摘要:
Improved DLL4 binding proteins are described, including antibodies, CDR-grafted antibodies, human antibodies, and DLL4 binding fragments thereof, proteins that bind DLL4 with high affinity, and DLL4 binding proteins that neutralize DLL4 activity. The DLL4 binding proteins are useful for treating or preventing cancers and tumors and especially for treating or preventing tumor angiogenesis, and/or other angiogenesis-dependent diseases such as ocular neovascularization, or angiogenesis-independent diseases characterized by aberrant DLL4 expression or activity such as autoimmune disorders including multiple sclerosis.
摘要:
Improved DLL4 binding proteins are described, including antibodies, CDR-grafted antibodies, human antibodies, and DLL4 binding fragments thereof, proteins that bind DLL4 with high affinity, and DLL4 binding proteins that neutralize DLL4 activity. The DLL4 binding proteins are useful for treating or preventing cancers and tumors and especially for treating or preventing tumor angiogenesis, and/or other angiogenesis-dependent diseases such as ocular neovascularization, or angiogenesis-independent diseases characterized by aberrant DLL4 expression or activity such as autoimmune disorders including multiple sclerosis.
摘要:
The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
摘要:
The present invention relates to a method and apparatus capable of generating frequency-modulation halftone dots in high speed and belongs to the field of the digital image halftone. In the prior art, read-write operation is usually carried out many times in error rows during processing each pixel so that halftone dots are generated in low speed. In the method according to the present invention, the error generated by the current pixel is buffered in a register file and the final accumulated error values are written in the error rows only after all of the relative pixels are processed. Thus, read-write operation is carried out only once in the error rows for processing each pixel. The present invention also provides an apparatus to implement the method. The apparatus comprises an error row memory, an error buffer register file, a gray generation circuit, a threshold comparison circuit, an error generation circuit, an error buffer register file control circuit, and an error row control circuit. The method and apparatus according to the present invention decrease the steps in operation and improve the speed for generating the frequency-modulation halftone dots.
摘要:
In a fluidized bed device 3 with a fluidized bed 2 of a bed material provided in a fluidized bed vessel 1 by a gas, the fluidized bed vessel 1 has a charge nozzle 4 connected to an upstream end of the vessel 1 in a direction of flow of the bed material; a charge port 4a of the charge nozzle 4 has a width equal to a width of the fluidized bed 2. The fluidized bed vessel 1 has a discharge nozzle 5 connected to a downstream end of the vessel 1 in the direction of flow of the bed material; a discharge port 5a of the discharge nozzle 5 has a width equal to the width of the fluidized bed 2.
摘要:
Compounds of the general formula (I) and compounds of the general formula (II) Use of compounds (I) or (II) as visible or invisible markers, for staining materials, in the laser welding of materials, for detecting bases, acids or pH changes, as a dispersing assistant, pigment additive for organic pigments and intermediates for the production of pigment additives, in heat management or energy management, in photovoltaics or in optical data storage.
摘要:
Disclosed are devices and methods for generating dots of an image by using two error row memories, which are capable of reading and writing data synchronously. A device disclosed comprises: a buffer memory A; a buffer memory B; and a memory controller. The memory controller may comprise a read-write control circuit for the buffer memory A, a read-write control circuit for the buffer memory B, and a buffer memory selection circuit. The buffer memory selection circuit is used to generate a read-write selection signal for the buffer memory A and the buffer memory B. The read-write control circuit for the buffer memory A is connected to the buffer memory A and used to implement a read operation or a write operation on the buffer memory A according to the read-write selection signal. The read-write control circuit for the buffer memory B is connected to the buffer memory B and used to implement a read operation or a write operation on the buffer memory B according to the read-write selection signal. The devices and methods are capable of implementing read and write operations on memories synchronously, which can improve the speed of error diffusion during use.
摘要:
Method and system are disclosed for modeling dynamic behavior of a transistor. The method includes representing static behavior of a transistor using a lookup table, selecting an instance of the transistor from the lookup table for modeling dynamic behavior of the transistor, computing a previous state of the instance using a non-quasi static analytical model, computing a variation in channel charge of the instance according to a rate of change in time, computing a current state of the instance using the previous state and the variation in channel charge, computing a modified terminal voltage that includes a dynamic voltage across a parasitic resistance at the terminal of the transistor according to the current state and previous state of the instance, and storing the modified terminal voltage in a memory device for modeling dynamic behavior of the transistor at the current state.
摘要:
The present invention belongs to the field of printing control technology, and is especially one kind of printing control method with reducing printing memory requirement. The available printing technology always needs complicated segment forming gratings in advance and occupying great amount of memory. The printing control method of the present invention includes interpreting the page data as banded intermediate format data, calculating the time for forming grating of each band of the intermediate format data, pre-analyzing the bands with time for forming grating greater than the printing time, and arranging the job of forming grating of the complicated bands in the idle print time as far as possible. The said method can reduce the band number of forming gratings in advance and reduce the printing memory requirement.
摘要:
Method and system are disclosed for repetitive circuit simulation. In one embodiment, a computer implemented method for performing multiple simulations of a circuit includes providing descriptions of connectivity, instants, signal activities, and statistical parameters of the circuit, parsing the circuit in accordance with the descriptions of connectivity, instants, signal activities, and statistical parameters of the circuit to form one or more circuit partitions, performing a first pass simulation of the one or more circuit partitions in accordance with a set of stimuli to generate a history of the first pass simulation, and performing subsequent simulation of the one or more circuit partitions using the history of the first pass simulation.