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    Phenylalanine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
    3.
    发明申请
    Phenylalanine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes 有权
    苯丙氨酸衍生物作为二肽基肽酶抑制剂用于治疗或预防糖尿病

    公开(公告)号：US20060111336A1

    公开(公告)日：2006-05-25

    申请号：US10537476

    申请日：2003-11-26

    申请人： Joseph Duffy ,  Robert Mathvink ,  Ann Weber ,  Jinyou Xu

    发明人： Joseph Duffy ,  Robert Mathvink ,  Ann Weber ,  Jinyou Xu

    IPC分类号： A61K31/426 ,  A61K31/401 ,  A61K31/397 ,  C07D277/56

    CPC分类号： C07D295/185 ,  A61K31/40 ,  C07D207/10 ,  C07D207/16 ,  C07D277/04

    摘要： The present invention is directed to phenylalanine derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

    摘要翻译： 本发明涉及作为二肽基肽酶-IV酶（“DP-IV抑制剂”）的抑制剂的苯丙氨酸衍生物，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病，例如 糖尿病，特别是2型糖尿病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。

    System and method for implementing time synchronization monitoring and detection in a safety instrumented system
    7.
    发明申请
    System and method for implementing time synchronization monitoring and detection in a safety instrumented system 失效
    在安全仪表化系统中实现时间同步监测和检测的系统和方法

    公开(公告)号：US20070142939A1

    公开(公告)日：2007-06-21

    申请号：US11642498

    申请日：2006-12-19

    申请人： Joseph Duffy ,  Ram Ramachandran ,  John Gabler

    发明人： Joseph Duffy ,  Ram Ramachandran ,  John Gabler

    IPC分类号： G05B11/01

    CPC分类号： G06F1/12

    摘要： An apparatus, system and process is provided for communicating safety-related data, over an open system, from a sender to a receiver. Safety-related components, including function blocks, flexible function blocks, resource blocks and transducer blocks, as well as, safety-related objects are provided. Also, a time synchronization monitor is provided for monitoring timing distributions and determining when such distributions have drifted beyond an acceptable limit.

    摘要翻译： 提供了一种装置，系统和过程，用于通过开放系统从发送器传送安全相关数据到接收器。 提供与安全相关的组件，包括功能块，灵活功能块，资源块和传感器块，以及与安全相关的对象。 此外，提供时间同步监视器用于监视定时分布，并确定这些分布何时漂移超过可接受的极限。

    Method and apparatus for determining a weight of a payload
    9.
    发明授权
    Method and apparatus for determining a weight of a payload 失效
    用于确定有效载荷的重量的方法和装置

    公开(公告)号：US06518519B1

    公开(公告)日：2003-02-11

    申请号：US09651173

    申请日：2000-08-30

    申请人： Carl D. Crane, III ,  Joseph Duffy

    发明人： Carl D. Crane, III ,  Joseph Duffy

    IPC分类号： G01G1908

    CPC分类号： E02F9/264

    摘要： Methods and apparatuses for determining a mass of a payload in a work machine. The work machine has a chassis, a cab coupled with the chassis, and a boom coupled with the cab. A first actuator is coupled with the boom and the cab and moves the boom relative to the cab. The work machine has a stick coupled with the boom, and a second actuator coupled with the stick and the boom that moves the stick relative to the boom. The work machine also has a bucket operable to receive the payload. The bucket is coupled with the stick, and a third actuator is coupled with the bucket and the stick and moves the bucket relative to the stick. A first joint angle of the boom relative to the cab is determined at at least two instances in time. A second joint angle of the stick relative to the boom is determined at at least two instances in time. A third joint angle of the bucket relative to the stick is determined at at least two instances in time. A first actuator force exerted on the first actuator is determined at at least two instances in time. A second actuator force exerted on the second actuator is determined at at least two instances in time. A third actuator force exerted on the third actuator is determined at at least two instances in time. A plurality of physical characteristics of the work machine is determined. The mass of the bucket and payload is determined as a function of the first joint angles, the second joint angles, the third joint angles, the first actuator forces, the second actuator forces, the third actuator forces, and the plurality of predetermined physical characteristics.

    摘要翻译： 用于确定作业机器中的有效载荷的质量的方法和装置。 工作机具有底盘，与底盘连接的驾驶室以及与驾驶室联动的动臂。 第一致动器与动臂和驾驶室联接，并使悬臂相对于驾驶室移动。 工作机具有与吊杆结合的杆，以及与杆和悬臂相耦合的第二致动器，其相对于悬臂移动杆。 工作机器还具有可操作以接收有效载荷的铲斗。 铲斗与杆联接，第三执行器与铲斗和棍子联接，并相对于棒移动铲斗。 在至少两个时间上确定起重臂相对于驾驶室的第一关节角度。 在至少两个时间的情况下确定棒相对于吊杆的第二关节角度。 在至少两个时间上确定桶相对于棒的第三关节角度。 在至少两个时间上确定施加在第一致动器上的第一致动器力。 在至少两个时间的情况下确定施加在第二致动器上的第二致动器力。 在至少两个时间上确定施加在第三致动器上的第三致动器力。 确定作业机器的多个物理特性。 铲斗和有效载荷的质量根据第一关节角度，第二关节角度，第三关节角度，第一致动器力，第二致动器力，第三致动器力和多个预定物理特性来确定 。