公开(公告)号：US20220281178A1

公开(公告)日：2022-09-08

申请号：US17686123

申请日：2022-03-03

申请人： Lung Biotechnology PBC

发明人： Greg Hurst ,  Masoud Modaresifar ,  Mohammadali Safavieh ,  Derek Morris ,  Luis Alvarez ,  Daniel Backman

IPC分类号： B29C64/393 ,  B33Y50/02 ,  G06T17/00

摘要： An additive manufacturing device includes an output device and a controller. The output device is configured to receive at least one material to generate a component. The controller includes one or more processors configured to receive a model including a plurality of pixels representing the component, identify at least one pixel of the plurality of pixels corresponding to a first surface of the component, modify the model to adjust an exposure corresponding to the at least one pixel based on a target exposure, and control operation of the output device to cause the output device to generate the component based on the modified model.

公开(公告)号：US20230256672A1

公开(公告)日：2023-08-17

申请号：US18108904

申请日：2023-02-13

申请人： Lung Biotechnology PBC

发明人： Mohammadali Safavieh ,  Akarsh Sivaprasad ,  Mora Melican ,  Masoud Modaresifar ,  Datta Saravana Kalyan Kumar Vydiam ,  Barbara Nsiah ,  Derek Morris ,  Luis Alvarez

IPC分类号： B29C64/245 ,  B33Y30/00

CPC分类号： B29C64/245 ,  B33Y30/00 ,  B33Y10/00

摘要： A platform form an apparatus for printing a 3D model comprises a base and a print layer. The base has a first side where the first side of the base has a first surface roughness thereon. The print layer is coupled first side of the base and includes a surface. The surface of the print layer is distal from the base and has a second surface roughness which is greater than the first surface roughness so as to promote adhesion of the 3D model being printed on the platform.

公开(公告)号：US20220055289A1

公开(公告)日：2022-02-24

申请号：US17410159

申请日：2021-08-24

申请人： Lung Biotechnology PBC

发明人： Mohammadali Safavieh ,  Daniel E. Backman ,  Kalyan Vydiam ,  Masoud Modaresifar ,  Lara A. Murcin ,  Luis Alvarez ,  Derek Morris ,  Akarsh Sivaprasad

IPC分类号： B29C64/124 ,  B29C64/245 ,  B29C64/321 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y40/00 ,  B33Y70/00 ,  B33Y80/00

摘要： Apparatus and method for forming a three-dimensional object. The apparatus includes a platform on which the three-dimensional object is formed. The apparatus includes an oxygen soluble liquid having a build surface. The build surface and the platform define a build region therebetween. The apparatus includes a photosensitive liquid disposed on the oxygen soluble liquid. The density of the oxygen soluble liquid is greater than the density of the photosensitive liquid. The apparatus includes an optically transparent member. The optically transparent member supports the oxygen soluble liquid. The apparatus includes a radiation source configured to irradiate the build region through the optically transparent member and the oxygen soluble liquid to form a solid polymer from the photosensitive liquid. The apparatus includes a controller configured to advance the platform away from the build surface.

公开(公告)号：US20220356433A1

公开(公告)日：2022-11-10

申请号：US17738833

申请日：2022-05-06

申请人： Lung Biotechnology PBC

发明人： Masoud Modaresifar ,  Mohammadali Safavieh ,  Keerthana Prakash ,  Greg Hurst ,  Daniel E. Backman ,  Derek Morris ,  Akbar Khalilpour ,  Rebecca Duffy ,  Aman Kaur ,  Isabel Arias ,  Barbara Nsiah ,  Luis Alvarez

IPC分类号： C12M1/12 ,  C12N5/071 ,  C12N5/00 ,  C12M3/06 ,  C12M1/00 ,  B01L3/00 ,  A61L27/38

摘要： The systems and methods of the present disclosure can be used to generate systems and models that are physiologically relevant to the human and animal system. These physiological conditions can be designed to mimic the actual human condition for cell differentiation and proliferation. The system and methods of this present disclosure allow the formation of an appropriate biomaterial to mimic that which exists in a human or animal scaffold. Utilizing 3D printing technology, a hydrogel scaffold can be printed at various resolution very close to human physiological geometry. Additionally, the architecture can be optimized for the selected application and appropriate cells can be seeded on the scaffold prior to testing.

公开(公告)号：US20220354954A1

公开(公告)日：2022-11-10

申请号：US17738736

申请日：2022-05-06

申请人： Lung Biotechnology PBC

发明人： Mora Carolynne Melican ,  Lara Murcin ,  Barbara Nsiah ,  Richmon Lin ,  Derek Morris ,  Lina Trigg ,  Luis Alvarez ,  Mohammadali Safavieh ,  Masoud Modaresifar ,  Kalyan Vydiam

IPC分类号： A61K47/32 ,  B29C64/264 ,  B33Y10/00 ,  B33Y80/00 ,  A61L27/52 ,  B29C64/112 ,  B33Y70/10 ,  A61P9/10 ,  B29L31/00 ,  B29K105/00 ,  B29K105/20

摘要： The present disclosure provides reinforced hydrogel structures, methods of reinforcing hydrogel structures, and methods of treating ischemic disorders using the reinforced hydrogel structures.