公开(公告)号：US08967846B2

公开(公告)日：2015-03-03

申请号：US13741483

申请日：2013-01-15

申请人： Lumencor, Inc.

发明人： Steven M. Jaffe ,  Claudia B. Jaffe ,  George S. Tylinski

IPC分类号： F21V7/00 ,  F21V9/16 ,  F21V9/08 ,  F21V29/00 ,  F21V8/00 ,  F21V29/02 ,  G02B21/16 ,  G02B27/14 ,  A61B1/06

CPC分类号： F21V9/30 ,  A61B1/0646 ,  A61B1/0669 ,  A61B1/0684 ,  F21V7/00 ,  F21V9/083 ,  G02B6/0001 ,  G02B6/0003 ,  G02B6/0006 ,  G02B6/4296 ,  G02B21/16 ,  G02B27/141

摘要： A solid state illumination system is provided as a replacement for conventional arc light, metal halide and Xenon white-light sources for applications in life sciences including, microscopy, fluorescence microscopy, and endoscopy. The solid state illumination system generates high quality white light output from LED light sources. The white light output is continuous in the visible spectrum from 380 nm to 650 nm and is suitable for imaging all the most common fluorophores and fluorescent proteins. In embodiments, an LED light pipe engine is used to generate a portion of the spectral content of the white light output. In alternative embodiments the solid state illumination system produces light output of a selectable color.

公开(公告)号：US20160123886A1

公开(公告)日：2016-05-05

申请号：US14927250

申请日：2015-10-29

申请人： LUMENCOR, INC.

发明人： Claudia B. Jaffe ,  Steven M. Jaffe

IPC分类号： G01N21/64

CPC分类号： G01N21/6458 ,  G01N21/64 ,  G01N21/6452 ,  G01N2021/6471

摘要： An integrated fluorescence scanning system is provided. The integrated fluorescence scanner combines an embedded computer, light engine, microscope, and motion stage into a compact rack-mountable network appliance that allows for automation of fluorescence microscopy. In an embodiment, the integrated fluorescence scanner includes a solid-state light engine which can provide intense, pure, and stable light across the spectrum required for imaging of all fluorophores of interest. The embedded computer allows for autonomous operation, and network appliance features including synchronous multi-scanner operation and monitoring, multisite operation via a single control terminal, and calibration for inter and intra instrument consistency.

摘要翻译： 提供了一个集成的荧光扫描系统。 集成的荧光扫描仪将嵌入式计算机，光引擎，显微镜和运动舞台组合成一个紧凑的可机架安装的网络设备，可实现荧光显微镜的自动化。 在一个实施例中，集成荧光扫描器包括固态光引擎，其可以在所有感兴趣的荧光团成像所需的光谱上提供强烈，纯净和稳定的光。 嵌入式计算机允许自主操作，网络设备功能包括同步多扫描仪操作和监控，通过单个控制终端进行多站点操作，以及校准仪器间和仪器内部的一致性。

公开(公告)号：US08998468B2

公开(公告)日：2015-04-07

申请号：US13788022

申请日：2013-03-07

申请人： Lumencor, Inc.

发明人： Claudia B. Jaffe ,  Steven M. Jaffe

IPC分类号： F21V7/04 ,  F21V11/00 ,  A61B1/06 ,  G02B21/16 ,  G02B27/14 ,  F21V8/00

CPC分类号： F21V11/00 ,  A61B1/0638 ,  A61B1/0669 ,  A61B1/0684 ,  G02B6/0003 ,  G02B6/0006 ,  G02B21/16 ,  G02B27/141

摘要： A solid state illumination system is provided as a replacement for conventional arc light, metal halide and Xenon light sources for applications in microscopy, fluorescence microscopy, and endoscopy. The illumination system includes hybrid optical and electrical control of output intensity in which the light output of one or more of the light sources is attenuated optically such that it is not necessary to reduce the electrical drive power/current of the LEDs at a level where the spectral power distribution is variable. One or more fixed, selectable, or variable neutral density filters is interposed in the output beam of one or more sources to achieve optical attenuation of the light output. The hybrid optical and electrical control of output intensity allows greater dynamic range of intensity to be achieved than could be achieved with electrical control of the LEDs alone while maintaining the desired spectral power distribution.

摘要翻译： 提供固态照明系统作为常规电弧光，金属卤化物和氙光源的替代品，用于显微镜，荧光显微镜和内窥镜检查。 照明系统包括输出强度的混合光学和电气控制，其中一个或多个光源的光输出被光学衰减，使得不需要将LED的电驱动功率/电流降低到 光谱功率分布是可变的。 在一个或多个源的输出光束中插入一个或多个固定的，可选择的或可变的中性密度滤光片，以实现光输出的光学衰减。 输出强度的混合光学和电气控制允许在保持所需的光谱功率分布的情况下，仅通过LED的电气控制可实现更大的强度动态范围。

公开(公告)号：US20130335992A1

公开(公告)日：2013-12-19

申请号：US13901727

申请日：2013-05-24

申请人： LUMENCOR, INC.

