermined shape for use in medical devices and medical device components. The hybrid polymers of the present disclosure are formed through a reactive extrusion process prior to being formed into the predetermined shape of the medical device or medical device component.
摘要翻译： 本公开涉及混合聚合物，制备这种杂化聚合物的方法，以及包括杂化聚合物的医疗装置。 这样的混合聚合物适用于形成用于医疗装置和医疗装置部件的预定形状的生物材料。 本公开的混合聚合物在形成医疗装置或医疗装置部件的预定形状之前通过反应性挤出工艺形成。
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