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    Methods to elicit, enhance and sustain immune responses against MHC class I-restricted epitopes, for prophylactic and therapeutic purposes
    3.
    发明申请
    Methods to elicit, enhance and sustain immune responses against MHC class I-restricted epitopes, for prophylactic and therapeutic purposes 审中-公开
    引起，增强和维持针对MHC I类限制性表位的免疫应答的方法，用于预防和治疗目的

    公开(公告)号：US20080014211A1

    公开(公告)日：2008-01-17

    申请号：US11879078

    申请日：2007-07-14

    申请人： Adrian Bot ,  Kent Smith

    发明人： Adrian Bot ,  Kent Smith

    IPC分类号： A61K39/00

    CPC分类号： A61K31/7068 ,  A61K31/675 ,  A61K31/704 ,  A61K31/7076 ,  A61K39/0011 ,  A61K45/06 ,  A61K2039/5154 ,  A61K2039/55561 ,  A61K2300/00

    摘要： Embodiments of the present invention relate to methods and compositions for inducing, entraining, and/or amplifying the immune response to MHC class-I restricted epitopes of carcinoma antigens to generate an effective anti-cancer immune response. The methods and compositions disclosed herein, can be used for prophylactic or therapeutic purposes. Further embodiments provide methods of treating a cell proliferative disease, such as cancer by providing to a subject in need thereof a therapeutic strategy comprising an immunogenic composition in combination with a chemotherapeutic agent.

    摘要翻译： 本发明的实施方案涉及用于诱导，携带和/或扩增对癌抗原的MHC I类限制性表位的免疫应答以产生有效的抗癌免疫应答的方法和组合物。 本文公开的方法和组合物可用于预防或治疗目的。 另外的实施方案提供了通过向有需要的受试者提供包含与化学治疗剂组合的免疫原性组合物的治疗策略来治疗细胞增殖性疾病例如癌症的方法。

    Efficacy of active immunotherapy by integrating diagnostic with therapeutic methods
    4.
    发明申请
    Efficacy of active immunotherapy by integrating diagnostic with therapeutic methods 审中-公开
    通过整合诊断与治疗方法的主动免疫治疗的功效

    公开(公告)号：US20050287068A1

    公开(公告)日：2005-12-29

    申请号：US11155928

    申请日：2005-06-17

    申请人： Adrian Bot ,  David Diamond

    发明人： Adrian Bot ,  David Diamond

    IPC分类号： A61K39/00 ,  A61K49/00

    CPC分类号： A61K39/0011 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/55561

    摘要： The invention described herein relates to improved strategies for designing and practicing treatments and clinical trials based upon active immunotherapy protocols, particularly by making diagnostic use of portions of the therapeutic regimen and adjusting the course of treatment if necessary. Embodiments of the invention include methods for determining a course of treatment and methods for treating a patient in which responsiveness to a non-final step of a multi-step active immunotherapy protocol is assessed to determine if, how and when to continue treatment, progress to a different stage of treatment, or discontinue treatment.

    摘要翻译： 本文描述的本发明涉及用于设计和实践基于主动免疫治疗方案的治疗和临床试验的改进策略，特别是通过诊断使用部分治疗方案并根据需要调整治疗过程。 本发明的实施方案包括用于确定治疗过程的方法和用于治疗患者的方法，其中评估对多步骤主动免疫治疗方案的非最终步骤的反应性，以确定是否，如何以及何时继续治疗进展到 不同的治疗阶段，或停止治疗。

    Combinations of tumor-associated antigens in compositions for various types of cancers
    5.
    发明申请
    Combinations of tumor-associated antigens in compositions for various types of cancers 审中-公开
    肿瘤相关抗原在各种类型癌症的组合物中的组合

