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公开(公告)号：US08623358B2
公开(公告)日：2014-01-07
申请号：US12870276
申请日：2010-08-27
申请人： Lorenzo Benatuil , Erwin R. Boghaert , Jijie Gu , Maria Harris , Jonathan A. Hickson , Chung-Ming Hsieh , Yuliya Kutskova , Yingchun Li , Zhihong Liu , Susan Morgan-Lappe
发明人： Lorenzo Benatuil , Erwin R. Boghaert , Jijie Gu , Maria Harris , Jonathan A. Hickson , Chung-Ming Hsieh , Yuliya Kutskova , Yingchun Li , Zhihong Liu , Susan Morgan-Lappe
IPC分类号： A61K39/395
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K7/06 , C07K7/08 , C07K14/47 , C07K16/18 , C07K2317/21 , C07K2317/33 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： Improved DLL4 binding proteins are described, including antibodies, CDR-grafted antibodies, human antibodies, and DLL4 binding fragments thereof, proteins that bind DLL4 with high affinity, and DLL4 binding proteins that neutralize DLL4 activity. The DLL4 binding proteins are useful for treating or preventing cancers and tumors and especially for treating or preventing tumor angiogenesis, and/or other angiogenesis-dependent diseases such as ocular neovascularization, or angiogenesis-independent diseases characterized by aberrant DLL4 expression or activity such as autoimmune disorders including multiple sclerosis.
摘要翻译： 描述了改进的DLL4结合蛋白，包括抗体，CDR-移植抗体，人抗体和DLL4结合片段，以高亲和力结合DLL4的蛋白质，以及中和DLL4活性的DLL4结合蛋白。 DLL4结合蛋白可用于治疗或预防癌症和肿瘤，特别是用于治疗或预防肿瘤血管生成和/或其它血管发生依赖性疾病，例如眼新生血管形成或以异常DLL4表达或活性为特征的血管发生非依赖性疾病，例如自身免疫 包括多发性硬化的疾病。
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公开(公告)号：US20110117079A1
公开(公告)日：2011-05-19
申请号：US12870276
申请日：2010-08-27
申请人： Lorenzo Benatuil , Erwin R. Boghaert , Jijie Gu , Maria Harris , Jonathan A. Hickson , Chung-Ming Hsieh , Yuliya Kutskova , Yingchun Li , Zhihong Liu , Susan Morgan-Lappe
发明人： Lorenzo Benatuil , Erwin R. Boghaert , Jijie Gu , Maria Harris , Jonathan A. Hickson , Chung-Ming Hsieh , Yuliya Kutskova , Yingchun Li , Zhihong Liu , Susan Morgan-Lappe
IPC分类号： A61K39/395 , C07K16/18 , C12N9/96 , C07H21/04 , C12N15/63 , C12N1/21 , C12N5/10 , C12N1/19 , C12P21/00 , A61P35/00 , A61P13/08 , A61P9/10 , A61P17/02 , A61P35/04
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K7/06 , C07K7/08 , C07K14/47 , C07K16/18 , C07K2317/21 , C07K2317/33 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： Improved DLL4 binding proteins are described, including antibodies, CDR-grafted antibodies, human antibodies, and DLL4 binding fragments thereof, proteins that bind DLL4 with high affinity, and DLL4 binding proteins that neutralize DLL4 activity. The DLL4 binding proteins are useful for treating or preventing cancers and tumors and especially for treating or preventing tumor angiogenesis, and/or other angiogenesis-dependent diseases such as ocular neovascularization, or angiogenesis-independent diseases characterized by aberrant DLL4 expression or activity such as autoimmune disorders including multiple sclerosis.
