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    Heterocyclic compounds for the treatment of migraine
    1.
    发明授权
    Heterocyclic compounds for the treatment of migraine 失效
    用于治疗偏头痛的杂环化合物

    公开(公告)号：US06716837B1

    公开(公告)日：2004-04-06

    申请号：US09709579

    申请日：2000-11-13

    申请人： Louise Edwards ,  Methvin Isaac ,  Shawn Maddaford ,  Abdelmalik Slassi ,  Tao Xin

    发明人： Louise Edwards ,  Methvin Isaac ,  Shawn Maddaford ,  Abdelmalik Slassi ,  Tao Xin

    IPC分类号： C07D40112

    CPC分类号： C07F7/0814 ,  C07D209/08 ,  C07D231/56 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04

    摘要： Described herein are compounds useful in the treatment of migraine, which have the general formula: wherein: W is a CH group or a N atom; Z is N or C—R4; B and D are selected independently from CH and N, with the proviso that at least one of B and D is CH and with the further proviso that one of B and D can represent N only when W and Z are both other than N; A is a group of Formula II, III or IV, such that group A contains at least 1 N atom; NR7 is either —NH— or —N═; is a single or double bond; X is a N atom, a CH group or a C(OH) group when is a single bond; or, when is a double bond, a C atom; Y is an NH, N-alkyl, N-benzyl or CH2 group; U and V each represent a N atom or a CH group, with the proviso that both cannot be N; a and b are, independently, 0 or 1; c is an integer from 0 to 3; d is an integer from 1 to 3; e is an integer from 1 to 2; f is an integer from 0 to 3; g is an integer from 3 to 6 and h is an integer from 2 to 3; such that the sum of c and d is at least 2 and the sum of e and f is at least 2; and salts and solvates thereof.

    摘要翻译： 本文描述了可用于治疗偏头痛的化合物，其具有以下通式：其中：W是CH基团或N原子; Z是N或C-R4; B和D独立地选自CH和N，条件是B和D中的至少一个是CH，进一步的条件是仅当W和Z都不是N时，B和D中的一个可以表示N; A是式II，III或IV的基团，使得A组含有至少1个N原子; NR 7是-NH-或-N =; 是单键或双键; 当是单键; 或者，当是双键时， 一个C原子; Y是NH，N-烷基，N-苄基或CH2基团; U和V各自表示N原子或CH基团，条件是两者不能为N; a和b独立地为0或1; c是0至3的整数; d为1〜3的整数; e为1〜2的整数; f为0〜3的整数; g为3〜6的整数，h为2〜3的整数， 使得c和d的和为至少2，e和f的和为至少2; 及其盐和溶剂合物。