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公开(公告)号:US08623358B2
公开(公告)日:2014-01-07
申请号:US12870276
申请日:2010-08-27
申请人: Lorenzo Benatuil , Erwin R. Boghaert , Jijie Gu , Maria Harris , Jonathan A. Hickson , Chung-Ming Hsieh , Yuliya Kutskova , Yingchun Li , Zhihong Liu , Susan Morgan-Lappe
发明人: Lorenzo Benatuil , Erwin R. Boghaert , Jijie Gu , Maria Harris , Jonathan A. Hickson , Chung-Ming Hsieh , Yuliya Kutskova , Yingchun Li , Zhihong Liu , Susan Morgan-Lappe
IPC分类号: A61K39/395
CPC分类号: C07K16/22 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K7/06 , C07K7/08 , C07K14/47 , C07K16/18 , C07K2317/21 , C07K2317/33 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要: Improved DLL4 binding proteins are described, including antibodies, CDR-grafted antibodies, human antibodies, and DLL4 binding fragments thereof, proteins that bind DLL4 with high affinity, and DLL4 binding proteins that neutralize DLL4 activity. The DLL4 binding proteins are useful for treating or preventing cancers and tumors and especially for treating or preventing tumor angiogenesis, and/or other angiogenesis-dependent diseases such as ocular neovascularization, or angiogenesis-independent diseases characterized by aberrant DLL4 expression or activity such as autoimmune disorders including multiple sclerosis.
摘要翻译: 描述了改进的DLL4结合蛋白,包括抗体,CDR-移植抗体,人抗体和DLL4结合片段,以高亲和力结合DLL4的蛋白质,以及中和DLL4活性的DLL4结合蛋白。 DLL4结合蛋白可用于治疗或预防癌症和肿瘤,特别是用于治疗或预防肿瘤血管生成和/或其它血管发生依赖性疾病,例如眼新生血管形成或以异常DLL4表达或活性为特征的血管发生非依赖性疾病,例如自身免疫 包括多发性硬化的疾病。
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公开(公告)号:US20110117079A1
公开(公告)日:2011-05-19
申请号:US12870276
申请日:2010-08-27
申请人: Lorenzo Benatuil , Erwin R. Boghaert , Jijie Gu , Maria Harris , Jonathan A. Hickson , Chung-Ming Hsieh , Yuliya Kutskova , Yingchun Li , Zhihong Liu , Susan Morgan-Lappe
发明人: Lorenzo Benatuil , Erwin R. Boghaert , Jijie Gu , Maria Harris , Jonathan A. Hickson , Chung-Ming Hsieh , Yuliya Kutskova , Yingchun Li , Zhihong Liu , Susan Morgan-Lappe
IPC分类号: A61K39/395 , C07K16/18 , C12N9/96 , C07H21/04 , C12N15/63 , C12N1/21 , C12N5/10 , C12N1/19 , C12P21/00 , A61P35/00 , A61P13/08 , A61P9/10 , A61P17/02 , A61P35/04
CPC分类号: C07K16/22 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K7/06 , C07K7/08 , C07K14/47 , C07K16/18 , C07K2317/21 , C07K2317/33 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要: Improved DLL4 binding proteins are described, including antibodies, CDR-grafted antibodies, human antibodies, and DLL4 binding fragments thereof, proteins that bind DLL4 with high affinity, and DLL4 binding proteins that neutralize DLL4 activity. The DLL4 binding proteins are useful for treating or preventing cancers and tumors and especially for treating or preventing tumor angiogenesis, and/or other angiogenesis-dependent diseases such as ocular neovascularization, or angiogenesis-independent diseases characterized by aberrant DLL4 expression or activity such as autoimmune disorders including multiple sclerosis.
