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    23-O-substituted 5-O-mycaminosyltylonide derivatives
    1.
    发明申请
    23-O-substituted 5-O-mycaminosyltylonide derivatives 审中-公开
    23-O-取代的5-O-碳霉糖基海藻衍生物

    公开(公告)号：US20050020823A1

    公开(公告)日：2005-01-27

    申请号：US10840948

    申请日：2004-05-07

    申请人： Ly Phan ,  Yao-Ling Qiu ,  Yat Or ,  Nha Vo ,  Tianying Jian ,  Ying Hou ,  Marina BusuyeK

    发明人： Ly Phan ,  Yao-Ling Qiu ,  Yat Or ,  Nha Vo ,  Tianying Jian ,  Ying Hou ,  Marina BusuyeK

    IPC分类号： A61P31/04 ,  C07H17/08

    CPC分类号： C07H17/08

    摘要： There are described novel 5-O-mycaminosyltylonide (OMT) analogs possessing increased antibacterial activity toward Gram positive and Gram negative bacteria as well as macrolide resistant Gram positives and pharmaceutically acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier. Also described are a method for treating bacterial infections by administering to a patient a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for the preparation of such compounds

    摘要翻译： 描述了具有对革兰氏阳性和革兰氏阴性细菌以及大环内酯抗性革兰氏阳性和药学上可接受的组合物具有增加的抗细菌活性的新型5-O-碳霉糖基托伦（OMT）类似物，其包含治疗有效量的本发明化合物与 药学上可接受的载体。 还描述了通过向患者施用含有治疗有效量的本发明化合物的药物组合物和用于制备这些化合物的方法来治疗细菌感染的方法

    23-O-substituted 5-O-mycaminosyltylonide derivatives
    4.
    发明授权
    23-O-substituted 5-O-mycaminosyltylonide derivatives 失效
    23-O-取代的5-O-碳霉糖基海藻衍生物

    公开(公告)号：US06753415B2

    公开(公告)日：2004-06-22

    申请号：US10126076

    申请日：2002-04-19

    申请人： Ly Tam Phan ,  Yao-Ling Qiu ,  Yat Sun Or ,  Nha Vo ,  Tianying Jian ,  Ying Hou ,  Marina Busuyek

    发明人： Ly Tam Phan ,  Yao-Ling Qiu ,  Yat Sun Or ,  Nha Vo ,  Tianying Jian ,  Ying Hou ,  Marina Busuyek

    IPC分类号： A61K317048

    CPC分类号： C07H17/08

    摘要： There are described novel 5-O-mycaminosyltylonide (OMT) analogs possessing increased antibacterial activity toward Gram positive and Gram negative bacteria as well as macrolide resistant Gram positives and pharmaceutically acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier. Also described are a method for treating bacterial infections by administering to a patient a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for the preparation of such compounds

    摘要翻译： 描述了具有对革兰氏阳性和革兰氏阴性细菌以及大环内酯抗性革兰氏阳性和药学上可接受的组合物具有增加的抗细菌活性的新型5-O-碳霉糖基托伦（OMT）类似物，其包含治疗有效量的本发明化合物与 药学上可接受的载体。 还描述了通过向患者施用含有治疗有效量的本发明化合物的药物组合物和用于制备这些化合物的方法来治疗细菌感染的方法

    6-11 Bridged oxime erythromycin derivatives
    5.
    发明申请
    6-11 Bridged oxime erythromycin derivatives 审中-公开
    6-11桥接肟红霉素衍生物

    公开(公告)号：US20060252710A1

    公开(公告)日：2006-11-09

    申请号：US11122251

    申请日：2005-05-04

    申请人： Guoqiang Wang ,  Ly Phan ,  Yat Or ,  Yao-Ling Qiu ,  Deqiang Niu ,  Yulin Peng ,  Marina Busuyek ,  Yanchun Wang ,  Suanne Nakajima

    发明人： Guoqiang Wang ,  Ly Phan ,  Yat Or ,  Yao-Ling Qiu ,  Deqiang Niu ,  Yulin Peng ,  Marina Busuyek ,  Yanchun Wang ,  Suanne Nakajima

    IPC分类号： C07H17/08 ,  A61K31/7052

    CPC分类号： C07H17/08

    摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes processes by which to make the compounds of the present invention.

    摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

    5-O-mycaminosyltylonide derivatives
    6.
    发明授权
    5-O-mycaminosyltylonide derivatives 失效

    公开(公告)号：US06710034B2

    公开(公告)日：2004-03-23

    申请号：US10125840

    申请日：2002-04-19

    申请人： Ly Tam Phan ,  Nha Vo ,  Yat Sun Or ,  Yao-Ling Qiu ,  Ying Hou

    发明人： Ly Tam Phan ,  Nha Vo ,  Yat Sun Or ,  Yao-Ling Qiu ,  Ying Hou

    IPC分类号： A61K3170

    CPC分类号： C07H17/08

    摘要： There are described novel 5-O-mycaminosyltylonide derivatives and pharmaceutically acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier. Also described are a method for treating bacterial infections by administering to an animal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for the preparation of such compounds.

    3,6-BRIDGED TYLOSIN DERIVATIVES
    7.
    发明申请
    3,6-BRIDGED TYLOSIN DERIVATIVES 审中-公开
    3,6-桥状酪氨酸衍生物

    公开(公告)号：US20080039406A1

    公开(公告)日：2008-02-14

    申请号：US11828473

    申请日：2007-07-26

    申请人： Yao-Ling Qiu ,  Tongzhu Liu ,  Yat Or ,  Ly Phan

    发明人： Yao-Ling Qiu ,  Tongzhu Liu ,  Yat Or ,  Ly Phan

    IPC分类号： A61K31/7048 ,  A61P25/00 ,  A61P31/04 ,  C07H17/08

    CPC分类号： C07H17/08

    摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

    摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

    Novel bicyclic 9a-azalide derivatives
    8.
    发明申请
    Novel bicyclic 9a-azalide derivatives 失效
    新型双环9a-氮杂衍生物

    公开(公告)号：US20060069048A1

    公开(公告)日：2006-03-30

    申请号：US11236043

    申请日：2005-09-27

    申请人： Yat Or ,  Yao-Ling Qiu ,  Guoqiang Wang ,  Deqiang Niu ,  Ly Phan

    发明人： Yat Or ,  Yao-Ling Qiu ,  Guoqiang Wang ,  Deqiang Niu ,  Ly Phan

    IPC分类号： C07H17/08 ,  A61K31/7052

    CPC分类号： C07H17/08

    摘要： The present invention discloses compounds of formulae I and II, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

    摘要翻译： 本发明公开了式I和II的化合物或其药学上可接受的盐，酯或前药：