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8 条记录 (耗时 0.037 秒)

    Benzylthioether-linked solid support-bound thiol compounds and method for peptide synthesis
    4.
    发明授权
    Benzylthioether-linked solid support-bound thiol compounds and method for peptide synthesis 失效
    苄硫醚连接的固体支持结合硫醇化合物和肽合成方法

    公开(公告)号：US4786684A

    公开(公告)日：1988-11-22

    申请号：US899209

    申请日：1986-08-21

    申请人： John D. Glass

    发明人： John D. Glass

    IPC分类号： C07K1/06 ,  A61K37/02 ,  C08F36/06 ,  C08F136/06

    CPC分类号： C07K1/067 ,  Y10S930/26

    摘要： A method for the synthesis of sulfydryl-containing peptides which comprises forming a benzylthioether-linked solid support-bound thiol compound having at least one functional group for generating at least one peptide bond, sequentially coupling at least one protected amino acid or peptide to the compound until a peptide having desired amino acid sequence is obtained, and cleaving the benzylthioether linkage to release the peptide from the support with concomitant regenertion of the sulfydryl group in the peptides. The invention also encompasses compounds having the general formula ##STR1## wherein X is H, NH.sub.2, ##STR2## or acyl-NHY, said acyl being an amino acid or a peptide; Y is H, COOH, CONHNH.sub.2, ##STR3## the ester COOR.sup.1 in which R.sup.1 is selected from the group consisting of methyl, ethyl, phenyl, ortho-nitrophenyl and para-nitrophenyl, the amide CONH.sub.2, or the amide CONHR.sup.2 in which R.sup.2 is an amino acid or peptide; and providing that X and Y cannot both be H.

    摘要翻译： 一种用于合成含有硫基的肽的方法，其包括形成具有至少一个官能团的苄硫醚连接的固体支持结合的硫醇化合物以产生至少一个肽键，将至少一种被保护的氨基酸或肽顺序偶联到化合物 直到获得具有所需氨基酸序列的肽，并且切断苄硫醚键以从肽中的巯基的伴生再生从载体释放肽。 本发明还包括具有通式“IMAGE”的化合物，其中X是H，NH 2，或酰基-NHY，所述酰基是氨基酸或肽; Y是H，COOH，CONHNH 2，其中R 1选自甲基，乙基，苯基，邻硝基苯基和对硝基苯基的酯COOR1，酰胺CONH 2或酰胺CONHR 2，其中R 2是 氨基酸或肽; 并且提供X和Y不能都是H.

    Boron containing amino acid compounds and methods for their use
    6.
    发明授权
    Boron containing amino acid compounds and methods for their use 有权
    含有氨基酸的硼化合物及其使用方法

    公开(公告)号：US6017902A

    公开(公告)日：2000-01-25

    申请号：US258105

    申请日：1999-02-25

    申请人： John D. Glass ,  Jeffrey A. Coderre

    发明人： John D. Glass ,  Jeffrey A. Coderre

    IPC分类号： A61K41/00 ,  C07F5/02 ,  A61K31/69

    CPC分类号： A61K41/0095 ,  C07F5/022

    摘要： The present invention provides new boron containing amino acid compounds and methods for making these compounds by contacting melphalan or another nitrogen mustard derivative and sodium borocaptate. The present invention also provides a method of treating a mammal having a tumor by administering to the mammal a therapeutically effective amount of the new boron containing amino acid compounds.

    摘要翻译： 本发明提供新的含硼氨基酸化合物和通过使美法仑或另一种氮芥衍生物与硼代巴因酸接触来制备这些化合物的方法。 本发明还提供了通过向哺乳动物施用治疗有效量的新的含硼氨基酸化合物来治疗具有肿瘤的哺乳动物的方法。

    Synthetic heparin-binding factor analogs
    7.
    发明授权
    Synthetic heparin-binding factor analogs 有权
    合成肝素结合因子类似物

    公开(公告)号：US07700563B2

    公开(公告)日：2010-04-20

    申请号：US10644703

    申请日：2003-08-19

    申请人： Louis A. Pena ,  Paul O. Zamora ,  Xinhua Lin ,  John D. Glass

    发明人： Louis A. Pena ,  Paul O. Zamora ,  Xinhua Lin ,  John D. Glass

    IPC分类号： A61K38/00 ,  A61K31/727 ,  A61K38/24 ,  C07K14/00 ,  C07K16/00 ,  C08H1/00

    CPC分类号： C07K14/4705 ,  A61K38/00 ,  A61K38/1709 ,  A61K38/1875 ,  A61L27/34 ,  C07H21/04 ,  C07K14/503 ,  C07K2319/00 ,  C08L89/00

    摘要： The invention provides synthetic heparin-binding growth factor analogs having at least one peptide chain, and preferably two peptide chains branched from a dipeptide branch moiety composed of two trifunctional amino acid residues, which peptide chain or chains bind a heparin-binding growth factor receptor and are covalently bound to a non-signaling peptide that includes a heparin-binding domain, preferably by a linker, which may be a hydrophobic linker. The synthetic heparin-binding growth factor analogs are useful as pharmaceutical agents, soluble biologics or as surface coatings for medical devices.

    摘要翻译： 本发明提供具有至少一个肽链的合成的肝素结合生长因子类似物，并且优选两个肽链从由两个三官能氨基酸残基组成的二肽分支部分分支，所述肽链或链结合肝素结合生长因子受体和 共价结合到非信号肽，其包括肝素结合结构域，优选通过接头，其可以是疏水性接头。 合成的肝素结合生长因子类似物可用作药物，可溶性生物制剂或作为医疗器械的表面涂层。

    GDNF-DERIVED PEPTIDES
    8.
    发明申请
    GDNF-DERIVED PEPTIDES 审中-公开
    GDNF衍生肽

    公开(公告)号：US20090069230A1

    公开(公告)日：2009-03-12

    申请号：US12030172

    申请日：2008-02-12

    申请人： Srinivas N. Pentyala ,  John D. Glass

    发明人： Srinivas N. Pentyala ,  John D. Glass

    IPC分类号： A61K38/22 ,  C07K14/575 ,  C07H21/04 ,  C12N15/64 ,  C12N5/10 ,  A61P25/28

    CPC分类号： C07K14/475 ,  A61K38/00

    摘要： Compositions that include peptides derived from glial-derived neurotrophic factor (GDNF) (e.g., substantially pure polypeptides comprising a fragment of a GDNF precursor protein) and biologically active variants thereof are provided. The compositions can include one or more types of peptides and can include other substances (e.g., pharmaceutically acceptable carriers or diluents or liposomes). Also provided are methods for using the compositions for treatment of neurological disorders (e.g., motor system disorders and sensory system disorders).

    摘要翻译： 提供了包含衍生自胶质神经营养因子（GDNF）的肽（例如，包含GDNF前体蛋白的片段的基本上纯的多肽）及其生物学活性变体的组合物。 组合物可以包括一种或多种类型的肽，并且可以包括其它物质（例如药学上可接受的载体或稀释剂或脂质体）。 还提供了使用组合物治疗神经障碍（例如运动系统障碍和感觉系统疾病）的方法。