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公开(公告)号：US06531587B2
公开(公告)日：2003-03-11
申请号：US09886150
申请日：2001-06-22
IPC分类号： C07H2104
CPC分类号： G01N33/56988 , A61K39/00 , C07K14/005 , C12N2740/16021 , C12N2740/16022 , C12N2740/16122 , C12N2740/16222 , C12Q1/703
摘要： A novel immunodeficiency virus is disclosed which has the designation MVP-5180/91 and which has been deposited with the European Collection of Animal Cell Cultures (ECACC) under No. V 920 52 318. The characteristic antigens which can be obtained from it and which can be employed for detecting antibodies against retroviruses which are associated with immunodeficiency diseases are also disclosed, as are the DNA and amino acid sequences of the virus.
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公开(公告)号：US06528626B2
公开(公告)日：2003-03-04
申请号：US09886156
申请日：2001-06-22
IPC分类号： C07K1600
CPC分类号： G01N33/56988 , A61K39/00 , C07K14/005 , C12N2740/16021 , C12N2740/16022 , C12N2740/16122 , C12N2740/16222 , C12Q1/703
摘要： A novel immunodeficiency virus is disclosed which has the designation MVP-5180/91 and which has been deposited with the European Collection of Animal Cell Cultures (ECACC) under No. V 920 52 318. The characteristic antigens which can be obtained from it and which can be employed for detecting antibodies against retroviruses which are associated with immunodeficiency diseases are also disclosed, as are the DNA and amino acid sequences of the virus.
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公开(公告)号：US06277561B1
公开(公告)日：2001-08-21
申请号：US09109916
申请日：1998-07-02
IPC分类号： C12Q170
CPC分类号： G01N33/56988 , A61K39/00 , C07K14/005 , C12N2740/16021 , C12N2740/16022 , C12N2740/16122 , C12N2740/16222 , C12Q1/703
摘要： A novel immunodeficiency virus is disclosed which has the designation MVP-5180/91 and which has been deposited with the European Collection of Animal Cell Cultures (ECACC) under No. V 920 92 318. The characteristic antigens which can be obtained from it and which can be employed for detecting antibodies against retroviruses which are associated with immuno-deficiency diseases are also disclosed, as are the DNA and amino acid sequences of the virus.
摘要翻译： 公开了一种新型免疫缺陷病毒，其具有命名为MVP-5180/91，并且已经保藏在欧洲动物细胞培养物库（ECACC）的第V 920 92 318号下。可从其中获得的特征性抗原，其中 可以用于检测与免疫缺陷相关的逆转录病毒的抗体，还公开了病毒的DNA和氨基酸序列。
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公开(公告)号：US5770427A
公开(公告)日：1998-06-23
申请号：US471770
申请日：1995-06-06
IPC分类号： A61K39/21 , A61K39/00 , A61P31/12 , A61P31/18 , C07K14/00 , C07K14/155 , C07K14/16 , C12N5/02 , C12N7/00 , C12N7/01 , C12N15/09 , C12N15/48 , C12P21/02 , C12Q1/68 , C12Q1/70 , G01N33/53 , G01N33/569 , G01N33/68 , C12N7/04
CPC分类号： G01N33/56988 , C07K14/005 , C12Q1/703 , A61K39/00 , C12N2740/16021 , C12N2740/16022 , C12N2740/16122 , C12N2740/16222
摘要： A novel immunodeficiency virus is disclosed which has the designation MVP-5180/91 (SEQ ID NO:56) and which has been deposited with the European Collection of Animal Cell Cultures (ECACC) under No. V 920 92 318. The characteristic antigens which can be obtained from it and which can be employed for detecting antibodies against retroviruses which are associated with immunodeficiency diseases are also disclosed, as are the DNA and amino acid sequences of the virus.