摘要翻译: 描述了改进的DLL4结合蛋白,包括抗体,CDR-移植抗体,人抗体和DLL4结合片段,以高亲和力结合DLL4的蛋白质,以及中和DLL4活性的DLL4结合蛋白。 DLL4结合蛋白可用于治疗或预防癌症和肿瘤,特别是用于治疗或预防肿瘤血管生成和/或其它血管发生依赖性疾病,例如眼新生血管形成或以异常DLL4表达或活性为特征的血管发生非依赖性疾病,例如自身免疫 包括多发性硬化的疾病。
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公开(公告)号:US08999331B2
公开(公告)日:2015-04-07
申请号:US13659647
申请日:2012-10-24
申请人: Chung-Ming Hsieh , Alexander Ivanov , Wendy Waegell , Yuliya Kutskova , John Memmott , Lorenzo Benatuil , Jacqueline Bixby , Emma Fung , Sahana Bose , Alyssa Brito
发明人: Chung-Ming Hsieh , Alexander Ivanov , Wendy Waegell , Yuliya Kutskova , John Memmott , Lorenzo Benatuil , Jacqueline Bixby , Emma Fung , Sahana Bose , Alyssa Brito
IPC分类号: A61K39/00 , A61K39/395 , C07K16/00 , C07K16/18 , C07K16/22 , C07K16/24 , A61K31/353 , A61K31/439 , A61K31/44 , A61K31/4439 , A61K31/519 , A61K31/56 , A61K38/13 , A61K38/17 , A61K38/18 , A61K38/19 , A61K38/20 , A61K38/21
CPC分类号: C07K16/468 , A61K31/353 , A61K31/439 , A61K31/44 , A61K31/4439 , A61K31/519 , A61K31/56 , A61K38/13 , A61K38/1793 , A61K38/18 , A61K38/1808 , A61K38/1816 , A61K38/19 , A61K38/191 , A61K38/2026 , A61K38/2066 , A61K38/2073 , A61K38/217 , A61K39/3955 , A61K2039/505 , C07K16/18 , C07K16/22 , C07K16/241 , C07K2317/21 , C07K2317/31 , C07K2317/565 , C07K2317/60 , C07K2317/64 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94
摘要: Proteins that bind sclerostin or sclerostin and TNF are described along with there use in composition and methods for treating, preventing, and diagnosing sclerostin related diseases and for detecting sclerostin or sclerostin and TNF in cells, tissues, samples, and compositions.
摘要翻译: 与用于治疗,预防和诊断硬化性相关疾病的组合物和方法一起描述了结合硬化蛋白或硬化性骨肉瘤和TNF的蛋白质,并用于检测细胞,组织,样品和组合物中的硬化蛋白或硬化性骨肉瘤和TNF。
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公开(公告)号:US20130164256A1
公开(公告)日:2013-06-27
申请号:US13659658
申请日:2012-10-24
申请人: Chung-Ming Hsieh , Tariq Ghayur , Lorenzo Benatuil , Yuliya Kutskova , John Memmott , Jennifer Perez , Suju Zhong , Carrie Goodreau , Anca Clabbers
发明人: Chung-Ming Hsieh , Tariq Ghayur , Lorenzo Benatuil , Yuliya Kutskova , John Memmott , Jennifer Perez , Suju Zhong , Carrie Goodreau , Anca Clabbers
CPC分类号: C07K16/241 , A61K39/3955 , A61K45/06 , A61K47/6847 , C07K16/464 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/64 , C07K2317/76 , C07K2317/92 , G01N33/6863
摘要: Isolated binding proteins, e.g., antibodies or antigen binding portions thereof, which bind to tumor necrosis factor-alpha (TNF-α), e.g., human TNF-α, and related antibody-based compositions and molecules are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, as well as therapeutic and diagnostic methods for using the antibodies.
