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公开(公告)号:US20050020823A1
公开(公告)日:2005-01-27
申请号:US10840948
申请日:2004-05-07
申请人: Ly Phan , Yao-Ling Qiu , Yat Or , Nha Vo , Tianying Jian , Ying Hou , Marina BusuyeK
发明人: Ly Phan , Yao-Ling Qiu , Yat Or , Nha Vo , Tianying Jian , Ying Hou , Marina BusuyeK
CPC分类号: C07H17/08
摘要: There are described novel 5-O-mycaminosyltylonide (OMT) analogs possessing increased antibacterial activity toward Gram positive and Gram negative bacteria as well as macrolide resistant Gram positives and pharmaceutically acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier. Also described are a method for treating bacterial infections by administering to a patient a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for the preparation of such compounds
摘要翻译: 描述了具有对革兰氏阳性和革兰氏阴性细菌以及大环内酯抗性革兰氏阳性和药学上可接受的组合物具有增加的抗细菌活性的新型5-O-碳霉糖基托伦(OMT)类似物,其包含治疗有效量的本发明化合物与 药学上可接受的载体。 还描述了通过向患者施用含有治疗有效量的本发明化合物的药物组合物和用于制备这些化合物的方法来治疗细菌感染的方法
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公开(公告)号:US20050159370A1
公开(公告)日:2005-07-21
申请号:US11042720
申请日:2005-01-25
申请人: Yat Or , Guoqiang Wang , Ly Phan , Deqiang Niu , Nha Vo , Yao-Ling Qiu , Yanchun Wang , Marina Busuyek , Ying Hou , Yulin Peng , Heejin Kim , Tongzhu Liu , Jay Farmer , Guoyou Xu
发明人: Yat Or , Guoqiang Wang , Ly Phan , Deqiang Niu , Nha Vo , Yao-Ling Qiu , Yanchun Wang , Marina Busuyek , Ying Hou , Yulin Peng , Heejin Kim , Tongzhu Liu , Jay Farmer , Guoyou Xu
IPC分类号: A61K31/7052 , A61K45/06 , C07H17/08
CPC分类号: C07H17/08 , A61K31/7052 , A61K45/06 , Y02A50/401 , Y02A50/478 , A61K2300/00
摘要: The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
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公开(公告)号:US20050037982A1
公开(公告)日:2005-02-17
申请号:US10429485
申请日:2003-05-05
申请人: Yat Or , Guoqiang Wang , Ly Phan , Deqiang Niu , Nha Vo , Yao-Ling Qiu , Yanchun Wang , Marina Busuyek , Ying Hou , Yulin Peng , Heejin Kim , Tongzhu Liu , Jay Farmer , Guoyou Xu
发明人: Yat Or , Guoqiang Wang , Ly Phan , Deqiang Niu , Nha Vo , Yao-Ling Qiu , Yanchun Wang , Marina Busuyek , Ying Hou , Yulin Peng , Heejin Kim , Tongzhu Liu , Jay Farmer , Guoyou Xu
IPC分类号: C07H17/08 , A61K31/7048
CPC分类号: C07H17/08
摘要: The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
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公开(公告)号:US20060252712A1
公开(公告)日:2006-11-09
申请号:US11416609
申请日:2006-05-03
申请人: Guoqiang Wang , Ly Phan , Yat Or , Yao-ling Qiu , Deqiang Niu , Yulin Peng , Marina Busuyek , Yanchun Wang , Suanne Nakajima
发明人: Guoqiang Wang , Ly Phan , Yat Or , Yao-ling Qiu , Deqiang Niu , Yulin Peng , Marina Busuyek , Yanchun Wang , Suanne Nakajima
IPC分类号: A61K31/7052 , C07H17/08
CPC分类号: C07H17/08
摘要: The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes processes by which to make the compounds of the present invention.
