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公开(公告)号：US20070167502A1
公开(公告)日：2007-07-19
申请号：US10593681
申请日：2005-03-30
IPC分类号： A61K31/427 , A61K31/423 , A61K31/404 , A61K31/355 , A61K31/12
CPC分类号： A61K31/428 , A61K9/2018 , A61K9/2059 , A61K31/15
摘要： A pharmaceutical composition for treatment of obesity associated with lipid and carbohydrate metabolism comprising (i) a substance which is useful in promoting lipid and carbohydrate metabolism, (ii) an antioxidant agent and, optionally, (iii) a pharmaceutically acceptable carrier or excipient, wherein the substance which promotes lipid and carbohydrate metabolism and the antioxidant agent are present in therapeutically effective dosages. Methods which are useful in treating conditions associated with obesity.
摘要翻译： 一种用于治疗与脂质和碳水化合物代谢相关的肥胖的药物组合物，其包含（i）可用于促进脂质和碳水化合物代谢的物质，（ii）抗氧化剂和任选地（iii）药学上可接受的载体或赋形剂，其中 促进脂质和碳水化合物代谢的物质和抗氧化剂以治疗有效剂量存在。 可用于治疗与肥胖相关的病症的方法。
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2.发明申请Association between a heterocyclic compound stimulating lipid and carbohydrate metabolisms and an antioxidant agent for treating obesity 审中-公开刺激脂质和碳水化合物代谢的杂环化合物与用于治疗肥胖症的抗氧化剂之间的关联公开(公告)号：US20060111407A1
公开(公告)日：2006-05-25
申请号：US10530945
申请日：2003-10-10
IPC分类号： A61K31/428 , A61K31/423 , A61K31/404
CPC分类号： A61K45/06 , A61K31/122 , A61K31/355 , A61K31/423 , A61K31/429 , A61K2300/00
摘要： The invention relates to a combination comprising a compound favouring lipid and carbohydrate metabolisms and an antioxidant agent and to pharmaceutical compositioins comprising the combination.
摘要翻译： 本发明涉及包含有利于脂质和碳水化合物代谢物的化合物和抗氧化剂以及包含该组合的药物组合物的组合。
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3.发明申请Association between a ppar ligand and an antioxidant agent and use thereof for treating obesity 审中-公开ppar配体和抗氧化剂之间的关联及其用于治疗肥胖症的用途公开(公告)号：US20060002911A1
公开(公告)日：2006-01-05
申请号：US10530771
申请日：2003-10-10
IPC分类号： A61K38/43 , A61K31/426
CPC分类号： A61K31/122 , A61K31/4439 , A61K45/06 , A61K2300/00
摘要： The invention relates to a combination comprising one or more ligands of peroxisome proliferator activated receptors and an antioxidant agent, and to pharmaceutical compostions comprising the combination.
摘要翻译： 本发明涉及包含一种或多种过氧化物酶体增殖物激活受体和抗氧化剂配体的组合物，以及包含该组合的药物组合物。
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4.发明授权公开(公告)号：US08945920B2
公开(公告)日：2015-02-03
申请号：US12161975
申请日：2007-01-26
CPC分类号： C12N5/0657 , A61K35/12 , C12N2506/1384
摘要： The invention concerns a method for culturing cells derived from the adipose tissue and in particular the stromal vascular fraction (SVF) to induce formation of cardiomyocytes, the use of the cells obtained by said culture method to reconstitute an ischemized cardiac zone, in particular following an infarction, as well as a pharmaceutical composition containing said cells. The method for obtaining cardiac cells comprises at least the following steps: a) selecting cardiomyogenic cells from the stromal vascular fraction (SVF); b) culturing the cells selected at step a) in a liquid medium optimized for expanding ex vivo the cardiomyogenic cells; c) maintaining and expanding said cells by successive passes in the liquid medium; and d) obtaining cardiac cells.
摘要翻译： 本发明涉及培养源自脂肪组织的细胞，特别是基质血管部分（SVF）以诱导心肌细胞形成的方法，使用通过所述培养方法获得的细胞重建缺血心脏区，特别是在 梗死，以及含有所述细胞的药物组合物。 获得心脏细胞的方法至少包括以下步骤：a）从基质血管部分（SVF）中选择心肌细胞; b）将在步骤a）中选择的细胞培养在优化用于扩增离心心肌细胞的液体培养基中; c）通过在液体介质中连续通过来维持和膨胀所述细胞; 和d）获得心脏细胞。
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5.发明申请Use Of Adipose Tissue Cells For Initiating The Formation Of A Functional Vascular Network 审中-公开用于起始形成功能性血管网络的脂肪组织细胞公开(公告)号：US20120207722A1
公开(公告)日：2012-08-16
申请号：US13369245
申请日：2012-02-08
申请人： Louis Casteilla , Jean-Sébastien Silvestre , Valérie Planat-Benard , Bernard Levy , Luc Penicaud , Alain Tedgui
发明人： Louis Casteilla , Jean-Sébastien Silvestre , Valérie Planat-Benard , Bernard Levy , Luc Penicaud , Alain Tedgui
CPC分类号： C12N5/0653 , A61K35/28 , A61K35/35 , C12N5/0691 , C12N2501/165 , C12N2502/1305 , C12N2510/00 , C12N2533/78
摘要： This invention relates to the use of cells of a medullary or extra-medullary white adipose tissue, in particular of an extra-medullary stromal vascular fraction (SVF) and/or mature dedifferentiated adipocytes of any origin for initiating the formation of a functional vascularisation.
