专利检索 ap:("Luc Chanteloup" OR "Bruno Chauveau" OR "Christina Corbin" OR "Robert Dhal" OR "Sonia Le Guen" OR "Arnaud Lamy" OR "Antoine Leze" OR "Jean-Pierre Robin") AND inv:"Antoine Leze" 第 1 页

1.

发明授权
Intermediates for the hemisynthesis of taxanes and preparation processes therefor 失效
标题翻译：紫杉烷类半合成中间体及其制备方法

公开(公告)号：US07432383B2

公开(公告)日：2008-10-07

申请号：US11714817

申请日：2007-03-07

申请人： Luc Chanteloup , Bruno Chauveau , Christina Corbin , Robert Dhal , Sonia Le Guen , Arnaud Lamy , Antoine Leze , Jean-Pierre Robin

发明人： Luc Chanteloup , Bruno Chauveau , Christina Corbin , Robert Dhal , Sonia Le Guen , Arnaud Lamy , Antoine Leze , Jean-Pierre Robin

IPC分类号： C07D305/00 , C07D407/00 , C07D493/00 , C07D263/00 , C07D413/00

CPC分类号： C07D263/16 , C07C229/34 , C07C233/87 , C07D263/20 , C07D263/26 , C07D303/48 , C07D305/14 , C07D413/12 , C07F7/0838 , C07F7/1804 , C07F7/1892

摘要： The present invention generally relates to at least one precursor compound and derivatives thereof, a process for preparing a taxane, and a baccatin derivative.

摘要翻译： 本发明一般涉及至少一种前体化合物及其衍生物，制备紫杉烷的方法和浆果赤霉素衍生物。

2.

发明授权
Intermediates for the hemisynthesis of taxanes and preparation processes therefor 失效
标题翻译：紫杉烷类半合成中间体及其制备方法

公开(公告)号：US07279586B2

公开(公告)日：2007-10-09

申请号：US10859953

申请日：2004-06-04

申请人： Luc Chanteloup , Bruno Chauveau , Christine Corbin , Robert Dhal , Sonia Le Guen , Arnaud Lamy , Antoine Leze , Jean-Pierre Robin

发明人： Luc Chanteloup , Bruno Chauveau , Christine Corbin , Robert Dhal , Sonia Le Guen , Arnaud Lamy , Antoine Leze , Jean-Pierre Robin

IPC分类号： C07D303/38

CPC分类号： C07D263/16 , C07C229/34 , C07C233/87 , C07D263/20 , C07D263/26 , C07D303/48 , C07D305/14 , C07D413/12 , C07F7/0838 , C07F7/1804 , C07F7/1892

摘要： The present invention generally relates to at least one precursor compound and derivatives thereof, a process for preparing a taxane, and a baccatin derivative.

摘要翻译： 本发明一般涉及至少一种前体化合物及其衍生物，制备紫杉烷的方法和浆果赤霉素衍生物。

3.

发明授权
Intermediates for the hemisynthesis of taxanes and preparation processes therefor 失效

公开(公告)号：US07220871B2

公开(公告)日：2007-05-22

申请号：US11076856

申请日：2005-03-11

申请人： Luc Chanteloup , Bruno Chauveau , Christine Corbin , Robert Dhal , Sonia Le Guen , Arnaud Lamy , Antoine Leze , Jean-Pierre Robin

发明人： Luc Chanteloup , Bruno Chauveau , Christine Corbin , Robert Dhal , Sonia Le Guen , Arnaud Lamy , Antoine Leze , Jean-Pierre Robin

IPC分类号： C07D305/00 , C07D407/00 , C07D493/00

CPC分类号： C07D263/16 , C07C229/34 , C07C233/87 , C07D263/20 , C07D263/26 , C07D303/48 , C07D305/14 , C07D413/12 , C07F7/0838 , C07F7/1804 , C07F7/1892

摘要： The present invention generally relates to at least one precursor compound and derivatives thereof, a process for preparing a taxane, and a baccatin derivative.

4.

