公开(公告)号：US20090326830A1

公开(公告)日：2009-12-31

申请号：US12431221

申请日：2009-04-28

申请人： Lindsey Foreman ,  Ian Evett ,  Susan Pope ,  John Buckleton ,  James Curran ,  Christopher Triggs

发明人： Lindsey Foreman ,  Ian Evett ,  Susan Pope ,  John Buckleton ,  James Curran ,  Christopher Triggs

IPC分类号： G06F19/00

CPC分类号： G16B20/00 ,  G01N2550/00

摘要： Methods for establishing the genotype of a DNA sample, and methods for investigating the potential sources of a DNA sample arising from a plurality of source, are provided, the methods being based on a method including: analysing the sample to produce a data profile for the sample for a locus; proposing a suggested genotype; generating a first stage profile for the locus for the suggested genotype; adjusting the first stage profile to account for one or more factors to give a simulation profile; and comparing the data profile and the simulation profile to provide an indication of the likelihood of the data profile given the suggested genotype. The methods in effect make adjustments to take the first stage profile, potentially through one or more intervening profiles, to the simulation profile, the simulation profile being an anticipation of the data profile which would be expected to occur for that suggested genotype in practice. The methods potentially include adjustments for one or more of preferential amplification and/or stutter and/or allele drop out and/or allele drop in and/or stochastic components and/or noise and/or preferential degradation and/or the relative contributions from the sources.

摘要翻译： 提供了建立DNA样品的基因型的方法以及用于研究由多个源产生的DNA样品的潜在来源的方法，所述方法基于一种方法，包括：分析样品以产生用于 一个地点的样本 提出建议的基因型; 为所建议的基因型产生基因座的第一阶段谱; 调整第一阶段轮廓以考虑一个或多个因素以给出模拟轮廓; 并且比较数据简档和模拟简档，以提供给定建议的基因型的数据简档的可能性的指示。 这些方法实际上可以通过一个或多个介入简档将模拟简档作为第一阶段简档进行调整，该模拟简档是预期将在实践中对该建议的基因型预期发生的数据简档。 这些方法可能包括对优先扩增和/或口吃和/或等位基因脱落和/或等位基因落入和/或随机组分中和/或噪声和/或优先降解和/或来自 来源。

公开(公告)号：US20050282197A1

公开(公告)日：2005-12-22

申请号：US11121290

申请日：2005-05-03

申请人： Lindsey Foreman ,  Ian Evett ,  Susan Pope ,  John Buckleton ,  James Curran ,  Christopher Triggs

发明人： Lindsey Foreman ,  Ian Evett ,  Susan Pope ,  John Buckleton ,  James Curran ,  Christopher Triggs

IPC分类号： C12Q1/68 ,  G01N33/48 ,  G01N33/50 ,  G06F19/00

CPC分类号： G16B20/00 ,  G01N2550/00

摘要： Methods for establishing the genotype of a DNA sample, and methods for investigating the potential sources of a DNA sample arising from a plurality of source, are provided, the methods being based on a method including: analysing the sample to produce a data profile for the sample for a locus; proposing a suggested genotype; generating a first stage profile for the locus for the suggested genotype; adjusting the first stage profile to account for one or more factors to give a simulation profile; and comparing the data profile and the simulation profile to provide an indication of the likelihood of the data profile given the suggested genotype. The methods in effect make adjustments to take the first stage profile, potentially through one or more intervening profiles, to the simulation profile, the simulation profile being an anticipation of the data profile which would be expected to occur for that suggested genotype in practice. The methods potentially include adjustments for one or more of preferential amplification and/or stutter and/or allele drop out and/or allele drop in and/or stochastic components and/or noise and/or preferential degradation and/or the relative contributions from the sources.

摘要翻译： 提供了建立DNA样品的基因型的方法以及用于研究由多个源产生的DNA样品的潜在来源的方法，所述方法基于一种方法，包括：分析样品以产生用于 一个地点的样本 提出建议的基因型; 为所建议的基因型产生基因座的第一阶段谱; 调整第一阶段轮廓以考虑一个或多个因素以给出模拟轮廓; 并且比较数据简档和模拟简档，以提供给定建议的基因型的数据简档的可能性的指示。 这些方法实际上可以通过一个或多个介入简档将模拟简档作为第一阶段简档进行调整，该模拟简档是预期将在实践中对该建议的基因型预期发生的数据简档。 这些方法可能包括对优先扩增和/或口吃和/或等位基因脱落和/或等位基因落入和/或随机组分中和/或噪声和/或优先降解和/或来自 来源。