摘要翻译: 公开了结合肿瘤坏死因子-α(TNF-α),例如人TNF-α和相关的基于抗体的组合物和分子的分离的结合蛋白,例如抗体或其抗原结合部分。 还公开了包含抗体的药物组合物,以及使用抗体的治疗和诊断方法。
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公开(公告)号:US20140348834A1
公开(公告)日:2014-11-27
申请号:US14260197
申请日:2014-04-23
申请人: Chung-Ming Hsieh , Margaret Hugunin , Anwar Murtaza , Bradford L. McRae , Yuliya Kutskova , John E. Memmott , Jennifer M. Perez , Suju Zhong , Edit Tarcsa , Anca Clabbers , Craig Wallace , Shaughn H. Bryant , Mary R. Leddy
发明人: Chung-Ming Hsieh , Margaret Hugunin , Anwar Murtaza , Bradford L. McRae , Yuliya Kutskova , John E. Memmott , Jennifer M. Perez , Suju Zhong , Edit Tarcsa , Anca Clabbers , Craig Wallace , Shaughn H. Bryant , Mary R. Leddy
IPC分类号: C07K16/24 , C07K16/46 , A61K39/395
CPC分类号: C07K16/468 , A61K39/3955 , A61K2039/505 , A61K2039/507 , A61K2300/00 , C07K16/241 , C07K16/244 , C07K2317/21 , C07K2317/31 , C07K2317/50 , C07K2317/565 , C07K2317/64 , C07K2317/76 , C07K2317/92 , Y02A50/386 , Y02A50/41 , Y02A50/412 , Y02A50/466
摘要: Proteins that bind IL-17 and/or IL-17F are described along with their use in composition and methods for treating, preventing, and diagnosing IL-17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions.
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公开(公告)号:US20140017246A1
公开(公告)日:2014-01-16
申请号:US13959648
申请日:2013-08-05
申请人: Chung-Ming Hsieh , Margaret Hugunin , Anwar Murtaza , Bradford L. McRae , Yuliya Kutskova , John E. Memmott , Jennifer M. Perez , Suju Zhong , Edit Tarcsa , Anca Clabbers , Craig Wallace , Shaughn H. Bryant , Mary R. Leddy
发明人: Chung-Ming Hsieh , Margaret Hugunin , Anwar Murtaza , Bradford L. McRae , Yuliya Kutskova , John E. Memmott , Jennifer M. Perez , Suju Zhong , Edit Tarcsa , Anca Clabbers , Craig Wallace , Shaughn H. Bryant , Mary R. Leddy
IPC分类号: C07K16/24
CPC分类号: C07K16/468 , A61K39/3955 , A61K2039/505 , A61K2039/507 , A61K2300/00 , C07K16/241 , C07K16/244 , C07K2317/21 , C07K2317/31 , C07K2317/50 , C07K2317/565 , C07K2317/64 , C07K2317/76 , C07K2317/92 , Y02A50/386 , Y02A50/41 , Y02A50/412 , Y02A50/466
摘要: Proteins that bind IL-17 and/or IL-17F are described along with there use in composition and methods for treating, preventing, and diagnosing IL-17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions.
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公开(公告)号:US20140343267A1
公开(公告)日:2014-11-20
申请号:US14261257
申请日:2014-04-24
申请人: Chung-Ming Hsieh , Margaret Hugunin , Anwar Murtaza , Bradford L. McRae , Yuliya Kutskova , John E. Memmott , Jennifer M. Perez , Suju Zhong , Edit Tarcsa , Anca Clabbers , Craig Wallace , Shaughn H. Bryant , Mary R. Leddy
发明人: Chung-Ming Hsieh , Margaret Hugunin , Anwar Murtaza , Bradford L. McRae , Yuliya Kutskova , John E. Memmott , Jennifer M. Perez , Suju Zhong , Edit Tarcsa , Anca Clabbers , Craig Wallace , Shaughn H. Bryant , Mary R. Leddy
CPC分类号: C07K16/468 , A61K39/3955 , A61K2039/505 , A61K2039/507 , A61K2300/00 , C07K16/241 , C07K16/244 , C07K2317/21 , C07K2317/31 , C07K2317/50 , C07K2317/565 , C07K2317/64 , C07K2317/76 , C07K2317/92 , Y02A50/386 , Y02A50/41 , Y02A50/412 , Y02A50/466
摘要: Proteins that bind IL-17 and/or IL-17F are described along with there use in composition and methods for treating, preventing, and diagnosing IL-17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions.