    公开(公告)号：US20050118186A1

    公开(公告)日：2005-06-02

    申请号：US10871708

    申请日：2004-06-17

    申请人： Chih-Sheng Chiang ,  Adrian Bot ,  John Simard ,  David Diamond

    发明人： Chih-Sheng Chiang ,  Adrian Bot ,  John Simard ,  David Diamond

    IPC分类号： A61K39/00 ,  A61K48/00

    CPC分类号： A61K39/0011 ,  A61K48/00 ,  A61K2039/53 ,  A61K2039/545

    摘要： Disclosed herein are methods and compositions for inducing an immune response against various combinations of tumor-associated antigens, which can promote effective immunologic intervention in pathogenic processes. Embodiments of the invention disclosed herein are directed to the use of effective combinations of TuAAs for the immunotherapy of patients with various types of cancer. Both immunogenic compositions for inducing an immune response to these combinations of antigens and methods for their use are disclosed.

    摘要翻译： 本文公开了用于诱导针对肿瘤相关抗原的各种组合的免疫应答的方法和组合物，其可以促进病原性过程中的有效免疫干预。 本文公开的本发明的实施方案涉及使用TuAAs的有效组合用于患有各种类型的癌症的患者的免疫治疗。 公开了用于诱导针对这些抗原组合的免疫应答的免疫原性组合物及其使用方法。

    EPITOPE ANALOGS
    6.
    发明申请
    EPITOPE ANALOGS 审中-公开
    EPITOPE模拟

    公开(公告)号：US20110301327A1

    公开(公告)日：2011-12-08

    申请号：US13037350

    申请日：2011-02-28

    申请人： Liping Liu ,  Adrian Bot ,  David C. Diamond

    发明人： Liping Liu ,  Adrian Bot ,  David C. Diamond

    IPC分类号： C07K1/107 ,  C07K2/00

    CPC分类号： C07K7/06 ,  A61K38/00 ,  C07K14/4748

    摘要： Some embodiments relate to analogs of peptides corresponding to class I MHC-restricted T cell epitopes and methods for their generation. These analogs can contain amino acid substitutions at residues that directly interact with MHC molecules, and can confer improved, modified or useful immunologic properties. Additionally classes of analogs, in which the various substitutions comprise the non-standard residues norleucine and/or norvaline, are disclosed.

    摘要翻译： 一些实施方案涉及对应于I类MHC限制性T细胞表位的肽类似物及其产生方法。 这些类似物可以在与MHC分子直接相互作用的残基处含有氨基酸取代，并且可以赋予改进的，修饰的或有用的免疫学特性。 公开了其中各种取代包含非标准残基正亮氨酸和/或正缬氨酸的类似物类别。

    NOVEL METHODS AND COMPOSITION FOR DELIVERING MACROMOLECULES TO OR VIA THE RESPIRATORY TRACT
    9.
    发明申请
    NOVEL METHODS AND COMPOSITION FOR DELIVERING MACROMOLECULES TO OR VIA THE RESPIRATORY TRACT 审中-公开
    用于将大分子提供给或通过呼吸道诱导的新方法和组合物

    公开(公告)号：US20070065369A1

    公开(公告)日：2007-03-22

    申请号：US11551166

    申请日：2006-10-19

    申请人： Adrian BOT ,  Luis Dellamary ,  Dan Smith

    发明人： Adrian BOT ,  Luis Dellamary ,  Dan Smith

    IPC分类号： A61K9/12

    CPC分类号： A61K9/127 ,  A61K9/1617

    摘要： A composition comprises a lipid-based microstructure with at least one bioactive macromolecule. The composition provides improved bioavailability and is capable of rapidly releasing a bioactive macromolecule. It is believed that the improved bioavailability is due, at least in part, to the reduction of scavenging by bronchoalveolar macrophages and/or mucociliary clearance.

    摘要翻译： 组合物包含具有至少一种生物活性大分子的脂质基微结构。 该组合物提供改进的生物利用度并且能够快速释放生物活性大分子。 据信，改善的生物利用度至少部分地归因于支气管肺泡巨噬细胞的清除和/或粘膜纤毛清除的减少。