发明人： Claudia B. Jaffe ,  Steven M. Jaffe ,  George S. Tylinski

IPC分类号： F21V29/00 ,  F21V8/00 ,  G02B27/10 ,  F21V11/00

CPC分类号： F26B3/28 ,  A61C19/003 ,  F21V11/00 ,  F21V29/83 ,  G02B6/0006 ,  G02B6/0008 ,  G02B6/3849 ,  G02B6/4269 ,  G02B6/4292 ,  G02B27/10 ,  G02B27/141 ,  G02B2006/4297

摘要： A compact passively-cooled solid state illumination system is provided as a replacement for conventional arc light, metal halide and Xenon white-light sources for photocuring applications. The solid state illumination system utilizes LED modules to generate high intensity light output suitable for photocuring. The light output is continuous in the visible spectrum from 380 nm to 530 nm and is suitable for photocuring using a wide range of photoinitiators. A touchscreen interface allows programming of spectral output, intensity and duration. Output can be initiated using the touchscreen interface and/or a foot pedal.

摘要翻译： 提供了一种紧凑的被动冷却固态照明系统，作为光固化应用的常规电弧光，金属卤化物和氙白光源的替代品。 固态照明系统利用LED模块产生适合于光固化的高强度光输出。 光输出在从380nm到530nm的可见光谱中是连续的，并且适用于使用宽范围的光引发剂的光固化。 触摸屏界面允许对频谱输出，强度和持续时间进行编程。 可以使用触摸屏界面和/或脚踏板启动输出。

公开(公告)号：US20130234047A1

公开(公告)日：2013-09-12

申请号：US13874645

申请日：2013-05-01

申请人： LUMENCOR, INC.

发明人： Claudia B. Jaffe ,  Steven M. Jaffe ,  David Larsen

IPC分类号： G01N21/64 ,  F21V23/04

CPC分类号： G01N21/645 ,  F21V23/0457 ,  G01J1/4257 ,  G01N21/64 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2021/6419 ,  G01N2021/6439 ,  G01N2201/061 ,  H05B33/0869

摘要： A system and method for controlled illumination in a bioanalysis or other system where excitation of fluorescent molecules is desirable. In an embodiment, an illumination system is described which can provide excitation light at a controlled intensity to provide quantitative results. In an embodiment, a solid state light engine is described which includes a plurality of color channels each providing light output suitable for exciting a fluorescent molecule, a light to frequency converter which receives a portion of the light output, a counter which maintains a count of a signal from the light to frequency converter, and a light intensity circuit, responsive to the counter, which adjusts the color channels to control the intensity of the light output.

摘要翻译： 在生物分析或其它系统中控制照明的系统和方法，其中期望荧光分子的激发。 在一个实施例中，描述了可以以受控强度提供激发光以提供定量结果的照明系统。 在一个实施例中，描述了一种固态光引擎，其包括多个颜色通道，每个颜色通道各自提供适于激发荧光分子的光输出，接收光输出的一部分的光频变换器，保持计数 来自光到频率转换器的信号，以及响应于计数器的光强度电路，其调节颜色通道以控制光输出的强度。

公开(公告)号：US20130188388A1

公开(公告)日：2013-07-25

申请号：US13741476

申请日：2013-01-15

申请人： Lumencor, Inc.

发明人： Steven M. Jaffe ,  Claudia B. Jaffe ,  George S. Tylinski

IPC分类号： F21V29/02 ,  F21V9/16 ,  F21V7/00 ,  F21V8/00

CPC分类号： F21V9/30 ,  A61B1/0646 ,  A61B1/0669 ,  A61B1/0684 ,  F21V7/00 ,  F21V9/083 ,  G02B6/0001 ,  G02B6/0003 ,  G02B6/0006 ,  G02B6/4296 ,  G02B21/16 ,  G02B27/141

摘要： A solid state illumination system is provided as a replacement for conventional arc light, metal halide and Xenon white-light sources for applications in life sciences including, microscopy, fluorescence microscopy, and endoscopy. The solid state illumination system generates high quality white light output from LED light sources. The white light output is continuous in the visible spectrum from 380 nm to 650 nm and is suitable for imaging all the most common fluorophores and fluorescent proteins. In embodiments, an LED light pipe engine is used to generate a portion of the spectral content of the white light output. In alternative embodiments the solid state illumination system produces light output of a selectable color.

