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1.发明申请Association between a heterocyclic compound stimulating lipid and carbohydrate metabolisms and an antioxidant agent for treating obesity 审中-公开刺激脂质和碳水化合物代谢的杂环化合物与用于治疗肥胖症的抗氧化剂之间的关联公开(公告)号：US20060111407A1
公开(公告)日：2006-05-25
申请号：US10530945
申请日：2003-10-10
IPC分类号： A61K31/428 , A61K31/423 , A61K31/404
CPC分类号： A61K45/06 , A61K31/122 , A61K31/355 , A61K31/423 , A61K31/429 , A61K2300/00
摘要： The invention relates to a combination comprising a compound favouring lipid and carbohydrate metabolisms and an antioxidant agent and to pharmaceutical compositioins comprising the combination.
摘要翻译： 本发明涉及包含有利于脂质和碳水化合物代谢物的化合物和抗氧化剂以及包含该组合的药物组合物的组合。
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公开(公告)号：US20070167502A1
公开(公告)日：2007-07-19
申请号：US10593681
申请日：2005-03-30
IPC分类号： A61K31/427 , A61K31/423 , A61K31/404 , A61K31/355 , A61K31/12
CPC分类号： A61K31/428 , A61K9/2018 , A61K9/2059 , A61K31/15
摘要： A pharmaceutical composition for treatment of obesity associated with lipid and carbohydrate metabolism comprising (i) a substance which is useful in promoting lipid and carbohydrate metabolism, (ii) an antioxidant agent and, optionally, (iii) a pharmaceutically acceptable carrier or excipient, wherein the substance which promotes lipid and carbohydrate metabolism and the antioxidant agent are present in therapeutically effective dosages. Methods which are useful in treating conditions associated with obesity.
摘要翻译： 一种用于治疗与脂质和碳水化合物代谢相关的肥胖的药物组合物，其包含（i）可用于促进脂质和碳水化合物代谢的物质，（ii）抗氧化剂和任选地（iii）药学上可接受的载体或赋形剂，其中 促进脂质和碳水化合物代谢的物质和抗氧化剂以治疗有效剂量存在。 可用于治疗与肥胖相关的病症的方法。
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公开(公告)号：US20050026973A1
公开(公告)日：2005-02-03
申请号：US10902345
申请日：2004-07-29
申请人： Veronique Leclerc , Sylvie Pailloux , Pascal Carato , Carine Introvigne , Nicolas Lebegue , Pascal Berthelot , Catherine Dacquet , Jean Boutin , Daniel Caignard , Pierre Renard
发明人： Veronique Leclerc , Sylvie Pailloux , Pascal Carato , Carine Introvigne , Nicolas Lebegue , Pascal Berthelot , Catherine Dacquet , Jean Boutin , Daniel Caignard , Pierre Renard
IPC分类号： C07D235/26 , A61K31/426 , A61K31/427 , A61P1/04 , A61P1/18 , A61P3/06 , A61P3/10 , A61P9/00 , A61P9/10 , A61P13/04 , A61P13/12 , A61P15/00 , A61P17/06 , A61P19/10 , A61P21/04 , A61P25/28 , A61P27/02 , A61P35/00 , C07D235/12 , C07D277/68 , C07D417/10 , C07D417/12 , C07D277/60 , A61K31/405 , A61K31/423 , A61K31/428 , C07D263/60
CPC分类号： C07D277/68 , C07D417/10
摘要： Compounds of formula (I): wherein: X represents oxygen or sulphur or a group CH2 or R1, R2, R3, R4, R5 and R6 are as defined in the description, A represents an alkylene chain as defined in the description, B represents alkyl or alkenyl substituted by a group or R9, or B represents a group or R9, D represents a benzene, pyridine, pyrazine, pyrimidine or pyridazine nucleus. Medicaments
摘要翻译： 式（I）化合物：其中：X表示氧或硫或基团CH 2或R 1，R 2，R 3，R 4，R 5和R 6如 在描述中定义，A代表如说明书中所定义的亚烷基链，B表示被基团或R 9取代的烷基或烯基，或B表示基团或R 9，D表示苯，吡啶，吡嗪 ，嘧啶或哒嗪核。 药剂
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4.发明申请Heterocyclic Oxime Compounds, A Process For Their Preparation And Pharmaceutical Compositions Containing Them. 审中-公开杂环肟化合物，其制备方法和含有它们的药物组合物。公开(公告)号：US20080113974A1
公开(公告)日：2008-05-15
申请号：US11883121
申请日：2006-01-26
申请人： Aurelie Hurtevent , Jean-Martial L' Helgoual' Ch , Pascal Carato , Nicolas Lebegue , Veronique Leclerc , Pascal Berthelot , Catherine Dacquet , Alain Ktorza , Daniel-Henri Caignard
发明人： Aurelie Hurtevent , Jean-Martial L' Helgoual' Ch , Pascal Carato , Nicolas Lebegue , Veronique Leclerc , Pascal Berthelot , Catherine Dacquet , Alain Ktorza , Daniel-Henri Caignard
IPC分类号： C07D279/16 , C07D265/36 , A61K31/5415 , A61K31/538
CPC分类号： C07D279/16 , C07D265/36
摘要： Compounds of formula (I): wherein: X represents an oxygen atom or a sulphur atom, R1, R2, R3 and R4 are as defined in the description, A represents an alkylene chain as defined in the description, and B represents an alkyl or alkenyl group substituted by a group or R7, or B represents a group or R7.