公开(公告)号：US20090215039A1

公开(公告)日：2009-08-27

申请号：US11909052

申请日：2006-03-20

申请人： James Curran ,  Christopher Triggs

发明人： James Curran ,  Christopher Triggs

IPC分类号： C12Q1/68

CPC分类号： G16B20/00

摘要： A method of investigation a sample is provided, the sample being a mixture of DNA arising from more than one source. The method includes analysing the sample to obtain a genotype for the DNA present in the sample and assigning a prior probability distribution to the genotype. The likelihood function is considered and a posterior probability distribution for the genotype is established. In this way a probabilistic assessment of the genotype of the major or minor contributor to the sample can be obtained. This is beneficial over prior methods which use a deterministic method, and so involve the use of rule based methods.

摘要翻译： 提供了一种调查样品的方法，该样品是由多于一种来源产生的DNA的混合物。 该方法包括分析样品以获得存在于样品中的DNA的基因型，并将先验概率分布分配给基因型。 考虑似然函数，建立基因型的后验概率分布。 以这种方式，可以获得对样品的主要或次要贡献者的基因型的概率评估。 这对使用确定性方法的先前方法是有益的，因此涉及使用基于规则的方法。

公开(公告)号：US09816188B2

公开(公告)日：2017-11-14

申请号：US13262779

申请日：2010-03-30

申请人： James Curran ,  Stephen Hutchins ,  Suman Shrestha

发明人： James Curran ,  Stephen Hutchins ,  Suman Shrestha

IPC分类号： C23C22/78 ,  C25D11/24 ,  C25D11/30 ,  C25D11/26 ,  B05D3/14 ,  C25D11/16 ,  C23C22/82 ,  C25D11/02

CPC分类号： C23C22/78 ,  B05D3/142 ,  B05D2202/20 ,  B05D2202/25 ,  B05D2202/30 ,  C23C22/82 ,  C25D11/026 ,  C25D11/16 ,  C25D11/24 ,  C25D11/26 ,  C25D11/30

摘要： A process for the corrosion protection of metals such as magnesium, aluminium or titanium, where at least two steps are used, including both plasma electrolytic oxidation and chemical passivation. The combination of these two processing steps enhances the corrosion resistance performance of the surface beyond the capability of either of the steps in isolation, providing a more robust protection system. This process may be used as a corrosion protective coating in its own right, or as a protection-enhancing pre-treatment for top-coats such as powder coat or e-coat. When used without an additional top-coat, the treated parts can still retain electrical continuity with and adjoining metal parts. Advantages include reduced cost and higher productivity than traditional plasma-electrolytic oxidation systems, improved corrosion protection, greater coating robustness and electrical continuity.

公开(公告)号：US20090222212A1

公开(公告)日：2009-09-03

申请号：US12296041

申请日：2007-03-28

申请人： James Curran

发明人： James Curran

IPC分类号： G06F19/00

CPC分类号： G16B20/00 ,  G16B30/00 ,  G16B40/00

摘要： A method of analysing DNA samples from mixed sources includes i) obtaining an observed result relating to a value set for a characteristic of the DNA; ii) randomly selecting a selected value set for that DNA characteristic and generating an expected result from that selected value set; iii) comparing the observed result and the expected result and quantifying the difference there between. The method also includes iv) considering the selected value set to be the optimal match; v) randomly selecting a different selected value set and generating another expected result from that selected value set; vi) comparing the observed result with the another expected result and quantifying the difference there between; vii) replacing the existing optimal value set with the different selected value set of step v) if a criteria is met. The method further includes viii) repeating steps v), vi) and vii) at least 10 times; ix) the last optimal match being taken to be the optimal match for the value set for the DNA.

摘要翻译： 从混合来源分析DNA样品的方法包括：i）获得与针对DNA特征设定的值相关的观察结果; ii）随机选择针对该DNA特征的选定值集合并从该选择的值集合产生预期结果; iii）比较观察结果与预期结果并量化其间的差异。 该方法还包括：iv）将所选择的值设为最优匹配; v）随机选择不同的选定值集合并从该选择的值集合生成另一预期结果; vi）将观察结果与另一预期结果进行比较并量化其间的差异; vii）如果满足标准，则用现有的最优值集替换步骤v）的不同选定值集合。 该方法还包括viii）重复步骤v），vi）和vii）至少10次; ix）最后一个最佳匹配被认为是为DNA设置的值的最佳匹配。

公开(公告)号：US20070041352A1

公开(公告)日：2007-02-22

申请号：US11206442

申请日：2005-08-18

申请人： James Frankel ,  James Curran

发明人： James Frankel ,  James Curran

IPC分类号： H04Q7/24

CPC分类号： B66B1/468 ,  B66B2201/4615 ,  B66B2201/4623 ,  B66B2201/4653 ,  H04W64/00 ,  H04W84/18

摘要： A system calls elevator cars using a wireless network of nodes. A mobile node at an unknown location broadcasts a request packet. The request packet includes an identification of the mobile node and an elevator call command. One or more fixed nodes at known locations measure a signal strength of the received request packet and determine a known location of the mobile node based on the signal strength and the known locations of the fixed nodes, and call an elevator car according to the known location of the mobile node and the elevator call command.

