利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

92 条记录 (耗时 0.056 秒)

    Heterocyclic compounds for the treatment of migraine
    1.
    发明授权
    Heterocyclic compounds for the treatment of migraine 失效
    用于治疗偏头痛的杂环化合物

    公开(公告)号：US06716837B1

    公开(公告)日：2004-04-06

    申请号：US09709579

    申请日：2000-11-13

    申请人： Louise Edwards ,  Methvin Isaac ,  Shawn Maddaford ,  Abdelmalik Slassi ,  Tao Xin

    发明人： Louise Edwards ,  Methvin Isaac ,  Shawn Maddaford ,  Abdelmalik Slassi ,  Tao Xin

    IPC分类号： C07D40112

    CPC分类号： C07F7/0814 ,  C07D209/08 ,  C07D231/56 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04

    摘要： Described herein are compounds useful in the treatment of migraine, which have the general formula: wherein: W is a CH group or a N atom; Z is N or C—R4; B and D are selected independently from CH and N, with the proviso that at least one of B and D is CH and with the further proviso that one of B and D can represent N only when W and Z are both other than N; A is a group of Formula II, III or IV, such that group A contains at least 1 N atom; NR7 is either —NH— or —N═; is a single or double bond; X is a N atom, a CH group or a C(OH) group when is a single bond; or, when is a double bond, a C atom; Y is an NH, N-alkyl, N-benzyl or CH2 group; U and V each represent a N atom or a CH group, with the proviso that both cannot be N; a and b are, independently, 0 or 1; c is an integer from 0 to 3; d is an integer from 1 to 3; e is an integer from 1 to 2; f is an integer from 0 to 3; g is an integer from 3 to 6 and h is an integer from 2 to 3; such that the sum of c and d is at least 2 and the sum of e and f is at least 2; and salts and solvates thereof.

    摘要翻译： 本文描述了可用于治疗偏头痛的化合物，其具有以下通式：其中：W是CH基团或N原子; Z是N或C-R4; B和D独立地选自CH和N，条件是B和D中的至少一个是CH，进一步的条件是仅当W和Z都不是N时，B和D中的一个可以表示N; A是式II，III或IV的基团，使得A组含有至少1个N原子; NR 7是-NH-或-N =; 是单键或双键; 当是单键; 或者，当是双键时， 一个C原子; Y是NH，N-烷基，N-苄基或CH2基团; U和V各自表示N原子或CH基团，条件是两者不能为N; a和b独立地为0或1; c是0至3的整数; d为1〜3的整数; e为1〜2的整数; f为0〜3的整数; g为3〜6的整数，h为2〜3的整数， 使得c和d的和为至少2，e和f的和为至少2; 及其盐和溶剂合物。