摘要翻译： 式（I）的化合物：其中：X表示氧原子或硫原子，R 1，R 2，R 3和R 3 如本说明书中所定义，A表示如说明书中所定义的亚烷基链，B表示被基团或R 7取代的烷基或链烯基，或 B表示基团或R 7。
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5.发明申请Heterocyclic Cycloalkyl Compounds, a Process for their Preparation and Pharmaceutical Compositions Containing Them 审中-公开杂环环烷基化合物，其制备方法和含有它们的药物组合物公开(公告)号：US20090239917A1
公开(公告)日：2009-09-24
申请号：US12224861
申请日：2007-03-05
申请人： Aurelie Hurtevent , Jean-Martial L'Helgoual'ch , Pascal Carato , Nicolas Lebegue , Veronique Leclerc , Morgan Le Naour , Pascal Berthelot , Catherine Dacquet , Alain Ktorza , Daniel-Henri Caignard
发明人： Aurelie Hurtevent , Jean-Martial L'Helgoual'ch , Pascal Carato , Nicolas Lebegue , Veronique Leclerc , Morgan Le Naour , Pascal Berthelot , Catherine Dacquet , Alain Ktorza , Daniel-Henri Caignard
IPC分类号： A61K31/428 , C07D277/68 , A61P3/04 , A61P3/10 , A61P9/10 , A61P25/28 , A61P19/10 , A61P35/00
CPC分类号： C07D277/68
摘要： Compounds of formula (I): wherein: R1 represents a (C3-C8)cycloalkyl group, R2 represents a group of formula (II) as defined in the description, X represents an oxygen atom or an N—OR′ group wherein R′ represents a hydrogen atom, a linear or branched (C1-C6)alkyl group, an aryl group or an aryl-(C1-C6)alkyl group in which the alkyl moiety may be linear or branched. Medicinal products containing the same which are useful as hypoglycaemic and hypolipaemic agents.
摘要翻译： 式（I）化合物：其中：R 1表示（C 3 -C 8）环烷基，R 2表示如说明书中定义的式（II）基团，X表示氧原子或N-OR'基团，其中R' 表示氢原子，其中烷基部分可以是直链或支链的直链或支链（C1-C6）烷基，芳基或芳基 - （C1-C6）烷基。 含有相同的药物，可用作低血糖和低血脂药。
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6.发明授权Heterocyclic derivatives, preparation method and pharmaceutical compositions containing same 失效杂环衍生物，制备方法和含有它们的药物组合物公开(公告)号：US06919362B2
公开(公告)日：2005-07-19
申请号：US10203113
申请日：2001-02-01
申请人： Daniel Lesieur , Elodie Blanc-Delmas , Said Yous , Patrick Depreux , Gérald Guillaumet , Catherine Dacquet , Nigel Levens , Jean Albert Boutin , Caroline Bennejean , Pierre Renard
发明人： Daniel Lesieur , Elodie Blanc-Delmas , Said Yous , Patrick Depreux , Gérald Guillaumet , Catherine Dacquet , Nigel Levens , Jean Albert Boutin , Caroline Bennejean , Pierre Renard
IPC分类号： A61K31/423 , A61K31/428 , A61K31/437 , A61K31/4439 , A61P1/00 , A61P1/04 , A61P1/14 , A61P1/18 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/00 , A61P9/00 , A61P9/10 , A61P9/14 , A61P13/00 , A61P13/12 , A61P15/00 , A61P17/06 , A61P19/10 , A61P21/00 , A61P21/04 , A61P25/28 , A61P35/00 , A61P43/00 , C07B61/00 , C07D263/58 , C07D277/68 , C07D417/06 , C07D471/04 , C07D498/04
CPC分类号： C07D263/58 , C07D277/68 , C07D471/04
摘要： Compounds of formula (I): wherein: X represents an oxygen or a sulphur or CH2 or R1 and R2 represent a hydrogen atom, or a group as defined in the description, A represents an alkylene chain as described in the description, B is as defined in the description, R3 and R4 represent a hydrogen atom or a group as defined in the description, D represents an optionally substituted benzene, optionally substituted pyrazine, optionally substituted pyrimidine or optionally substituted pyridazine and medicinal products containing the same which are useful in treating or preventing melatoninergic disorders.
