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公开(公告)号：US20080193490A1
公开(公告)日：2008-08-14
申请号：US11841087
申请日：2007-08-20
CPC分类号： B82Y30/00 , A61K9/0092 , A61K47/6949 , A61K49/0004 , B82Y5/00
摘要： Compositions and methods for administering a therapeutic agent to a mammal are disclosed. The compositions comprise either (i) vesicles comprising an amphiphilic substituted fullerene, wherein the therapeutic agent is present in the vesicle interior or between layers of the vesicle wall, (ii) a substituted fullerene, comprising a fullerene core and a functional moiety, wherein the therapeutic agent is associated with the substituted fullerene, or (iii) carbon nanotubes, wherein the therapeutic agent is associated with the carbon nanotubes.
摘要翻译： 公开了向哺乳动物施用治疗剂的组合物和方法。 所述组合物包含（i）包含两亲性取代的富勒烯的囊泡，其中所述治疗剂存在于泡囊内部或囊泡壁的层之间，（ii）包含富勒烯核心和功能部分的取代的富勒烯，其中 治疗剂与取代的富勒烯相关，或（iii）碳纳米管，其中治疗剂与碳纳米管相关联。
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公开(公告)号：US20080175892A1
公开(公告)日：2008-07-24
申请号：US11841524
申请日：2007-08-20
IPC分类号： A61K9/127 , A61K47/42 , A61K9/12 , A61P35/00 , A61K31/337
CPC分类号： A61K31/337 , A61K9/0078 , A61K9/127 , A61K47/6949 , B82Y5/00
摘要： Nanostructure-drug conjugates and associated methods of use are provided. In one embodiment, a nanostructure-drug conjugate comprising a Cn, a crosslinker, and a drug is provided, wherein Cn refers to a fullerene moiety or nanotube comprising n carbon atoms. A method of treating cancer is also provided, comprising administering a therapeutically effective amount of a nanostructure-drug conjugate comprising: a Cn, a crosslinker, and a drug, wherein Cn refers to a fullerene moiety comprising n carbon atoms to a mammal.
摘要翻译： 提供了纳米结构 - 药物共轭物和相关使用方法。 在一个实施方案中，提供了包含C n N，交联剂和药物的纳米结构药物缀合物，其中C n是指包含n碳的富勒烯部分或纳米管 原子 还提供了一种治疗癌症的方法，包括施用治疗有效量的纳米结构 - 药物缀合物，其包含：C n N，交联剂和药物，其中C n 指向哺乳动物包含n个碳原子的富勒烯部分。
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公开(公告)号：US07758889B1
公开(公告)日：2010-07-20
申请号：US10623110
申请日：2003-07-18
申请人： Uri Sagman , Michael G. Rosenblum , Lon J. Wilson
发明人： Uri Sagman , Michael G. Rosenblum , Lon J. Wilson
CPC分类号： A61K31/337 , A61K47/6855 , A61K47/6865 , A61K2039/505 , C07K16/3053 , C07K2317/622
摘要： Herein we disclose a composition, comprising a Cn-Ab, wherein Cn is a fullerene or nanotube comprising n carbon atoms, and Ab is a moiety comprising an antigen-binding site and is linked to the Cn. The composition can further comprise a therapeutic molecule associated with the Cn-Ab. Also, we disclose a method of treating a disease in a mammal, comprising administering to the mammal an effective amount of the composition.