摘要翻译: 与用于治疗,预防和诊断IL-17相关疾病和用于检测细胞,组织,样品和组合物中的IL-17的组合物和方法一起描述了结合IL-17和/或IL-17F的蛋白质。
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公开(公告)号:US20090291081A1
公开(公告)日:2009-11-26
申请号:US12006068
申请日:2007-12-28
申请人: Chung-Ming Hsieh , Bradford L. McRae , Yuliya Kutskova , John E. Memmott , Michael Roguska , Ian Tomlinson , Carrie Enever , Steven Grant , Mihriban Tuna
发明人: Chung-Ming Hsieh , Bradford L. McRae , Yuliya Kutskova , John E. Memmott , Michael Roguska , Ian Tomlinson , Carrie Enever , Steven Grant , Mihriban Tuna
CPC分类号: C07K16/468 , A61K39/3955 , A61K45/06 , C07K16/245 , C07K2317/569 , C07K2317/92
摘要: The invention provides an isolated, dual-specific antibody, or an antigen-binding portion thereof, which is specific for human IL-1α and human IL-1β. The dual specific antibodies of the invention also neutralize both human IL-1α and human IL-1β. The invention also provides domain antibodies (dAbs) specific for human IL-1α and human IL-1β.
摘要翻译: 本发明提供了对人IL-1α和人IL-1β特异的分离的双重特异性抗体或其抗原结合部分。 本发明的双重特异性抗体也中和人IL-1α和人IL-1beta。 本发明还提供了对人IL-1α和人IL-1β特异性的结构域抗体(dAb)。
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公开(公告)号:US20140335564A1
公开(公告)日:2014-11-13
申请号:US14258994
申请日:2014-04-22
申请人: Chung-Ming Hsieh , Margaret Hugunin , Anwar Murtaza , Bradford L. McRae , Yuliya Kutskova , John E. Memmott , Jennifer M. Perez , Suju Zhong , Edit Tarcsa , Anca Clabbers , Craig Wallace , Shaughn H. Bryant , Mary R. Leddy
发明人: Chung-Ming Hsieh , Margaret Hugunin , Anwar Murtaza , Bradford L. McRae , Yuliya Kutskova , John E. Memmott , Jennifer M. Perez , Suju Zhong , Edit Tarcsa , Anca Clabbers , Craig Wallace , Shaughn H. Bryant , Mary R. Leddy
IPC分类号: C07K16/24
CPC分类号: C07K16/468 , A61K39/3955 , A61K2039/505 , A61K2039/507 , A61K2300/00 , C07K16/241 , C07K16/244 , C07K2317/21 , C07K2317/31 , C07K2317/50 , C07K2317/565 , C07K2317/64 , C07K2317/76 , C07K2317/92 , Y02A50/386 , Y02A50/41 , Y02A50/412 , Y02A50/466
摘要: Proteins that bind IL-17 and/or IL-17F are described along with there use in composition and methods for treating, preventing, and diagnosing IL-17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions.
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公开(公告)号:US20140356909A1
公开(公告)日:2014-12-04
申请号:US14263724
申请日:2014-04-28
申请人: Chung-Ming Hsieh , Margaret Hugunin , Anwar Murtaza , Bradford L. McRae , Yuliya Kutskova , John E. Memmott , Jennifer M. Perez , Suju Zhong , Edit Tarcsa , Anca Clabbers , Craig Wallace , Shaughn H. Bryant , Mary R. Leddy
发明人: Chung-Ming Hsieh , Margaret Hugunin , Anwar Murtaza , Bradford L. McRae , Yuliya Kutskova , John E. Memmott , Jennifer M. Perez , Suju Zhong , Edit Tarcsa , Anca Clabbers , Craig Wallace , Shaughn H. Bryant , Mary R. Leddy
CPC分类号: C07K16/468 , A61K39/3955 , A61K2039/505 , A61K2039/507 , A61K2300/00 , C07K16/241 , C07K16/244 , C07K2317/21 , C07K2317/31 , C07K2317/50 , C07K2317/565 , C07K2317/64 , C07K2317/76 , C07K2317/92 , Y02A50/386 , Y02A50/41 , Y02A50/412 , Y02A50/466
摘要: Proteins that bind IL-17 and/or IL-17F are described along with their use in composition and methods for treating, preventing, and diagnosing IL-17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions.
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