公开(公告)号：US20220356433A1

公开(公告)日：2022-11-10

申请号：US17738833

申请日：2022-05-06

申请人： Lung Biotechnology PBC

发明人： Masoud Modaresifar ,  Mohammadali Safavieh ,  Keerthana Prakash ,  Greg Hurst ,  Daniel E. Backman ,  Derek Morris ,  Akbar Khalilpour ,  Rebecca Duffy ,  Aman Kaur ,  Isabel Arias ,  Barbara Nsiah ,  Luis Alvarez

IPC分类号： C12M1/12 ,  C12N5/071 ,  C12N5/00 ,  C12M3/06 ,  C12M1/00 ,  B01L3/00 ,  A61L27/38

摘要： The systems and methods of the present disclosure can be used to generate systems and models that are physiologically relevant to the human and animal system. These physiological conditions can be designed to mimic the actual human condition for cell differentiation and proliferation. The system and methods of this present disclosure allow the formation of an appropriate biomaterial to mimic that which exists in a human or animal scaffold. Utilizing 3D printing technology, a hydrogel scaffold can be printed at various resolution very close to human physiological geometry. Additionally, the architecture can be optimized for the selected application and appropriate cells can be seeded on the scaffold prior to testing.