摘要翻译： 描述了改进的DLL4结合蛋白，包括抗体，CDR-移植抗体，人抗体和DLL4结合片段，以高亲和力结合DLL4的蛋白质，以及中和DLL4活性的DLL4结合蛋白。 DLL4结合蛋白可用于治疗或预防癌症和肿瘤，特别是用于治疗或预防肿瘤血管生成和/或其它血管发生依赖性疾病，例如眼新生血管形成或以异常DLL4表达或活性为特征的血管发生非依赖性疾病，例如自身免疫 包括多发性硬化的疾病。
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公开(公告)号：US08999331B2
公开(公告)日：2015-04-07
申请号：US13659647
申请日：2012-10-24
申请人： Chung-Ming Hsieh , Alexander Ivanov , Wendy Waegell , Yuliya Kutskova , John Memmott , Lorenzo Benatuil , Jacqueline Bixby , Emma Fung , Sahana Bose , Alyssa Brito
发明人： Chung-Ming Hsieh , Alexander Ivanov , Wendy Waegell , Yuliya Kutskova , John Memmott , Lorenzo Benatuil , Jacqueline Bixby , Emma Fung , Sahana Bose , Alyssa Brito
IPC分类号： A61K39/00 , A61K39/395 , C07K16/00 , C07K16/18 , C07K16/22 , C07K16/24 , A61K31/353 , A61K31/439 , A61K31/44 , A61K31/4439 , A61K31/519 , A61K31/56 , A61K38/13 , A61K38/17 , A61K38/18 , A61K38/19 , A61K38/20 , A61K38/21
CPC分类号： C07K16/468 , A61K31/353 , A61K31/439 , A61K31/44 , A61K31/4439 , A61K31/519 , A61K31/56 , A61K38/13 , A61K38/1793 , A61K38/18 , A61K38/1808 , A61K38/1816 , A61K38/19 , A61K38/191 , A61K38/2026 , A61K38/2066 , A61K38/2073 , A61K38/217 , A61K39/3955 , A61K2039/505 , C07K16/18 , C07K16/22 , C07K16/241 , C07K2317/21 , C07K2317/31 , C07K2317/565 , C07K2317/60 , C07K2317/64 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94
摘要： Proteins that bind sclerostin or sclerostin and TNF are described along with there use in composition and methods for treating, preventing, and diagnosing sclerostin related diseases and for detecting sclerostin or sclerostin and TNF in cells, tissues, samples, and compositions.
摘要翻译： 与用于治疗，预防和诊断硬化性相关疾病的组合物和方法一起描述了结合硬化蛋白或硬化性骨肉瘤和TNF的蛋白质，并用于检测细胞，组织，样品和组合物中的硬化蛋白或硬化性骨肉瘤和TNF。
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公开(公告)号：US20130164256A1
公开(公告)日：2013-06-27
申请号：US13659658
申请日：2012-10-24
申请人： Chung-Ming Hsieh , Tariq Ghayur , Lorenzo Benatuil , Yuliya Kutskova , John Memmott , Jennifer Perez , Suju Zhong , Carrie Goodreau , Anca Clabbers
发明人： Chung-Ming Hsieh , Tariq Ghayur , Lorenzo Benatuil , Yuliya Kutskova , John Memmott , Jennifer Perez , Suju Zhong , Carrie Goodreau , Anca Clabbers
CPC分类号： C07K16/241 , A61K39/3955 , A61K45/06 , A61K47/6847 , C07K16/464 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/64 , C07K2317/76 , C07K2317/92 , G01N33/6863
摘要： Isolated binding proteins, e.g., antibodies or antigen binding portions thereof, which bind to tumor necrosis factor-alpha (TNF-α), e.g., human TNF-α, and related antibody-based compositions and molecules are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, as well as therapeutic and diagnostic methods for using the antibodies.
摘要翻译： 公开了结合肿瘤坏死因子-α（TNF-α），例如人TNF-α和相关的基于抗体的组合物和分子的分离的结合蛋白，例如抗体或其抗原结合部分。 还公开了包含抗体的药物组合物，以及使用抗体的治疗和诊断方法。
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公开(公告)号：US09200270B2
公开(公告)日：2015-12-01
申请号：US12380703
申请日：2009-03-03
摘要： This invention is directed to the transformation of yeast, and mutants thereof, by electroporation, which result in stably transformed yeast host cells that express recombinant products. This invention also is directed to transformed yeast cells and libraries.
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公开(公告)号：US20090264320A1
公开(公告)日：2009-10-22
申请号：US12380703
申请日：2009-03-03
摘要： This invention is directed to the transformation of yeast, and mutants thereof, by electroporation, which result in stably transformed yeast host cells that express recombinant products. This invention also is directed to transformed yeast cells and libraries.
