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公开(公告)号：US20130029359A1
公开(公告)日：2013-01-31
申请号：US13510901
申请日：2010-11-18
申请人： Nathalie Kertesz , Sutao Zhu , Chih-Sheng Chiang
发明人： Nathalie Kertesz , Sutao Zhu , Chih-Sheng Chiang
CPC分类号： G01N33/5748 , C07K14/47 , C07K16/18 , C07K16/3053 , C07K2317/21 , C07K2317/24 , C07K2317/34 , G01N33/5743 , G01N33/57484 , G01N2333/4704
摘要： The disclosure relates to antibodies to the preferentially expressed antigen in melanoma (PRAME), and the synovial sarcoma X breakpoint 2 (SSX-2) antigens, methods of use, and diagnostic kits thereof. In exemplary embodiments, the disclosure relates to monoclonal antibodies to specific epitopes of the PRAME and SSX-2 antigens and methods of using such antibodies.
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2.发明申请COMBINATIONS OF TUMOR-ASSOCIATED ANTIGENS IN DIAGNOSTICS FOR VARIOUS TYPES OF CANCERS 审中-公开肿瘤相关抗原在不同类型癌症诊断中的联合公开(公告)号：US20120258462A1
公开(公告)日：2012-10-11
申请号：US13453903
申请日：2012-04-23
IPC分类号： C12Q1/68 , G01N33/573 , G01N33/566
CPC分类号： G01N33/57484 , A61K39/0011 , A61K2039/53 , G01N33/574 , Y02A50/466
摘要： Disclosed herein are methods for matching a cancer condition with an appropriate immunotherapeutic agent and/or regimen. Also disclosed are methods for confirming diagnosis of a particular type of cancer. Embodiments of the invention disclosed herein are directed to the use of effective combinations of TuAAs to optimize the match between a patient's cancer condition and available immunotherapies.
摘要翻译： 本文公开了将癌症状况与适当的免疫治疗剂和/或方案进行匹配的方法。 还公开了用于确认特定类型的癌症的诊断的方法。 本文公开的本发明的实施方案涉及使用TuAAs的有效组合来优化患者的癌症状况与可用的免疫疗法之间的匹配。
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公开(公告)号：US4433061A
公开(公告)日：1984-02-21
申请号：US269155
申请日：1981-06-01
申请人： Chih-Sheng Chiang
发明人： Chih-Sheng Chiang
IPC分类号： G01N33/53 , G01N33/531 , G01N33/537
CPC分类号： G01N33/531 , G01N33/5308 , G01N33/537 , Y10S436/804 , Y10S436/815 , Y10S436/828
摘要： An improved radioimmunoassay for the determination of cyclic nucleotides in body fluids which comprises adding a source of divalent cation prior to assay minimizes the effects of both endogenous calcium ion and EDTA used as an anticoagulant in blood plasma samples.
摘要翻译： 用于测定体液中环状核苷酸的改进的放射免疫测定法，其包括在测定之前加入二价阳离子源，最小化在血浆样品中用作抗凝血剂的内源性钙离子和EDTA的作用。
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公开(公告)号：US20120148613A1
公开(公告)日：2012-06-14
申请号：US13336523
申请日：2011-12-23
申请人： Adrian Ion Bot , Chih-Sheng Chiang , David C. Diamond , Jian Gong , Kent Andrew Smith , Liping Liu , Xiping Liu , Zhiyong Qiu
发明人： Adrian Ion Bot , Chih-Sheng Chiang , David C. Diamond , Jian Gong , Kent Andrew Smith , Liping Liu , Xiping Liu , Zhiyong Qiu
CPC分类号： A61K39/0011 , A01K67/0275 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K39/00 , A61K2039/53 , A61K2039/545 , C07K14/4748 , C07K14/70539 , C12N15/8509
摘要： The present invention provides a method of treating a cell proliferative disease such as cancer by providing to a subject in need thereof an immunogenic composition comprising plasmid and peptide(s) or analogues thereof. In embodiments of the present invention there is provided methods and compositions for inducing, entraining, and/or amplifying the immune response to MHC class-I restricted epitopes of carcinoma antigens to generate an effective anti-cancer immune response.
