公开(公告)号：US11789028B2

公开(公告)日：2023-10-17

申请号：US15459463

申请日：2017-03-15

Applicant: MCMASTER UNIVERSITY ,  Yale University

Inventor： Peter Kavsak ,  Richard Whitlock ,  John Eikelboom ,  Chirag R. Parikh

IPC: G01N33/68 ,  C12Q1/6883

CPC classification number: G01N33/6893 ,  C12Q1/6883 ,  G01N33/6869 ,  C12Q2600/158 ,  G01N2333/47 ,  G01N2333/5412 ,  G01N2333/5428 ,  G01N2800/347 ,  G01N2800/50

Abstract: A method for determining the risk of acute kidney injury (AKI) in a mammal following cardiac surgery is provided. The method comprises determining the sample value of IL-6 or hFABP concentration, or the ratio of IL-6 to IL-10, in a biological sample from the mammal, either prior to cardiac surgery or within 6 hours following surgery; comparing the sample value to a corresponding reference value; and determining that the mammal is at risk of acute kidney injury following cardiac surgery if the sample value is greater than the corresponding reference value.

公开(公告)号：US20170248611A1

公开(公告)日：2017-08-31

申请号：US15459463

申请日：2017-03-15

Applicant: MCMASTER UNIVERSITY ,  Yale University

Inventor： Peter Kavsak ,  Richard Whitlock ,  John Eikelboom ,  Chirag R. Parikh

IPC: G01N33/68

CPC classification number: G01N33/6893 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N33/6869 ,  G01N2333/47 ,  G01N2333/5412 ,  G01N2333/5428 ,  G01N2800/347 ,  G01N2800/50

Abstract: A method for determining the risk of acute kidney injury (AKI) in a mammal following cardiac surgery is provided. The method comprises determining the sample value of IL-6 or hFABP concentration, or the ratio of IL-6 to IL-10, in a biological sample from the mammal, either prior to cardiac surgery or within 6 hours following surgery; comparing the sample value to a corresponding reference value; and determining that the mammal is at risk of acute kidney injury following cardiac surgery if the sample value is greater than the corresponding reference value.

公开(公告)号：US20140200184A1

公开(公告)日：2014-07-17

申请号：US14166264

申请日：2014-01-28

Applicant: YALE UNIVERSITY

Inventor： Jack A. Elias ,  Chirag R. Parikh ,  Lloyd G. Cantley

IPC: G01N33/68 ,  A61K38/47 ,  C12Q1/68

CPC classification number: A61K38/47 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N33/6887 ,  G01N33/6893 ,  G01N2333/924 ,  G01N2800/347 ,  G01N2800/52 ,  G01N2800/54 ,  G01N2800/56

Abstract: The present invention provides compositions and methods for the detection, treatment, and prevention of a kidney injury. The invention relates to the discovery that chitinase 3-like 1/Brp-39/YKL-40 serves as both a biomarker for the degree of kidney injury and a critical mediator of a reparative response in the kidney.

Abstract translation: 本发明提供了用于检测，治疗和预防肾损伤的组合物和方法。 本发明涉及几丁质酶3样1 / Brp-39 / YKL-40用作肾损伤程度的生物标志物和肾脏修复反应的关键介质的发现。