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    Expression vectors encoding epitopes of target-associated antigens and methods for their design
    2.
    发明授权
    Expression vectors encoding epitopes of target-associated antigens and methods for their design 失效
    编码靶标相关抗原表位的表达载体及其设计方法

    公开(公告)号：US08637305B2

    公开(公告)日：2014-01-28

    申请号：US10292413

    申请日：2002-11-07

    申请人： John J. L. Simard ,  David C. Diamond ,  Zhiyong Qiu ,  Xiang-Dong Lei

    发明人： John J. L. Simard ,  David C. Diamond ,  Zhiyong Qiu ,  Xiang-Dong Lei

    IPC分类号： C12N15/63 ,  A61K38/04 ,  C07K4/00

    CPC分类号： G01N33/6848 ,  A61K39/00 ,  A61K39/0011 ,  A61K2039/53 ,  A61K2039/6075 ,  C07K14/47 ,  C07K14/4748 ,  C07K2319/00 ,  C12N15/85 ,  C12N2760/16122 ,  C12N2840/203 ,  G01N33/68 ,  G01N33/6845 ,  G01N2500/00

    摘要： The invention disclosed herein is directed to methods of identifying a polypeptide suitable for epitope liberation including, for example, the steps of identifying an epitope of interest; providing a substrate polypeptide sequence including the epitope, wherein the substrate polypeptide permits processing by a proteasome; contacting the substrate polypeptide with a composition including the proteasome, under conditions that support processing of the substrate polypeptide by the proteasome; and assaying for liberation of the epitope. The invention further relates to vectors including a housekeeping epitope expression cassette. The housekeeping epitope(s) can be derived from a target-associated antigen, and the housekeeping epitope can be liberatable, that is capable of liberation, from a translation product of the cassette by immunoproteasome processing. The invention also relates to a method of activating a T cell comprising contacting a substrate polypeptide with an APC and contacting the APC with a T cell.

    摘要翻译： 本文公开的本发明涉及鉴定适于表位释放的多肽的方法，包括例如鉴定感兴趣的表位的步骤; 提供包括所述表位的底物多肽序列，其中所述底物多肽允许蛋白酶体加工; 在支持蛋白酶体处理底物多肽的条件下使底物多肽与包含蛋白酶体的组合物接触; 并测定表位的释放。 本发明还涉及包含持续用作表位表达盒的载体。 可以从目标相关抗原衍生一个或多个清洁表位，并且通过免疫蛋白酶体处理可以从盒的翻译产物释放能够释放的维持系统表位。 本发明还涉及一种激活T细胞的方法，包括使底物多肽与APC接触并使APC与T细胞接触。

    METHODS AND COMPOSITIONS TO ELICIT MULTIVALENT IMMUNE RESPONSES AGAINST DOMINANT AND SUBDOMINANT EPITOPES, EXPRESSED ON CANCER CELLS AND TUMOR STROMA
    3.
    发明申请
    METHODS AND COMPOSITIONS TO ELICIT MULTIVALENT IMMUNE RESPONSES AGAINST DOMINANT AND SUBDOMINANT EPITOPES, EXPRESSED ON CANCER CELLS AND TUMOR STROMA 失效
    针对癌细胞和肿瘤细胞表达的主要和亚细胞抗原决定多种免疫应答的方法和组合

    公开(公告)号：US20110269949A1

    公开(公告)日：2011-11-03

    申请号：US13179042

    申请日：2011-07-08

    申请人： Zhiyong Qiu ,  Adrian Ion Bot

    发明人： Zhiyong Qiu ,  Adrian Ion Bot

    IPC分类号： C07H21/04

    CPC分类号： A61K39/0011 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/70 ,  C07K14/4748 ,  C07K14/705

    摘要： The present invention provides a method of treating cancer by providing to a subject in need thereof an immunogenic composition comprising a nucleic acid construct encoding a polypeptide comprising CTL epitopes PSMA288-297 and PRAME425-433, or a cross-reactive analogue. In embodiments of the present invention there is provided methods and compositions for inducing, entraining, and/or amplifying the immune response to MHC class-I restricted epitopes of carcinoma antigens to generate an effective anti-cancer immune response.