摘要翻译： 式（I）化合物：其中：X表示氧或硫或CH 2或R 1和R 2表示氢原子 或说明书中所定义的基团，A表示如说明书中所述的亚烷基链，B如说明书中所定义，R 3和R 4代表 氢原子或描述中定义的基团，D表示任选取代的苯，任选取代的吡嗪，任选取代的嘧啶或任选取代的哒嗪及其可用于治疗或预防褪黑激素障碍的药用产品。
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7.发明申请Heterocyclic Oxime Compounds, Process for Their Preparation and Pharmaceutical Compositions Containing Them 审中-公开杂环肟化合物，其制备方法和含有它们的药物组合物公开(公告)号：US20090274674A1
公开(公告)日：2009-11-05
申请号：US12086785
申请日：2006-12-19
申请人： Franck Suzenet , Gerald Guillaumet , Christelle Pillard , Carine Bassene , Catherine Dacquet , Alain Ktorza , Daniel-Henri Caignard
发明人： Franck Suzenet , Gerald Guillaumet , Christelle Pillard , Carine Bassene , Catherine Dacquet , Alain Ktorza , Daniel-Henri Caignard
IPC分类号： A61K31/122 , C07D471/04 , A61K31/437 , A61P3/04
CPC分类号： C07D471/04
摘要： Compounds of formula (I): wherein: X represents a hydrogen or halogen atom or an alkyl group, R1, R2, R3 and R4 are as defined in the description, A represents an alkylene chain as defined in the description, B represents an alkyl or alkenyl group substituted by a group D represents a pyridine nucleus.
摘要翻译： 式（I）化合物：其中：X表示氢或卤素原子或烷基，R 1，R 2，R 3和R 4如说明书中所定义，A表示如说明书中所定义的亚烷基链，B表示烷基 或被基团D取代的链烯基表示吡啶核。
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公开(公告)号：US07071221B2
公开(公告)日：2006-07-04
申请号：US10902345
申请日：2004-07-29
申请人： Véronique Leclerc , Sylvie Pailloux , Pascal Carato , Carine Introvigne , Nicolas Lebegue , Pascal Berthelot , Catherine Dacquet , Jean Albert Boutin , Daniel Henri Caignard , Pierre Renard
发明人： Véronique Leclerc , Sylvie Pailloux , Pascal Carato , Carine Introvigne , Nicolas Lebegue , Pascal Berthelot , Catherine Dacquet , Jean Albert Boutin , Daniel Henri Caignard , Pierre Renard
IPC分类号： A61K31/428 , A61K31/423 , C07D277/68 , C07D263/58
CPC分类号： C07D277/68 , C07D417/10
摘要： Compounds of formula (I): wherein: X represents oxygen or sulphur or a group CH2 or R1, R2, R3, R4, R5 and R6 are as defined in the description, A represents an alkylene chain as defined in the description, B represents alkyl or alkenyl substituted by a group or R9, or B represents a group or R9, D represents a benzene, pyridine, pyrazine, pyrimidine or pyridazine nucleus. Medicaments
摘要翻译： 式（I）化合物：其中：X表示氧或硫或CH 2或R 1，R 2，R 2， R 3，R 4，R 5和R 6如说明书中所定义，A代表如所定义的亚烷基链 在说明书中，B表示被基团或R 9取代的烷基或链烯基，或B表示基团或R 9，D表示苯，吡啶，吡嗪，嘧啶 或哒嗪核。 药剂
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