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公开(公告)号：US10775388B2
公开(公告)日：2020-09-15
申请号：US15106223
申请日：2015-02-05
Applicant: MEDIMMUNE, LLC , ABBOTT LABORATORIES
Inventor： Partha S. Chowdhury , Reena Varkey , Meina Liang , Yen-Wah Lee , Katie Streicher , Koustubh Ranade , Ethan Grant , Lydia Greenlees , Yihong Yao , Melissa Parker , Gerard Davis , Nicolette Jeanblanc , Susan Brophy , Bruce Dille
IPC: G01N33/68 , C07K16/18 , A61P11/06 , A61P17/00 , A61P11/00 , A61K9/00 , A61K31/137 , A61K31/56 , A61K31/58 , A61K39/395 , C07K16/24 , C07K16/28 , A61K39/00
Abstract: This disclosure provides a robust, sensitive, and specific assay for the detection and measurement of periostin levels in samples obtained from human patients having, or suspected of having an IL-13-mediated disease or disorder. The disclosure further provides novel antiperiostin monoclonal antibodies that recognize at least isoforms 1, 2, 3, 4, 7, and 8 of human periostin, and assay kits comprising one or more of these antibodies.
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公开(公告)号：US20180196065A1
公开(公告)日：2018-07-12
申请号：US15106223
申请日：2015-02-05
Applicant: MEDIMMUNE, LLC , ABBOTT LABORATORIES
Inventor： Partha Chowdhury , Reena Varkey , Meina Liang , Yen-Wah Lee , Katie Streicher , Koustubh Ranade , Ethan Grant , Lydia Greenlees , Yihong Yao , Melissa Parker , Gerard Davis , Nicolette Jeanblanc , Susan Brophy , Bruce Dille
IPC: G01N33/68 , A61P11/06 , A61P11/00 , A61P17/00 , C07K16/24 , C07K16/28 , A61K31/56 , A61K31/58 , A61K31/137 , A61K39/395 , A61K9/00 , C07K16/18
Abstract: This disclosure provides a robust, sensitive, and specific assay for the detection and measurement of periostin levels in samples obtained from human patients having, or suspected of having an IL-13-mediated disease or disorder. The disclosure further provides novel antiperiostin monoclonal antibodies that recognize at least isoforms 1, 2, 3, 4, 7, and 8 of human periostin, and assay kits comprising one or more of these antibodies.
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公开(公告)号：US10597439B2
公开(公告)日：2020-03-24
申请号：US14356500
申请日：2012-11-06
Applicant: MEDIMMUNE, LLC , MEDIMMUNE LIMITED
Inventor： Antonio Digiandomenico , Paul Warrener , Charles Stover , Bret Sellman , Ralph Minter , Sandrine Guillard , Steven Rust , Mladen Tomich , Vignesh Venkatraman , Reena Varkey , Li Peng , Melissa Damschroder , Partha Chowdhury , Nazzareno Dimasi , Ryan Fleming , Binyam Bezabeh , Changshou Gao , Godfrey Rainey , Cuihua Gao
Abstract: This disclosure relates to combination therapies comprising anti-Pseudomonas Psl and PcrV binding molecules and related compositions, for use in prevention and treatment of Pseudomonas infection.
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公开(公告)号：US11912782B2
公开(公告)日：2024-02-27
申请号：US17215479
申请日：2021-03-29
Applicant: MedImmune, LLC
Inventor： Krista Kinneer , Reena Varkey , Xiaodong Xiao , Elaine M. Hurt , David Tice
IPC: C07K16/30 , C07K16/28 , A61K47/68 , A61P35/00 , A61K31/202 , A61K31/4741 , A61K31/551 , A61K31/7048 , C12N15/62 , A61K39/00
CPC classification number: C07K16/3061 , A61K31/202 , A61K31/4741 , A61K31/551 , A61K31/7048 , A61K47/6803 , A61K47/6849 , A61K47/6867 , A61P35/00 , C07K16/2878 , C12N15/62 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/73 , C07K2317/77 , C07K2317/92
Abstract: The disclosure is directed to an antibody-drug conjugate (ADC) comprising a monoclonal antibody, or an antigen-binding fragment thereof, directed against B-cell maturation antigen (BCMA) conjugated to a cytotoxin. The disclosure also provides compositions comprising the antibody-drug conjugate and methods of killing multiple myeloma cells (including multiple myeloma stems cells) that express BCMA by contacting multiple myeloma cells with the ADC.