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公开(公告)号:US20060252710A1
公开(公告)日:2006-11-09
申请号:US11122251
申请日:2005-05-04
申请人: Guoqiang Wang , Ly Phan , Yat Or , Yao-Ling Qiu , Deqiang Niu , Yulin Peng , Marina Busuyek , Yanchun Wang , Suanne Nakajima
发明人: Guoqiang Wang , Ly Phan , Yat Or , Yao-Ling Qiu , Deqiang Niu , Yulin Peng , Marina Busuyek , Yanchun Wang , Suanne Nakajima
IPC分类号: C07H17/08 , A61K31/7052
CPC分类号: C07H17/08
摘要: The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes processes by which to make the compounds of the present invention.
摘要翻译: 本发明公开了式I化合物或其药学上可接受的盐,酯或前药:其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物,用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。
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公开(公告)号:US20050187169A1
公开(公告)日:2005-08-25
申请号:US11029640
申请日:2005-01-05
IPC分类号: A61K31/70 , A61K31/7048 , C07H17/08
CPC分类号: C07H17/08
摘要: The present invention discloses compounds of formulaes I, II, III, or IV, or a racemate, enantiomer, regioisomer, salt, ester or prodrug thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
摘要翻译: 本发明公开了式I,II,III或IV的化合物或其外消旋体,对映异构体,区域异构体,盐,酯或前药:其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物,用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。
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公开(公告)号:US20080039406A1
公开(公告)日:2008-02-14
申请号:US11828473
申请日:2007-07-26
申请人: Yao-Ling Qiu , Tongzhu Liu , Yat Or , Ly Phan
发明人: Yao-Ling Qiu , Tongzhu Liu , Yat Or , Ly Phan
IPC分类号: A61K31/7048 , A61P25/00 , A61P31/04 , C07H17/08
CPC分类号: C07H17/08
摘要: The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
摘要翻译: 本发明公开了式I化合物或其药学上可接受的盐,酯或前药:其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物,用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。
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公开(公告)号:US20060069048A1
公开(公告)日:2006-03-30
申请号:US11236043
申请日:2005-09-27
申请人: Yat Or , Yao-Ling Qiu , Guoqiang Wang , Deqiang Niu , Ly Phan
发明人: Yat Or , Yao-Ling Qiu , Guoqiang Wang , Deqiang Niu , Ly Phan
IPC分类号: C07H17/08 , A61K31/7052
CPC分类号: C07H17/08
摘要: The present invention discloses compounds of formulae I and II, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
摘要翻译: 本发明公开了式I和II的化合物或其药学上可接受的盐,酯或前药:
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公开(公告)号:US20050171033A1
公开(公告)日:2005-08-04
申请号:US11031465
申请日:2005-01-07
申请人: Yao-Ling Qiu , Deqiang Niu , Zhe Wang , Ly Phan , Yat Or
发明人: Yao-Ling Qiu , Deqiang Niu , Zhe Wang , Ly Phan , Yat Or
CPC分类号: C07H17/08
摘要: The present invention discloses compounds of formula I, II, III, or IV, or a racemate, enantiomer, regioisomer, salt, ester or prodrug thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
摘要翻译: 本发明公开了式I,II,III或IV的化合物或其外消旋物,对映异构体,区域异构体,盐,酯或前药:其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物,用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。
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公开(公告)号:US20060154881A1
公开(公告)日:2006-07-13
申请号:US11324502
申请日:2006-01-03
申请人: Yat Or , Ly Phan , Guoqiang Wang , Yanchun Wang , Yulin Peng
发明人: Yat Or , Ly Phan , Guoqiang Wang , Yanchun Wang , Yulin Peng
IPC分类号: A61K31/7052 , C07H17/08
CPC分类号: C07H17/08
摘要: The present invention discloses compounds of formulae I and II, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
摘要翻译: 本发明公开了式I和II的化合物或其药学上可接受的盐,酯或前药:其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物,用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。
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