    摘要翻译： 本发明提供了一种通过向有需要的受试者提供包含编码包含CTL表位PSMA288-297和PRAME425-433或交叉反应性类似物的多肽的核酸构建体的免疫原性组合来治疗癌症的方法。 在本发明的实施方案中，提供了用于诱导，携带和/或扩增针对癌抗原的MHC I类限制性表位的免疫应答以产生有效的抗癌免疫应答的方法和组合物。

    MULTICISTRONIC VECTORS AND METHODS FOR THEIR DESIGN
    4.
    发明申请
    MULTICISTRONIC VECTORS AND METHODS FOR THEIR DESIGN 审中-公开
    多媒体矢量及其设计方法

    公开(公告)号：US20090131355A1

    公开(公告)日：2009-05-21

    申请号：US12126855

    申请日：2008-05-23

    申请人： Adrian Ion Bot ,  David C. Diamond ,  Zhiyong Qiu

    发明人： Adrian Ion Bot ,  David C. Diamond ,  Zhiyong Qiu

    IPC分类号： A61K31/7088 ,  C12N15/63 ,  C12N5/10

    CPC分类号： C12N15/111 ,  A61K39/00 ,  C12N15/1135 ,  C12N15/85 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/53 ,  C12N2330/30 ,  C12N2840/20

    摘要： Embodiments of the present invention relate to multicistronic vectors and methods for their design. Methods and compositions of the invention include a vector including at least two cistrons, wherein a first cistron includes a first promoter and a first nucleic acid sequence encoding one or more therapeutic agents, and wherein a second cistron comprises a second promoter and a second nucleic acid sequence encoding one or more RNA molecules that interfere with the expression of a biological response modifier or the therapeutic agent, wherein the expression of the first sequence is under control of the first promoter and expression of the second sequence is under control of the second promoter.

    摘要翻译： 本发明的实施方案涉及多顺反子载体及其设计方法。 本发明的方法和组合物包括包含至少两个顺反子的载体，其中第一顺反子包含第一启动子和编码一种或多种治疗剂的第一核酸序列，并且其中第二顺反子包含第二启动子和第二核酸 编码干扰生物反应调节剂或治疗剂表达的一种或多种RNA分子的序列，其中第一序列的表达受第一启动子的控制，第二序列的表达受第二启动子的控制。

    Method for enhancing T cell response
    5.
    发明申请
    Method for enhancing T cell response 审中-公开
    增强T细胞反应的方法

    公开(公告)号：US20080199485A1

    公开(公告)日：2008-08-21

    申请号：US12070156

    申请日：2008-02-15

    申请人： Thomas Kundig ,  Adrian Bot ,  Kent Andrew Smith ,  Zhiyong Qiu

    发明人： Thomas Kundig ,  Adrian Bot ,  Kent Andrew Smith ,  Zhiyong Qiu

    IPC分类号： A61K39/00 ,  A61K48/00 ,  A61K38/00 ,  A61K31/70

    CPC分类号： A61K39/39 ,  A61K2039/5152 ,  A61K2039/5154 ,  A61K2039/55516 ,  A61K2039/55522 ,  A61K2039/55561 ,  A61K2039/55577

    摘要： Embodiments of the invention disclosed herein relate to methods and compositions for exponentially increasing antigenic stimulation of class I MHC CD8+ T cell responses over that based in the art. Some embodiments relate to an immunogenic composition that enhances an immune response in a subject. In some embodiments, the immunogenic composition comprises an antigen in combination with an immunopotentiator or a biological response modifier (BRM). Overall, the invention disclosed herein demonstrates that increasing antigenic stimulation in a manner independent of the dose of the antigen enhances immunogenicity.

