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公开(公告)号：US5810735A
公开(公告)日：1998-09-22
申请号：US848764
申请日：1997-05-01
IPC分类号： A61B5/00 , A61B5/0215 , A61B5/03 , G01L19/02 , A61B5/02
CPC分类号： A61B5/7475 , A61B5/0002 , A61B5/02156 , A61B5/03 , G01L19/02 , A61B2560/0257 , A61B5/0031 , A61B5/1455
摘要： A system for long term monitoring of an internal patient medical parameter having an external reference and means to correct the internal measurements of the parameter via external measurements taken by the external reference. A coordinating device makes the correction and makes available a histogram-based record of the parameter over time. This information can be used to reprogram an implantable device or for other therapeutic or diagnostic purposes. Pressure sensor embodiment is detailed.
摘要翻译： 用于长期监测具有外部参考的内部患者医疗参数的系统，以及通过外部参考获得的外部测量来校正参数的内部测量的装置。 协调设备进行校正，并使随时间推移参数的直方图记录。 该信息可用于重新编程可植入装置或用于其他治疗或诊断目的。 压力传感器的实施例详细说明。
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公开(公告)号：US09867990B2
公开(公告)日：2018-01-16
申请号：US12915788
申请日：2010-10-29
申请人： Can Cinbis , David A. Anderson , Michael A. Reinert , Xiaonan Shen , James K. Carney , Michael B. Terry
发明人： Can Cinbis , David A. Anderson , Michael A. Reinert , Xiaonan Shen , James K. Carney , Michael B. Terry
CPC分类号： A61N1/37217 , A61B5/0028 , A61N1/08 , H04B13/005
摘要： Aspects of the present disclosure include a medical device system including an implantable medical device and an external device with three or more electrodes configured to contact a patient's skin. The external device either transmits or receives a test signal to or from the implantable medical device using a plurality of possible receive dipoles, where each possible receive dipole is formed by a pair of electrodes. A signal quality monitor, either at the implantable medical device or at the external device, measures a signal quality for the possible receive dipoles.
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3.发明授权Heart monitoring systems, apparatus and methods adapted to detect myocardial ischemia 有权适用于检测心肌缺血的心脏监测系统，装置和方法公开(公告)号：US09179852B2
公开(公告)日：2015-11-10
申请号：US11684794
申请日：2007-03-12
IPC分类号： A61B5/04 , A61B5/0452 , A61B5/0402 , A61B5/00
CPC分类号： A61B5/0452 , A61B5/0006 , A61B5/0031 , A61B5/0402 , A61B5/721 , A61B5/7475
摘要： Embodiments include heart monitoring systems, apparatus, and methods adapted to detect myocardial ischemia. An apparatus includes at least one first-tier sensor/analyzer adapted to sense a first input related to cardiac function, and to produce a first-tier trigger signal when the first input indicates myocardial ischemia. In an embodiment, a first-tier sensor/analyzer includes an ECG sensor/analyzer. In another embodiment, a first-tier sensor/analyzer includes a patient activator. An apparatus further includes at least one second-tier sensor/analyzer adapted to sense a second input related to cardiac function, and to produce a second-tier trigger signal when the second input indicates myocardial ischemia. In an embodiment, a second-tier sensor-analyzer includes a heart sound sensor/analyzer. A triggering element is adapted to produce a response-invoking signal in response to the first-tier trigger signal and the second-tier trigger signal. The response-invoking signal may invoke a patient alert, a message to an external system, and/or a cardiac stimulus.
摘要翻译： 实施例包括适于检测心肌缺血的心脏监测系统，装置和方法。 一种装置包括适于感测与心脏功能相关的第一输入的至少一个第一层传感器/分析器，以及当第一输入指示心肌缺血时产生第一层触发信号。 在一个实施例中，第一层传感器/分析器包括ECG传感器/分析器。 在另一个实施例中，第一层传感器/分析器包括患者激活器。 装置还包括适于感测与心脏功能相关的第二输入的至少一个第二层传感器/分析器，并且当第二输入指示心肌缺血时产生第二层触发信号。 在一个实施例中，第二层传感器分析仪包括心音传感器/分析器。 触发元件适于响应于第一层触发信号和第二层触发信号产生响应调用信号。 响应调用信号可以调用患者警报，到外部系统的消息和/或心脏刺激。
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4.发明授权Shock reduction using absolute calibrated tissue oxygen saturation and total hemoglobin volume fraction 有权使用绝对校准的组织氧饱和度和总血红蛋白体积分数进行减震公开(公告)号：US09126049B2
公开(公告)日：2015-09-08
申请号：US12797781
申请日：2010-06-10
IPC分类号： A61B5/00 , A61N1/362 , A61B5/02 , A61B5/145 , A61B5/1459 , A61N1/365 , A61N1/39 , A61B5/0215 , A61B5/042 , A61B5/11
CPC分类号： A61N1/3622 , A61B5/02028 , A61B5/0215 , A61B5/042 , A61B5/1116 , A61B5/14542 , A61B5/1459 , A61N1/36557 , A61N1/3956
摘要： An implantable medical device for detecting and treating an arrhythmia includes an optical sensor adapted for positioning adjacent to a blood-perfused tissue volume. In one embodiment for controlling arrhythmia therapies delivered by the device, the optical sensor is controlled to emit light in response to detecting an arrhythmia, detect light scattered by the volume of blood perfused tissue including measuring an optical sensor output signal corresponding to the intensity of scattered light for at least four spaced-apart wavelengths, and compute a volume-independent measure of tissue oxygen saturation from the detected light. The hemodynamic status of the arrhythmia is detected in response to the measure of tissue oxygen saturation.