发明授权
Intermediary compounds for the hemisynthesis of taxanes and preparation processes therefor 失效
标题翻译：紫杉烷半合成中间体化合物及其制备方法

公开(公告)号：US06265587B1

公开(公告)日：2001-07-24

申请号：US09065041

申请日：1998-04-27

申请人： Luc Chanteloup , Bruno Chauveau , Christine Corbin , Robert Dhal , Sonia Le Guen , Arnaud Lamy , Antoine Leze , Jean-Pierre Robin

发明人： Luc Chanteloup , Bruno Chauveau , Christine Corbin , Robert Dhal , Sonia Le Guen , Arnaud Lamy , Antoine Leze , Jean-Pierre Robin

IPC分类号： C07D26314

CPC分类号： C07D263/16 , C07C229/34 , C07C233/87 , C07D263/20 , C07D263/26 , C07D303/48 , C07D305/14 , C07D413/12 , C07F7/0838 , C07F7/1804 , C07F7/1892

摘要： The present invention relates to new intermediates for the semisynthesis of taxanes and their preparation processes. It relates to derivatives of oxazolidines or oxazolidinones, as well as to new derivatives of baccatine III. The general process for the synthesis of taxanes according to the invention enables to obtain a product such as PACLITAXEL in only five steps from products available in the market, compared to nine steps in general, for processes of the prior art.

摘要翻译： 本发明涉及紫杉烷类半合成的新中间体及其制备方法。它涉及恶唑烷衍生物或恶唑烷酮衍生物，以及新戊酰胺衍生物。根据本发明的紫杉烷类的合成的一般方法能够从现有技术中可获得的产品的五个步骤中获得诸如PACLITAXEL的产品，与现有技术方法的9个步骤相比。

5.

发明授权
Intermediates for the hemisynthesis of taxanes and preparation processes therefor 失效
标题翻译：紫杉烷类半合成中间体及其制备方法

公开(公告)号：US06825365B2

公开(公告)日：2004-11-30

申请号：US09836326

申请日：2001-04-18

申请人： Luc Chanteloup , Bruno Chauveau , Christine Corbin , Robert Dhal , Sonia Le Guen , Arnaud Lamy , Antoine Leze , Jean-Pierre Robin

发明人： Luc Chanteloup , Bruno Chauveau , Christine Corbin , Robert Dhal , Sonia Le Guen , Arnaud Lamy , Antoine Leze , Jean-Pierre Robin

IPC分类号： C07D30514

CPC分类号： C07D263/16 , C07C229/34 , C07C233/87 , C07D263/20 , C07D263/26 , C07D303/48 , C07D305/14 , C07D413/12 , C07F7/0838 , C07F7/1804 , C07F7/1892

摘要： The present invention relates to novel intermediates for the hemisynthesis of taxanes and to their processes of preparation. The compounds of the present invention include precursor compounds of taxane side chains.

摘要翻译： 本发明涉及紫杉烷半合成的新型中间体及其制备方法。本发明的化合物包括紫杉烷侧链的前体化合物。

6.

发明授权
Method for selective protection of baccatin derivatives and its application to taxane synthesis 失效
标题翻译：选择性保护浆果赤霉素衍生物的方法及其在紫杉烷合成中的应用

公开(公告)号：US06180802B2

公开(公告)日：2001-01-30

申请号：US09077099

申请日：1998-05-19

申请人： Luc Chanteloup , Bruno Chauveau , Christine Corbin , Robert Dhal , Sonia Le Guen , Arnaud Lamy , Antoine Leze , Jean-Pierre Robin

发明人： Luc Chanteloup , Bruno Chauveau , Christine Corbin , Robert Dhal , Sonia Le Guen , Arnaud Lamy , Antoine Leze , Jean-Pierre Robin

IPC分类号： C07D30514

CPC分类号： C07F7/188 , C07D305/14 , C07F7/1804

摘要： New processes for the selective protection of the 7-position of 7,10-dihydroxytaxane derivatives, using &bgr;-substituted-alkoxycarbonyl groups which are more hindered than 2,2,2-trichloroethoxycarbonyl, and which are capable of being removed by a &bgr;-elimination mechanism, and the new intermediates resulting from these processes. The new intermediates of the invention are useful for preparing taxol and analogs thereof.

摘要翻译： 选择性保护7,10-二羟基塔烷衍生物的7-位的新方法，使用比2,2,2-三氯乙氧基羰基更受阻碍的β-取代的 - 烷氧基羰基，并且其能够被β- 消除机制，以及这些过程产生的新中间体。本发明的新中间体可用于制备紫杉醇及其类似物。