Epitope analogs
    5.
    发明申请
    Epitope analogs 审中-公开
    表位类似物

    公开(公告)号:US20060057673A1

    公开(公告)日:2006-03-16

    申请号:US11156369

    申请日:2005-06-17

    IPC分类号: C07K14/74 C07H21/04 C12P21/06

    摘要: Some embodiments relate to analogs of peptides corresponding to class I MHC-restricted T cell epitopes and methods for their generation. These analogs can contain amino acid substitutions at residues that directly interact with MHC molecules, and can confer improved, modified or useful immunologic properties. Additionally classes of analogs, in which the various substitutions comprise the non-standard residues norleucine and/or norvaline, are disclosed.

    摘要翻译: 一些实施方案涉及对应于I类MHC限制性T细胞表位的肽类似物及其产生方法。 这些类似物可以在与MHC分子直接相互作用的残基处含有氨基酸取代,并且可以赋予改进的,修饰的或有用的免疫学特性。 公开了其中各种取代包含非标准残基正亮氨酸和/或正缬氨酸的类似物类别。

    Prame peptide analogues
    7.
    发明申请
    Prame peptide analogues 失效
    引物肽类似物

    公开(公告)号:US20070060524A1

    公开(公告)日:2007-03-15

    申请号:US11455278

    申请日:2006-06-16

    IPC分类号: A61K38/10 C07K7/08

    摘要: Some embodiments relate to analogs of peptides corresponding to class I MHC-restricted T cell epitopes and methods for their generation. These analogs can contain amino acid substitutions at residues that directly interact with MHC molecules, and can confer improved, modified or useful immunologic properties. Additionally, classes of analogs, in which the various substitutions comprise the non-standard residues norleucine and/or norvaline, are disclosed.

    摘要翻译: 一些实施方案涉及对应于I类MHC限制性T细胞表位的肽类似物及其产生方法。 这些类似物可以在与MHC分子直接相互作用的残基处含有氨基酸取代,并且可以赋予改进的,修饰的或有用的免疫学特性。 此外,公开了类似物类别,其中各种取代包括非标准残基正亮氨酸和/或正缬氨酸。

    NY-ESO-1 peptide analogs
    8.
    发明申请

    公开(公告)号:US20060094661A1

    公开(公告)日:2006-05-04

    申请号:US11155929

    申请日:2005-06-17

    IPC分类号: C07K7/08 A61K38/08

    摘要: Some embodiments relate to analogs of peptides corresponding to class I MHC-restricted T cell epitopes and methods for their generation. These analogs can contain amino acid substitutions at residues that directly interact with MHC molecules, and can confer improved, modified or useful immunologic properties. Additionally classes of analogs, in which the various substitutions comprise the non-standard residues norleucine and/or norvaline, are disclosed.

    Efficacy of active immunotherapy by integrating diagnostic with therapeutic methods
    9.
    发明申请
    Efficacy of active immunotherapy by integrating diagnostic with therapeutic methods 审中-公开
    通过整合诊断与治疗方法的主动免疫治疗的功效

    公开(公告)号:US20050287068A1

    公开(公告)日:2005-12-29

    申请号:US11155928

    申请日:2005-06-17

    IPC分类号: A61K39/00 A61K49/00

    摘要: The invention described herein relates to improved strategies for designing and practicing treatments and clinical trials based upon active immunotherapy protocols, particularly by making diagnostic use of portions of the therapeutic regimen and adjusting the course of treatment if necessary. Embodiments of the invention include methods for determining a course of treatment and methods for treating a patient in which responsiveness to a non-final step of a multi-step active immunotherapy protocol is assessed to determine if, how and when to continue treatment, progress to a different stage of treatment, or discontinue treatment.

    摘要翻译: 本文描述的本发明涉及用于设计和实践基于主动免疫治疗方案的治疗和临床试验的改进策略,特别是通过诊断使用部分治疗方案并根据需要调整治疗过程。 本发明的实施方案包括用于确定治疗过程的方法和用于治疗患者的方法,其中评估对多步骤主动免疫治疗方案的非最终步骤的反应性,以确定是否,如何以及何时继续治疗进展到 不同的治疗阶段,或停止治疗。

    Combinations of tumor-associated antigens in compositions for various types of cancers
    10.
    发明申请
    Combinations of tumor-associated antigens in compositions for various types of cancers 审中-公开
    肿瘤相关抗原在各种类型癌症的组合物中的组合

    公开(公告)号:US20050118186A1

    公开(公告)日:2005-06-02

    申请号:US10871708

    申请日:2004-06-17

    IPC分类号: A61K39/00 A61K48/00

    摘要: Disclosed herein are methods and compositions for inducing an immune response against various combinations of tumor-associated antigens, which can promote effective immunologic intervention in pathogenic processes. Embodiments of the invention disclosed herein are directed to the use of effective combinations of TuAAs for the immunotherapy of patients with various types of cancer. Both immunogenic compositions for inducing an immune response to these combinations of antigens and methods for their use are disclosed.

    摘要翻译: 本文公开了用于诱导针对肿瘤相关抗原的各种组合的免疫应答的方法和组合物,其可以促进病原性过程中的有效免疫干预。 本文公开的本发明的实施方案涉及使用TuAAs的有效组合用于患有各种类型的癌症的患者的免疫治疗。 公开了用于诱导针对这些抗原组合的免疫应答的免疫原性组合物及其使用方法。