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5 条记录 (耗时 0.022 秒)

    Acyl-phenoxy-propanesulfoacids and salts, and artificial sweetening compositions containing the same
    1.
    发明授权
    Acyl-phenoxy-propanesulfoacids and salts, and artificial sweetening compositions containing the same 失效
    酰基 - 苯氧基 - 丙磺酸和盐，以及含有它们的人造甜味组合物

    公开(公告)号：US4092346A

    公开(公告)日：1978-05-30

    申请号：US746350

    申请日：1976-12-01

    申请人： Lorand Farkas ,  Mihaly Nogradi ,  Todor Pfliegel ,  Sandor Antus ,  Agnes Gottsegen

    发明人： Lorand Farkas ,  Mihaly Nogradi ,  Todor Pfliegel ,  Sandor Antus ,  Agnes Gottsegen

    IPC分类号： A23L27/30 ,  C07C309/11 ,  C07C143/24 ,  A23L1/236

    CPC分类号： C07C309/11 ,  A23L27/30

    摘要： Compounds of the formula (1), or their salts, ##STR1## are prepared as follows: (A) A COMPOUND OF THE FORMULA (II) ##STR2## is reduced; or (B) A COMPOUND OF THE FORMULA (III) ##STR3## is reacted, e.g. after protecting the phenolic hydroxy group attached to position 3 of the ring, with a compound of the formula (IV), ##STR4## or (C) GROUP R.sup.1 of a compound of the formula (V) ##STR5## is removed in an acidic medium, AND, IF DESIRED, THE COMPOUND OF THE FORMULA (I) is converted into salt, or a salt of a compound of the formula (I) is converted into the free acid or another salt thereof.The compounds of the formula (I) and their salts are valuable artificial sweetening agents.In the above formulae"alkyl" is a C.sub.1-4 alkyl group,R is hydrogen or a protecting group capable of splitting off upon hydrogenolysis, preferably benzyl or benzyloxycarbonyl,M+ is a proton or another cation,X is a group of the general formula O.sup.- M.sup.+,Y is halogen, orX and Y together represent an oxygen atom, andR.sup.1 is a protecting group capable of splitting off in acidic media, such as 2-tetrahydropyranyl or 1-ethoxyethyl.

    摘要翻译： 式（1）化合物或其盐，如下制备：

    Process for the preparation of substituted acyl ureas
    2.
    发明授权
    Process for the preparation of substituted acyl ureas 失效
    制备取代酰基脲的方法

    公开(公告)号：US4355178A

    公开(公告)日：1982-10-19

    申请号：US198050

    申请日：1980-10-17

    申请人： Laszio Toke ,  Istvan Bitter ,  Eva Karpati nee Adam ,  Todor Pfliegel

    发明人： Laszio Toke ,  Istvan Bitter ,  Eva Karpati nee Adam ,  Todor Pfliegel

    IPC分类号： A01N47/34 ,  C07C273/18 ,  C07C275/54 ,  C07C127/22

    CPC分类号： C07C273/1854 ,  A01N47/34

    摘要： The invention relates to a process for the preparation of acyl ureas of formula (I) ##STR1## wherein R.sub.1 and R.sub.2 are the same of different and each is halogen atom, preferably fluorine or chlorine atom, andR.sub.3 is a substituted aryl group.The compounds of the invention can be prepared by reacting an urea of formula (II):R.sub.3 NHCONH.sub.2 (II)wherein R.sub.3 is as defined above, with an acid chloride of formula (III): ##STR2## wherein R.sub.1 and R.sub.2 are as defined above, in an inert organic solvent at a temperature of from 20.degree. C. to 100.degree. C.

    摘要翻译： 本发明涉及一种制备式（I）的酰基脲的方法，其中R 1和R 2相同，各自为卤素原子，优选氟或氯原子，R 3为取代的芳基 组。 本发明的化合物可以通过使式（II）的脲：R3NHCONH2（II）（其中R3如上定义）与式（III）的酰氯反应制备：其中R1和R2是 如上所述，在惰性有机溶剂中，温度为20℃至100℃。