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公开(公告)号：US20240294666A1
公开(公告)日：2024-09-05
申请号：US18414892
申请日：2024-01-17
Applicant: MedImmune, LLC
Inventor： Krista Kinneer , Reena Varkey , Xiaodong Xiao , Elaine M Hurt , David Tice
IPC: C07K16/30 , A61K31/202 , A61K31/4741 , A61K31/551 , A61K31/7048 , A61K39/00 , A61K47/68 , A61P35/00 , C07K16/28 , C12N15/62
CPC classification number: C07K16/3061 , A61K31/202 , A61K31/4741 , A61K31/551 , A61K31/7048 , A61K47/6803 , A61K47/6849 , A61K47/6867 , A61P35/00 , C07K16/2878 , C12N15/62 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/73 , C07K2317/77 , C07K2317/92
Abstract: The disclosure is directed to an antibody-drug conjugate (ADC) comprising a monoclonal antibody, or an antigen-binding fragment thereof, directed against B-cell maturation antigen (BCMA) conjugated to a cytotoxin. The disclosure also provides compositions comprising the antibody-drug conjugate and methods of killing multiple myeloma cells (including multiple myeloma stems cells) that express BCMA by contacting multiple myeloma cells with the ADC.
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Patent Agency Ranking
公开(公告)号：US10988546B2
公开(公告)日：2021-04-27
申请号：US16050944
申请日：2018-07-31
Applicant: MedImmune, LLC
Inventor： Krista Kinneer , Reena Varkey , Xiaodong Xiao , Elaine M. Hurt , David Tice
IPC: C07K16/30 , C07K16/28 , A61K47/68 , A61P35/00 , A61K31/202 , A61K31/4741 , A61K31/551 , A61K31/7048 , C12N15/62 , A61K39/00
Abstract: The disclosure is directed to an antibody-drug conjugate (ADC) comprising a monoclonal antibody, or an antigen-binding fragment thereof, directed against B-cell maturation antigen (BCMA) conjugated to a cytotoxin. The disclosure also provides compositions comprising the antibody-drug conjugate and methods of killing multiple myeloma cells (including multiple myeloma stems cells) that express BCMA by contacting multiple myeloma cells with the ADC.
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公开(公告)号：US09862762B2
公开(公告)日：2018-01-09
申请号：US15104502
申请日：2015-02-05
Applicant: MEDIMMUNE, LLC
Inventor： Partha Chowdhury , Reena Varkey , Meina Liang , Yen-Wah Lee , Katie Streicher , Koustubh Ranade , Ethan Grant , Lydia Greenlees , Yihong Yao , Melissa Parker
CPC classification number: G01N33/6884 , A61K9/0019 , A61K9/0053 , A61K9/0073 , A61K31/137 , A61K31/56 , A61K31/58 , A61K39/3955 , A61K2039/54 , A61P11/00 , A61P11/06 , A61P17/00 , C07K16/18 , C07K16/244 , C07K16/2866 , C07K2317/33 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2319/00 , C07K2319/30 , G01N33/68 , G01N33/6869 , G01N33/6881 , G01N2800/12 , G01N2800/122 , G01N2800/202 , G01N2800/52
Abstract: This disclosure provides a robust, sensitive, and specific assay for the detection and measurement of periostin levels in samples obtained from human patients having, or suspected of having an IL-13-mediated disease or disorder. The disclosure further provides novel antiperiostin monoclonal antibodies that recognize at least isoforms 1, 2, 3, 4, 7, and 8 of human periostin, and assay kits comprising one or more of these antibodies.