    摘要翻译： 本文公开的本发明的实施方案涉及用于指数增加I类MHC CD8 + T细胞应答的抗原性刺激的方法和组合。 一些实施方案涉及增强受试者的免疫应答的免疫原性组合物。 在一些实施方案中，免疫原性组合物包含与免疫增强剂或生物反应调节剂（BRM）组合的抗原。 总的来说，本文公开的发明证明以与抗原剂量无关的方式增加抗原刺激增强了免疫原性。

    METHOD AND APPARATUS FOR TRANSMITTING OVERHEAD INFORMATION
    6.
    发明申请
    METHOD AND APPARATUS FOR TRANSMITTING OVERHEAD INFORMATION 有权
    传输信息的方法和装置

    公开(公告)号：US20080107132A1

    公开(公告)日：2008-05-08

    申请号：US11958043

    申请日：2007-12-17

    申请人： Jianbin Huang ,  Tianxiang Wang ,  Zhiyong Qiu ,  Guixue Zhao ,  Feng Zhang ,  Jun Feng ,  Dejun Li ,  Yongiun Tu ,  Xiaobin Song

    发明人： Jianbin Huang ,  Tianxiang Wang ,  Zhiyong Qiu ,  Guixue Zhao ,  Feng Zhang ,  Jun Feng ,  Dejun Li ,  Yongiun Tu ,  Xiaobin Song

    IPC分类号： H04J3/22

    CPC分类号： H04J3/1611 ,  H04J2203/0035 ,  H04W52/58

    摘要： A method provided by the present invention for transmitting overhead information, includes dividing and reforming overhead information into at least two overhead parts, inserting the at least two overhead parts into overhead bytes of at least two corresponding data frames, and transmitting the at least two overhead parts via the it least two data frames which are microwave frames. Overhead information transmitting apparatus and overhead information receiving apparatus are also provided by the present invention. With the method and apparatus of the present invention, the channel bandwidth resources occupied by the overhead bytes or each microwave frame are greatly reduced. If the saved channel bandwidth is used for performing the error correction code on the transmitted information, the code gain is improved and the sensitivity requirement on the receiver is reduced so that the cost of a microwave transmitting system is reduced eventually.

    摘要翻译： 本发明提供的用于发送开销信息的方法包括：将开销信息划分和重构为至少两个开销部分，将至少两个开销部分插入到至少两个相应数据帧的开销字节中，以及发送至少两个开销 通过它至少两个数据帧是微波帧。 本发明还提供了开销信息发送装置和开销信息接收装置。 利用本发明的方法和装置，由开销字节或每个微波帧占用的信道带宽资源大大降低。 如果保存的信道带宽用于对发送的信息执行纠错码，则可以提高码增益，减少对接收机的灵敏度要求，从而最终降低微波发射系统的成本。