摘要翻译： 本发明提供了通过向有需要的受试者提供包含质粒和肽或其类似物的免疫原性组合来治疗细胞增殖性疾病如癌症的方法。 在本发明的实施方案中，提供了用于诱导，携带和/或扩增针对癌抗原的MHC I类限制性表位的免疫应答以产生有效的抗癌免疫应答的方法和组合物。
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5.发明申请Combinations of tumor-associated antigens in diagnostics for various types of cancers 审中-公开肿瘤相关抗原在各种类型癌症诊断中的组合公开(公告)号：US20060008468A1
公开(公告)日：2006-01-12
申请号：US11155288
申请日：2005-06-17
申请人： Chih-Sheng Chiang , John Simard
发明人： Chih-Sheng Chiang , John Simard
IPC分类号： G01N33/574 , A61K39/385
CPC分类号： G01N33/57484 , A61K39/0011 , A61K2039/53 , G01N33/574 , Y02A50/466
摘要： Disclosed herein are methods for matching a cancer condition with an appropriate immunotherapeutic agent and/or regimen. Also disclosed are methods for confirming diagnosis of a particular type of cancer. Embodiments of the invention disclosed herein are directed to the use of effective combinations of TuAAs to optimize the match between a patient's cancer condition and available immunotherapies.
摘要翻译： 本文公开了将癌症状况与适当的免疫治疗剂和/或方案进行匹配的方法。 还公开了用于确认特定类型的癌症的诊断的方法。 本文公开的本发明的实施方案涉及使用TuAAs的有效组合来优化患者的癌症状况与可用的免疫疗法之间的匹配。
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6.发明申请Combinations of tumor-associated antigens in compositions for various types of cancers 审中-公开肿瘤相关抗原在各种类型癌症的组合物中的组合公开(公告)号：US20050118186A1
公开(公告)日：2005-06-02
申请号：US10871708
申请日：2004-06-17
申请人： Chih-Sheng Chiang , Adrian Bot , John Simard , David Diamond
发明人： Chih-Sheng Chiang , Adrian Bot , John Simard , David Diamond
CPC分类号： A61K39/0011 , A61K48/00 , A61K2039/53 , A61K2039/545
摘要： Disclosed herein are methods and compositions for inducing an immune response against various combinations of tumor-associated antigens, which can promote effective immunologic intervention in pathogenic processes. Embodiments of the invention disclosed herein are directed to the use of effective combinations of TuAAs for the immunotherapy of patients with various types of cancer. Both immunogenic compositions for inducing an immune response to these combinations of antigens and methods for their use are disclosed.
摘要翻译： 本文公开了用于诱导针对肿瘤相关抗原的各种组合的免疫应答的方法和组合物，其可以促进病原性过程中的有效免疫干预。 本文公开的本发明的实施方案涉及使用TuAAs的有效组合用于患有各种类型的癌症的患者的免疫治疗。 公开了用于诱导针对这些抗原组合的免疫应答的免疫原性组合物及其使用方法。
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公开(公告)号：US08580508B2
公开(公告)日：2013-11-12
申请号：US13312882
申请日：2011-12-06
申请人： Chih-Sheng Chiang , Jose F. Cuan
发明人： Chih-Sheng Chiang , Jose F. Cuan
CPC分类号： C12Q1/6818 , C12Q1/707 , C12Q2565/101 , C12Q2537/161 , C12Q2525/204
摘要： A method is provided for detecting the presence of nucleotides or monitoring nucleotide amplification. It utilizes fluorescence energy transfer by competitive hybridization. Competitive hybridization is achieved by using unequal length complementary probes which have a fluorophore on one probe and a quencher on the other. The fluorophore and quencher are juxtaposed in a manner wherein the proximity of the quencher to the fluorophore produces quenching of the fluorescence of the fluorophore.