摘要翻译： 在本文中，我们公开了包含Cn-Ab的组合物，其中C n是包含n个碳原子的富勒烯或纳米管，Ab是包含抗原结合位点并与Cn连接的部分。 组合物还可以包含与Cn-Ab相关的治疗分子。 此外，我们公开了一种治疗哺乳动物疾病的方法，包括向哺乳动物施用有效量的组合物。
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公开(公告)号：US20090214101A1
公开(公告)日：2009-08-27
申请号：US12325849
申请日：2008-12-01
IPC分类号： G06K9/00 , C07K16/18 , G01N33/483
CPC分类号： A61K49/16 , A61K47/60 , A61K49/085
摘要： Compositions and methods related to targeted carbon nanostructures. More particularly, targeted carbon nanostructures comprising: a Cn, a cross-linker, and a targeting agent, wherein Cn refers to a fullerene moiety or nanotube comprising n carbon atoms. One example of a method may involve a method for imaging comprising: contacting a targeted carbon nanostructure and a cell; allowing the cell to internalize the carbon nanostructure; and detecting the presence of internalized carbon nanostructures.
摘要翻译： 与目标碳纳米结构相关的组成和方法。 更具体地，包括Cn，交联剂和靶向剂的靶向碳纳米结构，其中C n是指包含n个碳原子的富勒烯部分或纳米管。 方法的一个实例可以包括用于成像的方法，其包括：使目标碳纳米结构和细胞接触; 使细胞内化碳纳米结构; 并检测内在碳纳米结构的存在。
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公开(公告)号：US20060051290A1
公开(公告)日：2006-03-09
申请号：US11180088
申请日：2005-07-13
CPC分类号： B82Y30/00 , A61K49/1884 , A61K51/1251 , B82Y5/00 , Y10T428/2935
摘要： A method for delivering a radiotherapeutic agent to a target, comprises administering a composition comprising water-soluble nanotubes having an average length less than 50 nm and a radionuclide so as to expose the target to the composition. The nanotubes can be functionalized with a monoclonal antibody having an affinity for the target. The radionuclide can be contained in the nanotubes, which can be derivatized. The nanotubes can be loaded with I2 or 211AtI, another α-emitter, including but not limited to 211AtI, 225Ac, 212Bi, 213Bi, and combinations thereof. The nanotubes have an average length less than 40 nm, or an average length less than 30 nm.
摘要翻译： 将放射治疗剂递送至靶的方法包括施用包含平均长度小于50nm的水溶性纳米管和放射性核素的组合物，以将靶暴露于组合物。 纳米管可以用对靶具有亲和性的单克隆抗体进行功能化。 放射性核素可以包含在可以衍生的纳米管中。 纳米管可以加载另一个α发射体，其中包括但不限于二级，二级，二级，二级，二级， Bi，Bi，Bi，Bi，Bi及其组合。 纳米管的平均长度小于40nm，平均长度小于30nm。
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公开(公告)号：US20110288275A1
公开(公告)日：2011-11-24
申请号：US13094109
申请日：2011-04-26
IPC分类号： C07K17/02 , C07K14/415 , C07K17/00
CPC分类号： C07K14/415 , A61K38/00 , A61K2039/505 , C07K16/30 , C07K2317/34 , C07K2317/622 , C07K2319/00
摘要： The present invention concerns methods of reducing the antigenicity of a proteinaceous compound while maintaining the compounds biological activity, as well as proteinaceous compositions with biological activity but reduced antigenicity. These methods and compositions have significant benefits to a subject in need of such compounds and compositions. Also included are modified toxin compounds that are truncated and/or possess reduce antigenicity. Such designer toxins have therapeutic, diagnostic, and preventative benefits, particularly as immunotoxins. Methods of treating cancer using these immunotoxins are provided.
摘要翻译： 本发明涉及降低蛋白质化合物的抗原性同时保持化合物生物活性的方法，以及具有生物活性但降低的抗原性的蛋白质组合物。 这些方法和组合物对于需要这种化合物和组合物的受试者具有显着的益处。 还包括被截短和/或具有降低抗原性的经修饰的毒素化合物。 这样的设计毒素具有治疗，诊断和预防效果，特别是作为免疫毒素。 提供使用这些免疫毒素治疗癌症的方法。
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公开(公告)号：US08043831B2
公开(公告)日：2011-10-25
申请号：US12788005
申请日：2010-05-26
申请人： Michael G. Rosenblum , Yuying Liu
发明人： Michael G. Rosenblum , Yuying Liu
CPC分类号： C12N9/6467 , A61K38/00 , C07K14/4747 , C07K14/52 , C07K2319/00
摘要： The present invention relates to targeted killing of a cell utilizing a chimeric polypeptide comprising a cell-specific targeting moiety and a signal transduction pathway factor. In a preferred embodiment, the signal transduction pathway factor is an apoptosis-inducing factor, such as granzyme B, granzyme A, or Bax.
