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29 条记录 (耗时 0.032 秒)

    Cephalotaxanes: their method of preparation and their use in treatment of cancers, leukemias, parasites, including those resistant to usual chemotherapeutic agents, and as reversal agents
    9.
    发明授权
    Cephalotaxanes: their method of preparation and their use in treatment of cancers, leukemias, parasites, including those resistant to usual chemotherapeutic agents, and as reversal agents 有权
    头孢噻肟：它们的制备方法及其用于治疗癌症，白血病，寄生虫，包括对常规化学治疗剂有抗性的那些，以及作为逆转剂

    公开(公告)号：US06579869B1

    公开(公告)日：2003-06-17

    申请号：US09710870

    申请日：2000-11-14

    申请人： Jean-Pierre Robin ,  Robert Dhal ,  Freddy Drouye ,  Jean-Pierre Marie ,  Nina Radosevic ,  Julie Robin ,  Karine Souchaud ,  Patricia Bataille

    发明人： Jean-Pierre Robin ,  Robert Dhal ,  Freddy Drouye ,  Jean-Pierre Marie ,  Nina Radosevic ,  Julie Robin ,  Karine Souchaud ,  Patricia Bataille

    IPC分类号： A61K3155

    CPC分类号： C07D487/20 ,  C07D491/20 ,  C07D498/20 ,  Y02P20/55

    摘要： The present invention concerns a compound of formula (I) wherein: W represents O or NH, Q represents an unbranched or branched, saturated or unsaturated or aromatic, cyclic or acyclic or heterocyclic hydrocarbon radical containing 1 to 30 carbon atoms including or not heteroatom(s), R1 is H, OH, or OMe, O-(C1-C30)-alkyl, O-aryl-(C1-C30)-alkyl, O-(C2-C30)-alkenyl, O-(C3-C30)-cycloalkyl or null, and R2 is H or OH, or R1 and R2 form together —O—, R3=R4=OMe or R3 and R4 form together —OCH2O—, R is H, C1-C30 alkyl or O-protecting group and R6 represents an unbranched or branched, saturated or unsaturated or aromatic, cyclic or acyclic or heterocyclic hydrocarbon radical containing 1 to 30 carbon atoms including or not heteroatom(s), or R and R6 form together —CMe2—, n is 0 to 8, R5 is H, OH, OMe, O-(C1-C30)-alkyl, O-aryl-(C1-C30)-alkyl, O-(C2-C30)-alkenyl, O-(C3-C30)-cycloalkyl or O-aryl, the dotted line is null or forms a double bond depending on the meaning of R1. It also concerns their methods of preparation and their use in treatment of cancers, leukemias, parasites and as reversal agents of harringtonines.

    摘要翻译： 本发明涉及式（I）化合物，其中：W表示O或NH，Q表示含有或不含杂原子的含有1至30个碳原子的无支链，支链，饱和或不饱和或芳族，环状或无环或杂环烃基 （C1-C30） - 烷基，O-芳基 - （C1-C30） - 烷基，O-（C2-C30） - 烯基，O-（C3-C30） - 烷基， ） - 环烷基或无效，并且R 2是H或OH，或者R 1和R 2一起形成-O-，R 3 = R 4 = OMe或R 3和R 4一起形成-OCH 2 O-，R是H，C 1 -C 30烷基或O-保护基 并且R 6表示包含或不含杂原子的含有1至30个碳原子的非支链或支链，饱和或不饱和或芳族，环状或非环状或杂环的烃基，或者R和R 6一起形成-CMe 2 - ，n为0至8 ，R 5是H，OH，OMe，O-（C 1 -C 30） - 烷基，O-芳基 - （C 1 -C 30） - 烷基，O-（C 2 -C 30） - 烯基，O-（C 3 -C 30） - 环烷基 或O-芳基，虚线为无效或根据R 1的含义形成双键。还涉及它们的p的方法 赔偿及其在治疗癌症，白血病，寄生虫和作为肾上腺素的逆转剂中的应用。

    Cephalotaxanes, their method of preparation and their use in treatment of cancers, leukemias, parasites including those resistant to usual chemotherapeutic agents and as reversal agents
    10.
    发明授权
    Cephalotaxanes, their method of preparation and their use in treatment of cancers, leukemias, parasites including those resistant to usual chemotherapeutic agents and as reversal agents 有权
    头孢噻肟，它们的制备方法及其用于治疗癌症，白血病，寄生虫，包括耐药于常规化学治疗剂的寄生虫和作为逆转剂

    公开(公告)号：US07285546B2

    公开(公告)日：2007-10-23

    申请号：US10403506

    申请日：2003-04-01

    申请人： Jean-Pierre Robin ,  Robert Dhal ,  Freddy Drouye ,  Jean-Pierre Marie ,  Nina Radosevic ,  Julie Robin ,  Karine Souchaud ,  Patricia Bataille

    发明人： Jean-Pierre Robin ,  Robert Dhal ,  Freddy Drouye ,  Jean-Pierre Marie ,  Nina Radosevic ,  Julie Robin ,  Karine Souchaud ,  Patricia Bataille

    IPC分类号： A61P35/02 ,  A61P33/00 ,  A61K31/55 ,  C07D223/00 ,  C07D487/00

    CPC分类号： C07D491/22 ,  C07D491/20 ,  Y02P20/55

    摘要： The present invention concerns a compound of formula (I) wherein: W represents O or NH, Q represents an unbranched or branched, saturated or unsaturated or aromatic, cyclic or acyclic or heterocyclic hydrocarbon radical containing 1 to 30 carbon atoms including or not heteroatom(s), R1 is H, OH, or R1, R2 form together —O—, R3═R4═OMe or R3 and R4 form together —OCH2O—, R is H, C1-C30alkyl or O-protecting group and R6 represents an unbranched or branched, saturated or unsaturated or aromatic, cyclic or acyclic or heterocyclic hydrocarboned radical containing 1 to 30 carbon atoms including or not heteroatom(s), or R and R6 form together —CMe2-, n is 0 to 8, R5 is H, OH, OMe, O—(C1-C30)-alkyl, O-aryl-(C1-C30)-alkyl, O—(C2-C30)-alkenyl, O—(C3-C30)-cycloalkyl or O-aryl, the dotted line is null or forms a double bond depending on the meaning of R1. It also concerns their methods of preparation and their use in treatment of cancers, leukemias, parasites and as reversal agents of harringtonines.

    摘要翻译： 本发明涉及式（I）化合物，其中：W表示O或NH，Q表示含有或不含杂原子的含有1至30个碳原子的无支链，支链，饱和或不饱和或芳族，环状或无环或杂环烃基 s），R 1是H，OH或R 1，R 2一起形成-O-，R 3， SUP→-R 4 -OMe或R 3和R 4一起形成-OCH 2 O-，R 是H，C 1 -C 30烷基或O-保护基，R 6表示非支链或支链的饱和或不饱和或芳族的， 含有1至30个碳原子的环状或非环状或非环状或杂环烃基，包括或不包含杂原子，或R和R 6形成在一起-CMe 2 - ，n为0 至8，R 5是H，OH，OMe，O-（C 1 -C 30） - 烷基，O-芳基 - （ C 1 -C 30烷基，O-（C 2 -C 30） - 烯基，O（C 1 -C 3） - （C 3 -C 30） - 环 O-烷基或O-芳基，虚线为无效或根据R 1的含义形成双键。 它还涉及它们的制备方法及其在治疗癌症，白血病，寄生虫和作为哈丁顿的逆转剂中的用途。