摘要翻译： 提供固态照明系统作为常规电弧光，金属卤化物和氙白光源的替代物，用于包括显微镜，荧光显微镜和内窥镜在内的生命科学领域。 固态照明系统从LED光源产生高质量的白光输出。 白光输出在可见光谱范围内从380 nm到650 nm是连续的，适用于成像所有最常见的荧光团和荧光蛋白。 在实施例中，使用LED光管引擎来产生白光输出的光谱含量的一部分。 在替代实施例中，固态照明系统产生可选颜色的光输出。

公开(公告)号：US20130188384A1

公开(公告)日：2013-07-25

申请号：US13741480

申请日：2013-01-15

申请人： Lumencor, Inc.

发明人： Steven M. Jaffe ,  Claudia B. Jaffe ,  George S. Tylinski

IPC分类号： F21V8/00 ,  F21V29/00

CPC分类号： F21V9/30 ,  A61B1/0646 ,  A61B1/0669 ,  A61B1/0684 ,  F21V7/00 ,  F21V9/083 ,  G02B6/0001 ,  G02B6/0003 ,  G02B6/0006 ,  G02B6/4296 ,  G02B21/16 ,  G02B27/141

摘要： A solid state illumination system is provided as a replacement for conventional arc light, metal halide and Xenon white-light sources for applications in life sciences including, microscopy, fluorescence microscopy, and endoscopy. The solid state illumination system generates high quality white light output from LED light sources. The white light output is continuous in the visible spectrum from 380 nm to 650 nm and is suitable for imaging all the most common fluorophores and fluorescent proteins. In embodiments, an LED light pipe engine is used to generate a portion of the spectral content of the white light output. In alternative embodiments the solid state illumination system produces light output of a selectable color.

公开(公告)号：US20130188383A1

公开(公告)日：2013-07-25

申请号：US13741483

申请日：2013-01-15

申请人： Lumencor, Inc.

发明人： Steven M. Jaffe ,  Claudia B. Jaffe ,  George S. Tylinski

IPC分类号： F21V9/08

CPC分类号： F21V9/30 ,  A61B1/0646 ,  A61B1/0669 ,  A61B1/0684 ,  F21V7/00 ,  F21V9/083 ,  G02B6/0001 ,  G02B6/0003 ,  G02B6/0006 ,  G02B6/4296 ,  G02B21/16 ,  G02B27/141

摘要： A solid state illumination system is provided as a replacement for conventional arc light, metal halide and Xenon white-light sources for applications in life sciences including, microscopy, fluorescence microscopy, and endoscopy. The solid state illumination system generates high quality white light output from LED light sources. The white light output is continuous in the visible spectrum from 380 nm to 650 nm and is suitable for imaging all the most common fluorophores and fluorescent proteins. In embodiments, an LED light pipe engine is used to generate a portion of the spectral content of the white light output. In alternative embodiments the solid state illumination system produces light output of a selectable color.

公开(公告)号：US09642515B2

公开(公告)日：2017-05-09

申请号：US13741474

申请日：2013-01-15

申请人： Lumencor, Inc.

发明人： Steven M. Jaffe ,  Claudia B. Jaffe ,  George S. Tylinski

IPC分类号： F21S4/00 ,  F21V21/00 ,  A61B1/06 ,  F21V9/16 ,  F21V9/08 ,  F21V29/00 ,  F21V8/00 ,  F21V7/00 ,  F21V29/02 ,  G02B21/16 ,  G02B27/14 ,  G02B6/42

CPC分类号： F21V9/30 ,  A61B1/0646 ,  A61B1/0669 ,  A61B1/0684 ,  F21V7/00 ,  F21V9/083 ,  G02B6/0001 ,  G02B6/0003 ,  G02B6/0006 ,  G02B6/4296 ,  G02B21/16 ,  G02B27/141

摘要： A solid state illumination system is provided as a replacement for conventional arc light, metal halide and Xenon white-light sources for applications in microscopy, fluorescence microscopy, and endoscopy. The solid state illumination system generates high quality white light output from LED light sources. The white light output is continuous in the visible spectrum from 380 nm to 650 nm and is suitable for imaging all the most common fluorophores and fluorescent proteins. In embodiments, an LED light pipe engine is used to generate a portion of the spectral content of the white light output.

公开(公告)号：US09632302B2

公开(公告)日：2017-04-25

申请号：US14151504

申请日：2014-01-09

申请人： Lumencor, Inc.

发明人： Claudia B. Jaffe ,  Steven M. Jaffe

IPC分类号： G02B21/24 ,  G02B21/08 ,  G02B27/30

CPC分类号： G02B21/08 ,  G02B27/30

摘要： A solid state illumination system is provided as a replacement for conventional arc light, metal halide and Xenon white-light sources for applications in life sciences including, microscopy, fluorescence microscopy, and endoscopy. The solid state illumination system generates high quality white light output from LED light sources. In an embodiment, the solid state illumination system is coupled to a microscope using a liquid light guide. The liquid light guide is coupled to a microscope using an adjustable collimator which optimizes the light output for input to the optical train of the microscope.