摘要翻译： 用于检测和治疗心律失常的可植入医疗装置包括适于邻近于血液灌注的组织体积定位的光学传感器。 在用于控制由装置传送的心律失常治疗的一个实施例中，响应于检测到心律失常，控制光学传感器发光，检测由血液灌注组织的体积散射的光，包括测量对应于散射强度的光学传感器输出信号 用于至少四个间隔波长的光，并且从检测到的光计算组织氧饱和度的体积独立测量。 响应于组织氧饱和度的测量，检测心律失常的血液动力学状态。
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公开(公告)号：US08170650B2
公开(公告)日：2012-05-01
申请号：US12039242
申请日：2008-02-28
IPC分类号： A61B6/00
CPC分类号： A61B5/1459 , A61B5/0059 , A61B5/024 , A61B5/046 , A61B5/0464 , A61B5/14542 , A61B5/7214 , A61N1/3925
摘要： A medical device for sensing cardiac events that includes a plurality of light sources capable of emitting light at a plurality of wavelengths, and a detector to detect the emitted light. A processor generates an ambient light measurement in response to ambient light detected by the detector, generates a plurality of light measurements in response to the emitted light detected by the detector, and adjusts the plurality of light measurements in response to the ambient light measurement.
摘要翻译： 一种用于感测心脏事件的医疗装置，其包括能够发射多个波长的光的多个光源，以及检测器，用于检测发射的光。 处理器响应于由检测器检测到的环境光产生环境光测量，响应于由检测器检测到的发射光产生多个光测量，并且响应于环境光测量来调整多个光测量。
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公开(公告)号：US08090432B2
公开(公告)日：2012-01-03
申请号：US12039294
申请日：2008-02-28
申请人： Can Cinbis , James K. Carney
发明人： Can Cinbis , James K. Carney
IPC分类号： A61B6/00
CPC分类号： A61B5/1459 , A61B5/0059 , A61B5/024 , A61B5/046 , A61B5/0464 , A61B5/14542 , A61B5/7214 , A61N1/3925
摘要： A medical device for sensing cardiac events that includes a plurality of electrodes sensing cardiac signals utilized to identify a cardiac event, a plurality of light sources capable of emitting light at a plurality of wavelengths, and a detector to detect the emitted light. A processor determines a plurality of light measurements in response to the emitted light detected by the detector, an isobestic blood volume index in response to determined light measurements of the plurality of light measurements from a first light source of the plurality of light sources emitting light at an isobestic wavelength, determines an oxygen index associated with light measurements of the plurality of light measurements from a light source of the plurality of light sources other than the first light source, and verifies the identifying of the cardiac event in response to the determined isobestic blood volume index and the determined oxygen index.
摘要翻译： 一种用于感测心脏事件的医疗装置，其包括感测用于识别心脏事件的心脏信号的多个电极，能够发射多个波长的光的多个光源以及检测发射光的检测器。 处理器响应于由检测器检测到的发射光来确定多个光测量值，响应于来自多个光源中的多个光源的确定的光测量而测量的异常血液体积指数 异常波长，确定与来自除了第一光源之外的多个光源的光源的多个光测量的光测量相关联的氧指数，并且响应于所确定的异源血液来验证心脏事件的识别 体积指数和确定的氧指数。
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公开(公告)号：US20110218418A1
公开(公告)日：2011-09-08
申请号：US12771110
申请日：2010-04-30
申请人： Michael T. Green , James K. Carney , G. Sean Haag
发明人： Michael T. Green , James K. Carney , G. Sean Haag
IPC分类号： A61B5/04
CPC分类号： A61B5/0002 , A61B8/4236 , A61B8/4438 , A61B2562/08
摘要： A medical system that includes an identification patch having a memory that stores identification information associated with the patch. A monitoring device to be used with the identification patch interrogates the patch to obtain the identification information stored within the memory of the patch. The monitoring device determines whether the identification information is valid and, if so, measures values representing one or more parameters of the patient. If the identification information is not valid, monitoring device does not measure values representing the one or more parameters of the patient.