摘要翻译： 公开了一种新型免疫缺陷病毒，其名称为MVP-5180/91（SEQ ID NO：56），并已经在欧洲动物细胞培养物收集库（ECACC）V 920 92 318下保藏。特征抗原 可以从它获得并且可以用于检测与免疫缺陷病相关的逆转录病毒的抗体，并且还公开了病毒的DNA和氨基酸序列。
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公开(公告)号：US06551824B2
公开(公告)日：2003-04-22
申请号：US09886159
申请日：2001-06-22
IPC分类号： C12N506
CPC分类号： G01N33/56988 , A61K39/00 , C07K14/005 , C12N2740/16021 , C12N2740/16022 , C12N2740/16122 , C12N2740/16222 , C12Q1/703
摘要： A novel immunodeficiency virus is disclosed which has the designation MVP-5180/91 and which has been deposited with the European Collection of Animal Cell Cultures (ECACC) under No. V 920 52 318. The characteristic antigens which can be obtained from it and which can be employed for detecting antibodies against retroviruses which are associated with immunodeficiency diseases are also disclosed, as are the DNA and amino acid sequences of the virus.
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公开(公告)号：US06531137B2
公开(公告)日：2003-03-11
申请号：US09886149
申请日：2001-06-22
IPC分类号： A61K2104
CPC分类号： G01N33/56988 , A61K39/00 , C07K14/005 , C12N2740/16021 , C12N2740/16022 , C12N2740/16122 , C12N2740/16222 , C12Q1/703
摘要： A novel immunodeficiency virus is disclosed which has the designation MVP-5180/91 and which has been deposited with the European Collection of Animal Cell Cultures (ECACC) under No. V 920 52 318. The characteristic antigens which can be obtained from it and which can be employed for detecting antibodies against retroviruses which are associated with immunodeficiency diseases are also disclosed, as are the DNA and amino acid sequences of the virus.
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公开(公告)号：US5840480A
公开(公告)日：1998-11-24
申请号：US468059
申请日：1995-06-06
IPC分类号： A61K39/21 , A61K39/00 , A61P31/12 , A61P31/18 , C07K14/00 , C07K14/155 , C07K14/16 , C12N5/02 , C12N7/00 , C12N7/01 , C12N15/09 , C12N15/48 , C12P21/02 , C12Q1/68 , C12Q1/70 , G01N33/53 , G01N33/569 , G01N33/68 , C12N7/04
CPC分类号： G01N33/56988 , C07K14/005 , C12Q1/703 , A61K39/00 , C12N2740/16021 , C12N2740/16022 , C12N2740/16122 , C12N2740/16222
摘要： A novel immunodeficiency virus is disclosed which has the designation MVP-5180/91 (SEQ ID NO:56) and which has been deposited with the European Collection of Animal Cell Cultures (ECACC) under No. V 920 92 318. The characteristic antigens which can be obtained from it and which can be employed for detecting antibodies against retroviruses which are associated with immuno-deficiency diseases are also disclosed, as are the DNA and amino acid sequences of the virus.
摘要翻译： 公开了一种新型免疫缺陷病毒，其名称为MVP-5180/91（SEQ ID NO：56），并已经在欧洲动物细胞培养物收集库（ECACC）V 920 92 318下保藏。特征抗原 可以从它获得并且可以用于检测与免疫缺陷疾病相关的逆转录病毒的抗体，并且还公开了病毒的DNA和氨基酸序列。
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公开(公告)号：US06773915B2
公开(公告)日：2004-08-10
申请号：US10326090
申请日：2002-12-23
IPC分类号： C12N502
CPC分类号： G01N33/56988 , A61K39/00 , C07K14/005 , C12N2740/16021 , C12N2740/16022 , C12N2740/16122 , C12N2740/16222 , C12Q1/703
摘要： A novel immunodeficiency virus is disclosed which has the designation MVP-5180/91 and which has been deposited with the European Collection of Animal Cell Cultures (ECACC) under No. V 920 52 318. The characteristic antigens which can be obtained from it and which can be employed for detecting antibodies against retroviruses which are associated with immunodeficiency diseases are also disclosed, as are the DNA and amino acid sequences of the virus.
