公开(公告)号：US10775388B2

公开(公告)日：2020-09-15

申请号：US15106223

申请日：2015-02-05

Applicant: MEDIMMUNE, LLC ,  ABBOTT LABORATORIES

Inventor： Partha S. Chowdhury ,  Reena Varkey ,  Meina Liang ,  Yen-Wah Lee ,  Katie Streicher ,  Koustubh Ranade ,  Ethan Grant ,  Lydia Greenlees ,  Yihong Yao ,  Melissa Parker ,  Gerard Davis ,  Nicolette Jeanblanc ,  Susan Brophy ,  Bruce Dille

IPC: G01N33/68 ,  C07K16/18 ,  A61P11/06 ,  A61P17/00 ,  A61P11/00 ,  A61K9/00 ,  A61K31/137 ,  A61K31/56 ,  A61K31/58 ,  A61K39/395 ,  C07K16/24 ,  C07K16/28 ,  A61K39/00

Abstract: This disclosure provides a robust, sensitive, and specific assay for the detection and measurement of periostin levels in samples obtained from human patients having, or suspected of having an IL-13-mediated disease or disorder. The disclosure further provides novel antiperiostin monoclonal antibodies that recognize at least isoforms 1, 2, 3, 4, 7, and 8 of human periostin, and assay kits comprising one or more of these antibodies.

公开(公告)号：US20180196065A1

公开(公告)日：2018-07-12

申请号：US15106223

申请日：2015-02-05

Applicant: MEDIMMUNE, LLC ,  ABBOTT LABORATORIES

Inventor： Partha Chowdhury ,  Reena Varkey ,  Meina Liang ,  Yen-Wah Lee ,  Katie Streicher ,  Koustubh Ranade ,  Ethan Grant ,  Lydia Greenlees ,  Yihong Yao ,  Melissa Parker ,  Gerard Davis ,  Nicolette Jeanblanc ,  Susan Brophy ,  Bruce Dille

IPC: G01N33/68 ,  A61P11/06 ,  A61P11/00 ,  A61P17/00 ,  C07K16/24 ,  C07K16/28 ,  A61K31/56 ,  A61K31/58 ,  A61K31/137 ,  A61K39/395 ,  A61K9/00 ,  C07K16/18

Abstract: This disclosure provides a robust, sensitive, and specific assay for the detection and measurement of periostin levels in samples obtained from human patients having, or suspected of having an IL-13-mediated disease or disorder. The disclosure further provides novel antiperiostin monoclonal antibodies that recognize at least isoforms 1, 2, 3, 4, 7, and 8 of human periostin, and assay kits comprising one or more of these antibodies.

公开(公告)号：US09862762B2

公开(公告)日：2018-01-09

申请号：US15104502

申请日：2015-02-05

Applicant: MEDIMMUNE, LLC

Inventor： Partha Chowdhury ,  Reena Varkey ,  Meina Liang ,  Yen-Wah Lee ,  Katie Streicher ,  Koustubh Ranade ,  Ethan Grant ,  Lydia Greenlees ,  Yihong Yao ,  Melissa Parker

IPC: C07K16/18 ,  G01N33/68

CPC classification number: G01N33/6884 ,  A61K9/0019 ,  A61K9/0053 ,  A61K9/0073 ,  A61K31/137 ,  A61K31/56 ,  A61K31/58 ,  A61K39/3955 ,  A61K2039/54 ,  A61P11/00 ,  A61P11/06 ,  A61P17/00 ,  C07K16/18 ,  C07K16/244 ,  C07K16/2866 ,  C07K2317/33 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/30 ,  G01N33/68 ,  G01N33/6869 ,  G01N33/6881 ,  G01N2800/12 ,  G01N2800/122 ,  G01N2800/202 ,  G01N2800/52

Abstract: This disclosure provides a robust, sensitive, and specific assay for the detection and measurement of periostin levels in samples obtained from human patients having, or suspected of having an IL-13-mediated disease or disorder. The disclosure further provides novel antiperiostin monoclonal antibodies that recognize at least isoforms 1, 2, 3, 4, 7, and 8 of human periostin, and assay kits comprising one or more of these antibodies.