摘要翻译： 一种医疗系统，其包括具有存储器的识别补丁，所述存储器存储与所述补丁相关联的识别信息。 与识别补丁一起使用的监视装置会询问补丁以获得存储在补丁存储器内的识别信息。 监视装置确定识别信息是否有效，如果是，则测量表示患者的一个或多个参数的值。 如果识别信息无效，则监视装置不测量表示患者的一个或多个参数的值。
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8.发明申请Shock Reduction Using Absolute Calibrated Tissue Oxygen Saturation and Total Hemoglobin Volume Fraction 有权使用绝对校准的组织氧饱和度和总血红蛋白体积分数进行减震公开(公告)号：US20100318149A1
公开(公告)日：2010-12-16
申请号：US12797793
申请日：2010-06-10
IPC分类号： A61N1/365
CPC分类号： A61N1/3622 , A61B5/02028 , A61B5/0215 , A61B5/042 , A61B5/1116 , A61B5/14542 , A61B5/1459 , A61N1/36557 , A61N1/3956
摘要： An implantable medical device that includes an optical sensor for providing a signal corresponding to light attenuation by a volume of blood perfused tissue, a control module coupled to the optical sensor controlling the light emitted by the optical sensor, a monitoring module receiving an optical sensor output signal and measuring light attenuation, a tissue electrode for stimulating the volume of blood perfused tissue, a pulse generator coupled to the tissue electrode for delivering electrical stimulation to the volume of blood-perfused tissue, and a processor coupled to the cardiac electrode and the monitoring module and configured to detect an arrhythmia in response to the depolarization signals, compute a tissue oxygenation measurement and control the pulse generator to deliver electrical stimulation to the volume of blood-perfused tissue in response to detecting the arrhythmia, and detect a hemodynamic status of the arrhythmia in response to at least one of a detected rate of tissue oxygenation decline and a detected rate of tissue oxygenation recovery.
摘要翻译： 一种可植入医疗装置，其包括：光学传感器，用于通过一定量的血液灌注组织提供对应于光衰减的信号;耦合到所述光学传感器的控制模块，所述控制模块控制由所述光学传感器发射的光;监测模块，其接收光学传感器输出 信号和测量光衰减的组织电极，用于刺激血液灌注组织的体积的组织电极，耦合到组织电极的脉冲发生器，用于向血液灌注组织的体积输送电刺激;以及处理器，其耦合到心脏电极和监测 模块并且被配置为响应于去极化信号检测心律失常，计算组织氧合测量并控制脉冲发生器以响应于检测到心律失常而向血液灌注组织的体积递送电刺激，并且检测血液动力学状态 响应于检测到的tis的速率中的至少一种的心律失常 检测氧合反应的下降和组织氧合恢复率。
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公开(公告)号：US20080208269A1
公开(公告)日：2008-08-28
申请号：US12039326
申请日：2008-02-28
申请人： Can Cinbis , James K. Carney
发明人： Can Cinbis , James K. Carney
IPC分类号： A61N1/00
CPC分类号： A61B5/1459 , A61B5/0059 , A61B5/024 , A61B5/046 , A61B5/0464 , A61B5/14542 , A61B5/7214 , A61N1/3925
摘要： A medical device system for sensing cardiac events that includes a plurality of electrodes sensing cardiac signals utilized to identify a cardiac event, a plurality of light sources capable of emitting light at a plurality of wavelengths, and a detector to detect the emitted light. A processor determines a plurality of light measurements in response to the emitted light detected by the detector, determines changes in perfusion in response to first changes in the plurality of light measurements in a direction indicative of a decrease in blood oxygenation and second changes in a direction indicative of a decrease in blood volume, and adjusts delivery of therapy by the device in response to the determined loss of perfusion.
摘要翻译： 一种用于感测心脏事件的医疗装置系统，其包括感测用于识别心脏事件的心脏信号的多个电极，能够发射多个波长的光的多个光源和检测发射光的检测器。 处理器响应于由检测器检测到的发射光来确定多个光测量值，响应于多个光测量中指示血氧饱和度降低的方向和方向上的第二变化的方向响应于第一变化来确定灌注变化 指示血容量的减少，并且响应于确定的灌注损失来调整装置的治疗递送。
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公开(公告)号：US20080208066A1
公开(公告)日：2008-08-28
申请号：US12039242
申请日：2008-02-28
申请人： Can Cinbis , James K. Carney
发明人： Can Cinbis , James K. Carney
IPC分类号： A61B5/02
CPC分类号： A61B5/1459 , A61B5/0059 , A61B5/024 , A61B5/046 , A61B5/0464 , A61B5/14542 , A61B5/7214 , A61N1/3925
摘要： A medical device for sensing cardiac events that includes a plurality of light sources capable of emitting light at a plurality of wavelengths, and a detector to detect the emitted light. A processor generates an ambient light measurement in response to ambient light detected by the detector, generates a plurality of light measurements in response to the emitted light detected by the detector, and adjusts the plurality of light measurements in response to the ambient light measurement.
摘要翻译： 一种用于感测心脏事件的医疗装置，其包括能够发射多个波长的光的多个光源，以及检测器，用于检测发射的光。 处理器响应于由检测器检测到的环境光产生环境光测量，响应于由检测器检测到的发射光产生多个光测量，并且响应于环境光测量来调整多个光测量。
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