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1.
公开(公告)号:US07294471B2
公开(公告)日:2007-11-13
申请号:US10083576
申请日:2002-02-27
申请人: Linda H. Malkas , Robert J. Hickey , Pamela E. Bechtel , Min Park , Derek J. Hoelz , Dragana Tomic , Lauren Schnaper
发明人: Linda H. Malkas , Robert J. Hickey , Pamela E. Bechtel , Min Park , Derek J. Hoelz , Dragana Tomic , Lauren Schnaper
IPC分类号: G01N33/53
CPC分类号: G01N33/57484 , C07K14/4738
摘要: A method for purifying cancer-specific Proliferating Cell Nuclear Antigen (csPCNA) is described, as well as an immunoassay based thereon.
摘要翻译: 描述了用于纯化癌症特异性增殖细胞核抗原(csPCNA)的方法,以及基于其的免疫测定。
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2.
公开(公告)号:US07723487B2
公开(公告)日:2010-05-25
申请号:US11983939
申请日:2007-11-13
申请人: Linda H. Malkas , Robert J. Hickey , Pamela E. Bechtel , Min Park , Derek J. Hoelz , Dragana Tomic , Lauren Schnaper
发明人: Linda H. Malkas , Robert J. Hickey , Pamela E. Bechtel , Min Park , Derek J. Hoelz , Dragana Tomic , Lauren Schnaper
IPC分类号: C07K16/00
CPC分类号: G01N33/57484 , C07K14/4738
摘要: The method for developing an antibody that exclusively binds to csPCNA.
摘要翻译: 开发与csPCNA完全结合的抗体的方法。
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3.
公开(公告)号:US20080220540A1
公开(公告)日:2008-09-11
申请号:US11983939
申请日:2007-11-13
申请人: Linda H. Malkas , Robert J. Hickey , Pamela E. Bechtel , Min Park , Derek J. Hoelz , Dragana Tomic , Lauren Schnaper
发明人: Linda H. Malkas , Robert J. Hickey , Pamela E. Bechtel , Min Park , Derek J. Hoelz , Dragana Tomic , Lauren Schnaper
IPC分类号: G01N33/53
CPC分类号: G01N33/57484 , C07K14/4738
摘要: The method for developing an antibody that exclusively binds to csPCNA.
摘要翻译: 开发与csPCNA完全结合的抗体的方法。
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公开(公告)号:US07932023B2
公开(公告)日:2011-04-26
申请号:US11993252
申请日:2006-06-26
IPC分类号: C12Q1/00
CPC分类号: G01N33/6875 , C07K14/4738 , G01N33/57484
摘要: Methods and compositions to detect the presence of csPCNA isoform by identifying one or more posttranslational modifications are disclosed. Methods to identify csPCNA isoform through posttranslational modifications including methylesterification levels are disclosed.
摘要翻译: 公开了通过鉴定一个或多个翻译后修饰来检测csPCNA同种型的存在的方法和组合物。 公开了通过包括甲酯化水平在内的翻译后修饰来鉴定csPCNA同种型的方法。
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公开(公告)号:US20120258482A1
公开(公告)日:2012-10-11
申请号:US13500587
申请日:2010-10-07
CPC分类号: C12N9/1007 , G01N33/57415 , G01N2333/91011
摘要: Proliferating cell nuclear antigen (PCNA)-dependent glutamate methyltransferases are disclosed that can methylesterify one or more glutamic acid or aspartic acid residues of PCNA.
摘要翻译: 公开了能够对PCNA的一种或多种谷氨酸或天冬氨酸残基进行甲酯化的增殖细胞核抗原(PCNA)依赖性谷氨酸甲酯转移酶。
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公开(公告)号:US20090061432A1
公开(公告)日:2009-03-05
申请号:US11993252
申请日:2006-06-26
IPC分类号: C12Q1/68
CPC分类号: G01N33/6875 , C07K14/4738 , G01N33/57484
摘要: Methods and compositions to detect the presence of csPCNA isoform by identifying one or more posttranslational modifications are disclosed. Methods to identify csPCNA isoform through posttranslational modifications including methylesterification levels are disclosed.
摘要翻译: 公开了通过鉴定一个或多个翻译后修饰来检测csPCNA同种型的存在的方法和组合物。 公开了通过包括甲酯化水平在内的翻译后修饰来鉴定csPCNA同种型的方法。
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7.
公开(公告)号:US20130177546A1
公开(公告)日:2013-07-11
申请号:US13407442
申请日:2012-02-28
申请人: Derek J. Hoelz
发明人: Derek J. Hoelz
IPC分类号: A61K45/06
CPC分类号: A61K31/713 , A61K31/704 , A61K45/06
摘要: The invention relates to the treatment of cancer using DNA damaging agents. The invention provides methods for treating a mammal with cancer, the method comprising inhibiting in the mammal acidic residue methyltransferase (Arm1) in combination with administering to the mammal a DNA damaging agent. The invention further provides pharmaceutical formulations comprising an inhibitor of acidic residue methyltransferase (Arm1) and a DNA damaging agent.
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