公开(公告)号：US20180179272A1

公开(公告)日：2018-06-28

申请号：US15821716

申请日：2017-11-22

Applicant: MEDIMMUNE, LLC

Inventor： Partha Chowdhury ,  Reena Varkey ,  Meina Liang ,  Yen-Wah Lee ,  Katie Streicher ,  Koustubh Ranade ,  Ethan Grant ,  Lydia Greenlees ,  Yihong Yao ,  Melissa Parker

IPC: C07K16/18 ,  G01N33/68

CPC classification number: G01N33/6884 ,  A61K9/0019 ,  A61K9/0053 ,  A61K9/0073 ,  A61K31/137 ,  A61K31/56 ,  A61K31/58 ,  A61K39/3955 ,  A61K2039/54 ,  A61P11/00 ,  A61P11/06 ,  A61P17/00 ,  C07K16/18 ,  C07K16/244 ,  C07K16/2866 ,  C07K2317/33 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/30 ,  G01N33/68 ,  G01N33/6869 ,  G01N33/6881 ,  G01N2800/12 ,  G01N2800/122 ,  G01N2800/202 ,  G01N2800/52

Abstract: This disclosure provides a robust, sensitive, and specific assay for the detection and measurement of periostin levels in samples obtained from human patients having, or suspected of having an IL-13-mediated disease or disorder. The disclosure further provides novel antiperiostin monoclonal antibodies that recognize at least isoforms 1, 2, 3, 4, 7, and 8 of human periostin, and assay kits comprising one or more of these antibodies.

公开(公告)号：US10006026B2

公开(公告)日：2018-06-26

申请号：US14775233

申请日：2014-03-12

Applicant: MedImmune, LLC

Inventor： Katie Streicher ,  Jonathan Jacobs ,  Robert W. Georgantas, III ,  Lydia Greenlees ,  Koustubh Ranade ,  Michael Bowen

IPC: C12N15/113 ,  C12P21/02 ,  C07K14/705 ,  C07K16/00 ,  C07K16/42 ,  C12N9/00

CPC classification number: C12N15/113 ,  C07K14/705 ,  C07K16/00 ,  C07K16/4208 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/22 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/40 ,  C07K2317/565 ,  C07K2317/622 ,  C12N9/00 ,  C12N2310/113 ,  C12N2330/50 ,  C12N2501/65 ,  C12N2799/027 ,  C12P21/02 ,  C12Q2600/178

Abstract: Disclosed herein is a method for producing a recombinant polypeptide in a mammalian cell culture in which the mammalian cells have a modified microRNA activity level. In one embodiment, a microRNA activity level is increased. In another embodiment, a microRNA activity level is decreased. In a more particular embodiment, the mammalian cells have a reduced miRNA-let-7a activity level.

公开(公告)号：US20160311894A1

公开(公告)日：2016-10-27

申请号：US15104502

申请日：2015-02-05

Applicant: MEDIMMUNE, LLC

Inventor： Partha Chowdhury ,  Reena Varkey ,  Meina Liang ,  Yen-Wah Lee ,  Katie Streicher ,  Koustubh Ranade ,  Ethan Grant ,  Lydia Greenlees ,  Yihong Yao ,  Melissa Parker

IPC: C07K16/18 ,  G01N33/68

CPC classification number: G01N33/6884 ,  A61K9/0019 ,  A61K9/0053 ,  A61K9/0073 ,  A61K31/137 ,  A61K31/56 ,  A61K31/58 ,  A61K39/3955 ,  A61K2039/54 ,  A61P11/00 ,  A61P11/06 ,  A61P17/00 ,  C07K16/18 ,  C07K16/244 ,  C07K16/2866 ,  C07K2317/33 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/30 ,  G01N33/68 ,  G01N33/6869 ,  G01N33/6881 ,  G01N2800/12 ,  G01N2800/122 ,  G01N2800/202 ,  G01N2800/52

Abstract: This disclosure provides a robust, sensitive, and specific assay for the detection and measurement of periostin levels in samples obtained from human patients having, or suspected of having an IL-13-mediated disease or disorder. The disclosure further provides novel antiperiostin monoclonal antibodies that recognize at least isoforms 1, 2, 3, 4, 7, and 8 of human periostin, and assay kits comprising one or more of these antibodies.

Abstract translation: 该公开内容提供了用于检测和测量从患有或怀疑具有IL-13介导的疾病或病症的人类患者获得的样品中的骨膜素水平的稳健，灵敏和特异性测定。 本公开进一步提供了至少识别人骨膜素的同种型1,2,3,4,7和8的新型抗孕激素单克隆抗体，以及包含这些抗体中的一种或多种的测定试剂盒。