摘要翻译： 本发明涉及利用包含细胞特异性靶向部分和信号转导途径因子的嵌合多肽靶向杀死细胞。 在优选的实施方案中，信号转导途径因子是凋亡诱导因子，例如颗粒酶B，粒酶A或Bax。
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公开(公告)号：US07083957B2
公开(公告)日：2006-08-01
申请号：US10074596
申请日：2002-02-12
IPC分类号： C12N9/00
CPC分类号： C07K14/415 , A61K38/00 , A61K2039/505 , C07K16/30 , C07K2317/34 , C07K2317/622 , C07K2319/00
摘要： The present invention concerns methods of reducing the antigenicity of a proteinaceous compound while maintaining the compounds biological activity, as well as proteinaceous compositions with biological activity but reduced antigenicity. These methods and compositions have significant benefits to a subject in need of such compounds and compositions. Also included are modified toxin compounds that are truncated and/or possess reduce antigenicity. Such designer toxins have therapeutic, diagnostic, and preventative benefits, particularly as immunotoxins. Methods of treating cancer using these immunotoxins are provided.
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公开(公告)号：US20120252097A1
公开(公告)日：2012-10-04
申请号：US13281004
申请日：2011-10-25
申请人： Michael G. Rosenblum , Yuying Liu
发明人： Michael G. Rosenblum , Yuying Liu
CPC分类号： C12N9/6467 , A61K38/00 , C07K14/4747 , C07K14/52 , C07K2319/00
摘要： The present invention relates to targeted killing of a cell utilizing a chimeric polypeptide comprising a cell-specific targeting moiety and a signal transduction pathway factor. In a preferred embodiment, the signal transduction pathway factor is an apoptosis-inducing factor, such as granzyme B, granzyme A, or Bax.
摘要翻译： 本发明涉及利用包含细胞特异性靶向部分和信号转导途径因子的嵌合多肽靶向杀死细胞。 在优选的实施方案中，信号转导途径因子是凋亡诱导因子，例如颗粒酶B，粒酶A或Bax。
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公开(公告)号：US08138311B2
公开(公告)日：2012-03-20
申请号：US13094109
申请日：2011-04-26
IPC分类号： C07K14/00
CPC分类号： C07K14/415 , A61K38/00 , A61K2039/505 , C07K16/30 , C07K2317/34 , C07K2317/622 , C07K2319/00
摘要： The present invention concerns methods of reducing the antigenicity of a proteinaceous compound while maintaining the compounds biological activity, as well as proteinaceous compositions with biological activity but reduced antigenicity. These methods and compositions have significant benefits to a subject in need of such compounds and compositions. Also included are modified toxin compounds that are truncated and/or possess reduce antigenicity. Such designer toxins have therapeutic, diagnostic, and preventative benefits, particularly as immunotoxins. Methods of treating cancer using these immunotoxins are provided.
摘要翻译： 本发明涉及降低蛋白质化合物的抗原性同时保持化合物生物活性的方法，以及具有生物活性但降低的抗原性的蛋白质组合物。 这些方法和组合物对于需要这种化合物和组合物的受试者具有显着的益处。 还包括被截短和/或具有降低抗原性的经修饰的毒素化合物。 这样的设计毒素具有治疗，诊断和预防效果，特别是作为免疫毒素。 提供使用这些免疫毒素治疗癌症的方法。
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