摘要翻译： 系统使用节点的无线网络来呼叫电梯轿厢。 未知位置的移动节点广播请求分组。 请求分组包括移动节点的标识和电梯呼叫命令。 在已知位置处的一个或多个固定节点测量接收到的请求分组的信号强度，并且基于固定节点的信号强度和已知位置确定移动节点的已知位置，并根据已知位置呼叫电梯轿厢 的移动节点和电梯呼叫命令。

公开(公告)号：US20120031765A1

公开(公告)日：2012-02-09

申请号：US13262779

申请日：2010-03-30

申请人： James Curran ,  Stephen Hutchins ,  Suman Shrestha

发明人： James Curran ,  Stephen Hutchins ,  Suman Shrestha

IPC分类号： C25D11/00 ,  C25D11/34 ,  C25D11/30 ,  C25D11/04 ,  C25D11/24 ,  C25D7/00

CPC分类号： C23C22/78 ,  B05D3/142 ,  B05D2202/20 ,  B05D2202/25 ,  B05D2202/30 ,  C23C22/82 ,  C25D11/026 ,  C25D11/16 ,  C25D11/24 ,  C25D11/26 ,  C25D11/30

摘要： A process for the corrosion protection of metals such as magnesium, aluminium or titanium, where at least two steps are used, including both plasma electrolytic oxidation and chemical passivation. The combination of these two processing steps enhances the corrosion resistance performance of the surface beyond the capability of either of the steps in isolation, providing a more robust protection system. This process may be used as a corrosion protective coating in its own right, or as a protection-enhancing pre-treatment for top-coats such as powder coat or e-coat. When used without an additional top-coat, the treated parts can still retain electrical continuity with and adjoining metal parts. Advantages include reduced cost and higher productivity than traditional plasma-electrolytic oxidation systems, improved corrosion protection, greater coating robustness and electrical continuity.

摘要翻译： 使用至少两个步骤的金属（例如镁，铝或钛）的腐蚀保护方法，包括等离子体电解氧化和化学钝化。 这两个处理步骤的组合增强了表面的耐腐蚀性能，超出了孤立的任一步骤的能力，提供了更强大的保护系统。 该方法本身可用作防腐蚀涂层，或用作顶部涂层（例如粉末涂层或电泳涂层）的保护增强预处理。 当没有额外的外套使用时，经处理的部件仍然可以保持与金属部件的连接和连接。 优点包括降低成本，提高生产率，比传统的等离子体 - 电解氧化系统，改进的腐蚀保护，更好的涂层鲁棒性和电连续性。

公开(公告)号：US20090234621A1

公开(公告)日：2009-09-17

申请号：US11720721

申请日：2005-12-05

申请人： Peter Gill ,  James Curran

发明人： Peter Gill ,  James Curran

IPC分类号： G06F17/10 ,  G06G7/48 ,  G06F19/00 ,  G01N33/48

CPC分类号： C12Q1/6851 ,  G16B40/00 ,  G16B45/00 ,  C12Q2537/165

摘要： A method of optimizing one or more parameters in a process for considering a DNA containing sample using a method of modeling and a method of modeling itself are provided. The method of modeling the process for considering a DNA containing sample uses a graphical model. The model seeks to provide one or more optimized parameters for the consideration process. The methods aim to consider the whole process, for instance, the number of cells required for the process and/or the extraction efficiency and/or the sub-sample volume relative to the sample volume and/or the amplification efficiency and/or the optimum number of amplification cycles and/or the effect of degradation on the amount of amplifiable DNA in the sample.

摘要翻译： 提供了一种在使用建模方法考虑含DNA样品的过程中优化一个或多个参数的方法和自身建模方法。 用于考虑含DNA样品的过程进行建模的方法使用图形模型。 该模型试图为考虑过程提供一个或多个优化参数。 该方法旨在考虑整个过程，例如，相对于样品体积和/或放大效率和/或最佳值，该方法所需的细胞数量和/或提取效率和/或亚样品体积 扩增循环数和/或降解对样品中可扩增DNA量的影响。