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公开(公告)号：US20180179272A1
公开(公告)日：2018-06-28
申请号：US15821716
申请日：2017-11-22
Applicant: MEDIMMUNE, LLC
Inventor： Partha Chowdhury , Reena Varkey , Meina Liang , Yen-Wah Lee , Katie Streicher , Koustubh Ranade , Ethan Grant , Lydia Greenlees , Yihong Yao , Melissa Parker
CPC classification number: G01N33/6884 , A61K9/0019 , A61K9/0053 , A61K9/0073 , A61K31/137 , A61K31/56 , A61K31/58 , A61K39/3955 , A61K2039/54 , A61P11/00 , A61P11/06 , A61P17/00 , C07K16/18 , C07K16/244 , C07K16/2866 , C07K2317/33 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2319/00 , C07K2319/30 , G01N33/68 , G01N33/6869 , G01N33/6881 , G01N2800/12 , G01N2800/122 , G01N2800/202 , G01N2800/52
Abstract: This disclosure provides a robust, sensitive, and specific assay for the detection and measurement of periostin levels in samples obtained from human patients having, or suspected of having an IL-13-mediated disease or disorder. The disclosure further provides novel antiperiostin monoclonal antibodies that recognize at least isoforms 1, 2, 3, 4, 7, and 8 of human periostin, and assay kits comprising one or more of these antibodies.
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公开(公告)号：US20170114151A1
公开(公告)日：2017-04-27
申请号：US15230893
申请日：2016-08-08
Applicant: MedImmune, LLC , MedImmune Limited
Inventor： Nazzareno Dimasi , Ryan Fleming , Binyam Bezabeh , Changshou Gao , Antonio Digiandomenico , Paul Warrener , Charles Stover , Bret Sellman , Mladen Tomich , Reena Varkey , Partha S. Chowdhury , Ralph Minter , Sandrine Guillard , Steven Rust , Vignesh Venkatraman
IPC: C07K16/46
CPC classification number: C07K16/2863 , C07K16/00 , C07K16/1214 , C07K16/22 , C07K16/468 , C07K2317/31 , C07K2317/35 , C07K2317/41 , C07K2317/51 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/55 , C07K2317/56 , C07K2317/622 , C07K2317/64 , C07K2317/66 , C07K2317/73 , C07K2317/76 , C07K2317/94
Abstract: The disclosure generally provides proteins that bind two epitopes (e.g., a first and a second epitope) and that are bivalent for binding to each of the first and second epitopes. The disclosure also provides compositions comprising such proteins, nucleic acid molecules encoding such proteins and methods of making and using such proteins.
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公开(公告)号：US09580509B2
公开(公告)日：2017-02-28
申请号：US14356434
申请日：2012-11-06
Applicant: MedImmune, LLC
Inventor： Nazzareno Dimasi , Ryan Fleming , Binyam Bezabeh , Changshou Gao , Antonio Digiandomenico , Paul Warrener , Charles Stover , Bret Sellman , Mladen Tomich , Reena Varkey , Partha S. Chowdhury , Ralph Minter , Sandrine Guillard , Steven Rust , Vignesh Venkatraman
CPC classification number: C07K16/2863 , C07K16/00 , C07K16/1214 , C07K16/22 , C07K16/468 , C07K2317/31 , C07K2317/35 , C07K2317/41 , C07K2317/51 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/55 , C07K2317/56 , C07K2317/622 , C07K2317/64 , C07K2317/66 , C07K2317/73 , C07K2317/76 , C07K2317/94
Abstract: The disclosure generally provides proteins that bind two epitopes (e.g., a first and a second epitope) and that are bivalent for binding to each of the first and second epitopes. The disclosure also provides compositions comprising such proteins, nucleic acid molecules encoding such proteins and methods of making and using such proteins.
Abstract translation: 本公开通常提供结合两个表位（例如，第一和第二表位）的蛋白质，并且二价结合到第一和第二表位中的每一个。 本公开还提供了包含这种蛋白质的组合物，编码这种蛋白质的核酸分子以及制备和使用这些蛋白质的方法。
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