摘要翻译： 公开了一种新型免疫缺陷病毒，其名称为MVP-5180/91，并且已经在欧洲动物细胞培养物收集库（ECACC）V 920 52 318下保藏。可从其中获得的特征性抗原，其中 可以用于检测与免疫缺陷病相关的逆转录病毒的抗体，以及病毒的DNA和氨基酸序列也被公开。
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公开(公告)号：US5759770A
公开(公告)日：1998-06-02
申请号：US470202
申请日：1995-06-06
IPC分类号： A61K39/21 , A61K39/00 , A61P31/12 , A61P31/18 , C07K14/00 , C07K14/155 , C07K14/16 , C12N5/02 , C12N7/00 , C12N7/01 , C12N15/09 , C12N15/48 , C12P21/02 , C12Q1/68 , C12Q1/70 , G01N33/53 , G01N33/569 , G01N33/68 , C07K16/00 , C12N7/04
CPC分类号： G01N33/56988 , C07K14/005 , C12Q1/703 , A61K39/00 , C12N2740/16021 , C12N2740/16022 , C12N2740/16122 , C12N2740/16222
摘要： A novel immunodeficiency virus is disclosed which has the designation MVP-5180/91 (SEQ ID NO:56) and which has been deposited with the European Collection of Animal Cell Cultures (ECACC) under No. V 920 92 318. The characteristic antigens which can be obtained from it and which can be employed for detecting antibodies against retroviruses which are associated with immunodeficiency diseases are also disclosed, as are the DNA and amino acid sequences of the virus.
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10.发明授权Methodologies for the detection of human immunodeficiency virus nucleic acids employing oligonucleotide primer derived from the HIV-1 MVP5180/91 genome 有权使用衍生自HIV-1 MVP5180 / 91基因组的寡核苷酸引物检测人类免疫缺陷病毒核酸的方法公开(公告)号：US06335158B2
公开(公告)日：2002-01-01
申请号：US09131551
申请日：1998-08-10
申请人： Stefan Brust , Stefan Knapp , Manfred Gerken , Lutz G. Guertler
发明人： Stefan Brust , Stefan Knapp , Manfred Gerken , Lutz G. Guertler
IPC分类号： C12Q170
CPC分类号： C07K14/005 , A61K39/00 , C07K16/1045 , C07K2317/21 , C12N2740/16022 , C12N2740/16122 , C12N2740/16134 , C12Q1/703
摘要： The present invention is directed toward nucleic-acid based methodologies for the detection of human immunodeficiency virus (HIV) nucleic acids in a sample. A novel HIV-1 isolate, designated MVP5180/91, was isolated from a West African Cameroonian patient with immunodeficiency. Nucleic acid and amino acid sequence comparisons of this isolate, with other HIV-1 strains of subtypes A-E and HIV-2 isolates, demonstrated that this virus shares only limited homology with other known HIV-1 and -2 isolates. However, this virus does display some genetic relatedness to another Cameroonian isolate designated ANT-70. These viruses form the basis for a new HIV-1 group which has been designated subtype O. An immunologically important epitope, corresponding to amino acids 601-623 of the MVP5180/91 transmembrane envelope glycoprotein, was identified. Labeled nucleic acids can be prepared from the nucleotide sequence encoding this region and employed in standard hybridization assays to detect HIV-1 nucleic acids. Alternatively, oligonucleotide primers can also be prepared from this region and employed in polymerase chain reaction (PCR) assays to detect viral-specific nucleic acids.
摘要翻译： 本发明涉及用于检测样品中的人类免疫缺陷病毒（HIV）核酸的基于核酸的方法。 从具有免疫缺陷的西非喀麦隆患者中分离出一种名为MVP5180 / 91的新型HIV-1分离株。 该分离株与其他HIV-1亚型A-E和HIV-2分离株的核酸和氨基酸序列比较表明，该病毒与其他已知的HIV-1和-2分离株仅具有有限的同源性。 然而，这种病毒确实显示与另一个指定为ANT-70的喀麦隆分离株有一些遗传相关性。 这些病毒构成了已被指定为亚型O的新的HIV-1组的基础。鉴定了与MVP5180 / 91跨膜包膜糖蛋白的氨基酸601-623相当的免疫重要的表位。 标记的核酸可以从编码该区域的核苷酸序列制备，并用于标准杂交测定以检测HIV-1核酸。 或者，也可以从该区域制备寡核苷酸引物，并用于聚合酶链反应（PCR）测定中以检测病毒特异性核酸。
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