    Selfie stick tripod
    8.
    外观设计
    Selfie stick tripod 有权

    公开(公告)号：USD1019743S1

    公开(公告)日：2024-03-26

    申请号：US29906163

    申请日：2023-11-01

    申请人： Zhiyong Qiu

    设计人： Zhiyong Qiu

    摘要： FIG. 1 is a front, top, right perspective view of the selfie stick tripod in the first state, showing my new design;
    FIG. 2 is a rear, left, bottom perspective view thereof;
    FIG. 3 is a front, left, bottom perspective view thereof;
    FIG. 4 is a front elevational view thereof;
    FIG. 5 is a rear elevational view thereof;
    FIG. 6 is a left side view thereof;
    FIG. 7 is a right side view thereof;
    FIG. 8 is a top plan view thereof;
    FIG. 9 is a bottom plan view thereof;
    FIG. 10 is an enlarged view of detail 10 in FIG. 1;
    FIG. 11 is an enlarged view of detail 11 in FIG. 1;
    FIG. 12 is an enlarged view of detail 12 in FIG. 1;
    FIG. 13 is an enlarged view of detail 13 in FIG. 2;
    FIG. 14 is an enlarged view of detail 14 in FIG. 2;
    FIG. 15 is an enlarged view of detail 15 in FIG. 2;
    FIG. 16 is an enlarged view of detail 16 in FIG. 2;
    FIG. 17 is an enlarged view of detail 17 in FIG. 2;
    FIG. 18 is an enlarged view of detail 18 in FIG. 2;
    FIG. 19 is an enlarged view of detail 19 in FIG. 3;
    FIG. 20 is an enlarged view of detail 20 in FIG. 4;
    FIG. 21 is an enlarged view of detail 21 in FIG. 6;
    FIG. 22 is an enlarged view of detail 22 in FIG. 8;
    FIG. 23 is an enlarged view of detail 23 in FIG. 9;
    FIG. 24 is an enlarged view of detail 24 in FIG. 9;
    FIG. 25 is a front, top, right perspective view of the selfie stick tripod in the second state;
    FIG. 26 is a front, top, right perspective view of the selfie stick tripod in the third state;
    FIG. 27 is a front, top, right perspective view of the selfie stick tripod in the fourth state; and,
    FIG. 28 is a front, top, right perspective view of the selfie stick tripod in the fifth state.
    The dashed broken lines in the figures are for the purposes of illustrating portions of the selfie stick tripod that form no part of the claimed design.
    The dash-dot-dash broken lines are for notating enlarged views and form no part of the claimed design.

    Expression vectors encoding epitopes of target-associated antigens and methods for their design
    10.
    发明授权
    Expression vectors encoding epitopes of target-associated antigens and methods for their design 有权
    编码靶标相关抗原表位的表达载体及其设计方法

    公开(公告)号：US08252916B2

    公开(公告)日：2012-08-28

    申请号：US10837217

    申请日：2004-04-30

    申请人： John J. L. Simard ,  David C. Diamond ,  Zhiyong Qiu ,  Xiang-Dong Lei

    发明人： John J. L. Simard ,  David C. Diamond ,  Zhiyong Qiu ,  Xiang-Dong Lei

    IPC分类号： C07H21/04 ,  C07K1/00

    CPC分类号： G01N33/6848 ,  A61K39/00 ,  A61K39/0011 ,  A61K2039/53 ,  A61K2039/6075 ,  C07K14/47 ,  C07K14/4748 ,  C07K2319/00 ,  C12N15/85 ,  C12N2760/16122 ,  C12N2840/203 ,  G01N33/68 ,  G01N33/6845 ,  G01N2500/00

    摘要： The invention disclosed herein is directed to methods of identifying a polypeptide suitable for epitope liberation including, for example, the steps of identifying an epitope of interest; providing a substrate polypeptide sequence including the epitope, wherein the substrate polypeptide permits processing by a proteasome; contacting the substrate polypeptide with a composition including the proteasome, under conditions that support processing of the substrate polypeptide by the proteasome; and assaying for liberation of the epitope. The invention further relates to vectors including a housekeeping epitope expression cassette. The invention relates to epitope cluster regions and to vectors including epitope cluster regions. The invention also relates to a method of activating a T cell comprising contacting a substrate polypeptide with an APC and contacting the APC with a T cell.

    摘要翻译： 本文公开的本发明涉及鉴定适用于表位释放的多肽的方法，包括例如鉴定感兴趣的表位的步骤; 提供包括所述表位的底物多肽序列，其中所述底物多肽允许蛋白酶体加工; 在支持蛋白酶体处理底物多肽的条件下使底物多肽与包含蛋白酶体的组合物接触; 并测定表位的释放。 本发明还涉及包含持续用作表位表达盒的载体。 本发明涉及表位簇区域和涉及包含表位簇区域的载体。 本发明还涉及一种激活T细胞的方法，包括使底物多肽与APC接触并使APC与T细胞接触。