摘要翻译： 本发明涉及髓质或髓外白色脂肪组织，特别是任何来源的髓外基质血管部分（SVF）和/或成熟去分化脂肪细胞的细胞用于起始功能性血管形成的用途。
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6.发明申请METHOD FOR CULTURING CELLS DERIVED FROM THE ADIPOSE TISSUE AND USES THEREOF 有权用于培养从ADIPOSE组织衍生的细胞的方法及其用途公开(公告)号：US20090246182A1
公开(公告)日：2009-10-01
申请号：US12161975
申请日：2007-01-26
CPC分类号： C12N5/0657 , A61K35/12 , C12N2506/1384
摘要： The invention concerns a method for culturing cells derived from the adipose tissue and in particular the stromal vascular fraction (SVF) to induce formation of cardiomyocytes, the use of the cells obtained by said culture method to reconstitute an ischemized cardiac zone, in particular following an infarction, as well as a pharmaceutical composition containing said cells. The method for obtaining cardiac cells comprises at least the following steps: a) selecting cardiomyogenic cells from the stromal vascular fraction (SVF); b) culturing the cells selected at step a) in a liquid medium optimized for expanding ex vivo the cardiomyogenic cells; c) maintaining and expanding said cells by successive passes in the liquid medium; and d) obtaining cardiac cells.
摘要翻译： 本发明涉及培养源自脂肪组织的细胞，特别是基质血管部分（SVF）以诱导心肌细胞形成的方法，使用通过所述培养方法获得的细胞重建缺血心脏区，特别是在 梗死，以及含有所述细胞的药物组合物。 获得心脏细胞的方法至少包括以下步骤：a）从基质血管部分（SVF）中选择心肌细胞; b）将在步骤a）中选择的细胞培养在优化用于扩增离心心肌细胞的液体培养基中; c）通过在液体介质中连续通过来维持和膨胀所述细胞; 和d）获得心脏细胞。
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7.发明申请USE OF CELLS DERIVED FROM ADIPOSE TISSUE FOR THE PREPARATION OF AN ANTI-TUMOR MEDICAMENT 审中-公开使用从ADIPOSE组织获得的细胞用于制备抗肿瘤药物公开(公告)号：US20090186007A1
公开(公告)日：2009-07-23
申请号：US12301343
申请日：2007-05-18
申请人： Pierre Cordelier , Louis Buscail , Louis Casteilla , Beatrice Cousin-Delarue , Luc Penicaud , Jean-Marie Peron
发明人： Pierre Cordelier , Louis Buscail , Louis Casteilla , Beatrice Cousin-Delarue , Luc Penicaud , Jean-Marie Peron
CPC分类号： A61K48/0008 , A61K35/12 , A61K35/35 , C12N5/0667 , C12N2502/30
摘要： Use of cells isolated from extramedullary white adipose tissue, selected from the group consisting of the stromal-vascular fraction and a subpopulation of said stromal-vascular fraction consisting of adherent cells, for the preparation of an anti-tumor medicament.
摘要翻译： 使用分离自髓外白色脂肪组织的细胞，其选自基质血管部分和由贴壁细胞组成的所述基质 - 血管部分的亚群，用于制备抗肿瘤药物。
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8.发明申请Use of adipose tisue cells for initiating the formation of a fuctional vascular network 审中-公开使用脂肪组织细胞来引发功能性血管网络的形成公开(公告)号：US20070116674A1
公开(公告)日：2007-05-24
申请号：US10570458
申请日：2004-09-06
申请人： Louis Casteilla , Jean-Sebastien Silvestre , Valerie Planat-Benard , Bernard Levy , Luc Penicaud , Alain Tedgui
发明人： Louis Casteilla , Jean-Sebastien Silvestre , Valerie Planat-Benard , Bernard Levy , Luc Penicaud , Alain Tedgui
IPC分类号： A61K35/12
CPC分类号： C12N5/0653 , A61K35/28 , A61K35/35 , C12N5/0691 , C12N2501/165 , C12N2502/1305 , C12N2510/00 , C12N2533/78
摘要： The invention relates to the use of cells of a medullary or extra-medullary white adipose tissue, in particular of an extra-medullary stromal vascular fraction (SVF) and/or mature dedifferentiated adipocytes of any origin for initiating the formation of a functional vascularisation.
摘要翻译： 本发明涉及髓质或髓外白色脂肪组织的细胞，特别是任何来源的髓外基质血管部分（SVF）和/或成熟的去分化脂肪细胞的细胞用于起始功能性血管形成的形成。
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9.发明申请EXTRAMEDULLARY ADIPOSE TISSUE CELLS AND USE THEREOF FOR REGENERATING HEMATOPOIETIC AND MUSCULAR TISSUES 审中-公开外用ADIPOSE组织细胞及其用于再造血细胞和组织细胞的组织公开(公告)号：US20080206208A1
公开(公告)日：2008-08-28
申请号：US12034295
申请日：2008-02-20
申请人： Louis Casteilla , Beatrice Cousin , Luc Penicaud , Mireille Andre
发明人： Louis Casteilla , Beatrice Cousin , Luc Penicaud , Mireille Andre
CPC分类号： C12N5/0667 , A61K35/12 , A61K48/00 , C12N2510/00
摘要： The invention concerns cells derived from the cellular fraction of the vascular stroma of the extramedullary adipose tissue, methods for preparing them and their use in regeneration of hematopoietic lines and cardiac and skeletal muscular tissues, in particular for treating genetic or acquired hemopathies, myopathies and cardiomypathies.
摘要翻译： 本发明涉及来自髓外脂肪组织的血管基质的细胞部分的细胞，其制备方法及其在再生造血系和心脏和骨骼肌组织中的用途，特别是用于治疗遗传或获得性的血液病，肌病和心肌炎 。
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