摘要翻译： 提供了用于检测核苷酸存在或监测核苷酸扩增的方法。 它通过竞争性杂交利用荧光能量转移。 竞争性杂交通过使用不等长的互补探针来实现，该探针在一个探针上具有荧光团，而在另一个探针上具有猝灭剂。 荧光团和猝灭剂以其中猝灭剂与荧光团的接近度产生荧光团的荧光猝灭的方式并置。
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公开(公告)号：US08084592B2
公开(公告)日：2011-12-27
申请号：US11455279
申请日：2006-06-16
申请人： Adrian Ion Bot , Chih-Sheng Chiang , David C. Diamond , Jian Gong , Kent Andrew Smith , Liping Liu , Xiping Liu , Zhiyong Qiu
发明人： Adrian Ion Bot , Chih-Sheng Chiang , David C. Diamond , Jian Gong , Kent Andrew Smith , Liping Liu , Xiping Liu , Zhiyong Qiu
IPC分类号： C07H21/02
CPC分类号： A61K39/0011 , A01K67/0275 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K39/00 , A61K2039/53 , A61K2039/545 , C07K14/4748 , C07K14/70539 , C12N15/8509
摘要： The present invention provides a method of treating a cell proliferative disease such as cancer by providing to a subject in need thereof an immunogenic composition comprising plasmid and peptide(s) or analogues thereof. In embodiments of the present invention there is provided methods and compositions for inducing, entraining, and/or amplifying the immune response to MHC class-I restricted epitopes of carcinoma antigens to generate an effective anti-cancer immune response.
摘要翻译： 本发明提供了通过向有需要的受试者提供包含质粒和肽或其类似物的免疫原性组合来治疗细胞增殖性疾病如癌症的方法。 在本发明的实施方案中，提供了用于诱导，携带和/或扩增针对癌抗原的MHC I类限制性表位的免疫应答以产生有效的抗癌免疫应答的方法和组合物。
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公开(公告)号：US08846872B2
公开(公告)日：2014-09-30
申请号：US13510901
申请日：2010-11-18
申请人： Nathalie Kertesz , Sutao Zhu , Chih-Sheng Chiang
发明人： Nathalie Kertesz , Sutao Zhu , Chih-Sheng Chiang
IPC分类号： C07K16/30 , G01N33/574 , C07K14/47
CPC分类号： G01N33/5748 , C07K14/47 , C07K16/18 , C07K16/3053 , C07K2317/21 , C07K2317/24 , C07K2317/34 , G01N33/5743 , G01N33/57484 , G01N2333/4704
摘要： The disclosure relates to antibodies to the preferentially expressed antigen in melanoma (PRAME), and the synovial sarcoma X breakpoint 2 (SSX-2) antigens, methods of use, and diagnostic kits thereof. In exemplary embodiments, the disclosure relates to monoclonal antibodies to specific epitopes of the PRAME and SSX-2 antigens and methods of using such antibodies.
摘要翻译： 本公开涉及针对优先表达的黑素瘤抗原（PRAME）和滑膜肉瘤X断裂点2（SSX-2）抗原，其使用方法及其诊断试剂盒的抗体。 在示例性实施方案中，本公开涉及针对PRAME和SSX-2抗原的特异性表位的单克隆抗体以及使用所述抗体的方法。
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公开(公告)号：US20120122080A1
公开(公告)日：2012-05-17
申请号：US13312882
申请日：2011-12-06
申请人： Chih-Sheng Chiang , Jose F. Cuan
发明人： Chih-Sheng Chiang , Jose F. Cuan
CPC分类号： C12Q1/6818 , C12Q1/707 , C12Q2565/101 , C12Q2537/161 , C12Q2525/204
摘要： A method is provided for detecting the presence of nucleotides or monitoring nucleotide amplification. It utilizes fluorescence energy transfer by competitive hybridization. Competitive hybridization is achieved by using unequal length complementary probes which have a fluorophore on one probe and a quencher on the other. The fluorophore and quencher are juxtaposed in a manner wherein the proximity of the quencher to the fluorophore produces quenching of the fluorescence of the fluorophore.
摘要翻译： 提供了用于检测核苷酸存在或监测核苷酸扩增的方法。 它通过竞争性杂交利用荧光能量转移。 竞争性杂交通过使用不等长的互补探针来实现，该探针在一个探针上具有荧光团，而在另一个探针上具有猝灭剂。 荧光团和猝灭剂以其中猝灭剂与荧光团的接近度产生荧光团的荧光猝灭的方式并置。
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