摘要翻译： 本发明涉及通过电穿孔转化酵母及其突变体，其导致表达重组产物的稳定转化的酵母宿主细胞。 本发明还涉及转化的酵母细胞和文库。
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公开(公告)号：US20110256138A1
公开(公告)日：2011-10-20
申请号：US13085891
申请日：2011-04-13
申请人： Stefan Barghorn , Heinz Hillen , Andreas Striebinger , Simone Giaisi , Ulrich Ebert , Lorenzo Benatuil
发明人： Stefan Barghorn , Heinz Hillen , Andreas Striebinger , Simone Giaisi , Ulrich Ebert , Lorenzo Benatuil
IPC分类号： A61K39/395 , C07H21/00 , C12N15/63 , C12N5/10 , A61P25/28 , C12P21/02 , C12P21/08 , G01N33/566 , A61P25/16 , A61P25/00 , C07K16/18 , C12N1/00
CPC分类号： C07K16/18 , A61K39/3955 , A61K47/6835 , A61K49/00 , C07K14/4711 , C07K2317/21 , C07K2317/24 , C07K2317/30 , C07K2317/31 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/569 , C07K2317/622 , C07K2317/624 , C07K2317/626 , C07K2317/92
摘要： The present invention relates to amyloid-beta (Aβ) binding proteins. Antibodies of the invention have high affinity to Aβ(20-42) globulomer or any Aβ form that comprises the globulomer epitope. Method of making and method of using the antibodies of the invention are also provided.
摘要翻译： 本发明涉及淀粉样蛋白-β（A＆bgr）结合蛋白。 本发明的抗体对A和Bgr（20-42）球聚体或任何A＆bgr具有高亲和力; 形式，其包含球聚体表位。 还提供了制备方法和使用本发明抗体的方法。
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公开(公告)号：US08987419B2
公开(公告)日：2015-03-24
申请号：US13085891
申请日：2011-04-13
申请人： Stefan Barghorn , Heinz Hillen , Andreas Striebinger , Simone Giaisi , Ulrich Ebert , Lorenzo Benatuil
发明人： Stefan Barghorn , Heinz Hillen , Andreas Striebinger , Simone Giaisi , Ulrich Ebert , Lorenzo Benatuil
CPC分类号： C07K16/18 , A61K39/3955 , A61K47/6835 , A61K49/00 , C07K14/4711 , C07K2317/21 , C07K2317/24 , C07K2317/30 , C07K2317/31 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/569 , C07K2317/622 , C07K2317/624 , C07K2317/626 , C07K2317/92
摘要： The present invention relates to amyloid-beta (Aβ) binding proteins. Antibodies of the invention have high affinity to Aβ(20-42) globulomer or any Aβ form that comprises the globulomer epitope. Method of making and method of using the antibodies of the invention are also provided.
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公开(公告)号：US20110250130A1
公开(公告)日：2011-10-13
申请号：US13081212
申请日：2011-04-06
IPC分类号： A61K51/10 , A61K39/395 , C07H21/04 , A61K38/20 , A61P43/00 , A61P37/04 , A61P35/00 , A61P29/00 , A61P23/00 , A61P25/24 , A61P25/18 , A61P1/00 , A61P37/08 , A61P33/00 , A61P31/00 , A61P25/04 , C12N15/63 , C12N1/00 , C12N5/10 , C12N1/15 , C12N1/19 , C12N1/11 , C12P21/02 , G01N33/566 , C07K16/18
CPC分类号： C07K16/241 , A61K47/6845 , A61K51/1021 , A61K2039/505 , C07K2317/14 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , G01N33/6863 , G01N2333/7151 , Y02A50/386 , Y02A50/41 , Y02A50/412 , Y02A50/58
摘要： Isolated binding proteins, e.g., antibodies or antigen binding portions thereof, which bind to tumor necrosis factor-alpha (TNF-α), e.g., human TNF-α, and related antibody-based compositions and molecules are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, as well as therapeutic and diagnostic methods for using the antibodies.
摘要翻译： 公开了与肿瘤坏死因子-α（TNF-α）结合的分离的结合蛋白，例如结合肿瘤坏死因子-α（TNF-α）的抗体或其抗原结合部分以及相关的基于抗体的组合物和分子。 还公开了包含抗体的药物组合物，以及使用抗体的治疗和诊断方法。
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公开(公告)号：US20110318349A1
公开(公告)日：2011-12-29
申请号：US13167323
申请日：2011-06-23
IPC分类号： A61K39/395 , C12N9/96 , C07H21/00 , C12N15/63 , C12P21/00 , A61P35/00 , C12N5/10 , C12N1/21 , C12N1/15 , C12N1/00 , A61P29/00 , C07K16/24 , G01N33/566
CPC分类号： C07K16/2875 , C07K16/241 , C07K16/468 , C07K2317/31 , C07K2317/64
摘要： The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
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